Effect of the Fe Nanoparticles Generated by Pulsed Plasma in Liquid in the Catalyzed Ozone Removal of Phenolphthalein

We have synthesized, in this work, zero valent iron (ZVI) nanoparticles to improve the efficiency of degradation of phenolphthalein catalyzed by ozone in aqueous solution. The Fe nanoparticles were obtained using the pulsed plasma in liquid (PPL) method with water as the liquid medium. Such nanoparticles have a mean size of 12 nm and are composed of ~80% Fe0, while the rest are a mixture of Fe+2 and Fe+3 oxides. The degradation of phenolphthalein was carried on a glass reactor injecting a constant amount of ozone and introducing different concentrations of Fe nanoparticles to the system. When using pure ozone, the percentage of degradation of phenolphthalein measured by colorimetry after one hour of reaction was 84%. However, when Fe nanoparticles are used, such percentage can be as high as 98% in 50 minutes of reaction. Furthermore, the degradation rate constant was 0.0334 min−1 with only ozone and it can be as high as 0.0733 min−1 with Fe nanoparticles. Finally, the total mineralization of phenolphthalein was obtained by total organic carbon (TOC) determinations. It is shown that when using only ozone, we obtained a percentage of mineralization of 49% and 96% when using the highest concentration of Fe nanoparticles

Oral chondroitin sulfate and prebiotics for the treatment of canine Inflammatory Bowel Disease: a randomized, controlled clinical trial

BACKGROUND Canine inflammatory bowel disease (IBD) is a chronic enteropathy of unknown etiology, although microbiome dysbiosis, genetic susceptibility, and dietary and/or environmental factors are hypothesized to be involved in its pathogenesis. Since some of the current therapies are associated with severe side effects, novel therapeutic modalities are needed. A new oral supplement for long-term management of canine IBD containing chondroitin sulfate (CS) and prebiotics (resistant starch, β-glucans and mannaoligosaccharides) was developed to target intestinal inflammation and oxidative stress, and restore normobiosis, without exhibiting any side effects. This double-blinded, randomized, placebo-controlled trial in dogs with IBD aims to evaluate the effects of 180 days administration of this supplement together with a hydrolyzed diet on clinical signs, intestinal histology, gut microbiota, and serum biomarkers of inflammation and oxidative stress. RESULTS Twenty-seven client-owned biopsy-confirmed IBD dogs were included in the study, switched to the same hydrolyzed diet and classified into one of two groups: supplement and placebo. Initially, there were no significant differences between groups (p > 0.05) for any of the studied parameters. Final data analysis (supplement: n = 9; placebo: n = 10) showed a significant decrease in canine IBD activity index (CIBDAI) score in both groups after treatment (p < 0.001). After treatment, a significant decrease (1.53-fold; p < 0.01) in histologic score was seen only in the supplement group. When groups were compared, the supplement group showed significantly higher serum cholesterol (p < 0.05) and paraoxonase-1 (PON1) levels after 60 days of treatment (p < 0.01), and the placebo group showed significantly reduced serum total antioxidant capacity (TAC) levels after 120 days (p < 0.05). No significant differences were found between groups at any time point for CIBDAI, WSAVA histologic score and fecal microbiota evaluated by PCR-restriction fragment length polymorphism (PCR-RFLP). No side effects were reported in any group. CONCLUSIONS The combined administration of the supplement with hydrolyzed diet over 180 days was safe and induced improvements in selected serum biomarkers, possibly suggesting a reduction in disease activity. This study was likely underpowered, therefore larger studies are warranted in order to demonstrate a supplemental effect to dietary treatment of this supplement on intestinal histology and CIBDAI

ESPRESSO: The next European exoplanet hunter

The acronym ESPRESSO stems for Echelle SPectrograph for Rocky Exoplanets and Stable Spectroscopic Observations; this instrument will be the next VLT high resolution spectrograph. The spectrograph will be installed at the Combined-Coud\'e Laboratory of the VLT and linked to the four 8.2 m Unit Telescopes (UT) through four optical Coud\'e trains. ESPRESSO will combine efficiency and extreme spectroscopic precision. ESPRESSO is foreseen to achieve a gain of two magnitudes with respect to its predecessor HARPS, and to improve the instrumental radial-velocity precision to reach the 10 cm/s level. It can be operated either with a single UT or with up to four UTs, enabling an additional gain in the latter mode. The incoherent combination of four telescopes and the extreme precision requirements called for many innovative design solutions while ensuring the technical heritage of the successful HARPS experience. ESPRESSO will allow to explore new frontiers in most domains of astrophysics that require precision and sensitivity. The main scientific drivers are the search and characterization of rocky exoplanets in the habitable zone of quiet, nearby G to M-dwarfs and the analysis of the variability of fundamental physical constants. The project passed the final design review in May 2013 and entered the manufacturing phase. ESPRESSO will be installed at the Paranal Observatory in 2016 and its operation is planned to start by the end of the same year.Comment: 12 pages, figures included, accepted for publication in Astron. Nach

Atmospheric Rossiter-McLaughlin effect and transmission spectroscopy of WASP-121b with ESPRESSO

WASP-121b is one of the most studied Ultra-hot Jupiters: many recent analyses of its atmosphere report interesting features at different wavelength ranges. In this paper we analyze one transit of WASP-121b acquired with the high-resolution spectrograph ESPRESSO at VLT in 1-telescope mode, and one partial transit taken during the commissioning of the instrument in 4-telescope mode. We investigate the anomalous in-transit radial velocity curve and study the transmission spectrum of the planet. By analysing the in-transit radial velocities we were able to infer the presence of the atmospheric Rossiter-McLaughlin effect. We measured the height of the planetary atmospheric layer that correlates with the stellar mask (mainly Fe) to be 1.052$\pm$0.015 Rp and we also confirmed the blueshift of the planetary atmosphere. By examining the planetary absorption signal on the stellar cross-correlation functions we confirmed the presence of a temporal variation of its blueshift during transit, which could be investigated spectrum-by-spectrum. We detected significant absorption in the transmission spectrum for Na, H, K, Li, CaII, Mg, and we certified their planetary nature by using the 2D tomographic technique. Particularly remarkable is the detection of Li, with a line contrast of $\sim$0.2% detected at the 6$\sigma$ level. With the cross-correlation technique we confirmed the presence of FeI, FeII, CrI and VI. H$\alpha$ and CaII are present up to very high altitudes in the atmosphere ($\sim$1.44 Rp and $\sim$2 Rp, respectively), and also extend beyond the transit-equivalent Roche lobe radius of the planet. These layers of the atmosphere have a large line broadening that is not compatible with being caused by the tidally-locked rotation of the planet alone, and could arise from vertical winds or high-altitude jets in the evaporating atmosphere.Comment: 15 pages, 19 figures. Accepted for publication in A&

Warm terrestrial planet with half the mass of Venus transiting a nearby star

The advent of a new generation of radial velocity instruments has allowed us to break the one Earth-mass barrier. We report a new milestone in this context with the detection of the lowest-mass planet measured so far using radial velocities: L 98-59 b, a rocky planet with half the mass of Venus. It is part of a system composed of three known transiting terrestrial planets (planets b to d). We announce the discovery of a fourth nontransiting planet with a minimum mass of 3.06_{-0.37}^{+0.33} MEarth and an orbital period of 12.796_{-0.019}^{+0.020} days and report indications for the presence of a fifth nontransiting terrestrial planet. With a minimum mass of 2.46_{-0.82}^{+0.66} MEarth and an orbital period 23.15_{-0.17}^{+0.60} days, this planet, if confirmed, would sit in the middle of the habitable zone of the L 98-59 system. L 98-59 is a bright M dwarf located 10.6 pc away. Positioned at the border of the continuous viewing zone of the James Webb Space Telescope, this system is destined to become a corner stone for comparative exoplanetology of terrestrial planets. The three transiting planets have transmission spectrum metrics ranging from 49 to 255, which makes them prime targets for an atmospheric characterization with the James Webb Space Telescope, the Hubble Space Telescope, Ariel, or ground-based facilities such as NIRPS or ESPRESSO. With an equilibrium temperature ranging from 416 to 627 K, they offer a unique opportunity to study the diversity of warm terrestrial planets. L 98-59 b and c have densities of 3.6_{-1.5}^{+1.4} and 4.57_{-0.85}^{+0.77} this http URL^{-3}, respectively, and have very similar bulk compositions with a small iron core that represents only 12 to 14 % of the total mass, and a small amount of water. However, with a density of 2.95_{-0.51}^{+0.79} this http URL^{-3} and despite a similar core mass fraction, up to 30 % of the mass of L 98-59 d might be water

WASP-127b: A misaligned planet with a partly cloudy atmosphere and tenuous sodium signature seen by ESPRESSO

The study of exoplanet atmospheres is essential to understand the formation, evolution and composition of exoplanets. The transmission spectroscopy technique is playing a significant role in this domain. In particular, the combination of state-of-the-art spectrographs at low- and high-spectral resolution is key to our understanding of atmospheric structure and composition. Two transits of the close-in sub Saturn-mass planet,WASP-127b, have been observed with ESPRESSO in the frame of the Guaranteed Time Observations Consortium. Transit observations allow us to study simultaneously the system architecture and the exoplanet atmosphere. We found that this planet is orbiting its slowly rotating host star (veq sin(i)=0.53+/-0.07 km/s) on a retrograde misaligned orbit (lambda=-128.41+/-5.60 deg). We detected the sodium line core at the 9-sigma confidence level with an excess absorption of 0.3+/-0.04%, a blueshift of 2.7+/-0.79 km/s and a FWHM of 15.18+/-1.75 km/s. However, we did not detect the presence of other atomic species but set upper-limits of only few scale heights. Finally, we put a 3-sigma upper limit, to the average depth of the 1600 strongest water lines at equilibrium temperature in the visible band, of 38 ppm. This constrains the cloud-deck pressure between 0.3 and 0.5 mbar by combining our data with low-resolution data in the near-infrared and models computed for this planet. To conclude, WASP-127b, with an age of about 10 Gyr, is an unexpected exoplanet by its orbital architecture but also by the small extension of its sodium atmosphere (~7 scale heights). ESPRESSO allows us to take a step forward in the detection of weak signals, thus bringing strong constraints on the presence of clouds in exoplanet atmospheres. The framework proposed in this work can be applied to search for molecular species and study cloud-decks in other exoplanets.Comment: Accepted in A&A, 19 pages, 20 figure

Transcranial alternating current stimulation (tACS) at 40 Hz enhances face and object perception

Neurophysiological evidence suggests that face and object recognition relies on the coordinated activity of neural populations (i.e., neural oscillations) in the gamma-band range (> 30 Hz) over the occipito-temporal cortex. To test the causal effect of gamma-band oscillations on face and object perception we applied transcranial Alternating Current Stimulation (tACS) in healthy volunteers (N = 60). In this single-blind, sham-controlled study, we examined whether the administration of offline tACS at gamma-frequency (40 Hz) over the right occipital cortex enhances performance of perception and memory of face and object stimuli. We hypothesized that gamma tACS would enhance the perception of both categories of visual stimuli. Results, in line with our hypothesis, show that 40 Hz tACS enhanced both face and object perception. This effect is process-specific (i.e., it does not affect memory), frequency-specific (i.e., stimulation at 5 Hz did not cause any behavioural change), and site-specific (i.e., stimulation of the sensory-motor cortex did not affect performance). Our findings show that high-frequency tACS modulates human visual perception, and it is in line with neurophysiological studies showing that the perception of visual stimuli (i.e., faces and objects) is mediated by oscillations in the gamma-band range. Furthermore, this study adds insight about the design of effective neuromodulation protocols that might have implications for interventions in clinical settings

Revisiting Proxima with ESPRESSO

We aim to confirm the presence of Proxima b using independent measurements obtained with the new ESPRESSO spectrograph, and refine the planetary parameters taking advantage of its improved precision. We analysed 63 spectroscopic ESPRESSO observations of Proxima taken during 2019. We obtained radial velocity measurements with a typical radial velocity photon noise of 26 cm/s. We ran a joint MCMC analysis on the time series of the radial velocity and full-width half maximum of the cross-correlation function to model the planetary and stellar signals present in the data, applying Gaussian process regression to deal with stellar activity. We confirm the presence of Proxima b independently in the ESPRESSO data. The ESPRESSO data on its own shows Proxima b at a period of 11.218 $\pm$ 0.029 days, with a minimum mass of 1.29 $\pm$ 0.13 Me. In the combined dataset we measure a period of 11.18427 $\pm$ 0.00070 days with a minimum mass of 1.173 $\pm$ 0.086 Me. We find no evidence of stellar activity as a potential cause for the 11.2 days signal. We find some evidence for the presence of a second short-period signal, at 5.15 days with a semi-amplitude of merely 40 cm/s. If caused by a planetary companion, it would correspond to a minimum mass of 0.29 $\pm$ 0.08 Me. We find that the FWHM of the CCF can be used as a proxy for the brightness changes and that its gradient with time can be used to successfully detrend the radial velocity data from part of the influence of stellar activity. The activity-induced radial velocity signal in the ESPRESSO data shows a trend in amplitude towards redder wavelengths. Velocities measured using the red end of the spectrograph are less affected by activity, suggesting that the stellar activity is spot-dominated. The data collected excludes the presence of extra companions with masses above 0.6 Me at periods shorter than 50 days.Comment: 25 pages, 26 figure

A precise architecture characterization of the π\pi Men planetary system

The bright star $\pi$ Men was chosen as the first target for a radial velocity follow-up to test the performance of ESPRESSO, the new high-resolution spectrograph at the ESO's Very-Large Telescope (VLT). The star hosts a multi-planet system (a transiting 4 M$_\oplus$ planet at $\sim$0.07 au, and a sub-stellar companion on a $\sim$2100-day eccentric orbit) which is particularly appealing for a precise multi-technique characterization. With the new ESPRESSO observations, that cover a time span of 200 days, we aim to improve the precision and accuracy of the planet parameters and search for additional low-mass companions. We also take advantage of new photometric transits of $\pi$ Men c observed by TESS over a time span that overlaps with that of the ESPRESSO follow-up campaign. We analyse the enlarged spectroscopic and photometric datasets and compare the results to those in the literature. We further characterize the system by means of absolute astrometry with Hipparcos and Gaia. We used the spectra of ESPRESSO for an independent determination of the stellar fundamental parameters. We present a precise characterization of the planetary system around $\pi$ Men. The ESPRESSO radial velocities alone (with typical uncertainty of 10 cm/s) allow for a precise retrieval of the Doppler signal induced by $\pi$ Men c. The residuals show an RMS of 1.2 m/s, and we can exclude companions with a minimum mass less than $\sim$2 M$_\oplus$ within the orbit of $\pi$ Men c). We improve the ephemeris of $\pi$ Men c using 18 additional TESS transits, and in combination with the astrometric measurements, we determine the inclination of the orbital plane of $\pi$ Men b with high precision ($i_{b}=45.8^{+1.4}_{-1.1}$ deg). This leads to the precise measurement of its absolute mass $m_{b}=14.1^{+0.5}_{-0.4}$ M$_{Jup}$, and shows that the planetary orbital planes are highly misaligned.Comment: Accepted for publication on A&