7 research outputs found
Self-management of chronic pain in Malaysian patients: effectiveness trial with 1-year follow-up
- Author
- A Asghari
- AC Williams deC
- AKY Man
- AM Elliott
- C Bombardier
- F Mukhtar
- FM Blyth
- FM Blyth
- FM Blyth
- G Waddell
- H Breivik
- H Flor
- J Cohen
- J Guzmán
- JA Turner
- K Demyttenaere
- L McCracken
- L Swartz
- M Kitahara
- M Korff Von
- MJL Sullivan
- MK Nicholas
- MK Nicholas
- MK Nicholas
- MN Friesen
- MS Cardosa
- PF Lovibond
- R Buchbinder
- R Taylor
- S Morley
- S Morley
- T Bodenheimer
- WP Dunlop
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2011
- Field of study
Self-management of chronic illnesses has been widely recognised as an important goal on quality of life, health service utilisation and cost grounds. This study describes the first published account on the application of this approach to people suffering from chronic pain conditions in a Southeast Asian country, Malaysia. A heterogeneous sample of chronic pain patients in Malaysia attended a 2-week cognitive–behavioural pain management programme (PMP) aimed at improving daily functional activities and general psychological well-being. Complete datasets from 70 patients out of 102 patients who attended 11 programmes conducted from 2002 to 2007, as well as the 1-month and 1-year follow-up sessions at the hospital clinic, are reported. The pre- to post-treatment results on self-report measures indicate that significant gains were achieved on the dimensions of pain, disability and psychological well-being. These gains were maintained at both 1-month and 1-year follow-ups. The results mirror those reported from similar interventions in Europe and North America and indicate the concept of self-management of a chronic illness is acceptable and meaningful to Asian patients. Importantly, the achieved outcomes were independent of gender and ethnic group status
Fumonisins affect the intestinal microbial homeostasis in broiler chickens, predisposing to necrotic enteritis
- Author
- AB Poersch
- AC Ericsson
- AL Keyburn
- AL Keyburn
- An Martel
- AP Bracarense
- AR Gholamiandehkordi
- AR Gholamiandekhordi
- B Devriendt
- B Grenier
- B Shojadoost
- Barbara Novak
- Birgit Antlinger
- C Burel
- CG Baums
- CL Thompson
- D Stanley
- D Tardieu
- DR Ledoux
- E Streit
- EM Binder
- ENC Tessari
- European Commission
- F Immerseel Van
- F Immerseel Van
- F Wu
- Filip Van Immerseel
- Frank Pasmans
- Freddy Haesebrouck
- G Antonissen
- G Antonissen
- G Muyzer
- G Schatzmayr
- Gunther Antonissen
- HJ Dunham
- IP Oswald
- J Snel
- JF Leslie
- JG Songer
- JK Cheung
- K Basso
- KA Voss
- L Timbermont
- LF Kubena
- M Dec
- M Drew
- M Lessard
- Marc Verlinden
- Mathias Devreese
- MH Henry
- Mia Eeckhout
- N Liao
- P Pinton
- R Williams
- RD Pridmore
- RH Rauber
- Richard Ducatelle
- RM Ragione La
- RT Riley
- RT Riley
- S Bouhet
- S Bouhet
- S Monbaliu
- Sarah De Saeger
- SB Wu
- Siska Croubels
- ST Tran
- TP Brown
- TS Weibking
- Venessa Eeckhaut
- Z Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Fumonisins (FBs) are mycotoxins produced by Fusarium fungi. This study aimed to investigate the effect of these feed contaminants on the intestinal morphology and microbiota composition, and to evaluate whether FBs predispose broilers to necrotic enteritis. One-day-old broiler chicks were divided into a group fed a control diet, and a group fed a FBs contaminated diet (18.6 mg FB1+ FB2/kg feed). A significant increase in the plasma sphinganine/sphingosine ratio in the FBs-treated group (0.21 +/- 0.016) compared to the control (0.14 +/- 0.014) indicated disturbance of the sphingolipid biosynthesis. Furthermore, villus height and crypt depth of the ileum was significantly reduced by FBs. Denaturing gradient gel electrophoresis showed a shift in the microbiota composition in the ileum in the FBs group compared to the control. A reduced presence of low-GC containing operational taxonomic units in ileal digesta of birds exposed to FBs was demonstrated, and identified as a reduced abundance of Candidatus Savagella and Lactobaccilus spp. Quantification of total Clostridium perfringens in these ileal samples, previous to experimental infection, using cpa gene (alpha toxin) quantification by qPCR showed an increase in C. perfringens in chickens fed a FBs contaminated diet compared to control (7.5 +/- 0.30 versus 6.3 +/- 0.24 log10 copies/g intestinal content). After C. perfringens challenge, a higher percentage of birds developed subclinical necrotic enteritis in the group fed a FBs contaminated diet as compared to the control (44.9 +/- 2.22% versus 29.8 +/- 5.46%)
Electroweak parameters of the z0 resonance and the standard model
- Author
- Abbaneo D
- ABREU P
- Adam W
- Adami F
- ADEVA B
- Adriani O
- Adye T
- Aguilar-Benitez M
- Ajaltouni Z
- Akbari H
- Akesson T
- Albanese JP
- Alcaraz J
- Alekseev GD
- Alemany R
- Alexander G
- Allen P
- Allison J
- Allport PP
- Almehed S
- Aloisio A
- Alted F
- Altoon B
- Alverson G
- Alviggi MG
- Alvsvaag SJ
- Amaldi U
- Amendolia SR
- An Q
- Anassontzis EG
- Anderhub H
- Anderson AL
- Anderson KJ
- Andreev VP
- Angelov T
- Antilogus P
- Antonelli A
- Antonov L
- Antreasyan D
- Apel WD
- Apollinari G
- Arce P
- Arcelli S
- Arefev A
- Armitage JC
- Ashman JG
- Ashton P
- Asman B
- Astbury A
- Astier P
- Atwood WB
- Aubert JJ
- Augustin JE
- Augustinus A
- Axen D
- Azemoon T
- Aziz T
- Azuelos G
- Baba PVKS
- Badier J
- Bagliesi G
- Bagnaia P
- Bahan GA
- Baillon P
- Baines JTM
- Bakken JA
- Baksay L
- Baldini R
- Ball AH
- Ball RC
- Bambade P
- Banerjee S
- Banks J
- Bao J
- Barao F
- Barberio E
- Barbiellini G
- Barczewski T
- Bardadin-Otwinowska M
- Bardin DY
- Barker GJ
- Barlow RJ
- Baroncelli A
- Barone L
- Barring O
- Bartl W
- Bates MJ
- Batignani G
- Batley JR
- Battaglia M
- Baubillier M
- Bauerdick LAT
- Bay A
- Beaudoin G
- Beck A
- Becker J
- Becker U
- Becket H
- Becks KH
- Beeston CJ
- Begalli M
- Behnke T
- Behrens J
- Beilliere P
- Beingessner S
- Belk AT
- Bell KW
- Bella G
- Bellantoni L
- Belokopytov YA
- Belokopytov YA
- Beltran P
- Beltran P
- Benchouk C
- Bencivenni G
- Bencze GL
- Benedic D
- Benedic D
- Benlloch JM
- Benlloch JM
- Berdugo J
- Berges P
- Berggren M
- Berggren M
- Bernard V
- Bertin V
- Bertrand D
- Bertrand D
- Bertucci B
- Betev BL
- Betheke S
- Beuselinck R
- Biagi SF
- Biagi SF
- Bianchi F
- Bianchi F
- Bibby JH
- Bibby JH
- Biebel O
- Biland A
- Bilenky SM
- Bilenky SM
- Billoir P
- Billoir P
- Binder U
- Binnie DM
- Bird F
- Bizzarri R
- Bjarne J
- Blaising JJ
- Bloch D
- Bloch-Devaux B
- Bloemeke P
- Blondel A
- Bloodworth IJ
- Blucher E
- Blum W
- Blumenfeld B
- Blyth S
- Bobbink GJ
- Bocciolini M
- Bock P
- Boeck RK
- Boehm A
- Bogolubov PN
- Bologna G
- Bolognese T
- Bonapart M
- Bonesini M
- Bonissent A
- Bonivento W
- Bonneaud G
- Bonvicini G
- Booth CN
- Booth PSL
- Boratav M
- Borgeaud P
- Borgia B
- Borisov G
- Borner H
- Bosch HM
- Bosio C
- Bosisio L
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- Botterill DR
- Bottigli U
- Boucrot J
- Boudreau J
- Bougerolle S
- Bouquet B
- Bourilkov D
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- Bourquin M
- Boutigny D
- Bouwens BT
- Bowdery CK
- Boyle O
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- Brabson B
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- Braems F
- Braibant S
- Branchini P
- Brand KD
- Brandl B
- Brandt S
- Branson JG
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- Brenner RA
- Breuker H
- Bricman C
- Brient JC
- Brock IC
- Brodbeck TJ
- Brown D
- Brown RCA
- Brown RM
- Brummer N
- Brun R
- Brunet JM
- Bruyant F
- Bugge L
- Buijs A
- Buisson C
- Bujak A
- Buran T
- Burckhart HJ
- Burger JD
- Burkhardt H
- Burmeister H
- Burnett TH
- Burq JP
- Busenitz J
- Buttar C
- Buytaert J
- Caccia M
- Cai XD
- Callot O
- Calvi M
- Camacho-Rozas AJ
- Cameron W
- Campagne JE
- Campana P
- Campion A
- Camporesi T
- Canale V
- Candlin DJ
- Cao F
- Capell M
- Capiluppi P
- Capon G
- Carbonara F
- Cardenal F
- Carminati P
- Carnegie RK
- Carney R
- Carpinelli M
- Carroll L
- Carter AA
- Carter JM
- Carter JR
- Cartwright S
- Caso C
- Castelli E
- Castillo-Gimenez MV
- Catacci AM
- Catanesi MG
- Cattai A
- Cattaneo M
- Cattaneo P
- Cavallo FR
- Cerrada M
- Cerrito L
- Cerutti F
- Cesaroni F
- Chang CY
- Chang YH
- Chapkin MM
- Charlton DG
- Charpentier P
- Chaturvedi UK
- Checchia P
- Chelkov GA
- Chemarin M
- Chen A
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- Chen GM
- Chen HF
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- Chevalier L
- Chiarella V
- Chiefari G
- Chien CY
- Chikilev OG
- Chliapnikov PV
- Chollet F
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- Chrin JTM
- Cinabro D
- Ciocci MA
- Cirio R
- Civinini C
- Clara MP
- Clare I
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- Clift RW
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- Cohn HO
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- Commichau V
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- Contreras JL
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- Couch M
- Couchot F
- Coupland M
- Courvoisier D
- Cowan G
- Cowen DF
- Crawley HB
- Creanza D
- Crennell DJ
- Crespo JM
- Crijns F
- Criscuolo P
- Crosetti G
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- Crozon M
- Cuevas-Maestro J
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- Cui XY
- Czellar S
- D'Alessandro R
- D'Almagne B
- D'Ettorre-Piazzoli B
- Dado S
- Dagoret S
- Dahl-Jensen E
- Dai TS
- Dallavalle M
- Dam M
- Damgaard G
- Darbo G
- Daubie E
- Dauncey PD
- Davenport M
- David P
- Davier M
- De Angelis A
- de Asmundis R
- De Beer M
- De Boeck H
- de Boer W
- De Clercq C
- De Fez Laso MDM
- De Groot N
- De Jong S
- de La Vaissiere C
- De Lotto B
- de Notaristefani F
- de Palma M
- Debu P
- DECAMP D
- Defoix C
- Degre A
- Dehning B
- Deiters K
- Delfino M
- Delikaris D
- Dell'Orso R
- Delorme S
- Delpierre PA
- Demaria N
- Demin A
- Denes P
- Deninno MM
- Derkaoui JE
- Deschizeaux B
- Dhina M
- Di Ciaccio L
- DiBitonto D
- Dieckmann A
- Diemoz M
- Dietl H
- Diez Hedo F
- Dijkstra H
- Dimitrov HR
- Dinsdale M
- Dionisi C
- Dittmar M
- Divia R
- Dizit MS
- Djama F
- Dogru M
- Dolbeau J
- Donszelmann M
- Dornan PJ
- Doroba K
- Dova MT
- Dracos M
- Drago E
- Drees J
- Drevermann H
- Driever T
- Dris M
- Duchesneau D
- Duchovni E
- Duckeck G
- Duerdoth IP
- Dufour Y
- Dugeay S
- Duinker P
- Dulinski W
- Dumas DJP
- Duran I
- Dydak F
- Dzhelyadin RI
- Eckerlin G
- Edgecock TR
- Edwards M
- Eek L
- Eerola PAM
- Efthymiopoulos I
- Ekelof TJC
- Ekspong G
- El Fellous R
- El-Mamouni H
- Elliot-Peisert A
- Elxombe PA
- Engel JP
- Engler A
- Eppling FJ
- Erne FC
- Estabrooks PG
- Etienne F
- Etzion E
- Extermann P
- Fabbretti R
- Fabbri FL
- Faber G
- Fabre M
- Fackler O
- Falciano S
- Falvard A
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- Farilla A
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- Fay J
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- Folegati P
- Fong DG
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- Forconi G
- Foreman T
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- Gilles JD
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- Goldberg J
- Goldfarb S
- Golovatyuk VM
- Gomez-Cadenas JJ
- Gong ZF
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- Gruenewald MW
- Grupen C
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- Guy J
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- Hagemann J
- Hahn F
- Hahn M
- Haider S
- Hajduk Z
- Hakansson A
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- Hallgren A
- Hamacher K
- Hamel de Monchenault G
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- Hansl-Kozanecka T
- Hanson GG
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- Herbst I
- Hernandez JJ
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- Hobbs JD
- Hobson RR
- Hochman D
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- Hou SR
- Houlden MA
- Howarth CP
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- Hughes-Jones RE
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- Lohmann W
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- Loken JG
- Longo E
- Lopez-Aguera MA
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- Lorah JM
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- Marchionni A
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- Massaro GGG
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- Meola G
- Merk M
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- Moeller M
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- Morand G
- Morand R
- Morettini P
- Morganti S
- Mori T
- Morton WT
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- Never C
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- Oakham FG
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- Orito S
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- Ouraou A
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- Pepe-Altarelli M
- Perevozchikov V
- Perez P
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- Pernicka M
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- Perrotta A
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- Pieri M
- Pierre F
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- Pimenta M
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- Poffenberger PR
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- Roeser U
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- Spassoff T
- Spickermann T
- Spiess B
- Spillantini P
- Spiriti E
- Springer RW
- Sproston M
- Squarcia S
- St Denis R
- Stack H
- Stahl A
- Stanescu C
- Starosta R
- Stavropoulos GD
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- Stickland DP
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- Takashima M
- Takeda H
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- Tarem S
- Tarkovsky E
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- Treille D
- Trevisan U
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- Vogel H
- Vogt H
- Vollmer M
- Volponi S
- von Dardel G
- Von der Schmitt H
- Von Krogh J
- Vorobev I
- Vorobyov AA
- Voulgaris G
- Voutilainen M
- Vrba V
- Vuilleumier L
- Wachsmuth H
- Wadhwa M
- Wagner A
- Wahl C
- Wahlen H
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- Waldner F
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- Weisz S
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- Winter M
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- Wu RJ
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- Wu SL
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- Wunsch M
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- Wyslouch B
- Xie Y
- Xie YY
- Xu D
- Xu R
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- Xue ZL
- Yaari R
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- Yang CG
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- Yang Y
- Ye CH
- Ye JB
- Ye Q
- Yeh SC
- Yekutieli G
- Yepes P
- Yin ZW
- You JM
- Yzerman M
- Zaccardelli C
- Zacharov I
- Zaitsev A
- Zalewska-Bak A
- Zalewski P
- Zehnder L
- Zemp P
- Zeng M
- Zeng Y
- Zeuner W
- Zevgolatakos E
- Zhang DH
- Zhang G
- Zhang J
- Zhang Z
- Zhang ZP
- Zhao W
- Zhou JF
- Zhu RY
- Zhuang HL
- Zichichi A
- Zimin NI
- Zito G
- Zito M
- Zitoun R
- Zobernig G
- Zografou P
- Zomer F
- Zorn GT
- Zukanovich-Funchal R
- Zumerle G
- Zuniga J
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/1992
- Field of study
Contains fulltext :
124399.pdf (publisher's version ) (Open Access
Klinische Aspekte der EKT — Anwendungsrichtlinien und -empfehlungen
- Author
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- M Thuppal
- M Weinstein
- MA Hill
- Marcost
- MB Currier
- MB Weinger
- MC Kelsey
- MC Webb
- Mcallistertw
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- MV Rudorfer
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- MW Agelink
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- MZ Goldstein
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- N Bazin
- N Ghaziuddin
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- N Gormley
- N Kathmann
- N Kathmann
- N Loimer
- N Michael
- N Nedopil
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- N Savitsky
- N Savitsky
- NG Ranen
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- OC Zachrisson
- OF Weis
- OP Heinonen
- P Abiuso
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- RJ Ruxin
- RJ Zielinski
- RJ Zielinski
- RJ Zielinski
- RJ Zielinski
- RL Barrow
- RM Greenberg
- RM Parikh
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- RS Mallakh
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- RS Shiwach
- RS Shiwach
- Russo-NeustadtA
- RW Heinrichs
- S Al
- S Block
- S Curran
- S Gregory
- S Gupta
- S Gupta
- S Hirose
- S Holmberg
- S Khanna
- S Lippman
- S Mukherjee
- S Mukherjee
- S Mukherjee
- S Mukherjee
- S Pridmore
- S Reiter-Theil
- S Restifo
- S Safaris
- S Saito
- S Sikdar
- S Smith
- S Sudha
- SA Hunt
- SA Montgomery
- SB Guze
- SB Lippmann
- SC Bhatia
- SC Bhatia
- SD Levy
- SG Peters
- SH Bail
- SH Bail
- SH Bailine
- SH Lisanby
- SH Lisanby
- SJ Cunningham
- SJ Hartmann
- SK Ahmed
- SL Dubovsky
- SL Dubovsky
- SL Ruedrich
- SM Benbow
- SM Benbow
- SM Shnider
- SN Caroff
- SP Calloway
- SP Wengel
- SR Kay
- SS Snow
- Stoudemirea
- Suppest
- SV Faraone
- SY Dolinski
- T Abboud
- T Ali-Melkkila
- T Frodl
- T Lock
- T Pearlman
- T Pugh
- T Schwarz
- T Wetterling
- TA Tomac
- TD Hurwitz
- TD Schneekloth
- TF Aarre
- TF Rowe
- TR Price
- TR Price
- TT Nguyen
- TT Postolache
- U Cerletti
- U Müller
- U Viparelli
- V Milstein
- V Pfaffenrath
- V Rao
- W Carlyle
- W Chanpattana
- W Chanpattana
- W Chanpattana
- W Chanpattana
- W Chanpattana
- W Coryell
- W Fu
- W Fu
- W Fu
- W Kalow
- W Karliner
- W Mombour
- W Shellenberger
- WA Hauser
- WB Bundesärztekammer
- Wetterlingt
- WF Daniel
- WH Roccaforte
- WJ Bates
- WJ Burke
- WJ Burke
- WJ Pankratz
- WK Summers
- WK Tang
- WM Hooten
- WM Hooten
- WR Dubin
- WV Mccall
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- Z Ding
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- Z Kaplan
- Z Kaplan
- Z Wajima
- Z Wajima
- ZN Stowe
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2004
- Field of study
Clinical manifestations of intermediate allele carriers in Huntington disease
- Author
- 't Hart Ep
- Aanonsen No
- Aaserud O
- Acera Gil Ma
- Akhtar S
- Allain P
- Almagro Ca
- Almeida M
- Alonso Frech F
- Andrew A
- Andrews T
- Anjum U
- Anna Bryl Ja
- Antczak J
- Antequera Torres Mm
- Arbelo Jm
- Arkuszewski M
- Armstrong R
- Arques Pn
- Arran N
- Azulay Jp
- Baake V
- Baake V
- Babiloni B
- Bachmeier M
- Bachoud Lévi Ac
- Bachoud Lévi Ac
- Badei F
- Banaszkiewicz K
- Bandmann O
- Barbera Ma
- Barnett L
- Barral Vm
- Barth K
- Barth K
- Bartoli C
- Bas J
- Bascuñana M
- Bechtel N
- Beckmann H
- Bek J
- Bentivoglio Ar
- Berglund P
- Bertini E
- Bertrand M
- Bethwaite P
- Betz S
- Biunno I
- Bjørgo K
- Boczarska Jedynak M
- Boelmans K
- Bohlen S
- Bojakowska Jaremek K
- Bojarsky Jk
- Bonelli Rm
- Borgerød N
- Bos R
- Bos R
- Bosca M
- Boudali L
- Bourdet C
- Boćwińska D
- Bradbury A
- Brockie P
- Brown S
- Brugada Carmen Peiró Vilaplana Fc
- Bruno S
- Buck A
- Burguera Ja
- Burgunder Jm
- Burgunder Jm
- Busquets N
- Busse M
- Butcher C
- Bárcenas Ah
- Błaszczyk M
- Calado A
- Caldentey Jg
- Caldentey Jg
- Caldentey Jg
- Callaghan J
- Callaghan J
- Callaghan J
- Calopa M
- Calvas F
- Calzado N
- Campolongo A
- Cannella M
- Capodarca S
- Carruesco Gt
- Cass G
- Catena Jl
- Chabot C
- Charpentier S
- Cheriet S
- Chu E
- Ciach Wysocka E
- Ciesielska A
- Classen Sj
- Clayton C
- Clenaghan C
- Cléret L
- Coarelli G
- Codella V
- Coebergh J
- Coelho M
- Come A
- Connemann J
- Constantinescu R
- Cormio C
- Corrales Kb
- Cortegana Ep
- Cosgrove J
- Couette M
- Coulthard E
- Craufurd D
- Crooks J
- Cubillo Pt
- Cubillo Pt
- Cubo E
- Curtis A
- D'Alessio B
- Davidson L
- Davison J
- De Gregorio F
- De Michele G
- De Nicola A
- de Souza J
- de Tommaso M
- Debruxelles S
- Dec M
- Dedichá Nr
- Delfini M
- Dellomonaco Ar
- Descals Am
- Di Maio L
- Di Renzo M
- Diago Eb
- Dias M
- Diercks G
- Difruscolo O
- Dipple H
- Dixon K
- Doherty K
- Donovan Jo
- Dose M
- Downie L
- Dramstad E
- Dressler D
- Duché C
- Dumas Em
- Dunnett S
- Dunnett Sb
- Dziadkiewicz A
- Ecker D
- Ecker D
- Eddy C
- Edwards R
- Eklund P
- Elifani F
- Ellrichmann G
- Esposito C
- Eusebio A
- Fairtlough H
- Fannemel M
- Feliz Cf
- Fenollar Mdel M
- Fernandez de Bobadilla R
- Fernandez Jdel V
- Fernandez Cm
- Ferraldeschi M
- Ferreira Jj
- Ferreira Jj
- Ferrer Pq
- FIGORILLI MICHELA
- Fillingham K
- Finisterra Am
- Finisterra Am
- Fluchere F
- Focseneanu C
- Fortunato F
- Foster J
- Foustanos I
- Frades B
- Francis F
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- Fredlund G
- Frich J
- Frontali M
- Frost J
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- Gallantree D
- Ganos C
- García de Yébenes J
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- García A
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- Garreau C
- Gaston I
- Gayde Stephan S
- Geitner C
- Genoves C
- Gethin L
- Ghelli E
- Ghenam A
- Gill P
- Gilling M
- Ginestroni A
- Goerendt I
- Gogol A
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- Goizet C
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- Gomez Esteban Jc
- González A
- González S
- Gorospe A
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- Gorzolla H
- Gowers L
- Grabska N
- Grosjean H
- Guedes Lc
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- Guisasola Lm
- Gundersen H
- Guérid Ma
- Göpfert N
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- Haggag K
- Haider S
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- Handley Oj
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- Harrison D
- Hayward B
- Heiberg A
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- Heinicke W
- Held C
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- Hensman D
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- Herrera Cd
- Herrmann L
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- Hiivola H
- Hjermind L
- Hobson E
- Hoffmann R
- Hofstetter N
- Holmes K
- Horta Barba A
- Howard L
- Hughes M
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- Hypponen H
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- Høsterey Ugander U
- Illmann T
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- Jacopini G
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- Jamieson S
- Jamrozik Z
- Janik P
- Januário C
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- Johannessen Ch
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- José García Ruíz P
- José Sainz Artiga M
- Júlio F
- Kaczmarczyk A
- Kaelin A
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- Kampstra A
- Kazoka M
- Kesse A
- Khalil H
- Klebe S
- Klimberg A
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- Konkel A
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- Krysa W
- Kubowicz E
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- Kłodowska Duda G
- Lafoucrière D
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- Longthorpe M
- Lopera Mr
- Lovo F
- Lozano Ps
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- MARROSU FRANCESCO
- Martikainen K
- Martin Vp
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- Martinez Horta S
- Martinez Jaurrieta Md
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- Martino T
- Martín I
- Martínez Descals A
- Martínez Nr
- Massarelli M
- Mata Mp
- Matheson K
- Mazzante I
- Mcdonnell S
- Mcentagart M
- Mckenzie S
- Mechi C
- Mendes T
- Merino Bt
- Mestre T
- Mestre T
- Middleton J
- Miedzybrodzka Z
- Milkereit E
- Minet C
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- Monza D
- Moreau Lv
- Moreno Pg
- Morgado G
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- Mundler L
- Muroni A
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- Musacchio T
- Musgrave H
- Muñoz Jm
- Mühlbäck A
- Münchau A
- Mütze L
- Narożańska E
- Neleborn Lingefjärd L
- Nemeth Ah
- Nepper S
- Nevitt L
- Nielsen J
- Nielsen Je
- Niess A
- Noad R
- Novak M
- Nowak M
- Nowak M
- Nöth K
- O'Donovan K
- O'Donovan K
- Oehmen M
- Olivier A
- Opala G
- Orth M
- Orth M
- Oughton E
- Owen M
- Padieu H
- Paganini M
- Pagonabarraga J
- Palmer A
- Pardo Sa
- Pariente J
- Parkinson A
- Partington Jones L
- Pastor Bv
- Patel A
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- Patino Df
- Patton M
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- Periañez Jm
- Peterson M
- Petrollini M
- Peña Jc
- Phillips M.
- Piacentini S
- Piedad J
- Pierre M
- PIRAS VALERIA
- Powell K
- Pradella S
- Price K
- Prieto Mp
- Probst D
- Prouzet J
- Prundean A
- Pueyo Am
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- Quarrell O
- Rae D
- Rakowicz M
- Raman A
- Ramirez Il
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- Rola R
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- Romero I
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- Romoli Am
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- Rosa Mm
- Rosby O
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- Rothery J
- Rowett L
- Rudzińska M
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- Ruiz Idiago Jm
- Rummel J
- Rumpf S
- Russo Cv
- Ryglewicz D
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- Salgueiro A
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- Schiefer J
- Schlangen C
- Schmalfeld J
- Schneider A
- Schoonderbeek A
- Schrader C
- Schwenk D
- Schüpbach M
- Sciruicchio V
- Sebaiti M
- Sebastián Ar
- Sebastián Ar
- Seliverstov Y
- Semedo C
- Sempołowicz J
- Seris A
- Serpino C
- Sienkiewicz Jarosz H
- Sieradzan K
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- Sitek E
- Siuda G
- Slawek J
- Snowden J
- Solberg O
- Sollom A
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- Sorbi S
- Sorrentino P
- Spampinato U
- Squitieri F
- Stebler Y
- Stenwak A
- Stockholm J
- Stompel D
- Stopford C
- Stubbe L
- Stępniak I
- Summers F
- Sułek A
- Szczudlik A
- Szczygieł E
- Szinwelski M
- Sánchez V
- Süssmuth S
- Tabrizi S
- Tabrizi Sj
- Tacik P
- Tartari Díaz Zorita Jp
- Taylor C
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- Timewell E
- Timings L
- Toscano J
- Townhill J
- Townhill J
- Trautmann S
- Trender Gerhard I
- Tucci T
- Tuuha K
- Udaeta B
- Uhrova T
- Ure A
- VACCA MELISA IRIS SABINA
- Valadas A
- Valentine R
- van den Bogaard Sj
- van Hout Ms
- Van Paemel D
- van Vugt Jp
- van Walsem M
- van Walsem Mr
- Vandenberghe W
- Vangsted Hansen C
- Vaquie V
- Vaughn V
- Ventura Mf
- Verellen Dumoulin C
- Verellen Dumoulin C
- Verhoeven M
- Verny C
- Verstraelen N
- Vervoitte L
- Vezza M
- Vieira da Silva W
- Viladrich Cm
- Villa C
- Villanueva C
- Villanueva Má
- Vinther Jensen T
- Wahlström J
- Wahlström J
- Warner T
- Wasielewska A
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- Wehus R
- Werner Cj
- Westmoreland L
- Weydt P
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- Witkowski G
- Witkowski G
- Wiśniewski B
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- Yardumian P
- Yates S
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- Yudina E
- Zaremba J
- Zaremba J
- Zaugg Sw
- Zdzienicka E
- Zea Sevilla Ma
- Zielonka D
- Zielonka D
- Zielonka E
- Zinzi P
- Zinzi P
- Ziora Jakutowicz K
- Zittel S
- Šašinková P
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2016
- Field of study
Objective: There is controversy about the clinical consequences of intermediate alleles (IAs) in Huntington disease (HD). The main objective of this study was to establish the clinical manifestations of IA carriers for a prospective, international, European HD registry. Methods: We assessed a cohort of participants at risk with <36 CAG repeats of the huntingtin (HTT) gene. Outcome measures were the Unified Huntington's Disease Rating Scale (UHDRS) motor, cognitive, and behavior domains, Total Functional Capacity (TFC), and quality of life (Short Form-36 [SF-36]). This cohort was subdivided into IA carriers (27-35 CAG) and controls (<27 CAG) and younger vs older participants. IA carriers and controls were compared for sociodemographic, environmental, and outcome measures. We used regression analysis to estimate the association of age and CAG repeats on the UHDRS scores. Results: Of 12,190 participants, 657 (5.38%) with <36 CAG repeats were identified: 76 IA carriers (11.56%) and 581 controls (88.44%). After correcting for multiple comparisons, at baseline, we found no significant differences between IA carriers and controls for total UHDRS motor, SF-36, behavioral, cognitive, or TFC scores. However, older participants with IAs had higher chorea scores compared to controls (p 0.001). Linear regression analysis showed that aging was the most contributing factor to increased UHDRS motor scores (p 0.002). On the other hand, 1-year follow-up data analysis showed IA carriers had greater cognitive decline compared to controls (p 0.002). Conclusions: Although aging worsened the UHDRS scores independently of the genetic status, IAs might confer a late-onset abnormal motor and cognitive phenotype. These results might have important implications for genetic counseling. ClinicalTrials.gov identifier: NCT01590589
Clinical and genetic characteristics of late-onset Huntington's disease
- Author
- Aanonsen No
- Aaserud O
- Abbruzzese G
- Acera Gil Ma
- Ackermann O
- Adarmes A
- Agarwal V
- Agosti C
- Akhtar S
- Alaerts N
- Alarcón Md
- Albanese A
- Allain P
- Almagro Ca
- Almeida M
- Alonso-Frech F
- Alusi S
- Anderson M
- Andersson C
- Andrade C
- Andrew A
- Andrews T
- Andrews T
- Andrich J
- Anheim M
- Anjum U
- Anna Bryl Ja
- Annic A
- Antczak J
- Antequera Torres Mm
- Antonova V
- Arbelo Jm
- Arkuszewski M
- Armstrong R
- Armstrong R
- Arntsen V
- Arques Pn
- Arran N
- Azulay Jp
- Baake V
- Babiloni B
- Bachmeier M
- Bachoud-Lévi Ac
- Bachoud-Lévi Ac
- Badei F
- Bailey W
- Banaszkiewicz K
- Bandettini di Poggio M
- Bandmann O
- Barbera Ma
- Barker Ra
- Barlati S
- Barral Vm
- Barrero F
- Barrett W
- Barth K
- Barth K
- Barthélémy R
- Bartoli C
- Barun N
- Bas J
- Bascuñana M
- Becanovic K
- Bechtel N
- Beckmann H
- Bek J
- Bellonet M
- Benaich S
- Benaminov S
- Benito Dm
- Bentivoglio Ar
- Bentivoglio Ar
- Berglund M
- Berglund M
- Berglund P
- Bergmann U
- Bernal-Escudero M
- Bernard T
- Bertini E
- Bethwaite P
- Betz S
- Beuth M
- Bezdíček O
- Bijlsma Emilia K
- Bioux S
- Biunno I
- Björnsson E
- Bjørgo K
- Bjørnevoll I
- Bled D
- Bliaux E
- Blin S
- Blinkenberg Eø
- Blondeau L
- Boczarska-Jedynak M
- Boelmans K
- Bohlen S
- Boissé Mf
- Bojakowska-Jaremek K
- Bojarsky Jk
- Bonelli Rm
- Bonelli Rm
- Bonelli Rm
- Bonneau D
- Boogaerts A
- Boogaerts A
- Borgerød N
- Bos R
- Bos R
- Bosca M
- Bosredon C
- Bost M
- Boster S
- Boudali L
- Bove F
- Boćwińska D
- Bradbury A
- Braunwarth Em
- Brice A
- Brockie P
- Bronzova J
- Brown P
- Brugada Fc
- Brugger F
- Bruno S
- Bruun A
- Buchanan L
- Buck A
- Buongiorno Mt
- Buratti L
- Burguera Ja
- Burgunder Jm
- Burgunder Jm
- Burgunder Jm
- Burn J
- Burrows L
- Busquets N
- Busse M
- Butcher C
- Bárcenas Ah
- Böringer R
- Bürk K
- Błaszczyk M
- Cabaret M
- Calado A
- Calandra-Buonaura G
- Caldentey Jg
- Caldentey Jg
- Caldentey Jg
- Callaghan J
- Callaghan J
- Callaghan J
- Calmeyn G
- Calopa M
- Calvas F
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- Wiśniewski B
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- Yardumian P
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- Åman J
- Østern R
- Šašinková P
- Šenkárová Z
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30\u201350 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of 6435 or a UHDRS motor score of 645 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P <.001). Overall motor and cognitive performance (P <.001) were worse, however only disease motor progression was slower (coefficient, 120.58; SE 0.16; P <.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P <.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P <.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients
Clinical and genetic characteristics of late-onset Huntington's disease
- Author
- Aanonsen Nils Olaf
- Aaserud Olaf
- Abbruzzese Giovanni
- Acera Gil Maria Angeles
- Ackermann Oda
- Adarmes Astrid
- Agarwal Veena
- Agosti Chiara
- Akhtar Shahbana
- Alaerts Nick
- Alarcón María Dolores
- Albanese Alberto (ORCID:0000-0002-5864-0006)
- Allain Philippe
- Almagro Carmen Antúnez
- Almeida Manuel
- Alonso-Frech Fernando
- Alusi Sundus
- Anderson Mary
- Andersson Christian
- Andrade Carlos
- Andrew Alyson
- Andrews Thomasin
- Andrews Thomasin
- Andrich Jürgen
- Anheim Mathieu
- Anjum Uruj
- Anna Bryl Jacek Anioła
- Annic Agnès
- Antczak Jakub
- Antequera Torres María Martirio
- Antonova Victoria
- Arbelo José Matías
- Arkuszewski Michał
- Armstrong Richard
- Armstrong Richard
- Arntsen Vibeke
- Arques Penelope Navas
- Arran Natalie
- Azulay Jean-Philippe
- Baake Verena
- Babiloni Blandine
- Bachmeier Michael
- Bachoud-Lévi Anne-Catherine
- Bachoud-Lévi Anne-Catherine
- Badei Farideh
- Bailey Wendy
- Banaszkiewicz Krzysztof
- Bandettini di Poggio Monica
- Bandmann Oliver
- Barbera Miquel Aguilar
- Barker Roger A.
- Barlati Sergio
- Barral Verónica Mañanes
- Barrero Francisco
- Barrett Wendy
- Barth Katrin
- Barth Katrin
- Barthélémy Recka
- Bartoli Caterina
- Barun Nadia
- Bas Jordi
- Bascuñana Mónica
- Becanovic Kristina
- Bechtel Natalie
- Beckmann Heike
- Bek Judith
- Bellonet Marcellin
- Benaich Sandra
- Benaminov Stanislav
- Benito Dolors Moragues
- Bentivoglio Anna Rita (ORCID:0000-0002-9663-095X)
- Bentivoglio Anna-Rita
- Berglund Maria
- Berglund Måns
- Berglund Peter
- Bergmann Ulrike
- Bernal-Escudero Maravilla
- Bernard Tomáš
- Bertini Elisabetta
- Bethwaite Pamela
- Betz Sabrina
- Beuth Markus
- Bezdíček Ondřej
- Bijlsma Emilia K.
- Bioux Sandrine
- Biunno Ida
- Björnsson Elisabeth
- Bjørgo Kathrine
- Bjørnevoll Inga
- Bled Déborah
- Bliaux Evangeline
- Blin Stéphanie
- Blinkenberg Ellen Økland
- Blondeau Leily
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen Stefan
- Boissé Marie-Françoise
- Bojakowska-Jaremek Kamila
- Bojarsky Jaime Kulisevsky
- Bonelli Raphael M.
- Bonelli Raphael M.
- Bonelli Raphael M.
- Bonneau Dominique
- Boogaerts Andrea
- Boogaerts Andrea
- Borgerød Nancy
- Bos Reineke
- Bos Reineke
- Bosca Maria
- Bosredon Cecile
- Bost Marie
- Boster Sarah
- Boudali Lotfi
- Bove Francesco
- Boćwińska Dorota
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brice Alexis
- Brockie Peter
- Bronzova Juliana
- Brown Pauline
- Brugada Francisco Castera
- Brugger Florian
- Bruno Stefania
- Bruun Anu
- Buchanan Lindsay
- Buck Andrea
- Buongiorno María Teresa
- Buratti Lisa
- Burguera Juan Andres
- Burgunder Jean-Marc
- Burgunder Jean-Marc
- Burgunder Jean-Marc
- Burn John
- Burrows Liz
- Busquets Núria
- Busse Monica
- Butcher Cynthia
- Bárcenas Antonio Herranz
- Böringer Regina
- Bürk Katrin
- Błaszczyk Magdalena
- Cabaret Maryline
- Calado Ana
- Calandra-Buonaura Giovanna
- Caldentey Juan García
- Caldentey Juan García
- Caldentey Juan García
- Callaghan Jenny
- Callaghan Jenny
- Callaghan Jenny
- Calmeyn Godelinde
- Calopa Matilde
- Calvas Fabienne
- Calzado Noemi
- Campolongo Antonia
- Cannella Milena
- Capellari Sabina
- Capetian Philipp
- Capodarca Selene
- Cardoso Helena
- Carette Anne-Sophie
- Carrillo Fátima
- Carrière Nicolas
- Carruesco Gemma Tome
- Casado Rocío Villagrán
- Cass Ginette
- Castagliuolo Simona
- Castaldo Anna
- Catalli Claudio
- Catena Judit López
- Cavaco Sara
- Cação Gonçalo
- Charles Perrine
- Charpentier Sébastien
- Chen Simone
- Cheriet Samia
- Chiara Piccininni
- Chu Carol
- Chu Elvina
- Chu Elvina
- Ciach-Wysocka Ewelina
- Ciesielska Anna
- Classen Serge Jaumà
- Clayton Carole
- Clenaghan Catherine
- Cleret de Langavant Laurent
- Coarelli Giulia
- Codella Valentina
- Coebergh Jan
- Coelho Miguel
- Coleman Caroline
- Come Adrien
- Compostella Silvia
- Connemann Julia
- Constant Eric
- Constantinescu Radu
- Cormio Claudia
- Corrales Koldo Berganzo
- Cortelli Pietro
- Cosgrove Jeremy
- Costa Andreia
- Costa Cristina
- Coulthard Elizabeth
- Couttier Julien
- Craufurd David
- Craven Janet
- Craven Janet
- Crooks Jenny
- Cubillo Patricia Trigo
- Cubillo Patricia Trigo
- Cubo Esther
- Curtis Adrienne
- D'Alessio Barbara
- Damásio Joana
- Davidson Lynn
- Davies Rhys
- Davison Jill
- De Bruycker Christelle
- de Die-Smulders Christine EM.
- De Gregorio Francesca
- De Michele Giuseppe
- De Nicola Annunziata
- de Raedt Sylvie
- de Souza (Keylock) Jenny
- de Tommaso Marina
- Debilly Bérengère
- Debruxelles Sabrina
- Dec Małgorzata
- Decorte Eric
- Dedichá Nadia Rodríguez
- Defebvre Luc
- Deith Catherine
- Dekker Meike
- Delabaere Helène
- Delaigue Christine
- Delfini Marie
- Delliaux Marie
- Delval Arnaud
- Delvaux Isabelle
- Demonet Jean-François
- Depelchin Alizé
- Derost Philippe
- Descals Asunción Martínez
- Destee Alain
- Dewulf-Pasz Nelly
- Di Bella Daniela
- Di Donato Stefano
- Di Giacopo Raffaella
- Di Maio Luigi
- Di Maria Emilio
- Di Renzo Martina
- Diago Elena Bellosta
- Dias Margarida
- Diercks Gabriele
- Difruscolo Olimpia
- Dipple Heather
- Dixon Kathryn
- Dixon Kathryn
- Diéguez Esther
- Doherty Karen
- Dondaine Thibaut
- Donovan John O.
- Dose Matthias
- Dougherty Andrew
- Downie Lorna
- Dramstad Elisabeth
- Dressler Dirk
- Duché Charlotte
- Duffell Allison
- Dugauquier Florence
- Duits Annelien
- Dujardin Kathy
- Dumas Eve M.
- Dunnett Stephen
- Dunnett Stephen B.
- Duport Sophie
- Dupuis Michel
- Durif Franck
- Durr Alexandra
- Dziadkiewicz Artur
- Ecker Daniel
- Ecker Daniel
- Eddy Charlotte
- Edwards Maureen
- Edwards Rachel
- Eklund Pia
- Ekwall Camilla
- El-Nimr George
- Elifani Francesca
- Ellrichmann Gisa
- Esmaeilzadeh Mouna
- Esposito Chiara
- Esposito Federica
- Eusebio Alexandre
- Evans Carole
- Ewenczyk Claire
- Fairtlough Helen
- Fannemel Madeleine
- Fasano Alfonso
- Feliz Cici
- Fenollar María del Mar
- Fernandes Joana
- Fernandez de Bobadilla Ramon
- Fernandez Cristina Melgar
- Ferraldeschi Michela
- Ferrandes Giovanna
- Ferreira Joaquim J.
- Ferreira Joaquim J.
- Ferrer Pilar Quiléz
- Figorilli Michela
- Figuerola Begoña Jeweinat
- Fillingham Kay
- Finisterra Ana Maria
- Fisher Kate
- Flamez Anja
- Fletcher Amy
- Fluchere Frédérique
- Fortuna Lorenza
- Fortunato Fernanda
- Foster Jillian
- Foustanos Isabella
- Foy Kevin
- Frades Belén
- Fraisse Sonia
- Francis Flverly
- Francisque Hélène
- Franco Giovanni
- Fredlund Gunnel
- Freire-Patino Dawn
- Frich Jan
- Frich Jan C.
- Frontali Marina
- Frontali Marina
- Frost Julie
- Fullam Ruth
- Fullam Ruth
- Fullam Ruth
- Fuller Kathleen
- Fullerton Neil
- Gago Miguel
- Gallantree Deena
- Gallassi Roberto
- Gallentree Deena
- Ganos Christos
- Ganos Christos
- Garcia-Amigot Fermin
- García de Yébenes Justo
- García Moreno José Manuel
- García Ruíz Pedro José
- García Ana
- García-Ramos García Rocío
- Garde Monica Bascuñana
- Garrett Carolina
- Gaston Itziar
- Gayde-Stephan Sabine
- Geitner Carolin
- Gelderblom Harald
- Gellera Cinzia
- Genitrini Silvia
- Genoves Camille
- Germain Véronique
- Gerrans Emily
- Gerrtiz (nee Di Pietro) Anna
- Gethin Louise
- Ghelli Elena
- Gill Paul
- Gillardin Anne-Françoise
- Gilling Mette
- Ginestroni Andrea
- Girard Carole
- Giuliano Joe
- Goerendt Ines
- Gogol (formerly Kalbarczyk) Anna
- Gohier Bénédicte
- Goizet Cyril
- Golding Charlotte
- Golding Charlotte
- Gomez Esteban Juan Carlos
- González Amaia
- González Sonia
- Gonçalves Alexandra
- Good Jean-Marc
- Goodman Anna
- Gorzkowska Agnieszka
- Gorzolla Heike
- Gosling (nee Brown) Stefanie
- Goudie David
- Gowers Lesley
- Grabska Natalia
- Guedes Leonor Correia
- Guedes Leonor Correia
- Guenam Aicha
- Guia Dolors Badenes
- Guidubaldi Arianna
- Guimarães Joana
- Guisasola Luis Menéndez
- Gunner Kerry
- Guyant-Maréchal Lucie
- Guzman Natalie Valle
- Guérid Marie-Anne
- Göller Marie-Lousie
- Göpfert Nicole
- Gørvell Per F.
- Haggag Kathrine
- Haider Salman
- Haig-Brown Diane
- Haig-Brown Diane
- Hallam Caroline
- Hamer Stephanie
- Hamer Stephanie
- Hametner Eva-Maria
- Handley Olivia J.
- Handley Olivia J.
- Hannequin Didier
- Hannier Véronique
- Harding Alison
- Hare Marianne
- Hare Marianne
- Harris Kayla
- Harrison David
- Harrison Kaye
- Harrower Timothy
- Harrower Timothy
- Hartikainen Paivi
- Haug Marte Gjøl
- Hauge Erik
- Hayward Beverley
- Hayward Elaine
- Hecht Karen
- Heiberg Arvid
- Heiberg Arvid
- Heinicke Walburgis
- Held Christine
- Held Christine
- Hensman Davina
- Hepperger Caroline
- Hermoso Fátima Damas
- Hernanz Laura Casas
- Herranhof Brigitte
- Herrera Carmen Durán
- Herrmann Lennard
- Heywood Melanie
- Hidding Ute
- Hiivola Heli
- Hill Susan
- Hjermind Lena
- Ho Aileen
- Ho Carrie
- Hobson Emma
- Hoffmann Rainer
- Hofstetter Nina
- Hogenboom Marye
- Holas Christiane
- Holl (formerly Hödl) Anna
- Holmes Katrina
- Hopes Lucie
- Horta Andrea
- Horta Andrea
- Hotter Anna
- Howard Liz
- Hughes Max
- Hunger Ulrike
- Hunt Sarah
- Huson Susan
- Hussain Hasina
- Hussl Anna
- Hvalstedt Carina
- Hyppönen Hannele
- Hölzner Eva
- Høsterey-Ugander Ulrika
- Ialongo Tamara
- Ignatius Jaakko
- Illarioshkin Sergey
- Illarioshkin Sergey
- Illmann Torsten
- Ireland Jane
- Irvine Sarah
- Jacek (formerly Rödig
- Jachinska Katarzyna
- Jack Roisin
- Jacobs Milou
- Jacobsen Oda
- Jacopini Gioia
- Jacopini Gioia
- Jameau Laetitia
- Jamieson Stuart
- Jamrozik Zygmunt
- Janik Piotr
- Januário Cristina
- Jaramillo Javier Abril
- Jasińska-Myga Barbara
- Jauffret Céline
- Jesús Silvia
- Johannessen Cecilie Haggag
- Johansson Anders
- Johns Nicola
- Johnson Liz
- Jones Lesley
- Jones Mary
- Jones Una
- Jourdain Séverine
- Jung Hans H.
- Jurgens Caroline
- Justo Damian
- Jääskeläinen Outi
- Júlio Filipa
- Kaczmarczyk Aleksandra
- Kaelin Alain
- Kaiserova Michaela
- Kajula Outi
- Kaminska Anna
- Kaminski Barbara
- Kammel Gerit
- Kampstra Anne
- Kapfhammer Hans-Peter
- Kassar Abdulrahman
- Kavalier Fred
- Kazoka Mbombe
- Kennedy (nee Smith) Karen
- Kesse Andrea
- Keys Liane
- Khalil Hanan
- Khasanova Diana
- Kipps Christopher
- Klebe Stephan
- Klebe Stephan
- Klempir Jiri
- Klempíř Jiří
- Klempířová Olga
- Klimberg Aneta
- Klooster Jesper
- Klyushnikov Sergey
- Knight Caroline
- Koehli Jessica
- Kohl Zacharias
- Koivisto Susana Pro
- Koivisto Susana Pro
- Komati Suresh
- Konkel Agnieszka
- Kopishinskaya Svetlana
- Koppers Kerstin
- Koppitz Michael
- Korotysh Maria
- Kosinski Christoph Michael
- Kozay Christina
- Kramer Bianca
- Kraus Alison
- Kraus Alison
- Kraus Peter
- Krawczyk Malgorzata
- Kremer Berry
- Kremer Berry
- Krishnamoorthy Ashok
- Krysa Wioletta
- Krystkowiak Pierre
- Krystkowiak Pierre
- Kubowicz Ewelina
- Kurbatov Sergey
- Kwiecinski+ Hubert
- Kärppä Mikko
- Kłodowska – Duda Gabriela
- Ladurner Gunther
- Lafoucrière Danielle
- Lagha-Boukbiza Ouhaid
- Lahiri Nayana
- Lahiri Nayana
- Laing Hana
- Lamanna Claudia
- Lambeck Johann
- Landwehrmeyer Bernhard
- Landwehrmeyer G. Bernhard
- Lange Herwig
- Lange Herwig
- Larcher Barbara
- Large Sandra
- Larsen Ida Unmack
- Lashwood Alison
- Lau Puay Ngoh
- Laurà Matilde
- Laver Fiona
- Leenders Nico
- Legaz Agustina
- Legendre Perrine
- Lemaire Marie-Hélène
- Lemoine Laurie
- Lesne Fabien
- Levey Jamie
- Lewerenz Jan
- Lewerenz Jan
- Lewin Kajsa
- Lewis Monica
- Leypold Christine
- Lezius Franziska
- Liessens Dirk
- Ligon-Auer Maria
- Lilek Sabine
- Lilek Stefan
- Linder Christoph
- Lindquist Suzanne
- Linnsand Petra
- Loarte María del Valle
- Loiseau Sylvie
- Lolk Annette
- Longato Nadine
- Longinus Bernhard
- Longthorpe Mandy
- Lopera Monica Rodriguez
- Loria Giovanna
- Loureiro Rui
- Loutfi Ghada
- Lovo Francesca
- Lozano Pablo Sánchez
- Lucena Carolina Mendez
- Lundsgaard Marianne
- Léonard Marie-Claude
- López del Val Javier
- López Elena
- López Rosa Guerrero
- López-Sendón Moreno José Luis
- Löhle Matthias
- Lüsebrink Antje
- Maass Antonia
- MacKinnon Lesley
- Madsen Louise Hasselstrøm
- Magalhães Andreia
- Magalhães Marina
- Magnet Markus
- Magzhanov Rim
- Mahlknecht Philipp
- Majeed Tahir
- Majerová-Ibarburu Veronika
- Malec-Litwinowicz Michalina
- Malo de Molina Rocío
- Maltête David
- Mandich Paola
- Manouvrier Sylvie
- Manzanares Salvadora
- Marcel Christophe
- Marchese Roberta
- Marchina Eleonora
- Marcinkowski Jerzy
- Mariotti Caterina
- Mariscal Natividad
- Marit de Weert A.
- Markova Ivana
- Markova Ivana
- Marquard Ralf
- Marques Ana
- Marquine Laurent
- Marrosu Francesco
- Martikainen Kirsti
- Martin Veronica Puertas
- Martinez Laura Martinez
- Martinez-Horta Saul
- Martinez-Horta Saul
- Martinez-Jaurrieta Maria Dolores
- Martino Tiziana
- Martín Idaira
- Martínez Noelia Rodríguez
- Martínez-Descals Asunción
- María Andrés de la Cerda Santa
- Masmoudi Kamel
- Mason Sarah
- Massano João
- Massarelli Marco
- Mata Maite Paredes
- Matheson Kirsty
- Mazzante Irene
- McDonnell Sharon
- McEntagart Meriel
- McFadyen Paula
- McGill Marie
- McKenzie Sue
- McLean Tim
- Mechi Claudia
- Meier Simone
- Meireles Joana
- Mendes Tiago
- Mendes Tiago
- Merino Beatriz Tijero
- Merrick Daniel
- Mestre Tiago
- Mestre Tiago
- Middleton Julia
- Miedzybrodzka Zosia
- Mihaylova Violeta
- Milani Paolo
- Milkereit Eva
- Millán Salvador Jose Maria
- Minet Cécile
- Minkels Floor
- Minschke Rebecca
- Minster Sara
- Minster Sara
- Mir Pablo
- Modoni Anna
- Mohammed Zeid
- Moilanen Jukka
- Monin Marie-Lorraine
- Monnier Tiffany
- Monteiro Ana
- Montojo Teresa
- Monza Daniela
- Monza Daniela
- Morales Blas
- Moreira Inês
- Moreno Patrocinio Garcia
- Morgado Graca
- Morgado Joana
- Morgan Karen
- Morin Gilles
- Mundler Laura
- Muroni Antonella
- Murphy Helen
- Musacchio Thomas
- Musgrave Hannah
- Mustonen Aki
- Mutez Eugénie
- Muñoz Esteban
- Muñoz Juan Marín
- Mächtel Miriam
- Mäkipää Seija
- Möller Carsten
- Møller Anette Torvin
- Mühlau Mark
- Mühlbäck Alzbeta
- Müller Christoph
- Müller Nicole
- Münchau Alexander
- Münkel Kristina
- Mütze Lisanne
- Nanetti Lorenzo
- Narożańska Ewa
- Neleborn-Lingefjärd Liselotte
- Nemeth Andrea H.
- Nepper Solveig
- Neumann Christian
- Neutel Dulce
- Nevitt Louise
- Nguyen Karine
- Nielsen Jørgen
- Nielsen Jørgen E.
- Niemelä Valter
- Niess Anke
- Nikolai Tomáš
- Noad Rupert
- Novak Marianne
- Nowak Malgorzata
- Nuzzi Angela
- Nyberg Clara
- Nyholm Dag
- Nöth Kerstin
- O'Donovan Kirsty
- O'Keefe Deidre
- O'Neill Mari
- Oehmen Martin
- Ojala Marjut
- Olivier Audrey
- Ollokainen Mari
- Olofsson Carina
- Oosterloo Mayke
- Oosterloo Mayke
- Opala Grzegorz
- Orth Michael
- Orth Michael
- Ossig Christiana
- Otti Daniela
- Oughton Emma
- Owen Michael
- Pacheco Cortegana Eva María
- Padieu Helene
- Padovani Alessando
- Paganini Marco
- Pagonabarraga Javier
- Painold Annamaria
- Palanca Paloma Millan
- Pallett Andrew
- Palmer Amy
- Panzeri Marta
- Pardo Sonia Arribas
- Paridi Dominga
- Pariente Jérémie
- Parkinson Andrew
- Partington-Jones Lucy
- Pastor Barbara Vives
- Pate Louise
- Patel Aakta
- Paterski Laurent
- Patterson Kirsten
- Patton Michael
- Paucar Martin
- Paulsen Julie
- Paus Karin
- Peacy Caroline
- Pearson Pauline
- Peinemann Alexander
- Peippo Maarit
- Peluso Silvio
- Peppa Nadia
- Peppa Nadia
- Perea Fuensanta Noguera
- Perez Jesus Perez
- Periañez Juan Manuel
- Peter Mireille
- Petersen Jens A.
- Peterson Maria
- Petersén Åsa
- Petracca Martina
- Petrollini Martina
- Peña José Chacón
- Phillipps Clélie
- Phillips Michelle
- Piacentini Silvia
- Piano Carla
- Pica Emmanuel
- Piedad John
- Pierre Michèle
- Pinter Bernadette
- Piras Valeria
- Pirker Walter
- Plomhause Lucie
- Poda Roberto
- Poewe Werner
- Polo Cecilia Gil
- Pomies Elsa
- Porteous Mary
- Pouliquen Dorothée
- Powell Kingsley
- Pradella Silvia
- Price Kathleen
- Prieto Marta Para
- Priller Josef
- Probst Daniela
- Prouzet Julie
- Prundean Adriana
- Prüß Harald
- Pueyo Angel Martínez
- Purkayastha Debasish Das
- Päivärinta Markku
- Pålhagen Sven
- Pålhagen Sven
- Quaranta Davide
- Quarrell Oliver
- Quarrell Oliver
- Rae Daniela
- Rakowicz Maryla
- Raman Ashok
- Raman Ashok
- Ramirez Inés Legarda
- Ramos-Arroyo Maria
- Ramos-Arroyo Maria Antonia
- Redondo Luis
- Reetz Kathrin
- Regeur Lisbeth
- Reilmann Ralf
- Reimer Jan
- Reisinger Karin
- Reiter Eva-Magdalena
- Retterstøl Lars
- Ribacoba René
- Riballo Antonio Villa
- Ribas Guillermo García
- Ribaï Pascale
- Ribbat+ Michael
- Ribosa Roser
- Rickards Hugh
- Rijntjes Michel
- Rinaldi Carlo
- Rindal Beate
- Ristori Giovanni
- Ritchie Stuart
- Robert Misericordia Floriach
- Robertson Dene
- Robertson Nicola
- Robowski Piotr
- Roca Alessandro
- Roca Elvira
- Rodrigues Filipe
- Rogers Dawn
- Rogers Dawn
- Rohm Stefanie
- Rola Rafal
- Rolland Sandrine
- Romano Silvia
- Romano Silvia
- Romero Lemos María Dolores
- Romero Irene
- Romero Sandra Gutierrez
- Romoli Anna Maria
- Roos Peter
- Roos Raymund A. C.
- Roos Raymund A. C.
- Roos Raymund AC.
- Rose Sarah
- Rosser Anne
- Rosser Elisabeth
- Roth Jan
- Rothery Jean
- Roussel Martine
- Rowett Liz
- Rowett Liz
- Roze Emmanuel
- Ruddy Deborah
- Rudolf Gabrielle
- Rudzińska Monika
- Rudzińska Monika
- Ruiz Idiago Jesús Miguel
- Rummel Jutta
- Rumpf Silke
- Russo Cinzia Valeria
- Ryglewicz Danuta
- Røren (formerly Heinonen) Niini
- Røsby Oddveig
- Sablonnière Bernard
- Saft Carsten
- Saft Carsten
- Saifullina Elena
- Sainz Artiga María José
- Salgado Paula
- Salgueiro Ana
- Salvador Carlos
- Salvatore Elena
- Samara Husam
- Sando Sigrid Botne
- Santacruz Pilar
- Santala Maire
- Santhouse Alastair
- Santos Mariana
- Sass Christian
- Sass Christian
- Savage Lois
- Scaglione Cesa
- Scheibl Monika
- Schepers Sigrun
- Scherer-Gagou Clarisse
- Schiefer Johannes
- Schlangen Christiane
- Schmalfeld Jenny
- Schmidt Simone
- Schneider Ariane
- Schoonderbeek Anne
- Schrader Christoph
- Schwenk Daniela
- Schöggl Helmut
- Schüler Béatrice
- Schüpbach Michael
- Sciruicchio Vittorio
- Scott Adrienne
- Sebastián Ana Rojo
- Sebastián Ana Rojo
- Seliverstov Yury
- Seliverstov Yury
- Semedo Cristina
- Sempołowicz Justyna
- Seppi Klaus
- Serpino Claudia
- Sidorova Olga
- Sienkiewicz-Jarosz Halina
- Sieradzan Kasia
- Sikiric Alma
- Silva Mark
- Simonelli Maria
- Simonin Clémence
- Simpson Sheila A.
- Simpson Steve
- Simpson Steve
- Sinadinosa Daniela
- Singh Baldev
- Sipponen Marjatta
- Sitek Emilia
- Siuda Gill
- Slama Hichem
- Slawek Jaroslaw
- Smalley Sarah
- Smirnov Oleg
- Snowden Julie
- Soleti Francesco
- Solis Pilar
- Solito Marcella
- Soliveri Paola
- Sollom Andrea
- Soltan Witold
- Soltysiak Beverley
- Solís Pilar
- Somers Nele
- Sorbi Sandro
- Sorrentino Pierpaolo
- Souyris Corinne
- Spadaro Maria
- Spagnolo Francesca
- Spampinato Umberto
- Sprenger Fabienne
- Spruth Eike
- Squitieri Ferdinando
- Staffen Wolfgang
- Stamm Christiane
- Stattin Eva-Lena
- Stebler Yanik
- Steinmetz Gisèle
- Stenwak Agata
- Stockholm Jette
- Stokke Bodil
- Stompel Daniel
- Stopford Cheryl
- Storch Alexander
- Stoy Nicholas
- Stubbe Lars
- Stubbe Lars
- Stárková Irena
- Städtler Michael
- Størseth Hanna Haugan
- Stępniak Iwona
- Summers Fiona
- Sundblom Jimmy
- Sundblom Jimmy
- Supiot Frédéric
- Sułek Anna
- Svenningsson Per
- Swain Rachel
- Szczudlik Andrzej
- Szczygieł Elżbieta
- Szinwelski Michal
- Sánchez Jesús
- Sánchez Vicenta
- Sánchez Violeta Sánchez
- Süssmuth Sigurd
- t Hart Ellen P.
- Tabrizi Sarah
- Tabrizi Sarah J.
- Tacik Pawel
- Tadic Vera
- Tamburini Tiziano
- Tan Louis
- Tard Céline
- Taroni Franco
- Tartari Díaz-Zorita Juan Pablo
- Tataru Alina
- Taylor Anne-Marie
- Taylor Cat
- Taylor Catherine
- Taylor Rachel
- Tchikviladzé Maya
- Tedroff Joakim
- Thibault-Tanchou Stéphanie
- Thiel Silvia
- Thomas Gareth
- Thompson Jennifer
- Thomson Aileen
- Thomson David
- Tidswell Katherine
- Timewell Erika
- Timings Leanne
- Tir Mélissa
- Tomasello Chiara
- Tonner Alison
- Torlizzi Flavia
- Toscano Jean
- Townhill Jenny
- Townhill Jenny
- Tranchant Christine
- Trautmann Sonja
- Trender-Gerhard Iris
- Tucci Tecla
- Tuuha Katri
- Tyvoll Hilde
- Tähkäpää Sirkku
- Tübing Jennifer
- Udaeta Beatriz
- Uhrova Tereza
- Ulla Miguel
- Ullah Jasmin
- Ullah Jasmin
- Ure Alexandra
- Vacca Melisa
- Valadas Anabela
- Valentine Ruth
- van de Wyngaerde Françoise
- van den Bogaard Simon J. A.
- van Hout Monique S. E.
- van Kuijk Sander MJ.
- van Oostrom Joost
- Van Paemel Dominique
- van Reijen Dimphna
- van Vugt Jeroen P. P.
- van Walsem Marleen
- van Walsem Marleen R.
- Vandenberghe Wim
- Vandenberghe Wim
- Vangsted-Hansen Christina
- Vargas-González Laura
- Vaughan Vivien
- Vaughn Jenny
- Ventura Marta Fatás
- Verellen-Dumoulin Christine
- Verellen-Dumoulin Christine
- Verellen-Dumoulin Christine
- Verena Baake
- Verhoeven Marloes
- Vernon Nathan
- Verny Christophe
- Verstappen Carla
- Verstraelen (formerly Ritchie) Nichola
- Verstraelen (Ritchie) Nicola
- Vezza Maurizio
- Vidal Tiphaine
- Vieira da Silva Wildson
- Viladrich Cèlia Mareca
- Vilaplana Carmen Peiró
- Villa Carolina
- Villanueva Clara
- Villanueva Marina Ávila
- Vingerhoets Francois
- Vinther-Jensen Tua
- Vivancos Laura
- Vogel Melanie
- Vuillaume Isabelle
- Waber Mirella
- Wagner Caroline
- Wahlström+ Jan
- Wahlström+ Jan
- Wallden Tina
- Walleczek Anna Maria
- Wannepain Sandrine
- Warner Thomas
- Wasielewska Anna
- Weber Nathalia
- Weckx Petra
- Weekes Rebecca
- Weekes Rebecca
- Wehus Ragnhild
- Weindl Adolf
- Wenning Gregor
- Wermuth Lene
- Werner Cornelius J.
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Wider+ Christian
- Widner Håkan
- Wiklund Leif
- Wikström Birgitta
- Wild Edward
- Wild Sue
- Williams Josh
- Winkelmann Juliane
- Winkler Jürgen
- Winnberg Elisabeth
- Witjes-Ané Marie-Noelle
- Witjes-Ané Marie-Noëlle
- Witkowski Grzegorz
- Witkowski Grzegorz
- Wiśniewski Bartłomiej
- Wolz Annett
- Wolz Martin
- Wood Josh
- Wood Sue
- Wright Abigail
- Wright Abigail
- Wright Jan
- Wójcik Magdalena
- Yardumian Pam
- Yates Shona
- Youssov Katia
- Yudina Elizaveta
- Yudina Elizaveta
- Zalyalova Zuleykha
- Zaremba
- Zaremba Jacek
- Zaugg Sabine Weber
- Zdzienicka Elzbieta
- Zea Sevilla Maria Ascension
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Daniel
- Zielonka Eugeniusz
- Zimmermann Marie-Agathe
- Zinzi Paola
- Zinzi Paola
- Zinzi Paola
- Ziora-Jakutowicz Karolina
- Zittel Simone
- Zouitina Yassine
- Zucker Birgit
- Åman Jaana
- Østern Rune
- Šašinková Pavla
- Šenkárová Zuzana
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P <.001). Overall motor and cognitive performance (P <.001) were worse, however only disease motor progression was slower (coefficient, −0.58; SE 0.16; P <.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P <.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P <.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients