Isolation of 1-(3',4'-dihydroxyphenyl)-3-(2",4",6"-trihydroxyphenyl)-propan-2-ol from grape seed extract and evaluation of its antioxidant and antispasmodic potential

HPLC profiling of phenolics in grape seed extracts revealed a prominent peak of an unknown substance with concentrations up to 5.3%. Spectroscopic data allowed the identification of the compound 1 as 1-(3′,4′-dihydroxyphenyl)-3-(2″,4″,6″-trihydroxyphenyl)-propan-2-ol. 1 is known to be produced from catechin and epicatechin through anaerobic bacteria from human, as well as the rat, intestines. It was hypothesized that the marc remaining after expression of juice from grapes became infested during storage, resulting in the production of 1. Because compound 1 is infrequently found in nature and has never been found in grape seeds, its presence may be considered a marker of an unwanted anaerobic bacterial process occurring during production. The antioxidant potential of 1 was determined by DPPH, ABTS, and FRAP (ferric reducing antioxidant power) assays and compared to the potential of the following compounds: phloroglucine, pyrogallol, gallic acid, catechin, and epicatechin. Furthermore, it was established that 1 significantly reduced guinea pig ileum contraction induced by histamine

Sequence structure emission in The Red Rectangle Bands

We report high resolution (R~37,000) integral field spectroscopy of the central region (r<14arcsec) of the Red Rectangle nebula surrounding HD44179. The observations focus on the 5800A emission feature, the bluest of the yellow/red emission bands in the Red Rectangle. We propose that the emission feature, widely believed to be a molecular emission band, is not a molecular rotation contour, but a vibrational contour caused by overlapping sequence bands from a molecule with an extended chromophore. We model the feature as arising in a Polycyclic Aromatic Hydrocarbon (PAH) with 45-100 carbon atoms.Comment: 13 pages, 9 figures, accepted for publication in ApJ. A version of the paper with full resolution figures is available at: http://www.aao.gov.au/local/www/rgs/Sequence-Structure

GALEX FUV Observations of Comet C/2004 Q2 (Machholz): The Ionization Lifetime of Carbon

We present a measurement of the lifetime of ground state atomic carbon, C(^3P), against ionization processes in interplanetary space and compare it to the lifetime expected from the dominant physical processes likely to occur in this medium. Our measurement is based on analysis of a far ultraviolet (FUV) image of comet C/2004 Q2 (Machholz) recorded by the Galaxy Evolution Explorer (GALEX) on 2005 March 1. The bright CI 1561 A and 1657 A multiplets dominate the GALEX FUV band. We used the image to create high S/N radial profiles that extended beyond one million km from the comet nucleus. Our measurements yielded a total carbon lifetime of 7.1 -- 9.6 x 10^5 s (scaled to 1 AU). Which compares favorably to calculations assuming solar photoionization, solar wind proton change exchange and solar wind electron impact ionization are the dominant processes occurring in this medium and that comet Machholz was embedded in the slow solar wind. The shape of the CI profiles inside 3x10^5 km suggests that either the CO lifetime is shorter than previously thought and/or a shorter-lived carbon-bearing parent molecule, such as CH_4 is providing the majority of the carbon in this region of the coma of comet Machholz.Comment: 26 pages, 6 figures, accepted for publication in the Astrophysical Journa

Chemical and biological evaluation of rejects from the wood industry.

Este estudo visa a caracterização química e a avaliação da atividade antimicrobiana de extratos obtidos a partir de rejeitos resultantes do beneficiamento de madeiras nobres comercializadas no Paraná: Peroba-Rosa (Aspidosperma sp.), Roxinho (Peltogyne sp.), Jatobá (Hymenaea sp.), Curupixá (Micropholis sp.), Itaúba (Mezilaurus sp.), Cedrilho (Erisma sp.) e Imbúia-do-Norte (Licaria sp.), cujas identificações botânicas basearam-se em estudos anatômicos. Os extratos foram preparados com diversos solventes, analisados por CCD e espectrometria UV/VIS, testando-se contra: Proteus mirabilis ATCC15290, Escherichia coli ATCC25922, Enterobacter aerogenes ATCC13048, Staphylococcus aureus ATCC25923, Micrococcus luteus ATCC9341, Klebsiella pneumoniae ATCC13883, Pseudomonas aeroginosa ATCC27853, e Staphylococcus aureus, Streptococcus mutans e Bacillus cereus isolados da clínica. O extrato etanólico de Peroba-Rosa, contendo alcalóides, apresentou atividade contra P. mirabilis. Os extratos metanólicos do Jatobá, Itaúba e Imbúia, contendo fenóis, e o extrato de Roxinho obtido com acetato de etila contendo fenóis e terpenóides, foram ativos contra K. pneumoniae, M. luteus, E. coli, S. aureus e P. mirabilis. Nenhum dos extratos foi ativo contra P. aeroginosa, S. mutans e E. aerogenes

Functional outcome of traumatic spinopelvic instabilities treated with lumbopelvic fixation.

The aim of this study was to assess the functional outcome after lumbopelvic fixation (LPF) using the SMFA (short musculoskeletal functional assessment) score and discuss the results in the context of the existing literature. The last consecutive 50 patients who underwent a LPF from January 1st 2011 to December 31st 2014 were identified and administered the SMFA-questionnaire. Inclusion criteria were: (1) patient underwent LPF at our institution, (2) complete medical records, (3) minimum follow-up of 12 months. Out of the 50 recipients, 22 questionnaires were returned. Five questionnaires were incomplete and therefore seventeen were included for analysis. The mean age was 60.3 years (32-86 years; 9m/8f) and the follow-up averaged 26.9 months (14-48 months). Six patients (35.3%) suffered from a low-energy trauma and 11 patients (64.7%) suffered a high-energy trauma. Patients in the low-energy group were significantly older compared to patients in the high-energy group (72.2 vs. 53.8 years; p = 0.030). Five patients (29.4%) suffered from multiple injuries. Compared to patients with low-energy trauma, patients suffering from high-energy trauma showed significantly lower scores in daily activities (89.6 vs. 57.1; p = 0.031), mobility (84.7 vs. 45.5; p = 0.015) and function (74.9 vs. 43.4; p = 0.020). Our results suggest that patients with older age and those with concomitant injuries show a greater impairment according to the SMFA score. Even though mostly favorable functional outcomes were reported throughout the literature, patients still show some level of impairment and do not reach normative data at final follow-up

Effect of Gas Atmosphere on Catalytic Behaviour of Zirconia, Ceria and Ceria Zirconia Catalysts in Valeric Acid Ketonization

[EN] Ketonization of valeric acid, which can be obtained by lignocellulosic biomass conversion, was carried out in a fixed bed flow reactor over ZrO2, 5-20 % CeO2/ZrO2 and CeO2 both under hydrogen and nitrogen stream at 628 K and atmospheric pressure. Regardless gas-carrier 10 wt% CeO2/ZrO2 was found to show higher catalytic activity compared to zirconia per se as well as other ceria modified zirconia while ceria per se exhibited very low catalytic activity. All catalysts provided higher acid conversion in H-2 than in N-2 whereas selectivity to 5-nonanone was insensitive to gas atmosphere. XRD, FTIR, UV-Vis DRS, XPS, HRTEM methods were applied to characterize catalysts in reduced and unreduced states simulating corresponding reaction conditions during acid ketonization. XRD did not reveal any changes in zirconia and ceria/zirconia lattice parameters as well as crystalline phase depending on gas atmosphere while insertion of ceria in zirconia caused notable increase in lattice parameter indicating some distortion of crystalline structure. According to XPS, FTIR and UV-Vis methods, the carrier gas was found to affect catalyst surface composition leading to alteration in Lewis acid sites ratio. Appearance of Zr3+ cations was observed on the ZrO2 surface after hydrogen pretreatment whereas only Zr4+ cations were determined using nitrogen as a gas-carrier. These changes of catalyst's surface cation composition affected corresponding activity in ketonization probably being crucial for reaction mechanism involving metal cations catalytic centers for acid adsorption and COO- stabilization at the initial step.Financial support from the Russian Foundation of Basic Research (RFBR Grant No 11-03-94001-CSIC) is gratefully acknowledged. This work was supported by the Federal Program "Scientific and Educational Cadres of Russia'' (Grant No 2012-1.5-12-000-1013-002). The authors also wish to thank Dr. Evgeniy Gerasimov, Dr. Igor Prosvirin, Dr. Demid Demidov from the Department of Physicochemical Methods at the Boreskov Institute of Catalysis for TEM and XPS measurements.Zaytseva, YA.; Panchenko, VN.; Simonov, MN.; Shutilov, AA.; Zenkovets, GA.; Renz, M.; Simakova, IL.... (2013). Effect of Gas Atmosphere on Catalytic Behaviour of Zirconia, Ceria and Ceria Zirconia Catalysts in Valeric Acid Ketonization. Topics in Catalysis. 56(9-10):846-855. https://doi.org/10.1007/s11244-013-0045-yS846855569-10Alonso DM, Bond JQ, Dumesic JA (2010) Green Chem 12:1493–1513Serrano-Ruiz JC, Wang D, Dumesic JA (2010) Green Chem 12:574–577Malhotra SL, Wong RW, Breton MP (2002) Patent US 6461417Westfechtel A, Breucker C, Gutsche B, Jeromin L, Eierdanz H, Baumann H, Schmid KH, Nonnenkamp W (1993) Patent DE 4121117Seipel W, Hensen H, Boyxen N (2001) Patent DE 19958521Tomlinson AD (2001) Patent WO 2001094522Glinski M, Kijenski J, Jakubowski A (1995) Appl Catal A Gen 128:209–217Glinski M, Kijenski J (2000) React Kinet Catal Lett 69:123–128Parida K, Mishra HK (1999) J Mol Catal A Chem 139:73–80Serrano-Ruiz JC, Dumesic JA (2009) Green Chem 11:1101–1104Serrano-Ruiz JC, Dumesic JA (2009) ChemSusChem 2:581–586Leung A, Boocock DGB, Konar SK (1995) Energy Fuels 9:913–920Gaertner CA, Serrano-Ruiz JC, Braden DJ, Dumesic JA (2010) Ind Eng Chem Res 49:6027–6033Saito N (1996) Patent JP 08198796Yakerson VI, Rubinshtein AM, Gorskaya LA (1970) Patent GB 1208802Graille J, Pioch D (1991) Patent EP 457665Pioch D, Lescure R, Graille J (1995) Ol Corps Gras Lipides 2:386–389Mueller-Erlwein E, Rosenberger B (1990) Chem Ing Tech 62:512–513Corma A, Renz M, Schaverien C (2008) ChemSusChem 1:739–741Bayer (1911) Patent DE 256622Vavon G, Apchie A (1928) Bull Soc Chim 43:667–677Thorpe JF, Kon GAR (1941) Org Synth 1:192–194Nagashima O, Sato S, Takahashi R, Sodesawa T (2005) J Mol Catal A Chem 227:231–239Klein-Homann W (1988) Patent DE 3709765Stubenrauch J, Brisha E, Vohs JM (1996) Catal Today 28:431–441Pulido A, Oliver-Tomas B, Renz M, Boronat M, and Corma A (2013) ChemSusChem 6:141–151Hendren TS, Dooley KM (2003) Catal Today 85:333–351Novothy R, Paulsen S (1963) Patent DE 1158050Kim KS, Barteau MA (1990) J Catal 125:353–375Pestman R, Van Duijne A, Pieterse JAZ, Ponec V (1995) J Mol Catal A 103:175–180Martinez R, Huff MC, Barteau MA (2004) J Catal 222:404–409Matsuoka K, Tagawa K (1985) Patent JP 61207354Shutilov AA, Simonov MN, Zaytseva YuA, Zenkovets GA, and Simakova IL (2013) Kinet Catal 54:184–192Kuriacose JC, Swaminathan R (1969) J Catal 14:348–354Swaminathan R, Kuriacose JC (1970) J Catal 16:357–362Cressely J, Farkhani D, Deluzarche A, Kiennemann A (1984) Mater Chem Phys 11:413–431Kuriacose JC, Jewur SS (1977) J Catal 50:330–341Renz M, Corma A (2004) Eur J Org Chem 2004:2036–2039Taimoor AA, Favre-Reguillon A, Vanoye L, Pitault I (2012) Catal Sci Technol 2:359–363Kustov LM (1997) Top Catal 4:131–144Emmanuel NM (1978) Usp Khim 8:1329–1396Kaspar J, Fornasiero P (2002) In: Trovarelli A (ed) Catalysis by ceria and related materials. Imperial College Press, LondonReddy DD, Chowdhury B, Smirniotis PG (2001) Appl Catal A Gen 211:19–30Rango R, Kaspar G, Meriani S, di Monte R, Graziani M (1994) Catal Lett 24:107–112Rao G, Sahu H (2001) Proc Indian Acad Sci (Chem Sci) 113:651–658Navío JA, Hidalgo MC, Colón G, Botta SG, Litter MI (2001) Langmuir 17:202–210Timofeeva MN, Jhung SH, Hwang YK, Kim DK, Panchenko VN, Melgunov MS, Chesalov YA, Chang JS (2007) Appl Catal A Gen 317:1–10Kaneko H, Taku S, Tamaura Y (2011) Sol Energy 85:2321–2330Maia TA, Assaf JM, Assaf EM (2012) Mater Chem Phys 132:1029–1034Zhou HP, Si R, Song WG, Yan CH (2009) J Solid State Chem 182:2475–2485Si R, Zhang YW, Li SJ, Lin BX, Yan CH (2004) J Phys Chem B 108:12481–12488Hadjivanov KI, Vayssilov GN (2002) Adv Catal 47:307–511Vivier L, Duprez D (2010) ChemSusChem 3:654–678Vidruk R, Landau MV, Herskowitz M, Ezersky V, Goldbourt A (2011) J Catal 282:215–227Binet C, Daturi M, Lavalley JC (1999) Catal Today 50:207–225Conesa J (1995) Surf Sci 339:337–35

Insights into the ceria-catalyzed ketonization reaction for biofuels applications

The ketonization of small organic acids is a valuable reaction for biorenewable applications. Ceria has long been used as a catalyst for this reaction; however, under both liquid and vapor phase conditions, it was found that given the right temperature regime of about 150-300 °C, cerium oxide, which was previously believed to be a stable catalyst for ketonization, can undergo bulk transformations. This result, along with other literature reports, suggest that the long held belief of two separate reaction pathways for either bulk or surface ketonization reactions are not required to explain the interaction of cerium oxide with organic acids. X-ray photon spectroscopy, scanning electron microscopy, and temperature programmed decomposition results supported the formation of metal acetates and explained the occurrence of cerium reduction as well as the formation of cerium oxide/acetate whiskers. After thermogravimetry/mass spectrometry and FT-IR experiments, a single reaction sequence is proposed that can be applied to either surface or bulk reactions with ceria

Russia’s Legal Transitions: Marxist Theory, Neoclassical Economics and the Rule of Law

We review the role of economic theory in shaping the process of legal change in Russia during the two transitions it experienced during the course of the twentieth century: the transition to a socialist economy organised along the lines of state ownership of the means of production in the 1920s, and the transition to a market economy which occurred after the fall of the Soviet Union in the 1990s. Despite differences in methodology and in policy implications, Marxist theory, dominant in the 1920s, and neoclassical economics, dominant in the 1990s, offered a similarly reductive account of law as subservient to wider economic forces. In both cases, the subordinate place accorded to law undermined the transition process. Although path dependence and history are frequently invoked to explain the limited development of the rule of law in Russia during the 1990s, policy choices driven by a deterministic conception of law and economics also played a role.This is the author accepted manuscript. The final version is available from Springer via http://dx.doi.org/10.1007/s40803-015-0012-

Wishing for deburdening through a sustainable control after bariatric surgery

The aim of this study was an in-depth investigation of the change process experienced by patients undergoing bariatric surgery. A prospective interview study was performed prior to as well as 1 and 2 years after surgery. Data analyses of the transcribed interviews were performed by means of the Grounded Theory method. A core category was identified: Wishing for deburdening through a sustainable control over eating and weight, comprising three related categories: hoping for deburdening and control through surgery, feeling deburdened and practising control through physical restriction, and feeling deburdened and trying to maintain control by own willpower. Before surgery, the participants experienced little or no control in relation to food and eating and hoped that the bariatric procedure would be the first brick in the building of a foundation that would lead to control in this area. The control thus achieved in turn affected the participants' relationship to themselves, their roles in society, and the family as well as to health care. One year after surgery they reported established routines regarding eating as well as higher self-esteem due to weight loss. In family and society they set limits and in relation to health care staff they felt their concern and reported satisfaction with the surgery. After 2 years, fear of weight gain resurfaced and their self-image was modified to be more realistic. They were no longer totally self-confident about their condition, but realised that maintaining control was a matter of struggle to obtaining a foundation of sustainable control. Between 1 and 2 years after surgery, the physical control mechanism over eating habits started to more or less fade for all participants. An implication is that when this occurs, health care professionals need to provide interventions that help to maintain the weight loss in order to achieve a good long-term outcome