Radiative Corrections to the Ke3±K_{e3}^{\pm} Decay Revised

We consider the lowest order radiative corrections for the decay $K^{\pm}\to \pi^0 e^{\pm} \nu$, usually referred as $K_{e3}^{\pm}$ decay. This decay is the best way to extract the value of the $V_{us}$ element of the CKM matrix. The radiative corrections become crucial if one wants a precise value of $V_{us}$. The existing calculations were performed in the late 60's \cite{B,G} and are in disagreement. The calculation in \cite{G} turns out to be ultraviolet cutoff sensitive. The necessity of precise knowledge of $V_{us}$ and the contradiction between the existing results constitute the motivation of our paper. We remove the ultraviolet cutoff dependence by using A.Sirlin's prescription; we set it equal to the $W$ mass. We establish the whole character of small lepton mass dependence based on the renormalization group approach. In this way we can provide a simple explanation of Kinoshita--Lee--Nauenberg cancellation of singularities in the lepton mass terms in the total width and pion spectrum. We give an explicit evaluation of the structure--dependent photon emission based on ChPT in the lowest order. We estimate the accuracy of our results to be at the level of 1%. The corrected total width is $\Gamma=\Gamma_0(1+\delta)$ with $\delta=0.02\pm0.0002$. Using the formfactor value $f_+(0)=0.9842\pm 0.0084$ calculated in \cite{CKNRT} leads to $|V_{us}|=0.2172 \pm0.0055$.Comment: 29 pages, 4 figures, 2 tables, uses feynmf.st

Effects of a single aerobic exercise session on body image

Background and Objectives Most research on the effects of exercise on body image has concentrated on the benefits of regular exercise. However, some research has indicated that exercise has an immediate impact on body image. The aims of this study were to investigate the immediate effects of aerobic exercise in a fitness class and the at-home environment on body image, and to examine the impact of nutritional status (i.e., normal weight vs. overweight/obesity) and exercise addiction on these changes. Method 322 Hungarian women participated in the study with two different environmental conditions, fitness class condition (N = 155) and at-home video condition (N = 167). They completed the Body Appreciation Scale and Exercise Addiction Inventory before and after a one-hour aerobic exercise session. Self-report data on weight, height and exercise frequency were also collected. Results There were no significant differences between the fitness class and video groups in terms of age, educational level, BMI, body appreciation, exercise frequency and exercise addiction. We found that 7.5% (N = 24) of the participants were at risk for exercise addiction. Aerobic exercise had a significant positive effect on body appreciation (t(321) = 7.564, p < .001) independently from environment and nutritional status. Exercise addiction moderated the relationship between exercise and body image, the at risk for exercise addiction group showed the greatest improvement (F(1) = 3.252, p = .040). Conclusion The results indicate that even a one-hour aerobic exercise session has a positive effect on body image; this has important practical implications for intervention strategies and weight-loss treatments. | Elméleti háttér és célkitűzés Bár a legtöbb kutatás a rendszeres testedzés testképre gyakorolt pozitív hatására fókuszál, néhány vizsgálat eredménye a testedzés testképre tett azonnali hatására hívja fel a figyelmet. Jelen tanulmány célja az aerobik edzés testképre gyakorolt azonnali hatásának vizsgálata fitnesztermi és otthoni edzési körülmények között, továbbá a tápláltsági állapot (normális testsúly vs. túlsúly/elhízás) és a testedzésfüggőség potenciális moderátor szerepének vizsgálata az edzés és a testkép alakulása közötti kapcsolatban. Módszer A vizsgálatba aerobikedzést folytató nőket vontunk be (n = 322). A résztvevők egyik része edzőteremben folytatta a testgyakorlást (n = 155), másik része otthon végzett aerobik testedzést, video vagy DVD segítségével (n = 167). Mérőeszközök önbeszámolóval nyert testtömeg és testmagasság, a testedzés gyakoriságára vonatkozó kérdés, Testértékelési Skála, Testedzés Addikció Kérdőív. Az adatfelvétel az egyórás testgyakorlást megelőzően és azt követően történt. Eredmények Nem találtunk szignifikáns különbséget az edzőteremben és az otthonukban aerobik edzést folytató nők között az életkor, az iskolai végzettség, a BMI, a testértékelés, a testedzés gyakorisága és a testedzésfüggőség tekintetében. A válaszadók 7,5%-a (n = 24) esetében jelenik meg a testedzésfüggőség kockázata. Az egyórás testedzés szignifikáns, kedvező hatást gyakorolt a testképre (t(321) = 7,564; p < 0,001), amely hatás a testgyakorlás helyszínétől (edzőterem vs. otthon) és a tápláltsági állapottól függetlennek bizonyult. A testedzésfüggőség azonban moderálta a testgyakorlás és a testkép változásának kapcsolatát: a testedzést követően a testedzésfüggőség szempontjából veszélyeztetett csoportban mutatkozott meg a legnagyobb mértékű, pozitív irányú változás a testkép tekintetében (F(1) = 3,252; p = 0,040). Következtetés Eredményeink arra utalnak, hogy akár egy egyórás testgyakorlásnak is pozitív hatása lehet a testképre, amelynek jelentős gyakorlati implikációi vannak a testsúlycsökkentő kezelések szempontjából

Study of the Process e+ e- --> omega pi0 --> pi0 pi0 gamma in c.m. Energy Range 920--1380 MeV at CMD-2

The cross section of the process e+ e- --> omega pi0 --> pi0 pi0 gamma has been measured in the c.m. energy range 920-1380 MeV with the CMD-2 detector. Its energy dependence is well described by the interference of the rho(770) and rho'(1450) mesons decaying to omega pi0. Upper limits for the cross sections of the direct processes e+ e- --> pi0 pi0 gamma, eta pi0 gamma have been set.Comment: Accepted for publication in PL

Equilibria of Idealized Confined Astral Microtubules and Coupled Spindle Poles

Positioning of the mitotic spindle through the interaction of astral microtubules with the cell boundary often determines whether the cell division will be symmetric or asymmetric. This process plays a crucial role in development. In this paper, a numerical model is presented that deals with the force exerted on the spindle by astral microtubules that are bent by virtue of their confinement within the cell boundary. It is found that depending on parameters, the symmetric position of the spindle can be stable or unstable. Asymmetric stable equilibria also exist, and two or more stable positions can exist simultaneously. The theory poses new types of questions for experimental research. Regarding the cases of symmetric spindle positioning, it is necessary to ask whether the microtubule parameters are controlled by the cell so that the bending mechanics favors symmetry. If they are not, then it is necessary to ask what forces external to the microtubule cytoskeleton counteract the bending effects sufficiently to actively establish symmetry. Conversely, regarding the cases with asymmetry, it is now necessary to investigate whether the cell controls the microtubule parameters so that the bending favors asymmetry apart from any forces that are external to the microtubule cytoskeleton

INF2 promotes the formation of detyrosinated microtubules necessary for centrosome reorientation in T cells

T cell antigen receptor-proximal signaling components, Rho-family GTPases, and formin proteins DIA1 and FMNL1 have been implicated in centrosome reorientation to the immunological synapse of T lymphocytes. However, the role of these molecules in the reorientation process is not yet defined. Here we find that a subset of microtubules became rapidly stabilized and that their α-tubulin subunit posttranslationally detyrosinated after engagement of the T cell receptor. Formation of stabilized, detyrosinated microtubules required the formin INF2, which was also found to be essential for centrosome reorientation, but it occurred independently of T cell receptor-induced massive tyrosine phosphorylation. The FH2 domain, which was mapped as the INF2 region involved in centrosome repositioning, was able to mediate the formation of stable, detyrosinated microtubules and to restore centrosome translocation in DIA1-, FMNL1-, Rac1-, and Cdc42-deficient cells. Further experiments indicated that microtubule stabilization was required for centrosome polarization. Our work identifies INF2 and stable, detyrosinated microtubules as central players in centrosome reorientation in T cellsThis work was supported by grants BFU2009-07886 and CONSOLIDER COAT CSD2009-00016 to M.A. Alonso, and BFU2011-22859 to I. Correas (all of them from the Ministerio de Economía y Competitividad, Spain), and grant S2010/BMD-2305 from the Comunidad de Madrid to I. Correa

An Experimental and Computational Study of Effects of Microtubule Stabilization on T-Cell Polarity

T-killer cells eliminate infected and cancerous cells with precision by positioning their centrosome near the interface (immunological synapse) with the target cell. The mechanism of centrosome positioning has remained controversial, in particular the role of microtubule dynamics in it. We re-examined the issue in the experimental model of Jurkat cells presented with a T cell receptor-binding artificial substrate, which permits controlled stimulation and reproducible measurements. Neither 1-µM taxol nor 100-nM nocodazole inhibited the centrosome positioning at the “synapse” with the biomimetic substrate. At the same time, in micromolar taxol but not in nanomolar nocodazole the centrosome adopted a distinct peripheral rather than the normally central position within the synapse. This effect was reproduced in a computational energy-minimization model that assumed no microtubule dynamics, but only a taxol-induced increase in the length of the microtubules. Together, the experimental and computational results indicate that microtubule dynamics are not essential for the centrosome positioning, but that the fit of the microtubule array in the deformed body of the conjugated T cell is a major factor. The possibility of modulating the T-cell centrosome position with well-studied drugs and of predicting their effects in silico appears attractive for designing anti-cancer and antiviral therapies

How to integrate individual patient values and preferences in clinical practice guidelines? A research protocol

Background Clinical practice guidelines are largely conceived as tools that will inform health professionals' decisions rather than foster patient involvement in decision making. The time now seems right to adapt clinical practice guidelines in such a way that both the professional's perspective as care provider and the patients' preferences and characteristics are being weighed equally in the decision-making process. We hypothesise that clinical practice guidelines can be adapted to facilitate the integration of individual patients' preferences in clinical decision making. This research protocol asks two questions: How should clinical practice guidelines be adapted to elicit patient preferences and to support shared decision making? What type of clinical decisions are perceived as most requiring consideration of individual patients' preferences rather than promoting a single best choice? Methods Stakeholders' opinions and ideas will be explored through an 18-month qualitative study. Data will be collected from in-depth individual interviews. A purposive sample of 20 to 25 key-informants will be selected among three groups of stakeholders: health professionals using guidelines (e.g., physicians, nurses); experts at the macro- and meso-level, including guideline and decision aids developers, policy makers, and researchers; and patient representatives. Ideas and recommendations expressed by stakeholders will be prioritized by nominal group technique in expert meetings. Discussion One-for-all guidelines do not account for differences in patients' characteristics and for their preferences for medical interventions and health outcomes, suggesting a need for flexible guidelines that facilitate patient involvement in clinical decision making. The question is how this can be achieved. This study is not about patient participation in guideline development, a closely related and important issue that does not however substitute for, or guarantee individual patient involvement in clinical decisions. The study results will provide the needed background for recommendations about potential effective and feasible strategies to ensure greater responsiveness of clinical practice guidelines to individual patient's preferences in clinical decision-making

Study of the Process e+ e- ---> eta gamma in c.m. Energy Range 600-1380 MeV at CMD-2

The cross section of the process e+ e- ---> eta gamma has been measured in the 600-1380 MeV c.m. energy range with the CMD-2 detector. The following branching ratios have been determined: B(rho ---> eta gamma) = (3.28 +- 0.37 +- 0.23) 10^{-4}, B(omega ---> eta gamma) = (5.10 +- 0.72 +- 0.34) 10^{-4}, B(phi --> eta gamma) = (1.287 +- 0.013 +- 0.063) 10^{-2}. Evidence for the rho'(1450) ---> eta gamma decay has been obtained for the first time.Comment: 17pages, 4 figures, submited to Phys.Lett.

Study of the Process e+ e- --> pi0 pi0 gamma in c.m. Energy Range 600--970 MeV at CMD-2

The cross section of the process e+ e- --> pi0 pi0 gamma has been measured in the c.m. energy range 600--970 MeV with the CMD-2 detector. The following branching ratios have been determined: B(rho --> pi0 pi0 gamma) =(5.2^{+1.5}_{-1.3} +- 0.6)x10^{-5} and B(omega --> pi0 pi0 gamma) =(6.4^{+2.4}_{-2.0} +- 0.8)x10^{-5}. Evidence for the rho --> f0(600) gamma decay has been obtained: B(rho --> f0(600) gamma) = (6.0^{+3.3}_{-2.7}\pm 0.9)x10^{-5}. From a search for the process e+ e- --> eta pi0 gamma the following upper limit has been obtained: B(omega --> eta pi0 gamma) < 3.3 10^{-5} at 90% CL.Comment: 15 pages, 4 figure