50 research outputs found
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
- Author
- 14 | COVIDSurg COllabOratIVe Tzovaras G. (General University Hospital of Larissa)
- Aawsaj Y.
- Abad Gurumeta A.
- Abad-Motos A.
- Abate E.
- Abbott D.
- Abdalla M.
- Abdeldayem H.
- Abdelkader Salama I.
- Abdelkarim M.
- Abdur-Rahman L.
- Abel M. K.
- Aboelkassem Ibrahim A.
- Abou Chaar M. K.
- Abreu da Silva A.
- Abubakar A.
- Acebes GarcĂa F.
- Achalandabaso Boira M. Sales Mallafré R. (Hospital Universitari de Tarragona Joan XXIII)
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- Adamina M.
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- Adiamah A.
- Afonso J.
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- Alma Mater Studiorum University of Bologna)
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- Almeida J. I.
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- Alonso de la Fuente N. Jimenez Toscano M. (Hospital del Mar)
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- Alqannas M.
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- Aou Sassari)
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- Argentina: Alurralde C.
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- Campus Benjamin Franklin)
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- Clifford R.
- Clinical Centre of Serbia)
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- Coughlin P.
- COVIDSurg COllabOratIVe | 15 Violante T. (IRCCS Azienda Ospedaliero â Universitaria di Bologna
- Cozza V.
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- Cristian D.
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- Department of Biomedical Sciences
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- Government Medical College). Ireland: Aremu M.
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- Health Affairs
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- TU Dresden)
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- Universiti Sains Malaysia)
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- Velchuru V.
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- Venn M. (Royal London Hospital)
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- Vera Mansilla C. (Hospital Universitario Principe de Asturias)
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- Vergari R. (Ospedali Riuniti di Ancona)
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- Vervoort D.
- Vescio G. (University âMagna Graeciaâ of Catanzaro)
- Vezakis A. (Aretaieion Hospital)
- Videira J. F. (IPO Porto). RĂ©union: Kassir R.
- Vieira B. (Centro Hospitalar de TrĂĄs-Os-Montes e Alto Douro
- Vieira Caroço T. (IPO Coimbra)
- Vieira Paiva Lopes A. C. (Hospital de Torres Vedras â Centro Hospitalar do Oeste)
- Vignali A. (San Raffaele Scientific Institute
- Vigorita V. (Ălvaro Cunqueiro Hospital)
- Vijayan D. (Queen Elizabeth Hospital Birmingham)
- Villalabeitia Ateca I. (Hospital Universitario Cruces)
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- Vitali A. (Ospedale San Giovanni di Dio)
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- VĂĄzquez FernĂĄndez A. (Hospital ClĂnico Universitario de Valladolid)
- Wadham B. (The University Hospital of South Manchester)
- Walkes K. (Queen Elizabeth Hospital). Belgium: Flamey N.
- Wani R. (Sher-I-Kashmir Institute of Medical Sciences)
- Waqar S. H. (Pakistan Institute of Medical Sciences). Poland: Major P. (Jagiellonian University Medical College). Portugal: Azevedo C.
- Warren O. (Chelsea and Westminster Hospital)
- Watson L. J. (Sunderland Royal Hospital)
- Watson N. (Kingâs Mill Hospital)
- Weitz J.
- Welsch T. (Carl-Gustav-Carus University Hospital
- Werner J. (LMU Klinikum Campus Innenstadt)
- Westwood E. (James Paget University NHS Foundation Trust Hospital)
- Whelan M. (Tallaght University Hospital)
- Whitmore H. (Torbay and South Devon NHS Trust)
- Wilkin R. J. W. (South Warwickshire NHS Foundation Trust)
- Wilkins A. (Hull University Teaching Hospitals NHS Trust)
- Williams G. (Royal Gwent Hospital)
- Williams K. (St Georgeâs Hospital)
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- Wullschleger M. (Gold Coast University Hospital)
- Xavier R. G.
- Xenaki S.
- Xynos E. (University Hospital of Heraklion Crete and Interclinic Hospital of Crete). Hong Kong: Futaba K.
- Yang W.
- Yassin N. (Royal Wolverhampton NHS Trust)
- Ye G.
- Yesantharao P.
- Yetkin S. G. (Sisli Hamidiye Etfal Training and Research Hospital)
- YeĆilyurt D. (University of Health Sciences Tepecik Training and Research Hospital)
- Yiallourou A. (Nicosia General Hospital). Czechia: Martinek L.
- Yıldırım A.
- Yildiz A. (Yildirim Beyazit University Yenimahalle Training and Research Hospital). Uganda: Lule H.
- Young R. (York Teaching Hospitals NHS Trust)
- Yousof E. A. (Assiut University Hospital)
- Youssef M. (Norfolk and Norwich University Hospital)
- Yurttas C. (University Hospital Tuebingen)
- YĂĄnez C. (Royo Villanova)
- YĂŒksel E. (Kocaeli University Teaching Hospital)
- Zafar S. N. (University of Wisconsin)
- Zakaria A. D.
- Zakaria Z. (School of Medical Sciences and Hospital
- Zambon M. (Policlinico Umberto I Sapienza University of Rome)
- Zanus G. (Caâ Foncello Treviso â DISCOG â UniversitĂ di Padova)
- Zegarac M. (Institute for Oncology and Radiology of Serbia)
- ZeliÄ M. (University Hospital Center Rijeka)
- Zengin A. K. (Istanbul Universty â CerrahpaĆa Medical Faculty)
- Zerbib P. (CHU Lille)
- Zervas K.
- Zese M. (Santa Maria degli Angeli Hospital ULSS 5 â Adria)
- Zhang H. (Concord Repatriation General Hospital)
- Zizzo M. (Azienda UnitĂ Sanitaria Locale â IRCCS di Reggio Emilia)
- Zografos C. (Laiko University Hospital)
- Zorrilla OrtĂșzar J. (Hospital General Universitario Gregorio Marañón)
- Zourntou S. (General Hospital of Larissa âKoutlimpaneio and Triantafylleioâ)
- Zubaidi A. M. (King Saud University). Serbia: AleksiÄ L.
- Ăngelo M.
- Ăelebi F.
- Ăolak E.
- Ăfner D. (Medical University of Innsbruck)
- Ăhlberger L.
- Ăzçelık M. F.
- ĂÄĂŒcĂŒ H.
- ĂberrĂŒck L.
- Äoza I.
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic
Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study
- Author
- Abad RD
- Abe T
- Abroug F
- Adams JC
- Adamsson RO
- Adolfsson A
- Aguilar RZ
- Aguirre JS
- Aguirre-Bermeo H
- Aisa TM
- Aisiku I
- Ajetunmobi OO
- Aker M
- Akyol OO
- Al Dorzi HM
- Al Jabbary AS
- Albaiceta GM
- Albarrak MM
- Albiero D
- Alda RS
- Alejandro RV
- Alexander P
- Algaba Ă
- Aliaga FA
- Alisasis AU
- Allan RM
- Allue RM
- Almekhlaf G
- Alonso JG
- Altaf W
- Alvarez AM
- Alvarez J
- Amin P
- Amir F
- Amor M
- An Y
- Andersen FH
- Andoh K
- Andruszkiewicz P
- Aneman A
- Antonelli MM
- AntĂŽnio ACP
- Aoki N
- Appelberg H
- Arabi Y
- Arabi YM
- Araujo AM
- Arizmendi A
- Arnal JM
- Artiga MJD
- Artigas A
- Ascoli A
- Au SM
- Avila LE
- Azad R
- Azevedo LC
- Baboi L
- Badie JC
- Bailey IM
- Bailey MB
- Bajwa E
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- Banner-Goodspeed VM
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- Beegle SH
- Beitler JR
- Bellani G
- Bellani G.
- Beloncle F
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- Beraldo DO
- Berghe C
- Berkelmans F
- Besset SL
- Bettini LR
- Beuret P
- Bezzi MG
- Bhardwaj VK
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- Biehler J
- Bigot C
- Bihari S
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- Biscione RR
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- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2019
- Field of study
OBJECTIVES: To describe the characteristics and outcomes of patients with acute respiratory distress syndrome with or without spontaneous breathing and to investigate whether the effects of spontaneous breathing on outcome depend on acute respiratory distress syndrome severity. DESIGN: Planned secondary analysis of a prospective, observational, multicentre cohort study. SETTING: International sample of 459 ICUs from 50 countries. PATIENTS: Patients with acute respiratory distress syndrome and at least 2 days of invasive mechanical ventilation and available data for the mode of mechanical ventilation and respiratory rate for the 2 first days. INTERVENTIONS: Analysis of patients with and without spontaneous breathing, defined by the mode of mechanical ventilation and by actual respiratory rate compared with set respiratory rate during the first 48 hours of mechanical ventilation. MEASUREMENTS AND MAIN RESULTS: Spontaneous breathing was present in 67% of patients with mild acute respiratory distress syndrome, 58% of patients with moderate acute respiratory distress syndrome, and 46% of patients with severe acute respiratory distress syndrome. Patients with spontaneous breathing were older and had lower acute respiratory distress syndrome severity, Sequential Organ Failure Assessment scores, ICU and hospital mortality, and were less likely to be diagnosed with acute respiratory distress syndrome by clinicians. In adjusted analysis, spontaneous breathing during the first 2 days was not associated with an effect on ICU or hospital mortality (33% vs 37%; odds ratio, 1.18 [0.92-1.51]; p = 0.19 and 37% vs 41%; odds ratio, 1.18 [0.93-1.50]; p = 0.196, respectively ). Spontaneous breathing was associated with increased ventilator-free days (13 [0-22] vs 8 [0-20]; p = 0.014) and shorter duration of ICU stay (11 [6-20] vs 12 [7-22]; p = 0.04). CONCLUSIONS: Spontaneous breathing is common in patients with acute respiratory distress syndrome during the first 48 hours of mechanical ventilation. Spontaneous breathing is not associated with worse outcomes and may hasten liberation from the ventilator and from ICU. Although these results support the use of spontaneous breathing in patients with acute respiratory distress syndrome independent of acute respiratory distress syndrome severity, the use of controlled ventilation indicates a bias toward use in patients with higher disease severity. In addition, because the lack of reliable data on inspiratory effort in our study, prospective studies incorporating the magnitude of inspiratory effort and adjusting for all potential severity confounders are required
Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database
- Author
- Abad Rd
- Abe T
- Abroug F
- Adams Jc
- Adamsson Ro
- Adolfsson A
- Aguilar Rz
- Aguirre Js
- Aguirre-Bermeo H
- Aisa Tm
- Aisiku I
- Ajetunmobi Oo
- Aker M
- Akyol Oo
- Al Dorzi Hm
- Al Jabbary As
- Albaiceta Gm
- Albarrak Mm
- Albiero D
- Alda Rs
- Alejandro Rv
- Alexander P
- Algaba Ă
- Aliaga Fa
- Alisasis Au
- Allan Rm
- Allue Rm
- Almekhlafi G
- Alonso Jg
- Altaf W
- Alvarez Am
- Alvarez J
- Amin P
- Amir F
- Amor M
- An Y
- Andersen Fh
- Andoh K
- Andruszkiewicz P
- Aneman A
- Antonelli Mm
- AntĂŽnio Acp
- Aoki N
- Appelberg H
- Arabi Y
- Arabi Ym
- Arabi Ym
- Araujo Am
- Arizmendi A
- Arnal Jm
- Artiga Mjd
- Artigas A
- Ascoli A
- Au Sm
- Avila Le
- Azad R
- Azevedo Lc
- Baboi L
- Badie Jc
- Bailey Im
- Bailey Mb
- Bajwa E
- Balkhi H
- Baltus T
- Banner-Goodspeed Vm
- Barberet G
- Baron Rm
- Baronia Ak
- Barratt-Due A
- Barros Fm
- Barros Nc
- Batra H
- Battle Ce
- Bauer Pr
- Beck E
- Beck O
- Bedreag Oh
- Beegle Sh
- Beitler Jr
- Bellani G
- Bellani Giacomo
- Beloncle F
- Benslama A
- Beraldo Do
- Berkelmans F
- Besset Sl
- Bettini Lr
- Beuret P
- Bezzi Mg
- Bhardwaj Vk
- Bhowmick K
- Biehler J
- Bihari S
- Biondi Rs
- Biscione Rr
- Bisso Mc
- Black Cs
- Blakeman Tc
- Blanco J
- Bolon S
- Borello Sa
- Borotto Ee
- Botteri M
- Bouchoucha S
- Boukhazna M
- Bouw Mj
- Boyd O
- Boyle Andrew J.
- Bramall J
- Braschi A
- Braschi A
- Brazzi L
- Breen Dm
- Briquet A
- Brito Va
- Brizuela M
- Broman Lm
- Brown Sm
- Browne Ts
- Bruhn Scar
- Brunettini B
- Bruns Mm
- Buensuseso Ja
- Bugedo G
- Buise Mp
- Bulpa Pa
- Bumbasierevic V
- Bumbasirevic V
- Burtenshaw Aj
- Burtin P
- Buzancais G
- BĂ©duneau G
- Camsooksai J
- Cani A
- Carbayo-Gorriz C
- Cardonnet Lp
- Careless Jp
- Carpentier D
- Carreño Ng
- Carteaux G
- Casalena P
- Casement J
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- Ăamendys-Silva Sa
- Ănal N
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with acute hypoxemic respiratory failure (AHRF). Methods: An ancillary analysis of a global, multi-centre prospective observational study (LUNG SAFE) was undertaken. LUNG SAFE evaluated all patients admitted to an intensive care unit (ICU) over a 4-week period, that required mechanical ventilation and met AHRF criteria. Patients who had their AHRF fully explained by cardiac failure were excluded. Important clinical characteristics were included in a stepwise selection approach (forward and backward selection combined with a significance level of 0.05) to identify a set of independent variables associated with having ARDS at any time, developing ARDS (defined as ARDS occurring after day 2 from meeting AHRF criteria) and with hospital mortality. Furthermore, propensity score analysis was undertaken to account for the differences in baseline characteristics between patients with and without diabetes mellitus, and the association between diabetes mellitus and outcomes of interest was assessed on matched samples. Results: Of the 4107 patients with AHRF included in this study, 3022 (73.6%) patients fulfilled ARDS criteria at admission or developed ARDS during their ICU stay. Diabetes mellitus was a pre-existing co-morbidity in 913 patients (22.2% of patients with AHRF). In multivariable analysis, there was no association between diabetes mellitus and having ARDS (OR 0.93 (0.78-1.11); p = 0.39), developing ARDS late (OR 0.79 (0.54-1.15); p = 0.22), or hospital mortality in patients with ARDS (1.15 (0.93-1.42); p = 0.19). In a matched sample of patients, there was no association between diabetes mellitus and outcomes of interest. Conclusions: In a large, global observational study of patients with AHRF, no association was found between diabetes mellitus and having ARDS, developing ARDS, or outcomes from ARDS. Trial registration: NCT02010073. Registered on 12 December 2013
Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries
- Author
- Abad RD
- Abe T
- Abe T.
- Abroug F
- Adams JC
- Adamsson RO
- Adolfsson A
- Aguilar RZ
- Aguirre JS
- Aguirre-Bermeo H
- Aisa TM
- Aisiku I
- Ajetunmobi OO
- Aker M
- Akyol OO
- Al Dorzi HM
- Al Jabbary AS
- Albaiceta GM
- Albarrak MM
- Albiero D
- Alda RS
- Alejandro RV
- Alexander P
- Algaba Ă
- Aliaga FA
- Alisasis AU
- Allan RM
- Allue RM
- Almekhlafi G
- Alonso JG
- Altaf W
- Alvarez AM
- Alvarez J
- Amin P
- Amir F
- Amor M
- An Y
- Andersen FH
- Andoh K
- Andruszkiewicz P
- Aneman A
- Antonelli MM
- AntĂŽnio ACP
- Aoki N
- Appelberg H
- Arabi Y
- Arabi YM
- Arabim YM
- Araujo AM
- Arizmendi A
- Arnal JM
- Artiga MJD
- Artigas A
- Ascoli A
- Au SM
- Avila LE
- Azad R
- Azevedo LC
- Baboi L
- Badie JC
- Bailey IM
- Bailey MB
- Bajwa E
- Balkhi H
- Baltus T
- Banner-Goodspeed VM
- Barberet G
- Baron RM
- Baronia AK
- Barratt-Due A
- Barros FM
- Barros NC
- Batra H
- Battle CE
- Bauer PR
- Beck E
- Beck O
- Bedreag OH
- Beegle SH
- Beitler JR
- Bellani G
- Bellani G.
- Beloncle F
- Benslama A
- Beraldo DO
- Berghe C
- Berkelmans F
- Besset SL
- Bettini LR
- Beuret P
- Bezzi MG
- Bhardwaj VK
- Bhowmick K
- Biehler J
- Bigot C
- Bihari S
- Biondi RS
- Biscione RR
- Bisso MC
- Black CS
- Blakeman TC
- Blanco J
- Bolon S
- Borello SA
- Borotto EE
- Botteri M
- Bouchoucha S
- Boukhazna M
- Bouw MJ
- Boyd O
- Bramall J
- Braschi A
- Brazzi L
- Breen DM
- Briquet A
- Brito VA
- Brizuela M
- Brochard L
- Broman LM
- Brown SM
- Browne TS
- Bruhn AR
- Brunettini B
- Bruns MM
- Buensuseso JA
- Bugedo G
- Buise MP
- Bulpa PA
- Bumbasierevic V
- Bumbasirevic V
- Burtenshaw AJ
- Burtin P
- Buzancais G
- BĂ©duneau G
- Camsooksai J
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- Zogheib EH
- Ăamendys-Silva SA
- Ănal N
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: To better understand the epidemiology and patterns of tracheostomy practice for patients with acute respiratory distress syndrome (ARDS), we investigated the current usage of tracheostomy in patients with ARDS recruited into the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG-SAFE) study. Methods: This is a secondary analysis of LUNG-SAFE, an international, multicenter, prospective cohort study of patients receiving invasive or noninvasive ventilation in 50 countries spanning 5 continents. The study was carried out over 4 weeks consecutively in the winter of 2014, and 459 ICUs participated. We evaluated the clinical characteristics, management and outcomes of patients that received tracheostomy, in the cohort of patients that developed ARDS on day 1-2 of acute hypoxemic respiratory failure, and in a subsequent propensity-matched cohort. Results: Of the 2377 patients with ARDS that fulfilled the inclusion criteria, 309 (13.0%) underwent tracheostomy during their ICU stay. Patients from high-income European countries (n = 198/1263) more frequently underwent tracheostomy compared to patients from non-European high-income countries (n = 63/649) or patients from middle-income countries (n = 48/465). Only 86/309 (27.8%) underwent tracheostomy on or before day 7, while the median timing of tracheostomy was 14 (Q1-Q3, 7-21) days after onset of ARDS. In the subsample matched by propensity score, ICU and hospital stay were longer in patients with tracheostomy. While patients with tracheostomy had the highest survival probability, there was no difference in 60-day or 90-day mortality in either the patient subgroup that survived for at least 5 days in ICU, or in the propensity-matched subsample. Conclusions: Most patients that receive tracheostomy do so after the first week of critical illness. Tracheostomy may prolong patient survival but does not reduce 60-day or 90-day mortality. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
Evolution of the use of corticosteroids for the treatment of hospitalised COVID-19 patients in Spain between March and November 2020: SEMI-COVID national registry
- Author
- Abad M.D.C.B.
- Abanedes C.I.S.
- Aizpuru E.M.F.
- AlcalĂĄ J.N.
- AlegrĂa J.G.
- Amezua C.H.
- Amodeo Oblitas C.M.
- Andreu M.D.M.G.
- AntĂșnez M.G.
- Arenzana C.B.
- Aseguinolaza M.G.
- Ayala-Gutiérrez M.M.
- Ayuso B.
- BailĂłn M.M.
- Balaz D.
- Bandera V.A.
- Beamonte E.D.C.
- Beato R.A.
- Benbunan C.C.
- Bengoa G.D.
- Bermejo C.L.
- BermĂșdez M.
- Blanco A.L.
- Bueso T.S.
- Buonaiuto V.A.
- Caleya J.F.L.
- Calvo C.M.
- Campo B.M.
- Candalija A.C.
- CapitĂĄn C.F.
- Carmona J.M.
- Carracedo E.F.
- Carrasco A.G.
- Carrillo R.
- Carvajal M.C.C.
- Casado L.P.
- Casanova P.C.
- Casas L.A.
- Casas-Rojo J.-M.
- Castro S.M.
- Cañas C.A.
- CebriĂĄn M.B.
- Chamorro L.M.T.
- Christophel A.T.F.-T.
- Clotet N.C.
- Corbella X.
- Corral J.B.
- Corral-Gudino L.
- Cruz A.F.
- Cuchillo J.B.
- CĂĄnovas J.S.
- De Blas P.A.
- De La Calle G.M.
- De La Chica M.N.
- De Luque C.M.C.
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- De Pedro I.P.
- De Santos S.
- De Windt F.
- Del Pino J.L.
- Delgado C.M.
- Do Rego A.T.
- ElĂas A.E.C.
- Escalante M.D.M.
- Escudero S.C.
- Estrada A.D.B.
- Etayo M.Z.
- Fernandez-Bravo I.G.
- Fernandez-Castelao S.
- FernĂĄndez A.M.
- FernĂĄndez F.A.
- FernĂĄndez M.S.
- FernĂĄndez P.C.
- Fernåndez-Garcés M.
- FernĂĄndez-Llamazares G.S.
- Fonseca J.B.
- Fontan P.M.P.
- FontĂĄn P.M.P.
- FrĂas M.C.
- Galeano Valle F.
- Galvañ V.G.
- Garcia A.
- Garcia M.V.V.
- GarcĂa A.T.
- GarcĂa C.A.
- GarcĂa GarcĂa G.M.
- GarcĂa J.G.
- GarcĂa S.L.
- Gil C.R.H.
- Godoy R.M.
- Gonzalo J.L.
- Gonzalo L.A.
- Grela A.G.
- Guerrero M.B.
- Guillan E.M.P.
- Gurjian A.A.
- Gutiérrez J.C.M.
- GĂłmez A.E.
- GĂłmez C.R.
- GĂłmez J.A.
- HernĂĄndez A.L.
- HernĂĄndez C.D.
- HernĂĄndez M.J.J.
- Homs N.
- Hontañón V.
- Huelgas R.G.
- Huerta L.J.
- Hurtado Oliver J.A.
- Ibåñez L.J.
- Iglesias M.F.G.
- Iscar C.O.
- Jansen-Chaparro S.
- Jenaro M.M.F.-M.
- Jimeno V.M.
- Jiménez P.D.
- JimĂ©nez-GarcĂa N.
- Klepzig J.L.G.
- Lahoz C.
- Laorden C.J.
- Ledesma S.M.
- Leoni M.E.G.
- Lezaun C.G.
- Llorente B.P.
- Lora-Tamayo J.
- Lorenzo-HernĂĄndez E.
- LĂłpez C.M.O.
- LĂłpez I.B.
- LĂłpez M.M.M.
- LĂłpez M.N.
- LĂłpez R.B.
- LĂłpez-Carmona M.D.
- MacĂas M.T.
- Manau J.V.
- Manglano J.D.
- Manuel E.C.
- MartĂnez D.L.
- MartĂnez J.M.H.
- MartĂnez L.F.C.
- MartĂnez M.L.T.
- MartĂnez R.F.-M.
- Mayoral M.V.
- Mendo C.L.
- Mera I.F.
- Molina S.C.
- Montero A.
- Montes J.T.
- Mora-LujĂĄn J.M.
- MorejĂłn J.B.
- Moreno A.D.C.
- Moreno M.C.
- Mozo A.N.
- Murgui R.M.
- Muriel C.C.
- Muñoz B.G.
- Muñoz E.C.
- Muñoz J.A.
- MĂguez A.M.
- Narciso C.G.S.
- Nohales C.M.
- Nuñez M.P.
- NĂșñez-CortĂ©s J.M.
- Ocaña P.G.
- Olleros C.L.
- Ortega L.O.
- Palacios L.C.
- Pampyn M.P.
- Pedroche C.D.
- PelĂĄez E.P.
- Peralta E.E.D.
- Perpiña B.O.
- Pineda-Cantero A.
- Prieto J.M.M.
- Prieto M.M.
- PurificaciĂłn A.S.
- PĂ©rez S.C.
- PĂ©rez V.E.
- PĂ©rez-Belmonte L.M.
- Quintana F.B.
- Quirantes P.L.
- Ramos J.C.
- Reyne A.G.
- Rhyman N.
- Ricci M.
- Rivera N.A.
- Robles E.M.
- Rodriguez V.N.
- RodrĂguez-Mancheño A.L.
- Romero F.N.
- Romero M.A.F.
- Royo Trallero L.E.
- Rubio-Rivas M.
- Ruiz D.P.
- Ruiz S.P.
- Ruperto L.R.
- Saavedra M.O.F.
- Saldaña A.M.
- Samaniego N.T.
- Sampalo A.L.
- Sanz M.T.M.
- Sanz M.T.P.
- Sevilla J.J.M.
- Sierra J.O.
- Simon R.D.
- SimĂłn M.A.Q.
- SuĂĄrez A.M.Ă.
- SĂĄnchez S.P.
- Tabares Y.U.
- Tejido S.C.
- Torre R.S.
- Troncoso J.Ă.
- Veganzones L.I.
- Vergés C.D.
- Vidal A.D.
- Vieitez A.C.
- Vilan L.D.
- Villarreal G.
- Virto A.P.
- Wikman-Jorgensen P.E.
- Yeguas I.A.
- Zapico A.M.
- Publication venue
- 'MDPI AG'
- Publication date
- 01/01/2021
- Field of study
Objectives: Since the results of the RECOVERY trial, WHO recommendations about the use of corticosteroids (CTs) in COVID-19 have changed. The aim of the study is to analyse the evolutive use of CTs in Spain during the pandemic to assess the potential influence of new recommendations. Material and methods: A retrospective, descriptive, and observational study was conducted on adults hospitalised due to COVID-19 in Spain who were included in the SEMI-COVID- 19 Registry from March to November 2020. Results: CTs were used in 6053 (36.21%) of the included patients. The patients were older (mean (SD)) (69.6 (14.6) vs. 66.0 (16.8) years; p < 0.001), with hypertension (57.0% vs. 47.7%; p < 0.001), obesity (26.4% vs. 19.3%; p < 0.0001), and multimorbidity prevalence (20.6% vs. 16.1%; p < 0.001). These patients had higher values (mean (95% CI)) of C-reactive protein (CRP) (86 (32.7-160) vs. 49.3 (16-109) mg/dL; p < 0.001), ferritin (791 (393-1534) vs. 470 (236- 996) ”g/dL; p < 0.001), D dimer (750 (430-1400) vs. 617 (345-1180) ”g/dL; p < 0.001), and lower Sp02/Fi02 (266 (91.1) vs. 301 (101); p < 0.001). Since June 2020, there was an increment in the use of CTs (March vs. September; p < 0.001). Overall, 20% did not receive steroids, and 40% received less than 200 mg accumulated prednisone equivalent dose (APED). Severe patients are treated with higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%. Conclusions: Patients with greater comorbidity, severity, and inflammatory markers were those treated with CTs. In severe patients, there is a trend towards the use of higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
- Author
- AbellĂĄn Javier
- Acosta-isaac René
- Aguado Jose MarĂa
- Aguilar Carlos
- Aguilera-albesa Sergio
- Ahmadi Sabbagh Abdolah
- Alba Jorge
- Albu Sergiu
- AlcalĂĄ-gallardo Karla A. M.
- Alcoba-florez Julia
- Alcolea Batres Sergio
- Algarin-lara Holmes Rafael
- Almadana Virginia
- Almeida Julia
- Almoguera Berta
- Alonso MarĂa R.
- Andreu-bernabeu Ălvaro
- Antonijoan Maria Rosa
- Arana-arri Eunate
- Aranda Carlos
- Arango Celso
- Araque Carolina
- Araujo Izabel M. T.
- Araujo Nathalia K.
- Arcanjo Ana C.
- Arnaiz Ana
- Arnalich FernĂĄndez Francisco
- Arranz MarĂa J.
- Arribas López José Ramón
- Artiga Maria-jesĂșs
- Avello-malaver Yubelly
- Ayuso Carmen
- Balagué-dobón Laura
- Baldion Ana MarĂa
- Ballina MartĂn BelĂ©n
- Baptista-rosas RaĂșl C.
- Barranco-dĂaz Andrea
- Barreda-sĂĄnchez MarĂa
- Barrera-penagos Viviana
- Belhassen-garcia Moncef
- Bernal Enrique
- Bernal-bello David
- Bezerra Joao F.
- Bezerra Marcos A. C.
- Blanca-lĂłpez Natalia
- Blancas Rafael
- Boix-palop LucĂa
- Borobia Alberto
- Bravo Elsa
- Brion MarĂa
- Brochado-kith Ăscar
- Brugada RamĂłn
- Bustos Matilde
- Cabello Alfonso
- Calbo Esther
- CalderĂłn Enrique J.
- Camacho Shirley
- Campos Marcela C.
- Carbonell Cristina
- Cardona-huerta Servando
- Carioca Antonio Augusto F.
- Carpio Segura Carlos
- Carracedo Ăngel
- Carratto ThĂĄssia M. T.
- Carrillo-avila José Antonio
- Carvalho Maria C. C.
- Casasnovas Carlos
- Castaño Carlos F.
- Castaño Luis
- Castelao Jose E.
- Castellano Candalija Aranzazu
- Castillo MarĂa A.
- Cañadas Yolanda
- Ceballos Francisco C.
- Chaux Jessica G.
- Chaves-santiago Walter G.
- Chiquillo-gĂłmez Sylena
- Cid-lĂłpez Marco A.
- Cienfuegos-jimĂ©nez Ăscar
- Conde-vicente Rosa
- Cordero-lorenzana M. Lourdes
- Corella Dolores
- Corrales Almudena
- Corton Marta
- Cortés-sånchez Jose L.
- Costa Tatiana X.
- Cruz Marina S.
- Cruz Raquel
- Cuesta Luisa
- Cunha Gabriela C. R.
- CĂĄceres Alejandro
- CĂĄceres-agra Juan J.
- Dalmau David
- Dantas-komatsu Raquel C. S.
- Darnaude M. Teresa
- De Andrés Raimundo
- De AraĂșjo JĂ©ssica N. G.
- De Juan Carmen
- De La Cruz Troca Juan J.
- De La Horra Carmen
- De La Hoz Ana B.
- De Martino-rodrĂguez Alba
- De Sousa Alves Neri Julianna Lys
- Del Campo-pérez Victor
- Delgado-cuesta Juan
- Diaz De Bustamante Aranzazu
- Dietl Beatriz
- Diz-de Almeida Silvia
- Do Monte Alves Manoella
- DomĂnguez-garrido Elena
- Dos Santos Katiusse A.
- Duarte Alice L.
- DĂaz-caneja Covadonga M.
- DĂaz-pĂ©rez Anderson
- Echave-sustaeta Jose
- Eiros RocĂo
- Enciso-olivera CĂ©sar O.
- Escudero Gabriela
- Esko Tonu
- España Pedro Pablo
- Estigarribia Sanabria Gladys
- Fariñas MarĂa Carmen
- Fernandes Marianne R.
- Fernandez-nestosa MarĂa J.
- FernĂĄndez MartĂnez Yolanda
- FernĂĄndez RamĂłn
- FernĂĄndez Ruth
- FernĂĄndez-caballero Lidia
- FernĂĄndez-capitĂĄn Carmen
- FernĂĄndez-cruz Ana
- FernĂĄndez-ferrero Silvia
- FernĂĄndez-robelo UxĂa
- FernĂĄndez-rodrĂguez Amanda
- FernĂĄndez-sampedro Marta
- FernĂĄndez-villa Tania
- Flores Carlos
- Flores-pérez Patricia
- Friaza Vicente
- Fuenmayor-hernĂĄndez LĂĄcides
- Fuertes-nĂșñez Marta
- FumadĂł Victoria
- Gadea Ignacio
- Gagliardi Lidia
- Gago-domĂnguez Manuela
- Gallego Natalia
- Galoppo Cristina
- Garcia-garcĂa Josefina
- GarcĂa TorrejĂłn MarĂa Carmen
- GarcĂa InĂ©s
- GarcĂa Leticia
- GarcĂa Mercedes
- GarcĂa-cerrada Carlos
- GarcĂa-de-vicuña Aitor
- GarcĂa-garcĂa Irene
- GarcĂa-ibarbia Carmen
- GarcĂa-montero AndrĂ©s C.
- GarcĂa-soidĂĄn Ana
- GarcĂa-vĂĄzquez Elisa
- Garza-frias Emiliano
- Gentile Angela
- Gil-fournier Belén
- Gonzalez-sagrado Manuel
- Gonzalo-benito Hugo
- GonzĂĄlez Bernaldo De QuirĂłs FernĂĄn
- GonzĂĄlez Ălvarez Beatriz
- GonzĂĄlez Juan R.
- GonzĂĄlez Juan R.
- GonzĂĄlez-montelongo Rafaela
- GonzĂĄlez-neira Anna
- Gonzålez-peñas Javier
- Gorgojo-galindo Oscar
- Guaragna Florencia
- Guegel Genilson P.
- GuillĂ©n-guĂo Beatriz
- Guillén-navarro Encarna
- Guisado-vasco Pablo
- Gutiérrez-bautista Juan F.
- Gutiérrez-castañeda Luz D.
- GĂłmez Carrera Luis
- GĂłmez GarcĂa MarĂa
- GĂłmez SacristĂĄn Ăngela
- GĂłmez-arrue Javier
- GĂłmez-duque Mario
- GĂłrgolas Miguel
- Heili-frades Sara
- HernĂĄndez Estefania
- HernĂĄndez-moro Cristina
- HernĂĄndez-ortega Luis D.
- Hernåndez-pérez Guillermo
- HernĂĄndez-vaquero Rebeca
- Herranz M. Teresa
- Herrera MarĂa
- Herrero MarĂa JosĂ©
- Herrero-gonzĂĄlez Antonio
- Herråez Belén
- Horcajada Juan P.
- Imaz-ayo Natale
- Intxausti-urrutibeaskoa Maider
- Jacomo Rafael H.
- Jara Rubén
- Jiménez Pilar
- JimĂ©nez Ăngel
- Jiménez-alfaro Ignacio
- JimĂ©nez-sousa MarĂa A.
- Jordan Iolanda
- Laguna-goya RocĂo
- Laorden Daniel
- Lapunzina Pablo
- Lasa-lĂĄzaro MarĂa
- Lattig MarĂa Claudia
- Lauriente Ailen
- Liger Borja Anabel
- Llanos LucĂa
- Lopez-garcia Esther
- Lopez-rodriguez Rosario
- Lorente Leonardo
- Lorenzo-salazar José M.
- Lozano José E.
- Lozano-espinosa MarĂa
- Luchessi Andre D.
- LĂłpez De Heredia Miguel
- LĂłpez De Heredia Miguel
- LĂłpez-bernĂșs Amparo
- LĂłpez-granados Eduardo
- LĂłpez-ruz Miguel A.
- Mahillo Ignacio
- Mancebo Esther
- Mar Carmen
- Marcelo Calvo Cristina
- Marcos Miguel
- Marcos-delgado Alba
- Mariscal-aguilar Pablo
- Martin-fernandez Marta
- Martin-pedraza Laura
- Martinez Amalia
- Martinez-paz Pedro
- MartĂn MarĂa Dolores
- MartĂn MarĂa M.
- MartĂn Vicente
- MartĂn-lĂłpez Caridad
- MartĂn-oterino JosĂ©-Ăngel
- MartĂn-vicente MarĂa
- MartĂnez Juan JosĂ©
- MartĂnez Ricardo
- MartĂnez Silvia
- MartĂnez-aquino Eleno
- MartĂnez-gonzĂĄlez Ăscar
- MartĂnez-lĂłpez Iciar
- MartĂnez-nieto Ăscar
- MartĂnez-pĂ©rez Ăngel
- MartĂnez-ramas Andrea
- MartĂnez-resĂ©ndez Michel F.
- MartĂnez-robles Violeta
- Marzal Laura
- MarĂn-candĂłn Alicia
- Maya BelĂ©n RodrĂguez
- Mazzeu Juliana F.
- Medeiros Jeane F. P.
- Medeiros Kelliane A.
- Medrano Francisco J.
- Meijome Xose M.
- Mejuto-montero Natalia
- Mendes Ingrid
- Mendoza Charris Humberto
- Merayo MacĂas Eleuterio
- Mercadillo FĂĄtima
- Mercado-sesma Arieh R.
- Molina Antonio J. J.
- Molina-roldĂĄn Elena
- Montoya Juan José
- Moraes Vitor M. S.
- Moreira-escriche Patricia
- Morelos-arnedo Xenia
- Moreno Cuerda VĂctor
- Moreno FernĂĄndez Alberto
- Moreno RocĂo
- Moreno-docĂłn Antonio
- Moreno-escalante Junior
- Morilla Rubén
- Muñoz GarcĂa Patricia
- MĂ©ndez-echevarrĂa Ana
- MĂnguez Pablo
- Neira Pablo
- Nevado JuliĂĄn
- Nieto-gañån Israel
- Nunes Joana F. R.
- Nuñez-torres RocĂo
- Obrador-hevia AntĂČnia
- Ocejo-vinyals J. Gonzalo
- Olivar Virginia
- Oliveira Silviene F.
- Olivera MarĂa Rubio
- Ondo Lorena
- Orfao Alberto
- Ortega Luis
- Ortega-paino Eva
- Ortiz-flores Fernando
- Ortiz-lĂłpez RocĂo
- Oteo José A.
- Pacheco Manuel
- Pacheco-miranda Fredy Javier
- Padilla-conejo Irene
- Panadero-fajardo Sonia
- Parellada Mara
- Pariente-rodrĂguez Roberto
- Paz-artal Estela
- Peces-barba GermĂĄn
- Pedromingo Kus Miguel S.
- Perales Celia
- Perucho Teresa
- Pichardo Lisbeth A.
- Pinho Susana M. T.
- Pinsach-abuin Mel·lina
- PinzĂłn Luz Adriana
- Pita Guillermo
- Pla-juncĂ Francesc
- Planas-serra Laura
- Pompa-mera Ericka N.
- Porras-hurtado Gloria L.
- Pujol Aurora
- PĂ©rez Alexandra
- PĂ©rez CĂ©sar
- PĂ©rez MarĂa JazmĂn
- PĂ©rez Patricia
- PĂ©rez-de-nanclares Gustavo
- PĂ©rez-garcĂa Felipe
- PĂ©rez-jurado Luis A.
- PĂ©rez-matute Patricia
- PĂ©rez-tomĂĄs M. Elena
- Quevedo-chĂĄvez MarĂa Eugenia
- Quijada Maria Angeles
- Quintela Inés
- Quintela Inés
- Ramiro-leĂłn Soraya
- Rascado Sedes Pedro
- Recalde Delia
- Recio-fernĂĄndez Emma
- Resino Salvador
- Riancho José A.
- Ribeiro Adriana P.
- Rivadeneira-chamorro Carlos S.
- Roa-agudelo Diana
- Robelo Pardo Montserrat
- Rodriguez Marilyn Johanna
- Rodriguez-nicolas Antonio
- Rodriguez-palmero AgustĂ
- Rodriguez-urrego Paula A.
- RodrĂguez-artalejo Fernando
- RodrĂguez-ferrer Marena
- RodrĂguez-gallego Carlos
- RodrĂguez-garcĂa JosĂ© A.
- RodrĂguez-hernĂĄndez MarĂa A.
- RodrĂguez-novoa German Ezequiel
- RodrĂguez-ruiz Emilio
- Rojas-martinez Augusto
- Rojo Federico
- Romero-coronado Andrea
- RondĂłn-garcĂa Filomeno
- Rosa Lidia S.
- Rosales-castillo Antonio
- Rubio Cladelis
- Ruiz Montserrat
- Ruiz-cabello Francisco
- Ruiz-casares Eva
- Ruiz-cubillan Juan J.
- Ruiz-hornillos Javier
- Ryan Pablo
- Salamanca Hector D.
- Salazar-garcĂa Lorena
- Salgueiro-origlia Giorgina Gabriela
- Sancho-sainz Cristina
- Sande Esther
- Sangil Anna
- Santos Arnoldo
- Santos Ney P. C.
- SchlĂŒter Agatha
- Scourge Cohort Group
- Segovia Sonia
- Serra-llovich Alex
- Sevil-puras Fernando
- Sevilla-porras Marta
- Sicolo Miguel A.
- Silbiger Vivian N.
- Silva Fabiola T. C.
- Silva Gabriela V.
- Silva Nayara S.
- SilvĂĄn-fuentes Cristina
- Solé-violån Jordi
- Soria José Manuel
- SorlĂ Jose V.
- Sousa Renata R.
- Souto Juan Carlos
- Souza Karla S. C.
- Souza Vanessa S.
- Sprockel John J.
- Suårez-rama José Javier
- SuĂĄrez-zamora David A.
- SĂĄnchez LĂłpez Antonio J.
- SĂĄnchez Pedro-luis
- SĂĄnchez-carpintero Abad MarĂa
- SĂĄnchez-pablo Clara
- SĂĄnchez-pernaute Olga
- SĂĄnchez-prados MarĂa ConcepciĂłn
- SĂĄnchez-real Javier
- SĂĄnchez-redondo Jorge
- Taboada-fraga Xiana
- Tamayo Eduardo
- Tamayo-velasco Alvaro
- Taracido-fernĂĄndez Juan Carlos
- Tavares Nathali A. C.
- TellerĂa Carlos
- Tenorio-castaño Jair Antonio
- Teper Alejandro
- Torres-gutiérrez Ronald P.
- Torres-macho Juan
- Torres-tobar Lilian
- Troya JesĂșs
- Urioste Miguel
- Valencia-ramos Juan
- Valido AgustĂn
- Vargas-gallo Juan Pablo
- Varón Belén
- Vasconcelos Romero H. T.
- Vega Tomas
- Velasco-quirce Santiago
- Vidån-estévez Julia
- Vieitez-santiago Miriam
- Vilches Carlos
- Villalobos Lavinia
- Villar Felipe
- Villar-garcia Judit
- Villaverde Cristina
- Villoslada-blanco Pablo
- Virseda-berdices Ana
- VĂ©lez-santamarĂa Valentina
- VĂctor Virginia
- Yåñez Zuleima
- Zapatero-gaviria Antonio
- Zarate Ruth
- Zazo Sandra
- Ălvarez Nuria
- Ălvarez-benĂtez Yady
- Ălvarez-navia Felipe
- Ălvarez-sala Walther Rodolfo
- Ăñigo-campos Antonio
- Ăñiguez MarĂa
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 08/05/2024
- Field of study
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi Hasan M.
- Al Jabbary Ahmed S.
- Albaiceta Guillermo M.
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Algaba Ăngela
- Aliaga Felipe A.
- Alisasis Alain U.
- Allan Russell M.
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez AntĂłnio M.
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Abdellatif Benslama Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- AntĂŽnio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana M.
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie M.
- Barberet Guillaume
- Baron Rebecca M.
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa M.
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri E.
- Bauer Philippe R.
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H.
- Beegle Scott H.
- Beitler Jeremy R.
- Bellani Giacomo
- Bellani Giacomo
- Beloncle Francois
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien L.
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj Vallish K.
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Biondi Rodrigo S.
- Biscione Roberto R.
- Bisso Mariano Carboni
- Black Colin S.
- Blakeman Thomas C.
- Bolon Stefan
- Borello Silvina A.
- Borotto Erika E.
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J.
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito Vania A.
- Brizuela Matias
- Brochard Laurent
- Brochard Laurent
- Broman Lars M.
- Brown Samuel M.
- Browne Troy S.
- Bruhn Alejandro R.
- Brunettini Barbara
- Bruns Monique M.
- Buensuseso Juan A.
- Bugedo Guillermo
- Buise Marc P.
- Bulpa Pierre A.
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew J.
- Burtin Philippe
- Buzancais Gautier
- BĂ©duneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis P.
- Careless Jon P.
- Carpentier Dorothée
- Carreño Nicolås G.
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro G.
- Castro Silvia
- Catorze Nuno T.
- Cazorla-Barranquero Francisca G.
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria I.
- Cervantes Mavy Ramirez
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon K.
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy Perez
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- CitalĂĄn Johanna E.
- Claraco-Vega Luis M.
- Clarkson Kevin
- Clarkson Kevin P.
- Claverias Laura
- Cohen Jason E.
- Cole Jade M.
- Collins Daniel V.
- Collyer Thomas
- Colombo Riccardo
- Combaux Daniele M.
- Combes Alain
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan E.
- Cortegiani Andrea
- Cortez Cesar A.
- Coxo Cristina M.
- Cracchiolo Andrea N.
- Cranshaw Julius H.
- Crapelli Giulia
- Crouch Daniel R.
- Crova Philippe J.
- Csabi Peter
- Curley Gerard
- Curto Elena Gallego
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin C. dric
- Daviaud Fabrice
- Davies Kyle G.
- Dawson Heidi
- de Cima-Iglesias Sara
- de Gordoa Laura Ortiz-Ruiz
- de Haro Candelaria
- de Pablo Raul
- de Prost Nicolas
- Dean Michael N.
- Declercq Pierre-Louis M.
- Dector Dulce
- Dector Dulce M.
- Deicas Alberto
- del Carmen Lorente Maria
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane Tarek
- Depuydt P.
- Depuydt Pieter
- Derman Suleyman S.
- di Tomasso Nora N.
- di Yu D.
- Diaz-Rodriguez Esther
- Dive Alain M.
- Dixit Subhal B.
- Do Vale Fernandes Antero
- Dolva Merete S.
- Donnelly Adrian
- Dowling Anna T.
- Doyen Denis
- Dres Martin
- Dreyer Kyle R.
- Dunne Eimhin S.
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- DĂ©mpaire Gabriel
- Ebeid Alejandro
- Elatrous Souheil
- Elisabet Garcia M.
- Elkhayari Mina
- Ellis Helen E.
- Elmasri Mary
- Erbabacan Emre
- Eriksson Karin E.
- Esteban Andres
- Estenssoro Elisa
- Esteve Francisco
- Estilita Joana M.
- Estrella Claudia R.
- Ezzouine Hanane
- Fan Eddy
- Fan Eddy
- Fartoukh Muriel
- FarĂas Pamela A.
- Fawkes Danielle A.
- Ferguson Andrew
- Ferguson Niall D.
- Fernandez Adriana M.
- Fernandez Ruben O.
- Fierro Jonathan M.
- Floris Leda
- Follin Arnaud
- Fontenele Danielle C.
- Formenti Paolo
- Forteza Catalina
- Fossali Tommaso
- Foti Giuseppe
- Franco Nieves
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- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
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- Zhou Suming
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- Zhu Wei H.
- Zogheib Elie H.
- Ăamendys-Silva Silvio A.
- Ănal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ℠0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe
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- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 14/06/2016
- Field of study
Background: Epidemiological evidence suggests a cardioprotective role of αâlinolenic acid (ALA), a plantâderived Ïâ3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine Ïâ3 fatty acids (longâchain nâ3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to allâcause and cardiovascular disease mortality. We also examined the effect of meeting the society's recommendation for longâchain nâ3 polyunsaturated fatty acids (â„500 mg/day). Methods and Results: We longitudinally evaluated 7202 participants in the PREvenciĂłn con DIeta MEDiterrĂĄnea (PREDIMED) trial. Multivariableâadjusted Cox regression models were fitted to estimate hazard ratios. ALA intake correlated to walnut consumption (r=0.94). During a 5.9ây followâup, 431 deaths occurred (104 cardiovascular disease, 55 coronary heart disease, 32 sudden cardiac death, 25 stroke). The hazard ratios for meeting ALA recommendation (n=1615, 22.4%) were 0.72 (95% CI 0.56â0.92) for allâcause mortality and 0.95 (95% CI 0.58â1.57) for fatal cardiovascular disease. The hazard ratios for meeting the recommendation for longâchain nâ3 polyunsaturated fatty acids (n=5452, 75.7%) were 0.84 (95% CI 0.67â1.05) for allâcause mortality, 0.61 (95% CI 0.39â0.96) for fatal cardiovascular disease, 0.54 (95% CI 0.29â0.99) for fatal coronary heart disease, and 0.49 (95% CI 0.22â1.01) for sudden cardiac death. The highest reduction in allâcause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [95% CI 0.45â0.87]). Conclusions: In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to allâcause mortality, whereas protection from cardiac mortality is limited to fishâderived longâchain nâ3 polyunsaturated fatty acids. Clinical Trial Registration URL: http://www.Controlled-trials.com/. Unique identifier: ISRCTN35739639
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
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- Ć imko K.
- ĆœateckĂœ J.
- Publication venue
- Oxford University Press (OUP)
- Publication date
- 01/07/2023
- Field of study
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and lowâmiddle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of âsingle-useâ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for lowâmiddle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both highâ and lowâmiddleâincome countries
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
- Author
- Abdukahil Sheryl Ann
- Abdukahil Sheryl,
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Abreu Julia,
- Absil Lara
- Acker Andrew
- Adachi Shingo
- Adam Elisabeth
- AdriĂŁo Diana
- Ainscough Kate
- Akimoto Takako
- Al Qasim Eman
- Al-Dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alex Beatrice
- Alexandre KĂ©vin
- Alfoudri Huda
- Alidjnou Kazali Enagnon
- Alidjnou Kazali,
- Aliudin Jeffrey
- Allavena Clotilde
- Allou Nathalie
- Alves JoĂŁo
- Alves Rita
- Amaral Maria
- Ammerlaan Heidi
- Ampaw Phoebe
- Andini Roberto
- Andrejak Claire
- Angheben Andrea
- ANGOULVANT François
- Ansart SĂ©verine
- Antonelli Massimo
- Arabi Yaseen
- Aragao Irene
- Arcadipane Antonio
- Arenz Lukas
- Arlet Jean-BenoĂźt
- Arnold-Day Christel
- Arora Lovkesh
- Artaud-Macari Elise
- Asensio Angel
- Assie Jean Baptiste
- Assie Jean,
- Atique Anika
- Auchabie Johann
- Aumaitre Hugues
- Azemar LaurĂšne
- Azoulay CĂ©cile
- Bach Benjamin
- Bachelet Delphine
- Baillie J. Kenneth,
- Bak Erica
- Bakakos Agamemnon
- Banisadr Firouzé
- Barbalho Renata
- Barclay Wendy,
- Barnikel Michaela
- Barrelet Audrey
- Barrigoto Cleide
- Basmaci Romain
- Bassi Gianluigi Li
- Bassi Gianluigi,
- Bedossa Alexandra
- Behilill Sylvie
- Bekken Gry Kloumann
- Bekken Gry,
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bennett Suzanne
- Bento LuĂs
- Berdal Jan-Erik
- Bergeaud Delphine
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bhavsar Krishna
- Bissuel François
- Biston Patrick
- Bitker Laurent
- Blanco-Schweizer Pablo
- Blot Mathieu
- Boccia Filomena
- Bogaert Debby
- Bompart François
- Booth Gareth
- Borges Diogo
- Borie Raphaël
- Bos Jeannet
- Bosse Hans Martin
- Bosse Hans,
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller KĂ©vin
- Bouillet Laurence
- Bouisse Camille
- Boureau Anne-Sophie
- Bouscambert Maude
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brickell Kathy
- Brozzi Nicolas
- Buchtele Nina
- Buesaquillo Christian
- Bugaeva Polina
- Buisson Marielle
- Burhan Erlina
- Bustos Ingrid,
- Butnaru Denis
- Cabie André
- Cabral Susana
- Caceres Eder
- Callahan Mia
- Calligy Kate
- Calvache Jose Andres
- Calvache Jose,
- Campana Valentine
- Campbell Paul
- CamÔes João
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Sofia
- Carelli Simone
- Carlier Nicolas
- Carney Gayle
- Carpenter Chloe
- Carret Marie-Christine
- Carrier François Martin
- Carrier François,
- Carson Gail
- Casanova Maire-Laure
- CascĂŁo Mariana
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- CastrillĂłn Henry
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavalli Giulio,
- Cavayas Alexandros
- Ceccato Adrian
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chas Julie
- Chassin Camille
- Chen Anjellica
- Chen Yih-Sharng
- Cheng Matthew Pellan
- Cheng Matthew,
- Cheret Antoine
- Chiarabini Thibault
- Chica Julian
- Chirouze Catherine
- Chiumello Davide
- Cho Hwa Jin
- Cho Hwa,
- Cho Sung Min
- Cho Sung,
- Choez Xavier SĂĄnchez
- Choez Xavier,
- Choileain Orna Ni
- Choileain Orna,
- Cholley Bernard
- Cidade Jose Pedro
- Cidade Jose,
- Citarella Barbara Wanjiru
- Citarella Barbara,
- Ciullo Anna
- Clarke Jennifer
- Clohisey Sara
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Colombo Sebastiano,
- Combs Pamela
- Connelly J.,
- Connor Marie
- Conrad Anne
- Contreras SofĂa
- Cooke Graham,
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cormican Sarah
- Cornelis Sabine
- Corpuz Arianne Joy
- Corpuz Arianne,
- Corvaisier Grégory
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cucino Alberto
- Cullen Caroline
- Cummings Matthew
- Curley Gerard
- Curlier Elodie
- Curto Elena Gallego
- Curto Elena,
- Custodio Paula
- CĂĄrcel Sheila
- Da Silva Filipe Ana
- Da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew,
- Dalton Heidi
- Dalton Jo
- Daneman Nick
- Dankwa Emmanuelle,
- Dantas Jorge
- De AraĂșjo Mariz Carolline
- De Brito Carlos Alexandre Antunes
- De Brito Carlos,
- De Castro Nathalie
- De Mendoza Diego
- De Oliveira França Rafael Freitas
- De Oliveira França Rafael,
- De Rosa Rosanna
- De Silva Thushan
- De Vries Peter
- Dean David
- Debray Marie-Pierre
- Dechert William
- Deconninck Lauren
- Decours Romain
- Delacroix Isabelle
- Delavigne Karen
- Deligiannis Ionna
- Dellâamore Andrea
- Delobel Pierre
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Desai Mehul
- Descamps Diane
- Desvallée Mathilde
- Devouge Eglantine Ferrand
- Devouge Eglantine,
- Dewayanti Santi Rahayu
- Dewayanti Santi,
- Diallo Alpha
- Diamantis Sylvain
- Dias André
- Diaz Juan Jose Diaz
- Diaz Juan,
- DIAZ Rodrigo
- Didier KĂ©vin
- Diehl Jean-Luc
- Dieperink Wim
- Dimet JĂ©rĂŽme
- Dinot Vincent
- Diouf Alphonsine
- Dishon Yael
- Djossou FĂ©lix
- Docherty Annemarie,
- Dominguez Carmen Infante
- Dominguez Carmen,
- Dong Andy
- Donnelly Christl,
- Donnelly Maria
- Donohue Chloe
- Dorival CĂ©line
- Douglas James Joshua
- Douglas James,
- Douma Renee
- Dournon Nathalie
- Downer Triona
- Downing Mark
- Drake Tom
- Dubee Vincent
- DUBOS François
- Ducancelle Alexandra
- Dudman Susanne
- Dunning Jake
- Duranti Silvia
- Durham Lucian
- Dussol Bertrand
- Duval Xavier
- Dyrhol-Riise Anne Margarita
- Dyrhol-Riise Anne,
- Dâaragon FrĂ©dĂ©rick
- DâOrleans Charles Crepy
- Dâorleans Charles,
- DâOrtenzio Eric
- Eid Charbel Maroun
- Eid Charbel,
- Eira Carla
- Elapavaluru Subbarao
- Elharrar Brigitte
- Elkheir Natalie
- Ellerbroek Jacobien
- Ellis Rachael
- Eloy Philippine
- Elshazly Tarek
- Enderle Isabelle
- Engelmann Ilka
- Enouf Vincent
- Epaulard Olivier
- Esperatti Mariano
- Esperou HĂ©lĂšne
- Esposito-Farese Marina
- EstevĂŁo JoĂŁo
- Etienne Manuel
- Ettalhaoui Nadia
- Everding Anna Greti
- Everding Anna,
- Evers Mirjam
- Fabre Isabelle
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron,
- Faria Pedro
- Farshait Nataly
- Fatoni Arie Zainul
- Fatoni Arie,
- Faure Karine
- Fayed Mohamed
- Feely Niamh
- Fernandes Jorge
- Fernandes MarĂlia
- Fernandes Susana
- Ferraz MĂĄrio
- Ferreira Benigno
- Ferrer-Roca Ricard
- FerrĂŁo Joana
- Figueiredo-Mello Claudia
- Flateau Clara
- Fletcher Tom
- Florio Letizia Lucia
- Florio Letizia,
- Foley Claire
- Fomin Victor
- Fonseca Claudio Duarte
- Fonseca Claudio,
- Fonseca Tatiana
- Fontela Patricia
- Forsyth Simon
- Foti Giuseppe
- Fourn Erwan
- Fowler Rob
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John
- Freire Marcela Vieira
- Freire Marcela,
- Friedrich Caren
- Fry Stéphane
- Fuentes Nora
- Fukuda Masahiro
- Gaborieau Valérie
- Gachet BenoĂźt
- Gaci Rostane
- Gagliardi Massimo
- Gagnard Jean-Charles
- Gagneux-Brunon Amandine
- GaiĂŁo SĂ©rgio
- Gallagher Phil
- Gamble Carrol
- Garan Arthur
- Garcia Rebekha
- Garcia-Gallo Esteban
- GarcĂa Ruth NoemĂ Jorge
- GarcĂa Ruth,
- Garot Denis
- Garrait Valérie
- Gault Nathalie
- Gavin Aisling
- Gaymard Alexandre
- Gebauer Johannes
- Germano Nuno
- Ghosn Jade
- Giani Marco
- Giaquinto Carlo
- Gibson Jess
- Gigante Tristan
- Gilg Morgane
- Giordano Guillermo
- Girvan Michelle
- Gissot Valérie
- Giwangkancana Gezy
- Glikman Daniel
- Glybochko Petr
- Gnall Eric
- Goco Geraldine
- Goehringer François
- Goepel Siri
- Goffard Jean-Christophe
- Golob Jonathan
- Gorenne Isabelle
- Goujard CĂ©cile
- Goulenok Tiphaine
- Grable Margarite
- Grandin Edward Wilson
- Grandin Edward,
- Granier Pascal
- Grasselli Giacomo
- Green Christopher,
- Greenhalf William
- Greffe SegolĂšne
- Grieco Domenico Luca
- Grieco Domenico,
- Griffee Matthew
- Griffiths Fiona
- Grigoras Ioana
- Groenendijk Albert
- Gruner Heidi
- Gu Yusing
- Guedj Jérémie
- Guellec Dewi
- Guerguerian Anne-Marie
- Guerreiro Daniela
- Guery Romain
- Guillaumot Anne
- Guilleminault Laurent
- Guimard Thomas
- GĂłmez-Junyent Joan
- Haber Daniel
- Hakak Sheeba
- Hall Matthew
- Halpin Sophie
- Hamer Ansley
- Hamidfar Rebecca
- Hammond Terese
- Hardwick Hayley
- Harley Kristen
- Harrison Ewen,
- Harrison Janet
- Hays Leanne
- Heerman Jan
- Heggelund Lars
- Hendry Ross
- Hennessy Martina
- Henriquez-Trujillo Aquiles
- Hentzien Maxime
- Hernandez-Montfort Jaime
- Herreros Jose Miguel Cisneros
- Herreros Jose,
- Hidayah Astarini
- Higgins Dawn
- Higgins Eibhilin
- Hinton Samuel
- HipĂłlito-Reis Ana
- Hiraiwa Hiroaki
- Hiscox Julian,
- Ho Antonia Ying Wai
- Ho Antonia,
- Hoctin Alexandre
- Hoffmann Isabelle
- Hoiting Oscar
- Holt Rebecca
- Holten Aleksander Rygh
- Holten Aleksander,
- Holter Jan Cato
- Holter Jan,
- Horby Peter
- Horcajada Juan Pablo
- Horcajada Juan,
- Hoshino Koji
- Hoshino Kota
- Hough Catherine,
- Hssain Ali Ait
- Hssain Ali,
- Hsu Jimmy Ming-Yang
- Hulot Jean-SĂ©bastien
- Humaid Felwa Bin
- Humaid Felwa,
- Ijaz Samreen
- Illes Hajnal-Gabriela
- InĂĄcio Hugo
- Iosifidis Elias
- Irvine Lacey
- Isgett Sarah
- Isidoro Tiago
- Isnard Margaux
- Itai Junji
- Ivulich Daniel
- Jaafoura Salma
- Jabot Julien
- Jackson Clare
- Jamieson Nina
- Jaureguiberry Stéphane
- Javidfar Jeffrey
- Jean-BenoĂźt Zabbe
- Jego Florence
- Jenum Synne
- Jimenez Juan Fernado Masa
- Jimenez Juan,
- Johal Simreen Kaur
- Johal Simreen,
- Joseph CĂ©dric
- Joseph Mark
- Jouvet Philippe
- Jung Hanna
- Kafif Ouifiya
- Kaguelidou Florentia
- Kali Sabina
- Kalomoiri Smaragdi
- Kandamby Darshana Hewa
- Kandamby Darshana,
- Kandel Chris
- Kant Ravi
- Kartsonaki Christiana
- Kasugai Daisuke
- Katz Kevin
- Keating Sean
- Kelly Andrea
- Kelly Sadie
- Kennedy Lisa
- Kennon Kalynn
- Kerroumi Younes
- Kestelyn Evelyne
- Khalid Imrana
- Khalil Antoine
- Khan Coralie
- Khan Irfan
- Kho Michelle,
- Khoo Saye
- Kida Yuri
- Kiiza Peter
- Kildal Anders Benjamin
- Kildal Anders,
- Kimmoun Antoine
- Kindgen-Milles Detlef
- Kitamura Nobuya
- Klenerman Paul
- Knight Stephen
- Kobbe Robin
- Korten Volkan
- Kosgei Caroline
- Krawczyk Karolina
- KUMAR Deepali
- Kurtzman Ethan
- Kutsogiannis Demetrios
- Kyriakoulis Konstantinos
- LACHATRE Marie
- Lacoste Marie
- Laffey John,
- Lagrange Marie
- Laine Fabrice
- Lambert Marc
- Lamontagne François
- Langelot-Richard Marie
- Lantang Eka Yudha
- Lantang Eka,
- Lanza Marina
- Laouénan Cédric
- Laribi Samira
- Lariviere Delphine
- Launay Odile
- Lavie-Badie Yoan
- Law Andrew
- Le Bihan Clément
- Le Bris Cyril
- Le Coustumier Eve
- Le Falher Georges
- Le Gac Sylvie
- Le Hingrat Quentin
- Le Maréchal Marion
- Le Mestre Soizic
- Le Moing Vincent
- Le Nagard Hervé
- Le Turnier Paul
- Le Van Tan
- Le Minh
- Leal Ema
- Lee James
- Lee Su Hwan
- Lee Su,
- Lee Todd
- Leeming Gary
- Lefebvre Bénédicte
- Lefebvre Laurent
- Lefevre Benjamin
- Lellouche François
- Lemaignen Adrien
- Lemee VĂ©ronique
- Lemmink Gretchen
- Leone Michela
- Lepiller Quentin
- Lescure François-Xavier
- Lesens Olivier
- Lesouhaitier Mathieu
- Levy Bruno
- Levy Yves
- Levy-Marchal Claire
- LeĂłn Rafael
- Liang Janet
- Lim Wei Shen
- Lim Wei,
- Lina Bruno
- Lind Andreas
- Lingas Guillaume
- Lion-Daolio Sylvie
- Liu Keibun
- Loforte Antonio
- Lolong Navy
- Lopes Diogo
- Lopez-Colon Dalia
- Lordemann Anja Grosse
- Lordemann Anja,
- Loubet Paul
- Lucet Jean Christophe
- Lucet Jean,
- Luna Carlos,
- Lungu Olguta
- Luong Liem
- Luton Dominique
- Lyons Ruth
- LâHer Erwan
- Maasikas Olavi
- Macdonald Sarah
- Machado MoĂŻse
- Macheda Gabrielle
- Madhok Jai
- Mahieu Rafael
- Mahy Sophie
- Maier Lars Siegfrid
- Maier Lars,
- Maillet MylĂšne
- Maitre Thomas
- Malaque Ana
- Maldonado Hugo Miranda
- Maldonado Hugo,
- Malfertheiner Maximilian
- Malik Nadia
- Maltez Fernando
- Malvy Denis
- MAMBERT Marina
- Manda Victoria
- Mandei Jose,
- Mangoni Emanuele Durante
- Mangoni Emanuele,
- Manning Edmund
- Manuel Aldric
- Marino FlĂĄvio
- Marques Ana
- Marquis Catherine
- Marsh Brian
- Marsh Laura
- Marshall John
- Martelli Celina Turchi
- Martelli Celina,
- Martin Dori-Ann
- Martin Emily
- Martin-Blondel Guillaume
- Martin-Loeches Ignacio
- Martin-Quiros Alejandro
- Martinot Martin
- Martins Ana
- Martins JoĂŁo
- Martucci Gennaro
- Marwali Eva Miranda
- Marwali Eva,
- Maslove David
- Mason Sabina
- Matan Moshe
- Mathieu Daniel
- Mattei Mathieu
- Matulevics Romans
- Maulin Laurence
- Mc Evoy Natalie
- Mccarthy Aine
- Mccloskey Colin
- Mcconnochie Rachael
- Mcdermott Sherry
- McDonald Sarah
- Mcelwee Samuel
- Mcevoy Natalie
- McGeer Allison
- Mcguinness Niki
- Mclean Kenneth,
- Mcnicholas Bairbre
- Meaney Edel
- Mear-Passard CĂ©cile
- Mechlin Maggie
- Mele Ferruccio
- Menon Kusum
- Mentré France
- Mentzer Alexander,
- Mercier Noémie
- Merckx Antoine
- Mergler Blake
- Merson Laura
- Mesquita AntĂłnio
- Meybeck AgnĂšs
- Meynert Alison,
- Meyssonnier Vanina
- Meziane Amina
- Mezidi Medhi
- Michelanglei CĂ©line
- MihnovitĆĄ Vladislav
- Mohammed Nassima Si
- Mohammed Nassima,
- Moin Asma
- Molina David
- Molinos Elena
- Mone Mary
- Monteiro Agostinho
- Montes Claudia
- Montrucchio Giorgia
- Moore Sarah
- Moore Shona,
- Morales-Cely Lina
- Morlaes Louis Gerbaud
- Morlaes Louis,
- Moro Lucia
- Motos Ana
- Mouquet Hugo
- Moyet Julien
- Mullaert Jimmy
- Munblit Daniel
- Murphy Derek
- Murris MarlĂšne
- Myrodia Dimitra Melia
- Myrodia Dimitra,
- MĂŒller Fredrik
- MĂŒller Karl Erik
- MĂŒller Karl,
- Neant NadĂšge
- Neb Holger
- Nekliudov Nikita,
- Neto Raul
- Neumann Emily
- Neves Bernardo
- Ng Pauline Yeung
- Ng Pauline,
- Ng Wing Yiu
- Ng Wing,
- Nichol Alistair
- Nonas Stephanie
- Noret Marion
- Norman Lisa
- Notari Alessandra
- Noursadeghi Mahdad
- Nowicka Karolina
- Nseir Saad
- Nunez Jose,
- Nuñez Maria Angelica Rivera
- Nuñez Maria,
- Nyamankolly Elsa
- NâGuyen Yohan
- Occhipinti Giovanna
- Ogston Tawnya
- Ogura Takayuki
- Oh Tak-Hyuk
- Ohshimo Shinichiro
- Oinam Budha Charan Singh
- Oinam Budha,
- Oliveira Ana Pinho
- Oliveira Ana,
- Oliveira JoĂŁo
- Olliaro Piero
- Ong David,
- Oosthuyzen Wilna
- Openshaw Peter,
- Orozco-Chamorro Claudia Milena
- Orozco-Chamorro Claudia,
- Orquera Andrés
- Osatnik Javier
- Ouamara Nadia
- Ouissa Rachida
- Owyang Clark
- Oziol Eric
- Oâdonnell Max
- Oâhearn Katie
- Oâneil Conar
- Pagadoy MaĂŻder
- Pages Justine
- Palacios Mario
- Palmarini Massimo
- Panarello Giovanna
- Panda Prasan Kumar
- Panda Prasan,
- Panigada Mauro
- Pansu Nathalie
- Papadopoulos Aurélie
- Parra Briseida
- Pasquier Jérémie
- Patauner Fabian
- PatrĂŁo LuĂs
- Paul Christelle
- Paul Mical
- Paulos Jorge
- Paxton William,
- Payen Jean-François
- Pearse India
- Peek Giles,
- Peelman Florent
- Peiffer-Smadja Nathan
- Peigne Vincent
- Pejkovska Mare
- Peltan Ithan,
- Pereira Rui
- Perez Daniel
- Perpoint Thomas
- Perrot Clara Mouton
- Perrot Clara,
- Pesenti Antonio
- PetrouĆĄovĂĄ Lenka
- Petrov-Sanchez Ventzislava
- Peytavin Gilles
- Pharand Scott
- Piagnerelli Michael
- Picard Walter
- Picone Olivier
- Piel-Julian Marie
- Pierobon Carola
- Pimentel Carlos
- Piroth Lionel
- Pius Riinu
- Piva Simone
- Plantier Laurent
- Plotkin Daniel
- Poissy Julien
- Pokorska-Spiewak Maria
- Poli Sergio
- Pollakis Georgios
- Popielska Jolanta
- Postma Douwe,
- Povoa Pedro
- Powis Jeff
- Prapa Sofia
- Prebensen Christian
- Preiser Jean-Charles
- Prestre Vincent
- Price Nicholas
- Prinssen Anton
- Pritchard Mark,
- Proença LĂșcia
- Purcell Gregory
- Puéchal Oriane
- PĂłvoas Diana
- Quesada Luisa
- Quist-Paulsen Else
- Quraishi Mohammed
- Rabaud Christian
- Rafiq Marie
- Ragazzo Gabrielle
- Rainieri Fernando
- Ramakrishnan Nagarajan
- Ramanathan Kollengode
- Rammaert Blandine
- Rapp Christophe
- Rasmin Menaldi
- Rau Cornelius
- Rebaudet Stanislas
- Redl Sarah
- Reeve Brenda
- Rego Caroline Martins
- Rego Caroline,
- Reid Liadain
- Reis Renato
- Remppis Jonathan
- Remy Martine
- Renk Hanna
- Resende Liliana
- Resseguier Anne-Sophie
- Revest Matthieu
- Rewa Oleksa
- Reyes Luis Felipe
- Reyes Luis,
- Ribeiro Ana Freitas
- Ribeiro Ana,
- Richardson David
- Richardson Denise
- Richier Laurent
- Riera Jordi
- Rincon Diego Fernando Bautista
- Rincon Diego,
- Rios Ana LĂșcia
- Rios Ana,
- Rishu Asgar
- Rispal Patrick
- Risso Karine
- Rizer Nicholas
- Roberto André
- Roberts Stephanie
- Robertson David,
- Robineau Olivier
- Roche-Campo Ferran
- Rodari Paola
- Rodeia SimĂŁo
- Roilides Emmanuel
- Rojek Amanda
- Romaru Juliette
- Roncon-Albuquerque Roberto
- Roriz MĂ©lanie
- Rosa-Calatrava Manuel
- Rose Michael
- Rosenberger Dorothea
- Rossanese Andrea
- Rossignol Bénédicte
- Rossignol Patrick
- Roy Carine
- Roze BenoĂźt
- Russell Clark,
- Ryckaert Steffi
- RĂ€tsep Indrek
- Rössler Bernhard
- Saba Isabela
- Sadat Musharaf
- Saidani Nadia
- Salazar Leonardo
- Sales Gabriele
- Sallaberry Stéphane
- Salvator HĂ©lĂšne
- Sanchez Juan Macias
- Sanchez Juan,
- Sanchez Olivier
- Sanchez-Miralles Angel
- Sancho-Shimizu Vanessa
- Sandhu Gyan
- Sandulescu Oana
- Sanharawi Mohammed El
- Sanharawi Mohammed,
- Sant Ceila Maria
- Sant Ceila,
- Santos Marlene
- Santos Marta Leal
- Santos Marta,
- Santos-Olmo Rosario Maria Torres
- Santos-Olmo Rosario,
- Sarfo-Mensah Shirley
- Sarton Benjamine
- Saviciute Egle
- Savvidou Parthena
- Scarsbrook Joshua
- Schermer Tjard
- Scherpereel Arnaud
- Schneider Marion
- Schroll Stephan
- Schwameis Michael
- Scott Janet,
- Scott-Brown James
- Sedillot Nicholas
- Seitz Tamara
- Semaille Caroline
- Semple Malcolm,
- Senneville Eric
- Sequeira Filipa
- Sequeira TĂąnia
- Shadowitz Ellen
- Shamsah Mohammad
- Sharma Pratima
- Shaw Catherine,
- Shaw Victoria
- Shiban Nisreen
- Shime Nobuaki
- Shimizu Hiroaki
- Shimizu Keiki
- Shrapnel Sally
- Shum Hoi Ping
- Shum Hoi,
- Sigfrid Louise
- Silva Catarina
- Silva Maria Joao
- Silva Maria,
- Sin Wai Ching
- Sin Wai,
- Skogen Vegard
- Smith Sue
- Smood Benjamin
- Smyth Michelle
- Snacken Morgane
- So Dominic
- Solis Monserrat
- Solomon Joshua
- Solomon Tom
- Somers Emily
- Sommet AgnĂšs
- Song Myung Jin
- Song Myung,
- Song Rima
- Song Tae
- Sonntagbauer Michael
- Sotomayor Ruth Jimbo
- Sotomayor Ruth,
- Soum Edouard
- Sousa Marta
- Souza-Dantas Vicente
- Sperry Alexandra
- Sriskandan Shiranee
- Staudinger Thomas
- Stecher Stephanie-Susanne
- Stienstra Ymkje
- Stiksrud Birgitte
- Streinu-Cercel Adrian
- Streinu-Cercel Anca
- Strudwick Samantha
- Stuart Ami
- Stuart David
- Suen Jacky,
- Sultana Asfia
- Summers Charlotte
- Svistunov Magdalena SurovcovĂĄ Andrey A.
- Svistunov Magdalena,
- Syrigos Konstantinos
- Sztajnbok Jaques
- Szuldrzynski Konstanty
- Tabrizi Shirin
- Tagherset Lysa
- Talarek Ewa
- Taleb Sara
- Talsma Jelmer
- Tamlihat Younes Ait
- Tamlihat Younes,
- Tanaka Hiroyuki
- Tanaka Taku
- Taniguchi Hayato
- Tardivon Coralie
- Tattevin Pierre
- Taufik M. Azhari,
- Tedder Richard,
- Teixeira JoĂŁo
- Tellier Marie-Capucine
- Terpstra Pleun
- Terrier Olivier
- Terzi Nicolas
- Tessier-Grenier Hubert
- Thibault V.
- Thiberville Simon-Djamel
- Thill BenoĂźt
- Thompson A.,
- Thompson Shaun
- Thomson David
- Thomson Emma,
- Thuy Duong Bich
- Thuy Duong,
- Thwaites Ryan,
- Timashev Peter,
- Timsit Jean-François
- Toki Maria
- Tonby Kristian
- Torres Antoni
- Torres Margarida
- Trieu Huynh Trung
- Trieu Huynh,
- Trioux Théo
- Tromeur CĂ©cile
- Trontzas Ioannis
- Troost Jonathan
- Trouillon Tiffany
- Tual Christelle
- Tubiana Sarah
- Tuite Helen
- Turtle Lance,
- Tutillo Diego Rolando Morocho
- Tutillo Diego,
- Twardowski Pawel
- Téoulé François
- Uchiyama Makoto
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uva Maria,
- Val-Flores LuĂs
- Van De Velde Stijn
- Van Den Berge Marcel
- Van Der Feltz Machteld
- Van Der Vekens Nicky
- Van Der Voort Peter
- Van Der Werf Sylvie
- Van Dyk Marlice
- Van Gulik Laura
- Van Hattem Jarne
- Van Lelyveld Steven
- Van Netten Carolien
- Van Vinh Chau Nguyen
- Vanel Noémie
- Vanoverschelde Henk
- Vasconcelos Malte Kohns
- Vasconcelos Malte,
- Vauchy Charline
- Vecham Pavan Kumar
- Vecham Pavan,
- Veislinger Aurélie
- Velazco Jorge
- Ventura Sara
- Verbon Annelies
- Vidal José Ernesto
- Vidal José,
- Vieira CĂ©sar
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Vijayaraghavan Bharath,
- Villanueva Joy Ann
- Villanueva Joy,
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vuorinen Aapeli
- Vuotto Fanny
- Wang Chih-Hsien
- Wei Jia
- Weil Katharina
- Wesselius Sanne
- Wham Murray
- Whelan Bryan
- White Nicole
- Wiedemann Aurélie
- Wille Keith
- Wils Evert-Jan
- Xynogalas Ioannis
- Yacoub Sophie
- Yamazaki Masaki
- Yazdanpanah Yazdan
- Yelnik CĂ©cile
- Yerkovich Stephanie
- Yokoyama Toshiki
- Yonis Hodane
- Young Paul
- Yuliarto Saptadi
- Zabbe Marion
- Zacharowski Kai
- Zahran Maram
- Zambon Maria
- Zanella Alberto
- Zawadka Konrad
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
Background:
The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms.
Methods:
International, prospective observational study of 60â109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms.
Results:
âTypicalâ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (â€â18 years: 69, 48, 23; 85%), older adults (â„â70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each Pâ<â0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country.
Interpretation:
This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men