Manipulation of the surface density of states of Ag(111) by means of resonators. Experiment and theory.

We show that the density of surface Shockley states of Ag(111) probed by the differential conductance G(V ) = d I /d V by a scanning-tunneling microscope (STM) can be enhanced significantly at certain energies and positions introducing simple arrays of Co or Ag atoms on the surface, in contrast to other noble-metal surfaces. Specifically we have studied resonators consisting of two parallel walls of five atoms deposited on the clean Ag(111) surface. A simple model in which the effect of the adatoms is taken into account by an attractive local potential and a small hybridization between surface and bulk at the position of the adatoms explains the main features of the observed G(V ) and allows us to extract the proportion of surface and bulk states sensed by the STM tip. These results might be relevant to engineer the surface spectral density of states, to study the effects of surface states on the Kondo effect, and to separate bulk and surface contributions in STM studies of topological surface states

Spin-sensitive shape asymmetry of adatoms on noncollinear magnetic substrates

The spin-resolved density of states of Co atoms on a noncollinear magnetic support displays a distinct shape contrast, which is superimposed on the regular height contrast in spin-polarized scanning tunneling microscopy. The apparent atom height follows the well-known cosine dependence on the angle formed by the tip and adatom local magnetization directions, whereas the shape contrast exhibits a sine dependence. We explain this effect in terms of a noncollinear spin density induced by the substrate, which in our case is the spin spiral of the Mn monolayer on W(110). The two independent contrast channels, apparent height and shape, are identified with the Co magnetization projections onto two orthogonal axes. As a result, all components of the overall atom magnetic moment vector can be determined with a single spin-sensitive tip in the absence of an external magnetic field. This result should be general for any atom deposited on noncollinear magnetic layers

UC-177 Day Easy Phone Application

DayEasy is a phone application that is designed to promote clean eating and workout habits by providing services such as a calendar, workout planner, hydration and calorie journal, pedometer, fasting timer, and a meal planner. The application will have the functions to: • The user will be able to create an account. • The user will be able to change their password when they forget it. This will be done by sending an email. • The user will be able to save their sign in credentials. • The user will be able to view their daily schedule. • The user will be able to create new tasks. • These tasks are repeatable. • The user will be able to add how much water they drink in oz/ml • The user can set a daily drinking goal. • The user will be able to see how many steps they have taken. • The user can set a daily step goal. • The user will be able to plan their workout by selecting various customized movements. • The user will be able to select a movement (possibly a GIF) and see information about it. • The user will be able to go to muscle option and select a muscle part they want to work on and plan their workout. • The user will be able to plan their meals by keeping a journal. This journal will include calories. • The user will be able to pick a customized meal plan based on dietary selections. • The user will be able to add up their calories. • The user will be able to set a daily calorie goal

Nitric oxide produces HLA-G nitration and induces metalloprotease-dependent shedding creating a tolerogenic milieu

Human leucocyte antigen G (HLA-G) is a tolerogenic molecule that protects the fetus from maternal immune attack, may favour tumoral immunoescape and is up-regulated in viral and inflammatory diseases. The aim of this work was to discover if nitric oxide (NO) could affect HLA-G expression or function because NO is an important modulator of innate and adaptive immunity. For this purpose HLA-G expression and function were analysed following treatment with a NO donor or a peroxynitrite donor in various cell lines expressing HLA-G either spontaneously or upon transfection. Results showed NO-dependent nitration of both cellular and soluble HLA-G protein, but not all HLA-G moieties underwent nitration. Endogenous biosynthesis of NO by both U-937-HLA-G1 and M8-HLA-G5 stable transfectants also caused HLA-G nitration. The NO decreased total HLA-G cellular protein content and expression on the cell surface, while increasing HLA-G shedding into the culture medium. This effect was post-transcriptional and the result of metalloprotease activity. By contrast, NO pretreatment did not affect HLA-G capability to suppress NK cytotoxicity and lymphocyte proliferation. Our studies show that NO regulates the availability of HLA-G molecules without modifying their biological activities

Evaluation of an integrated system for classification, assessment and comparison of services for long-term care in Europe: the eDESDE-LTC study

The harmonization of European health systems brings with it a need for tools to allow the standardized collection of information about medical care. A common coding system and standards for the description of services are needed to allow local data to be incorporated into evidence-informed policy, and to permit equity and mobility to be assessed. The aim of this project has been to design such a classification and a related tool for the coding of services for Long Term Care (DESDE-LTC), based on the European Service Mapping Schedule (ESMS). Methods. The development of DESDE-LTC followed an iterative process using nominal groups in 6 European countries. 54 researchers and stakeholders in health and social services contributed to this process. In order to classify services, we use the minimal organization unit or "Basic Stable Input of Care" (BSIC), coded by its principal function or "Main Type of Care" (MTC). The evaluation of the tool included an analysis of feasibility, consistency, ontology, inter-rater reliability, Boolean Factor Analysis, and a preliminary impact analysis (screening, scoping and appraisal). Results: DESDE-LTC includes an alpha-numerical coding system, a glossary and an assessment instrument for mapping and counting LTC. It shows high feasibility, consistency, inter-rater reliability and face, content and construct validity. DESDE-LTC is ontologically consistent. It is regarded by experts as useful and relevant for evidence-informed decision making. Conclusion: DESDE-LTC contributes to establishing a common terminology, taxonomy and coding of LTC services in a European context, and a standard procedure for data collection and international comparison

CONNECTIVITY BETWEEN POPULATIONS OF THE MARINE CRAB LIOCARCINUS DEPURATOR IN THE ATLANTO-MEDITERRANEAN TRANSITION: A FIVE YEAR SERIES

Abstract: We carried out a spatial and temporal genetic differentiation analysis using seven populations of the marine crab Liocarcinus depurator to elucidate the effect of three oceanographic discontinuities in the Atlanto-Mediterranean coast: Gibraltar Strait, Almeria-Oran Front and Ibiza Channel. To conduct this study, a 527 bp fragment of the mitochondrial COI gene was sequenced in individuals captured in the period 2014-2018 from the following Iberian coast populations: Cádiz, West Alboran, East Alboran, Alacant, Valencia, Ebro Delta and North Catalonia. Two haplogroups were detected; one characteristic of Atlantic waters and the other of Mediterranean. Their differential distribution allowed understanding the connectivity between populations. The effect of the oceanographic fronts on gene flow varied over time. Their effects were significant for the Gibraltar Strait (2014 and 2017), Almeria Oran Front (2013, 2014, 2015, 2016 and 2017) and Ibiza Channel (2015). Interestingly, the joint analysis of West Alboran, East Alboran and Alacant populations allowed a more precise detection of the location of the Almeria Oran Front biological effects. Finally, significant differences were observed in connectivity between Valencia and Ebro Delta in 2015, although there is not an oceanographic discontinuity between them. The main conclusion is that the gene flow is mediated by oceanographic fronts, but their intensity and effects change over time.CTM2017-88080 AEI/FEDER, UE) (CTM2015-66400-C3-3-R MINECO/FEDER) (2017 SGR 1120)

REST APIs: A large-scale analysis of compliance with principles and best practices

Quickly and dominantly, REST APIs have spread over the Web and percolated into modern software development practice, especially in the Mobile Internet where they conveniently enable offloading data and computations onto cloud services. We analyze more than 78GB of HTTP traffic collected by Italy’s biggest Mobile Internet provider over one full day and study how big the trend is in practice, how it changed the traffic that is generated by applications, and how REST APIs are implemented in practice. The analysis provides insight into the compliance of state-of-the-art APIs with theoretical Web engineering principles and guidelines, knowledge that affects how applications should be developed to be scalable and robust. The perspective is that of the Mobile Internet

Parotid sialolithiasis in Stensen´s duct

Salivary duct lithiasis is a condition characterized by the obstruction of a salivary gland or its excretory duct due to the formation of calcareous concretions or sialoliths resulting in salivary ectasia and even provoking the subsequent dilation of the salivary gland. Sialolithiasis accounts for 30% of salivary diseases and most commonly involves the submaxillary gland (83 to 94%) and less frequently the parotid (4 to 10%) and sublingual glands (1 to 7%). The present study reports the case of a 45-year-old male patient complaining of bad breath and foul-tasting mouth at meal times and presenting with a salivary calculus in left Stensen´s duct. Once the patient was diagnosed, the sialolith was surgically removed using local anesthesia. In this paper we have also updated a series of concepts related to the etiology, diagnosis and treatment of sialolithiasis

DNA methylation screening after roux-en Y gastric bypass reveals the epigenetic signature stems from genes related to the surgery per se

[Abstract] Background/objectives: Obesity has been associated with gene methylation regulation. Recent studies have shown that epigenetic signature plays a role in metabolic homeostasis after Roux-en Y gastric bypass (RYGB). To conduct a genome-wide epigenetic analysis in peripheral blood to investigate whether epigenetic changes following RYGB stem from weight loss or the surgical procedure per se. Subjects/methods: By means of the Infinium Human Methylation 450 BeadChip array, global methylation was analyzed in blood of 24 severely obese women before and 6 months after RYGB and in 24 normal-weight women (controls). Results: In blood cells, nine DMCpG sites showed low methylation levels before surgery, methylation levels increased after RYGB and neared the levels measured in the controls. Additionally, 44 CpG sites associated with the Wnt and p53 signaling pathways were always differently methylated in the severely obese patients as compared to the controls and were not influenced by RYGB. Finally, 1638 CpG sites related to inflammation, angiogenesis, and apoptosis presented distinct methylation in the post-surgery patients as compared to the controls. Conclusion: Bariatric surgery per se acts on CpGs related to inflammation, angiogenesis, and endothelin-signaling. However, the gene cluster associated with obesity remains unchanged, suggesting that weight loss 6 months after RYGB surgery cannot promote this effect.This study’s data collection, DNA and statistical analysis was supported by São Paulo Research Foundation (FAPESP) (grants #2017/07220–7, #2016/05638–1 and #2015/18669–0). Also, statistical and bioinformatics analysis was supported by “Centro de Investigacion Biomedica En Red” (CIBERobn) and grants (PI17/01287) from the “Instituto de Salud Carlos III” (ISCIII), Spain, co-financed by the European Regional Development Fund (FEDER), MINECO grants MTM2014–52876-R and MTM2017–82724-R, and by the Xunta de Galicia (Grupos de Referencia Competitiva ED431C-2016-015 and Centro Singular de Investigación de Galicia ED431G/01), all of them through the ERDF. A Diaz-Lagares is funded by a research contract “Juan Rodés” (JR17/00016) and Ana B Crujeiras is funded by a research contract “Miguel Servet” (CP17/00088) from the ISCIII, co-financed by the European Regional Development Fund (FEDER)Brasil. Fundação de Amparo à Pesquisa do Estado de São Paulo; #2017/07220–7Brasil. Fundação de Amparo à Pesquisa do Estado de São Paulo; #2016/05638–1Brasil. Fundação de Amparo à Pesquisa do Estado de São Paulo; #2015/18669–0Xunta de Galicia; ED431C-2016-015Xunta de Galicia; ED431G/0