326 research outputs found
Strategic Priorities and Lean Manufacturing Practices in Automotive Suppliers. Ten Years After
Changes in the Association between European Workers' Employment Conditions and Employee Well-Being in 2005, 2010 and 2015
[EN] The aim of this paper is to study whether there is a change in the association between employment conditions and European employees' well-being at three different time points (the years 2005, 2010 and 2015), characterized by different socio-economic contexts. We based our study on the European Working Conditions Survey. Logistic regressions were performed by adjusting for gender, age, level of education, seniority, occupation, establishment size, activity sector and economic activity. Adjusted odds ratios (ORadj) and 95% confidence intervals (95% CI) are reported. In general, the association between employment conditions (type of employment contract, supervising, weekly working hours, long working hours, other paid jobs, working at weekends or doing shifts) and well-being indicators (anxiety, fatigue and dissatisfaction) seemed to continue being harmful, or had even changed for the worse since 2005. The paper briefly discusses the possible reasons for this situation and calls for future research on the relation between well-being and irregular type of contracts, self-employment, supervising others or hours worked per week. Some implications in public health policies are also discussed.The APC was funded by the Grant PGC2018-100675-B-I00, Spanish Ministry of Science, Innovation and Universities (Spain). The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript.Marin-Garcia, JA.; Bonavia, T.; Losilla, J. (2020). Changes in the Association between European Workers' Employment Conditions and Employee Well-Being in 2005, 2010 and 2015. International Journal of Environmental research and Public Health (Online). 17(3):1-22. https://doi.org/10.3390/ijerph17031048S122173LaMontagne, A. D., Milner, A., Krnjacki, L., Schlichthorst, M., Kavanagh, A., Page, K., & Pirkis, J. (2016). Psychosocial job quality, mental health, and subjective wellbeing: a cross-sectional analysis of the baseline wave of the Australian Longitudinal Study on Male Health. BMC Public Health, 16(S3). doi:10.1186/s12889-016-3701-xStansfeld, S., & Candy, B. (2006). Psychosocial work environment and mental health—a meta-analytic review. Scandinavian Journal of Work, Environment & Health, 32(6), 443-462. doi:10.5271/sjweh.1050Van der Doef, M., & Maes, S. (1999). The Job Demand-Control (-Support) Model and psychological well-being: A review of 20 years of empirical research. Work & Stress, 13(2), 87-114. doi:10.1080/026783799296084Nappo, N. (2019). Is there an association between working conditions and health? An analysis of the Sixth European Working Conditions Survey data. PLOS ONE, 14(2), e0211294. doi:10.1371/journal.pone.0211294Nappo, N. (2018). Working Conditions and Anxiety. An Analysis on the Sixth European Working Conditions Survey Data. International Journal of Humanities and Social Science, 8(10). doi:10.30845/ijhss.v8n10p17Malard, L., Chastang, J.-F., Schütte, S., Parent-Thirion, A., Vermeylen, G., & Niedhammer, I. (2013). Changes in Psychosocial Work Exposures Among Employees Between 2005 and 2010 in 30 Countries in Europe. Journal of Occupational & Environmental Medicine, 55(10), 1135-1141. doi:10.1097/jom.0b013e3182a3eb90Benach, J. (2004). Types of employment and health in the European Union: Changes from 1995 to 2000. The European Journal of Public Health, 14(3), 314-321. doi:10.1093/eurpub/14.3.314Trends in Job Quality during the Great Recession: A Comparative Approach for the EU. Working Paper nº 161-1 https://halshs.archives-ouvertes.fr/halshs-00966898Wood, S., & Ogbonnaya, C. (2016). High-Involvement Management, Economic Recession, Well-Being, and Organizational Performance. Journal of Management, 44(8), 3070-3095. doi:10.1177/0149206316659111Rostila, M. (2008). The Swedish labour market in the 1990s: The very last of the healthy jobs? Scandinavian Journal of Public Health, 36(2), 126-134. doi:10.1177/1403494807085067Julià, M., Vanroelen, C., Bosmans, K., Van Aerden, K., & Benach, J. (2017). Precarious Employment and Quality of Employment in Relation to Health and Well-being in Europe. International Journal of Health Services, 47(3), 389-409. doi:10.1177/0020731417707491Robert, G., Martinez, J. M., Garcia, A. M., Benavides, F. G., & Ronda, E. (2014). From the boom to the crisis: changes in employment conditions of immigrants in Spain and their effects on mental health. The European Journal of Public Health, 24(3), 404-409. doi:10.1093/eurpub/cku020Utzet, M., Moncada, S., Molinero, E., Llorens, C., Moreno, N., & Navarro, A. (2014). The changing patterns of psychosocial exposures at work in the South of Europe: Spain as a labor market laboratory. American Journal of Industrial Medicine, 57(9), 1032-1042. doi:10.1002/ajim.22334Blank, C., Gatterer, K., Leichtfried, V., Pollhammer, D., Mair-Raggautz, M., Duschek, S., … Schobersberger, W. (2018). Short Vacation Improves Stress-Level and Well-Being in German-Speaking Middle-Managers—A Randomized Controlled Trial. International Journal of Environmental Research and Public Health, 15(1), 130. doi:10.3390/ijerph15010130Maharaj, S., Lees, T., & Lal, S. (2018). Prevalence and Risk Factors of Depression, Anxiety, and Stress in a Cohort of Australian Nurses. International Journal of Environmental Research and Public Health, 16(1), 61. doi:10.3390/ijerph16010061Wong, V., & Au‐Yeung, T. C. (2018). Expediting youth’s entry into employment whilst overlooking precariousness: Flexi‐employability and disciplinary activation in Hong Kong. Social Policy & Administration, 53(5), 793-809. doi:10.1111/spol.12418Ronda, E., Briones-Vozmediano, E., Galon, T., García, A. M., Benavides, F. G., & Agudelo-Suárez, A. A. (2015). A qualitative exploration of the impact of the economic recession in Spain on working, living and health conditions: reflections based on immigrant workers’ experiences. Health Expectations, 19(2), 416-426. doi:10.1111/hex.12365Sorensen, G., Peters, S., Nielsen, K., Nagler, E., Karapanos, M., Wallace, L., … Wagner, G. R. (2019). Improving Working Conditions to Promote Worker Safety, Health, and Wellbeing for Low-Wage Workers: The Workplace Organizational Health Study. International Journal of Environmental Research and Public Health, 16(8), 1449. doi:10.3390/ijerph16081449Chambel, M. J., & Farina, A. (2015). HRM and temporary workers’ well-being: a study in Portugal and Brazil. Cross Cultural Management, 22(3), 447-463. doi:10.1108/ccm-07-2013-0105Lorente, L., Tordera, N., & Peiró, J. (2018). How Work Characteristics Are Related to European Workers’ Psychological Well-Being. A Comparison of Two Age Groups. International Journal of Environmental Research and Public Health, 15(1), 127. doi:10.3390/ijerph15010127Meyer, S.-C., & Hünefeld, L. (2018). Challenging Cognitive Demands at Work, Related Working Conditions, and Employee Well-Being. International Journal of Environmental Research and Public Health, 15(12), 2911. doi:10.3390/ijerph15122911Van Aerden, K., Puig-Barrachina, V., Bosmans, K., & Vanroelen, C. (2016). How does employment quality relate to health and job satisfaction in Europe? A typological approach. Social Science & Medicine, 158, 132-140. doi:10.1016/j.socscimed.2016.04.017Pieper, C., Schröer, S., & Eilerts, A.-L. (2019). Evidence of Workplace Interventions—A Systematic Review of Systematic Reviews. International Journal of Environmental Research and Public Health, 16(19), 3553. doi:10.3390/ijerph16193553Lopes, H., Lagoa, S., & Calapez, T. (2014). Work autonomy, work pressure, and job satisfaction: An analysis of European Union countries. The Economic and Labour Relations Review, 25(2), 306-326. doi:10.1177/1035304614533868Curtarelli, M., Fric, K., Vargas, O., & Welz, C. (2014). Job quality, industrial relations and the crisis in Europe. International Review of Sociology, 24(2), 225-240. doi:10.1080/03906701.2014.933024Piasna, A. (2017). Scheduled to work hard: The relationship between non-standard working hours and work intensity among European workers (2005-2015). Human Resource Management Journal, 28(1), 167-181. doi:10.1111/1748-8583.12171Boada-Grau, J., Robert-Sentís, L., Gil-Ripoll, C., & Vigil-Colet, A. (2013). RL-14: Desarrollo, consistencia interna, fiabilidad y validez de una escala de riesgos laborales en lengua española. Anales de Psicología, 29(1). doi:10.6018/analesps.29.1.138021Bergström, O. (2018). Changing restructuring regimes in 11 European countries during and after the financial crisis. European Journal of Industrial Relations, 25(2), 95-111. doi:10.1177/0959680118770747Guest, D. E., & Isaksson, K. (2018). Temporary employment contracts and employee well-being during and after the financial crisis: Introduction to the special issue. Economic and Industrial Democracy, 40(2), 165-172. doi:10.1177/0143831x18804706Benavides, F. G. (2000). How do types of employment relate to health indicators? Findings from the Second European Survey on Working Conditions. Journal of Epidemiology & Community Health, 54(7), 494-501. doi:10.1136/jech.54.7.494Artazcoz, L., Cortes, I., Puig-Barrachina, V., Benavides, F. G., Escriba-Aguir, V., & Borrell, C. (2013). Combining employment and family in Europe: the role of family policies in health. The European Journal of Public Health, 24(4), 649-655. doi:10.1093/eurpub/ckt170Bartoll, X., Cortès, I., & Artazcoz, L. (2014). Full- and part-time work: gender and welfare-type differences in European working conditions, job satisfaction, health status, and psychosocial issues. Scandinavian Journal of Work, Environment & Health, 40(4), 370-379. doi:10.5271/sjweh.3429Muckenhuber, J., Burkert, N., Großschädl, F., & Freidl, W. (2014). Income Inequality as a Moderator of the Relationship between Psychological Job Demands and Sickness Absence, in Particular in Men: An International Comparison of 23 Countries. PLoS ONE, 9(2), e86845. doi:10.1371/journal.pone.0086845Statistical Office of the European Communities: EU Labour Force Survey http://ec.europa.eu/eurostat/statisticsexplained/index.php/EU_labour_force_survey_-_methodologyLepold, A., Tanzer, N., Bregenzer, A., & Jiménez, P. (2018). The Efficient Measurement of Job Satisfaction: Facet-Items versus Facet Scales. International Journal of Environmental Research and Public Health, 15(7), 1362. doi:10.3390/ijerph15071362Schwendimann, R., Dhaini, S., Ausserhofer, D., Engberg, S., & Zúñiga, F. (2016). Factors associated with high job satisfaction among care workers in Swiss nursing homes – a cross sectional survey study. BMC Nursing, 15(1). doi:10.1186/s12912-016-0160-8Dowler, K. (2005). Job Satisfaction, Burnout, and Perception of Unfair Treatment: The Relationship Between Race and Police Work. Police Quarterly, 8(4), 476-489. doi:10.1177/1098611104269787Kinzl, J. F., Knotzer, H., Traweger, C., Lederer, W., Heidegger, T., & Benzer, A. (2005). Influence of working conditions on job satisfaction in anaesthetists. British Journal of Anaesthesia, 94(2), 211-215. doi:10.1093/bja/aei035Employment Conditions and Health Inequalities http://cdrwww.who.int/entity/social_determinants/resources/articles/emconet_who_report.pdfVan Aerden, K., Moors, G., Levecque, K., & Vanroelen, C. (2013). Measuring Employment Arrangements in the European Labour Force: A Typological Approach. Social Indicators Research, 116(3), 771-791. doi:10.1007/s11205-013-0312-0Brydsten, A., Hammarström, A., & San Sebastian, M. (2016). The impact of economic recession on the association between youth unemployment and functional somatic symptoms in adulthood: a difference-in-difference analysis from Sweden. BMC Public Health, 16(1). doi:10.1186/s12889-016-2917-0Wagenaar, A. F., Kompier, M. A. J., Houtman, I. L. D., Bossche, S. N. J., & Taris, T. W. (2012). Impact of Employment Contract Changes on Workers’ Quality of Working Life, Job Insecurity, Health and Work‐related Attitudes. Journal of Occupational Health, 54(6), 441-451. doi:10.1539/joh.12-0098-oaDe Moortel, D., Thévenon, O., De Witte, H., & Vanroelen, C. (2017). Working Hours Mismatch, Macroeconomic Changes, and Mental Well-being in Europe. Journal of Health and Social Behavior, 58(2), 217-231. doi:10.1177/0022146517706532Angrave, D., & Charlwood, A. (2015). What is the relationship between long working hours, over-employment, under-employment and the subjective well-being of workers? Longitudinal evidence from the UK. Human Relations, 68(9), 1491-1515. doi:10.1177/0018726714559752Julià, M., Belvis, F., Vives, A., Tarafa, G., & Benach, J. (2018). Informal employees in the European Union: working conditions, employment precariousness and health. Journal of Public Health, 41(2), e141-e151. doi:10.1093/pubmed/fdy111Lofstrom, M. (2011). Does self-employment increase the economic well-being of low-skilled workers? Small Business Economics, 40(4), 933-952. doi:10.1007/s11187-011-9402-zHetschko, C. (2016). On the misery of losing self-employment. Small Business Economics, 47(2), 461-478. doi:10.1007/s11187-016-9730-0Gevaert, J., Moortel, D. D., Wilkens, M., & Vanroelen, C. (2018). What’s up with the self-employed? A cross-national perspective on the self-employed’s work-related mental well-being. SSM - Population Health, 4, 317-326. doi:10.1016/j.ssmph.2018.04.001Bernhard-Oettel, C., Leineweber, C., & Westerlund, H. (2018). Staying in or switching between permanent, temporary and self-employment during 2008–2010: Associations with changing job characteristics and emotional exhaustion. Economic and Industrial Democracy, 40(2), 215-237. doi:10.1177/0143831x18804648Sánchez-García, J. C., Vargas-Morúa, G., & Hernández-Sánchez, B. R. (2018). Entrepreneurs’ Well-Being: A Bibliometric Review. Frontiers in Psychology, 9. doi:10.3389/fpsyg.2018.01696Kamerāde, D., Wang, S., Burchell, B., Balderson, S. U., & Coutts, A. (2019). A shorter working week for everyone: How much paid work is needed for mental health and well-being? Social Science & Medicine, 241, 112353. doi:10.1016/j.socscimed.2019.06.006Taylor, J. (2016). Working Extra Hours in the Australian Public Service: Organizational Drivers and Consequences. Review of Public Personnel Administration, 38(2), 193-217. doi:10.1177/0734371x16658335Seitz, J., & Rigotti, T. (2018). How do differing degrees of working-time autonomy and overtime affect worker well-being? A multilevel approach using data from the German Socio-Economic Panel (SOEP). German Journal of Human Resource Management: Zeitschrift für Personalforschung, 32(3-4), 177-194. doi:10.1177/239700221878063
Studies on ''corky rugose wood'' of grapevine and on the diagnosis of grapevine virus B
Vines affected by corky rugose wood (CRW), a field syndrome characterized by pronounced cork production by the scion of several grapevine varieties just above the graft union, contain a number of filamentous and isometric phloem-limited viruses, such as grapevine leafroll-associated virus 1, 2, and 3 (GLRaV-1, GLRaV-2, GLRaV-3), grapevine virus A and B (GVA and GVB), and grapevine fleck virus (GFkV). However, the same viruses, with the exception of GVB, are widely represented also in vines with rugose wood without excessive corkyness. Although GVB was found in all vines indexing positive in LN 33 for corky bark disease, iis occurrence in CRW-affected vines was not consistent enough to suggest that it may have a determining role in the induction of this syndrome. Monoclonal antibodies to GVB raised previously were characterized and their possible use for reliable detection of GVB in field-grown vines investigated in detail. A triple antibody sandwich ELISA protocol that under our experimental conditions afforded consistent and repeatable results, was based on the use of crude cortical scraping extracts from mature canes collected in autumn, antibodies from a polyclonal antiserum for plate coating (trapping) and a monoclonal antibody for antigen detection
Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice
Recognition of other's emotions influences the way social animals interact and adapt to the environment. The neuropeptide oxytocin (OXT) has been implicated in different aspects of emotion processing. However, the role of endogenous OXT brain pathways in the social response to different emotional states in conspecifics remains elusive. Here, using a combination of anatomical, genetic, and chemogenetic approaches, we investigated the contribution of endogenous OXT signaling in the ability of mice to discriminate unfamiliar conspecifics based on their emotional states. We found that OXTergic projections from the paraventricular nucleus of the hypothalamus (PVN) to the central amygdala (CeA) are crucial for the discrimination of both positively and negatively valenced emotional states. In contrast, blocking PVN OXT release into the nucleus accumbens, prefrontal cortex, and hippocampal CA2 did not alter this emotion discrimination. Furthermore, silencing each of these PVN OXT pathways did not influence basic social interaction. These findings were further supported by the demonstration that virally mediated enhancement of OXT signaling within the CeA was sufficient to rescue emotion discrimination deficits in a genetic mouse model of cognitive liability. Our results indicate that CeA OXT signaling plays a key role in emotion discrimination both in physiological and pathological conditions. Is endogenous oxytocin implicated in emotion discrimination? Ferretti, Maltese et al. demonstrate that oxytocin signaling in the central amygdala plays a key role in the ability of mice to discriminate unfamiliar conspecifics based on their emotional state, both in physiological and genetically determined pathological conditions
A human coronavirus responsible for the common cold massively kills dendritic cells but not monocytes
Copyright @ 2012, American Society for Microbiology.Human coronaviruses are associated with upper respiratory tract infections that occasionally spread to the lungs and other organs. Although airway epithelial cells represent an important target for infection, the respiratory epithelium is also composed of an elaborate network of dendritic cells (DCs) that are essential sentinels of the immune system, sensing pathogens and presenting foreign antigens to T lymphocytes. In this report, we show that in vitro infection by human coronavirus 229E (HCoV-229E) induces massive cytopathic effects in DCs, including the formation of large syncytia and cell death within only few hours. In contrast, monocytes are much more resistant to infection and cytopathic effects despite similar expression levels of CD13, the membrane receptor for HCoV-229E. While the differentiation of monocytes into DCs in the presence of granulocyte-macrophage colony-stimulating factor and interleukin-4 requires 5 days, only 24 h are sufficient for these cytokines to sensitize monocytes to cell death and cytopathic effects when infected by HCoV-229E. Cell death induced by HCoV-229E is independent of TRAIL, FasL, tumor necrosis factor alpha, and caspase activity, indicating that viral replication is directly responsible for the observed cytopathic effects. The consequence of DC death at the early stage of HCoV-229E infection may have an impact on the early control of viral dissemination and on the establishment of long-lasting immune memory, since people can be reinfected multiple times by HCoV-229E
IGF-1R/epithelial-to-mesenchymal transition (EMT) crosstalk suppresses the erlotinib-sensitizing effect of EGFR exon 19 deletion mutations
Using non-small cell lung carcinoma (NSCLC) cells harboring the erlotinib-sensitizing Epidermal Growth Factor Receptor (EGFR) exon 19 mutation delE746-A750, we developed erlotinib-refractory derivatives in which hyperactive Insulin-like Growth Factor-1 Receptor (IGF-1R) signaling associated with enrichment in epithelial-to-mesenchymal transition (EMT)-related morphological and transcriptional features. We then explored whether an IGF-1R/EMT crosstalk was sufficient to promote erlotinib refractoriness in the absence of second-site EGFR mutations, MET and AXL hyperactivation. Transforming Growth Factor-beta1 (TGF beta 1)-induced mesenchymal trans-differentiation was sufficient to impede erlotinib functioning in the presence of drug-sensitive delE746-A750 EGFR mutation. Pharmacological blockade of IGF-1R fully prevented the TGF beta 1's ability to activate an EMT protein signature [E-cadherin low/vimentin high]. The sole presence of erlotinib was capable of rapidly activate an IGF-1R-dependent, vimentin-enriched mesenchymal-like phenotype in delE746-A750-mutated epithelial cells. Even if transient, NSCLC cells' intrinsic plasticity to undergo crosstalk between IGF-1R and EMT signaling pathways can sufficiently eliminate the erlotinib-sensitizing effect of highly prevalent EGFR mutations and suggests the urgent need for dual IGF-1R/EMT-targeting strategies to circumvent erlotinib resistance
Silibinin suppresses EMT-driven erlotinib resistance by reversing the high miR-21/low miR-200c signature in vivo
The flavolignan silibinin was studied for its ability to restore drug sensitivity to EGFR-mutant NSCLC xenografts with epithelial-to-mesenchymal transition (EMT)-driven resistance to erlotinib. As a single agent, silibinin significantly decreased the tumor volumes of erlotinib-refractory NSCLC xenografts by approximately 50%. Furthermore, the complete abrogation of tumor growth was observed with the co-treatment of erlotinib and silibinin. Silibinin fully reversed the EMT-related high miR-21/low miR-200c microRNA signature and repressed the mesenchymal markers SNAIL, ZEB, and N-cadherin observed in erlotinib-refractory tumors. Silibinin was sufficient to fully activate a reciprocal mesenchymal-to-epithelial transition (MET) in erlotinib-refractory cells and prevent the highly migratogenic phenotype of erlotinib-resistant NSCLC cells. Given that the various mechanisms of resistance to erlotinib result from EMT, regardless of the EGFR mutation status, a water-soluble, silibinin-rich milk thistle extract might be a suitable candidate therapy for upcoming clinical trials aimed at preventing or reversing NSCLC progression following erlotinib treatment
Efficacy of Benralizumab in severe asthma in real life and focus on nasal polyposis
Introduction: Severe asthma occurs in 5–10% of asthmatic patients, with nasal polyposis as one of the most frequent comorbidity. Benralizumab was recently marketed, thus we could analyse its effects in real-life in severe asthma, and compare the effects of the drug in patients with and without polyposis. Methods: Patients with severe asthma, receiving Benralizumab were enrolled in Italian asthma centres. The efficacy criteria for asthma (exacerbation rate, oral corticosteroid intake, hospitalizations, pulmonary function, exhaled nitric oxide) were evaluated at baseline and after 24 weeks of treatment. Patients were then sub-analysed according to the presence/absence of nasal polyposis. Results: Fifty-nine patients with severe uncontrolled asthma (21 males, age range 32–78) and treated with benralizumab for at least 24 weeks has been evaluated, showing significant improvements in asthma-related outcomes, except for pulmonary function and exhaled nitric oxide. This included a reduction in the sino-nasal outcome-22 score versus baseline of 13.7 points (p = .0037) in the 34 patients with nasal polyposis. Anosmia disappeared in 31% patients (p = .0034). When comparing the groups with and without nasal polyposis, a similar reduction of exacerbations was seen, with a greater reduction of the steroid dependence in patients with polyposis (−72% vs −53%; p < .0001), whereas lung function was significantly more improved (12% vs 34%, p = .0064) without polyposis patients. Conclusions: Benralizumab, after 6 months of treatment, confirmed its efficacy in severe asthma, and also in nasal polyposis, which is the most frequent comorbidity. The efficacy of Benralizumab in reducing steroid dependence was even higher in patients with polyposis
Exploring working conditions as determinants of job satisfaction: an empirical test among Catalonia service workers
Job satisfaction is particularly important in the service industry since it involves direct contact with customers and thus has a direct influence on company performance. We analyzed the impact of ten working conditions on job satisfaction by means of structural equation modelling in a representative stratified random sample of 1553 service sector employees in Catalonia (Spain). We found significant effects in social aspects (recognition of a job well done and social support), followed by psychological loads (emotional demands and job insecurity) and by task contents (development & meaning and predictability). These variables explained 50% of the variance in job satisfaction
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