Myeloablative conditioning for allo-HSCT in pediatric ALL: FTBI or chemotherapy?—A multicenter EBMT-PDWP study

Although most children with acute lymphoblastic leukemia (ALL) receive fractionated total body irradiation (FTBI) as myeloablative conditioning (MAC) for allogeneic hematopoietic stem cell transplantation (allo-HSCT), it is an important matter of debate if chemotherapy can effectively replace FTBI. To compare outcomes after FTBI versus chemotherapy-based conditioning (CC), we performed a retrospective EBMT registry study. Children aged 2-18 years after MAC for first allo-HSCT of bone marrow (BM) or peripheral blood stem cells (PBSC) from matched-related (MRD) or unrelated donors (UD) in first (CR1) or second remission (CR2) between 2000 and 2012 were included. Propensity score weighting was used to control pretreatment imbalances of the observed variables. 3.054 patients were analyzed. CR1 (1.498): median follow-up (FU) after FTBI (1.285) and CC (213) was 6.8 and 6.1 years. Survivals were not significantly different. CR2 (1.556): median FU after FTBI (1.345) and CC (211) was 6.2 years. Outcomes after FTBI were superior as compared with CC with regard to overall survival (OS), leukemia-free survival (LFS), relapse incidence (RI), and nonrelapse mortality (NRM). However, we must emphasize the preliminary character of the results of this retrospective "real-world-practice" study. These findings will be prospectively assessed in the ALL SCTped 2012 FORUM trial.Transplantation and immunomodulatio

Fenites associated with carbonatite complexes : a review

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.Carbonatites and alkaline-silicate rocks are the most important sources of rare earth elements (REE) and niobium (Nb), both of which are metals imperative to technological advancement and associated with high risks of supply interruption. Cooling and crystallizing carbonatitic and alkaline melts expel multiple pulses of alkali-rich aqueous fluids which metasomatize the surrounding country rocks, forming fenites during a process called fenitization. These alkalis and volatiles are original constituents of the magma that are not recorded in the carbonatite rock, and therefore fenites should not be dismissed during the description of a carbonatite system. This paper reviews the existing literature, focusing on 17 worldwide carbonatite complexes whose attributes are used to discuss the main features and processes of fenitization. Although many attempts have been made in the literature to categorize and name fenites, it is recommended that the IUGS metamorphic nomenclature be used to describe predominant mineralogy and textures. Complexing anions greatly enhance the solubility of REE and Nb in these fenitizing fluids, mobilizing them into the surrounding country rock, and precipitating REE- and Nb-enriched micro-mineral assemblages. As such, fenites have significant potential to be used as an exploration tool to find mineralized intrusions in a similar way alteration patterns are used in other ore systems, such as porphyry copper deposits. Strong trends have been identified between the presence of more complex veining textures, mineralogy and brecciation in fenites with intermediate stage Nb-enriched and later stage REE enriched magmas. However, compiling this evidence has also highlighted large gaps in the literature relating to fenitization. These need to be addressed before fenite can be used as a comprehensive and effective exploration tool.This research has received funding from the European Union’s Horizon 2020 research and innovation programme under grant No 689909

Dichotomy of reductive addition of amines to cyclopropyl ketones vs pyrrolidine synthesis

An interesting catalytic dichotomy was discovered: switching between simple ligand-free catalysts leads to fundamentally different outcomes of reductive reaction between amines and α-carbonylcyclopropanes. Whereas a rhodium catalyst leads to the traditional reductive amination product, ruthenium catalysis enables a novel reaction of pyrrolidine synthesis via ring expansion. The protocols do not require an external hydrogen source and employ carbon monoxide as a deoxygenative agent. The developed methodologies are perfectly compatible with a number of synthetically important functionalities such as ester, carboxyl, bromo, and Cbz moieties. © 2016 American Chemical Society

Dichotomy of reductive addition of amines to cyclopropyl ketones vs pyrrolidine synthesis

An interesting catalytic dichotomy was discovered: switching between simple ligand-free catalysts leads to fundamentally different outcomes of reductive reaction between amines and α-carbonylcyclopropanes. Whereas a rhodium catalyst leads to the traditional reductive amination product, ruthenium catalysis enables a novel reaction of pyrrolidine synthesis via ring expansion. The protocols do not require an external hydrogen source and employ carbon monoxide as a deoxygenative agent. The developed methodologies are perfectly compatible with a number of synthetically important functionalities such as ester, carboxyl, bromo, and Cbz moieties. © 2016 American Chemical Society

New approaches for the reductive formation of the C-N bond

This work was supported by the Grant for Young Scientists (No. MK-520.2017.3) and RUDN University Program “5-100”

Increasing efficiency of equipment work for preliminary separation of non-ferrous metals

The article provides an overview of the methods for pre-sorting sulfide ores, as well as the design of separators for implementing these methods. The practical prospects of the use of radioresonance and X-ray fluorescence separation for the preliminary preparation of sulfide ores are shown. The use of not one, but two or more different physical properties of the separated ore components during radiometric beneficiation opens up additional possibilities in increasing the selectivity of this process and expanding the scope of its application. It is proposed to reduce the energy intensity of crushing processes, due to the impact on the rock electrical breakdown of ore in order to reduce its strength. In this case, the processes of crushing and grinding are replaced by processes of selective destruction along the boundaries of inclusions of the useful component. The substantiation of the technology for the separation of poor copper-zinc ores is presented. The relationship of sulfide content and electrical breakdown voltage is shown.The results of experiments in determination the specific energy consumption for the electrical processing of lean ore, depending on the sulfide content, are presented. The principle is substantiated, and a simulation model of the separation process is developed. The block diagram of the separation process algorithm is given.A description of the methodology for working with software is done. The energy costs of a new technology for the separation of poor sulfide ores are determined

Conceptual approaches to overcoming turbulence in the innovative development of Russian industrial enterprises

The article attempts to give scientific justification to rational construction of the National strategy of overcoming turbulence in the innovative development of Russian industrial enterprises that is expected to help identify new competitive advantages and improve those connected with the growth of scientific and technological potential, of both the state and business. It is argued that in the current socio-economic conditions, the most promising direction is the development of cutting-edge technologies. The role of knowledge, innovation market, and other points of high-tech growth are determined. The necessity of the development of innovative territorial clusters based on the interaction between representatives of science, business and the government is substantiated. The choice of priority directions of innovation development is made keeping in mind international institutional, scientific, technical and technological forecasts and trends and is aimed at successful identification of the determinants of high-tech growth and formation of competitive advantages of the Russian economy that will allow to overcome the turbulence in the innovative development of the Russian economy. © Serials Publications Pvt. Ltd