Research on the Effectiveness of Students’ Communicative Competence Formation

The formation of communicative competence among university students is becoming especially relevant in the uncertain and changeable world. In the study, competencies of a general nature are called invariant by the theory of the structure of the content of education, developed by Academician V. S. Lednev. The paper focuses on the effectiveness of the formation of students’ invariant communicative competence in a nontraditional form of education - joint training of Russian and international students. The results of the study show that co-education of Russian and foreign students contributes to the development of their invariant communicative competencies better than traditional education. The novelty of the research is the formation of students’ invariant communicative competence occurs in conditions different from traditional teaching. Namely, it occurs in the process of joint training of Russian students with foreign citizens. Research materials can be used in the work of higher educational institutions

Corrosion resistance of neodymium and dysprosium hydrides

This paper describes the methods of obtaining hydrides of rare earth elements such as dysprosium and neodymium. The properties and corrosion resistance of these elements are investigated. A synthesis method of monophasic dysprosium and neodymium dihydrides is presented. Synthesized dihydrides are agglomerates with an average size of 3-50 µm and are formed by crystalline grains of a nanometer size. BET specific surface area, morphology, elemental analyses and composition of samples have been studied. Corrosion stability in aqueous solutions of hydrochloric acid and sodium hydroxide were studied. It was determined that both hydrides undergo hydrolysis in acid and alkaline mediums. Neodymium hydride is more stable to corrosion than dysprosium hydride, which is proved by its longer exposure to aggressive medium to hydrides. The formation of insoluble /poorly soluble products of corrosion can make a significant contribution to the process of powder dissolution

Macrophage phenotype after human refluxate exposure, esophageal dysmotility and their correlation with gastroesophageal reflux disease

Aim of the study. To investigate the esophageal dysmotility, changes in the esophageal mucosa and the immune response depending on the type of refluxate in gastroesophageal reflux disease (GERD) patients.Material and methods. 68 patients with GERD were recruited: 28 (14 men; mean age, 45.74 ± 2.23 years) nonerosive reflux disease (NERD), 22 (15 men; mean age, 45.0 ± 3.24 years) erosive reflux disease (EE), 18 (13 men; mean age, 47.22 ± 2.95) Barrett’s Esophagus (BE). GERD patients underwent esophageal high-resolution manometry (HRM) with a 22-channel water-perfused catheter and Solar GI system (Medical Measurements Systems, Enschede, the Netherlands), 24-hour impedance and pH monitoring using the Ohmega Ambulatory Impedance pH Recorder (Medical Measurements Systems). We analyzed receptor characteristics of monocyte-derived macrophages in all groups of patients.Results. On HRM examination, we showed that DCI (distal contractile integral) in NERD patients was higher than in EE (p = 0.088) and BE (p = 0.076), also LES RP (lower esophageal sphincter resting pressure) in NERD patients was higher than in EE (p = 0.039) and BE (p = 0.012). The analysis of reflux characteristics showed that the total reflux time with pH < 4 for BE patients was longer than that for NERD and EE patients. An analysis of receptor characteristics of monocyte-derived macrophages showed the prevalence of CD25 and CD80 expression in all groups of patients.Conclusion. An analysis of the phenotype of macrophages derived from blood monocytes of GERD patients revealed a prevalence of М1 macrophages that was typical for the Th1 type of immune response. The degree of esophageal dysmotility was correlated with GERD severity and type

EXPERIMENTAL STUDY OF CAUSES OF REFUSED OF COPPER BUSBARES WHILE PRESSING ON THE LINE OF CONTINUOUS EXTRUSION "CONFORM-400"

В работе экспериментально исследован характер течения металла в очаге деформации при прессовании медных шин на линии непрерывной экструзии (ЛНЭ) «Conform-400». Подтверждена гипотеза исключающая преимущественное влияние температуры, скорости прессования и толщины облоя на возникновение пузырей и расслоений в медных шинах. Доказан факт затягивания окисленного слоя металла из колеса в форкамеру.In operation the character of a current of metal in the deformation center when molding copper busbares on the Conform 400 line of the continuous extrusion (LCE) experimentally is probed. The hypothesis excluding preferential influence of temperature, speed and value of a burr on origin of surface blowhole and lamination in copper busbares is confirmed. A fact of tightening of the oxidized metal layer from a wheel to the prechamber is proved

Practical efficacy and safety of Konsilar D24 in patients with hypertension: data from the KONSONANS program

Aim. In practice, to evaluate the efficacy, safety and long-term adherence to therapy with a fixed-dose combination of ramipril/indapamide (Konsilar-D24) in patients with grade 1-2 hypertension (HTN) who have not achieved blood pressure (BP) control with prior therapy or have not taken antihypertensive therapy.Material and methods. This multicenter open-label observational program included 524 patients with grade 1-2 HTN who did not take antihypertensive therapy or did not reach the target BP level with mono or dual antihypertensive therapy, as well as patients shifted to Konsilar-D24 therapy no later than two weeks before the start of the program. All patients signed a written informed consent to participate in the program. The safety analysis set includes all patients who have taken at least one dose of a fixed-dose combination of ramipril/indapamide and have visited physician at least once during the program. The effectiveness analysis set included all patients in the safety population who completed the study in accordance with protocol (n=511). Clinical systolic blood pressure (SBP), diastolic BP (DBP) and heart rate were assessed at baseline, as well as at 0,5, 1, 3 and 6 months of treatment. A post hoc subgroup analysis of changes in BP and heart rate was performed depending on age, sex and baseline body mass index.Results. The fixed-dose combination of ramipril with indapamide significantly reduced SBP and DBP after 2-week treatment (-20,9±10,1 mm Hg; pConclusion. Despite the limitations inherent in observational studies, the KONSONANS program has demonstrated high efficacy and safety of fixed-dose combination of ramipril/indapamide taken once a day in hypertensive patients. Ramipril/indapamide fixed-dose combination therapy significantly improved BP control and achieved even lower individual target BP levels in the majority of hypertensive patients

ОТЛОЖЕНИЯ ТАНХОЙСКОГО ТРЕТИЧНОГО ПОЛЯ, ЮЖНОБАЙКАЛЬСКАЯ ВПАДИНА: СТРАТИГРАФИЯ, КОРРЕЛЯЦИИ И СТРУКТУРНЫЕ ПЕРЕСТРОЙКИ В БАЙКАЛЬСКОМ РЕГИОНЕ

Biostratigraphic and lithofacial studies of sediments in the Tankhoi Tertiary field, which evolution reflects transformations of the terrain in the Baikal region at the Oligocene-Miocene, Early-Middle Miocene, Miocene-Pliocene and Early-Late Pliocene transitions. The main part of the field is composed of clastic molassoids formed during 'early orogen' stage in the coastal part of an extensive paleobasin with a slow water current and in shallow lakes of the Mishikha-Klyuevka and Osinovka river paleobasins that formed, respectively, at the Oligocene-Miocene and Early-Middle Miocene boundaries. In the Miocene, as suggested by analyses of malacofauna and diatoms, South Baikal was a major, quite deep paleolake. These water bodies were related in the Miocene as evidenced by the partial similarity of diatom species found in South Baikal and the Tunka valley, as well as the presence of similar endemic fauna species in the sediments. Accumulated coarse, mainly proluvial-alluvial deposits are indicators of the tectonic activity that resulted in a dramatic ‘late orogen’ increase of contrasting features of the regional terrain.Выполнены биостратиграфические и литолого-фациальные исследования осадочных отложений Танхойского третичного поля, в формировании которого отражены перестройки рельефа Прибайкалья, происходившие на рубежах олигоцена–миоцена, раннего–среднего миоцена, миоцена–плиоцена и раннего–позднего плиоцена. Основная часть поля сложена тонкообломочными молассоидами, сформировавшимися на «раннеорогенном» этапе в слабопроточной береговой части обширного палеобассейна и в мелких озерах–старицах Мишихинско-Клюевской и Осиновской речных палеодолин, заложившихся, соответственно, на рубежах олигоцена–миоцена и раннего–среднего миоцена. Из результатов анализа малакофауны и диатомовых водорослей следует, что Южный Байкал представлял собой в миоцене крупное и достаточно глубокое палеоозеро. Частичная общность диатомовых видов Южного Байкала и Тункинской долины, а также присутствие сходной эндемичной фауны в отложениях свидетельствуют о связи миоценовых водоемов этих территорий. Тектоническая активизация, повлекшая за собой резкое «позднеорогенное» увеличение контрастности рельефа, обозначилась накоплением грубообломочных преимущественно пролювиально-аллювиальных отложений.

Euro+Med-Checklist Notulae, 13

This is the thirteenth of a series of miscellaneous contributions, by various authors, where hitherto unpublished data relevant to both the Med-Checklist and the Euro+Med (or Sisyphus) projects are presented. This instalment deals with the families Amaryllidaceae (incl. Alliaceae), Apocynaceae, Caryophyllaceae, Chenopodiaceae, Compositae, Crassulaceae, Cucurbitaceae, Gramineae, Hydrocharitaceae, Iridaceae, Labiatae, Liliaceae, Malvaceae, Meliaceae, Myrtaceae, Orobanchaceae, Oxalidaceae, Papaveraceae, Pittosporaceae, Primulaceae (incl. Myrsinaceae), Ranunculaceae, Rhamnaceae, Rubiaceae, Solanaceae and Umbelliferae. It includes new country and area records and taxonomic and distributional considerations for taxa in Allium, Anthemis, Atriplex, Centaurea, Chasmanthe, Chenopodium, Delphinium, Digitaria, Elodea, Erigeron, Eucalyptus, Hypecoum, Leptorhabdos, Luffa, Malvaviscus, Melia, Melica, Momordica, Nerium, Oxalis, Pastinaca, Phelipanche, Physalis, Pittosporum, Salvia, Scorzoneroides, Sedum, Sesleria, Silene, Spartina, Stipa, Tulipa and Ziziphus, new combinations in Cyanus, Lysimachia, Rhaponticoides and Thliphthisa, and the reassessment of a replacement name in Sempervivum

International longitudinal registry of patients with atrial fibrillation and treated with rivaroxaban: RIVaroxaban Evaluation in Real life setting (RIVER)

Background Real-world data on non-vitamin K oral anticoagulants (NOACs) are essential in determining whether evidence from randomised controlled clinical trials translate into meaningful clinical benefits for patients in everyday practice. RIVER (RIVaroxaban Evaluation in Real life setting) is an ongoing international, prospective registry of patients with newly diagnosed non-valvular atrial fibrillation (NVAF) and at least one investigator-determined risk factor for stroke who received rivaroxaban as an initial treatment for the prevention of thromboembolic stroke. The aim of this paper is to describe the design of the RIVER registry and baseline characteristics of patients with newly diagnosed NVAF who received rivaroxaban as an initial treatment. Methods and results Between January 2014 and June 2017, RIVER investigators recruited 5072 patients at 309 centres in 17 countries. The aim was to enroll consecutive patients at sites where rivaroxaban was already routinely prescribed for stroke prevention. Each patient is being followed up prospectively for a minimum of 2-years. The registry will capture data on the rate and nature of all thromboembolic events (stroke / systemic embolism), bleeding complications, all-cause mortality and other major cardiovascular events as they occur. Data quality is assured through a combination of remote electronic monitoring and onsite monitoring (including source data verification in 10% of cases). Patients were mostly enrolled by cardiologists (n = 3776, 74.6%), by internal medicine specialists 14.2% (n = 718) and by primary care/general practice physicians 8.2% (n = 417). The mean (SD) age of the population was 69.5 (11.0) years, 44.3% were women. Mean (SD) CHADS2 score was 1.9 (1.2) and CHA2DS2-VASc scores was 3.2 (1.6). Almost all patients (98.5%) were prescribed with once daily dose of rivaroxaban, most commonly 20 mg (76.5%) and 15 mg (20.0%) as their initial treatment; 17.9% of patients received concomitant antiplatelet therapy. Most patients enrolled in RIVER met the recommended threshold for AC therapy (86.6% for 2012 ESC Guidelines, and 79.8% of patients according to 2016 ESC Guidelines). Conclusions The RIVER prospective registry will expand our knowledge of how rivaroxaban is prescribed in everyday practice and whether evidence from clinical trials can be translated to the broader cross-section of patients in the real world

Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications

Superparamagnetic iron oxide nanoparticles can providemultiple benefits for biomedical applications in aqueous environments such asmagnetic separation or magnetic resonance imaging. To increase the colloidal stability and allow subsequent reactions, the introduction of hydrophilic functional groups onto the particles’ surface is essential. During this process, the original coating is exchanged by preferably covalently bonded ligands such as trialkoxysilanes. The duration of the silane exchange reaction, which commonly takes more than 24 h, is an important drawback for this approach. In this paper, we present a novel method, which introduces ultrasonication as an energy source to dramatically accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove the generic character, different functional groups were introduced on the surface including polyethylene glycol chains, carboxylic acid, amine, and thiol groups. Their colloidal stability in various aqueous buffer solutions as well as human plasma and serum was investigated to allow implementation in biomedical and sensing applications.status: publishe