Interval cancers in a national colorectal cancer screening programme

BACKGROUND: Little is known about interval cancers (ICs) in colorectal cancer (CRC) screening. OBJECTIVE: The purpose of this study was to identify IC characteristics and compare these with screen-detected cancers (SCs) and cancers in non-participants (NPCs) over the same time period. DESIGN: This was an observational study done in the first round of the Scottish Bowel Screening Programme. All individuals (772,790), aged 50–74 years, invited to participate between 1 January 2007 and 31 May 2009 were studied by linking their screening records with confirmed CRC records in the Scottish Cancer Registry (SCR). Characteristics of SC, IC and NPC were determined. RESULTS: There were 555 SCs, 502 ICs and 922 NPCs. SCs were at an earlier stage than ICs and NPCs (33.9% Dukes’ A as against 18.7% in IC and 11.3% in NPC), screening preferentially detected cancers in males (64.7% as against 52.8% in IC and 59.7% in NPC): this was independent of a different cancer site distribution in males and females. SC in the colon were less advanced than IC, but not in the rectum. CONCLUSION: ICs account for 47.5% of the CRCs in the screened population, indicating approximately 50% screening test sensitivity: guaiac faecal occult blood testing (gFOBT) sensitivity is less for women than for men and gFOBT screening may not be effective for rectal cancer

Exploring the contribution of alternative food networks to food security. A comparative analysis

[EN] Food (in)security has become a challenge not only for developing economies but also for High Income Countries. In parallel, food scholars have actively investigated the contribution of alternative food networks (AFNs) to the development of more sustainable and just food systems, paying attention to drivers, initiatives and policies supporting the development of alternatives to the dominant industrialised food system and its detrimental environmental and socio-economic impacts. However, few studies have directly addressed the contribution of AFNs to food security in the Global North. This paper aims to establish new linkages between food security debates and critical AFNs literature. For that purpose, we conduct a place-based approach to food security in a comparative analysis of initiatives of three different European contexts: Cardiff city-region (UK), the Flemish Region (Belgium) and the peri-urban area of the city of Valencia (Spain). The results unfold: i) how AFNs weave a more localised socio-economic fabric that creates new relationships between food security outcomes and specific territories, ii) hybridization processes within alternative but also conventional systems and iii) the role of advocacy and collective action at different levels. The analysis allows identification of key elements on which food security debates hinge and provides new insights to ground conceptual discussions on territorial and place-based food security approaches.This research is part of the project "Assessment of the impact of global drivers of change on Europe's food security" (TRANSMANGO), granted by the EU under 7th Framework Programme; theme KBBE.2013.2.5-01; Grant agreement no: 613532. Dr. Ana Moragues-Faus also acknowledges the funding of the European Commission and the Welsh Government that currently supports her Ser Cymru fellowship. These results reflect only the authors' view; the funders are not liable for any use that may be made of the information contained therein.Cerrada-Serra, P.; Moragues-Faus, A.; Zwart, TA.; Adlerova, B.; Ortiz-Miranda, D.; Avermaete, T. (2018). Exploring the contribution of alternative food networks to food security. A comparative analysis. Food Security. 10(6):1371-1388. https://doi.org/10.1007/s12571-018-0860-xS13711388106Arcuri, S., Brunori, G., & Galli, F. (2017). Insights on the role of private and public actors in food assistance provision: A literature review for high income countries. Economia agro-alimentare. https://doi.org/10.3280/ECAG2017-001006 .Barca, F., McCann, P., & Rodríguez-Pose, A. (2012). The case for regional development intervetion: Place-based versus place-neutral approaches. Journal of Regional Science, 52, 134–152. https://doi.org/10.1111/j.1467-9787.2011.00756.x .Bauler, T., Mutombo, E., van Gameren, V., Crivits, M., Paredis, E., Boulanger, P., . . . Ruwet, C., (2011). Construction of scenarios and exploration of transition pathways for sustainable consumption patterns. Brussels: Belgian Science Policy.Brown, J. C., & Purcell, M. (2005). There’s nothing inherent about scale: Political ecology, the local trap, and the politics of development in the Brazilian Amazon. Geoforum, 36, 607–624. https://doi.org/10.1016/j.geoforum.2004.09.001 .Bourne, N. (2012) Fruit and vegetable community co-ops rise to 350 in Wales, BBC Wales News, Available at http://www.bbc.co.uk/news/uk-wales-17938418 . Accessed Sept 2017.Brunori, G., Malandrin, V., & Rossi, A. (2013). Trade-off or convergence? The role of food security in the evolution of food discourse in Italy. Journal of Rural Studies, 29, 19–29. https://doi.org/10.1016/j.jrurstud.2012.01.013 .Cistulli, V., Rodríguez-Pose, A., Escobar, G., Marta, S., & Schejtman, A. (2014). Addressing food security and nutrition by means of a territorial approach. Food Security, 6, 879–894. https://doi.org/10.1007/s12571-014-0395-8 .Clay, E. (2002). Food security; concept and measurement. Paper for FAO expert consultation on trade and food security: Conceptualising the linkages. Rome http://www.fao.org/docrep/005/y4671e/y4671e06.htm . Accessed Sept 2017.Cox, I. (2015). Interim report: Adding value and demonstrating sustainable development in the community food co-ops in Wales, EcoStudio.Crivits, M., & Paredis, E. (2013). Designing an explanatory practice framework: Local food systems as a case. Journal of Consumer Culture, 13, 306–336. https://doi.org/10.1177/1469540513484321joc.sagepub.com .CSM (2016). Connecting small-holders to farmers: an analytical guide.Dedeurwaedere, T., de Schutter, O., Hudon, M., Mathijs, E., Annaert, B., Avermaete, T., et al. (2015). Working paper: Social enterprise based transition movements between transformation and reform. The case of transition initiatives in local food networks. BRAIN-be. Food4Sustainability annual report 2. Deliverable 2.2.Dixon, J., & Richards, C. (2016). On food security and alternative food networks: Understanding and performing food security in the context of urban bias. Agriculture and Human Values, 33, 191–202. https://doi.org/10.1007/s10460-015-9630-y .Ekers, M., Levkoe, C. Z., Walker, S., & Dale, B. (2015). Will work for food: Agricultural interns, apprentices, volunteers, and the agrarian question. Agriculture and Human Values, 33, 705–720. https://doi.org/10.1007/s10460-015-9660-5 .Elliott, E., Parry, O., Ashdown-Lambert, J. (2004). Evaluation of community food co-ops, Working Paper 85, Cardiff School of Social Sciences, Cardiff University.FAO (1998). Report: Sustaining agricultural biodiversity and agro-ecosystem functions. http://www.fao.org/sd/EPdirect/EPre0080.htm . Accessed Nov 2017.FAO (2001). Report: The state of food insecurity in the world. http://www.fao.org/docrep/003/y1500e/y1500e00.htm . Accessed Nov 2017.Gibson-Graham, J. K. (2006). A postcapitalist politics. Minessota: University of Minnesota Press.Goodman, M. K. (2004). Reading fair trade: Political ecological imaginary and the moral economy of fair trade foods. Political Geography, 23, 891–915. https://doi.org/10.1016/j.polgeo.2004.05.013 .Goodman, D., DuPuis, E.M., Goodman, M.K. (2012). Alternative food networks: Knowledge, place and politics. Routledge, Oxon, New York. ISBN: 9780203804520.Goodman, D., DuPuis, E. M., & Goodman, M. K. (2013). Engaging alternative food networks: Commentaries and research agendas. International Journal of Sociology of Agriculture and Food, 20, 425–431.Guinot, E. (2008) El paisaje de la Huerta de Valencia. Elementos de interpretación de su morfología espacial de origen medieval. Historia de la Ciudad V. Tradición y progreso, 98–111. Valencia: Icaro-Colegio Territorial de Arquitectos de Valencia-Universidad Politécnica de Valencia.Guthman, J. (2004). Agrarian dreams: The paradox of organic farming in California. University of California Press, Berkeley. ISBN-10: 0520240952.Hubeau, M., Coteur, I., Mondelaers, K., & Marchand, F. (2015). Systeembeschrijving van het Vlaamse Landbouw- en Voedingssysteem: een nulmeting. Merelbeke, Belgie: ILVO.Ilbery, B., & Maye, D. (2005). Alternative (shorter) food supply chains and specialist livestock products in the Scottish - English borders. Environment and Planning, 37, 823–844. https://doi.org/10.1068/a3717 .IPCC (2012). Glossary of terms. In C. B. Field, V. Barros, T. F. Stocker, D. Qin, D. J. Dokken, K. L. Ebi et al. (Eds.), Managing the Risks of Extreme Events and Disasters to Advance Climate Change Adaptation. A Special Report of Working Groups I and II of the Intergovernmental Panel on Climate Change (IPCC), (pp. 555–564). Cambridge: Cambridge University Press.Jarosz, L. (2007). The city in the country: Growing alternative food networks in metropolitan areas. Journal of Rural Studies, 24, 231–244. https://doi.org/10.1016/j.jrurstud.2007.10.002 .Jones, I. (2012). Evaluation of the community food co-operative programme in Wales, BMG research, Welsh Government social research, 22/2012.Kirwan, J., & Maye, D. (2013). Food security framings within the UK and the integration of local food systems. Journal of Rural Studies, 29, 91–100. https://doi.org/10.1016/j.jrurstud.2012.03.002 .Lamine, C. (2015). Sustainability and resilience in Agrifood systems: Reconnecting agriculture, food and the environment. Sociologia Ruralis, 55, 41–61. https://doi.org/10.1111/soru.12061 .Loopstra, R., Reeves, A., McKee, M., & Stuckler, D. (2016). Food insecurity and social protection in Europe: Quasi-natural experiment of Europe’s great recessions 2004–2012. Preventive Medicine, 89, 44–50. https://doi.org/10.1016/j.ypmed.2016.05.010 .MacMillan, T., & Dowler, E. (2012). Just and sustainable? Examining the rhetoric and potential realities of UK food security. Journal of Agricultural and Environmental Ethics, 25, 181–204. https://doi.org/10.1007/s10806-011-9304-8 .Marsden, T., Banks, J., Bristow, G. (2000). Food supply chain approaches: exploring their role in rural development. Sociologia Ruralis, https://doi.org/10.1111/1467-9523.00158Maxwell, S. (1996). Food security: A post-modern perspective. Food Policy, 21, 155–170. https://doi.org/10.1016/0306-9192(95)00074-7 .Mooney, P.H., Hunt, S.A. (2009). Food security: The elaboration of contested claims to a consensus frame. Sociologia Ruralis. https://doi.org/10.1111/j.1549-0831.2009.tb00701.x .Moragues-Faus, A. (2016). Participative action research: Transforming Cardiff’s food system through students’ live projects. Report available at http://foodcardiff.com/wp-content/uploads/2016/10/Report-live-projects-2016-cut-.pdf. . Accessed Sept 2017.Moragues-Faus, A. (2017a). Emancipatory or neoliberal food politics? Exploring the “politics of collectivity” of buying groups in the search for egalitarian food democracies. Antipode, 49, 455–476. https://doi.org/10.1111/anti.12274 .Moragues-Faus, A. (2017b). Problematising justice definitions in public food security debates: Towards global and participative food justices. Geoforum, 84, 95–106. https://doi.org/10.1016/j.geoforum.2017.06.007 .Moragues-Faus, A., & Marsden, T. (2017). The political ecology of food: Carving “spaces of possibility” in a new research agenda. Journal of Rural Studies, 55, 275–288. https://doi.org/10.1016/j.jrurstud.2017.08.016 .Moragues-Faus, A., Sonnino, R., 2012. Embedding quality in the agro-food system: The dynamics and implications of place-making strategies in the olive oil sector of alto Palancia, Spain. Sociologia Ruralis, https://doi.org/10.1111/j.1467-9523.2011.00558.x .Morgan, K., & Sonnino, R. (2010). The urban foodscape: World cities and the new food equation. Cambridge Journal of Regions, Economy and Society, 3, 209–224. https://doi.org/10.1093/cjres/rsq007 .Murdoch, J., & Miele, M. (1999). “Back to nature”: Changing “worlds of production” in the food sector. Sociologia Ruralis, 39, 465–483. https://doi.org/10.1111/1467-9523.00119 .Murdoch, J., Marsden, T., & Banks, J. (2000). Quality, nature, and embeddedness: Some theoretical considerations in the context of the food sector. Economic Geography, 76, 107–125. https://doi.org/10.1111/j.1944-8287.2000.tb00136.x .OECD, FAO, UNCDF (2016). Adopting a territorial approach to food security and nutrition policy. Paris. https://doi.org/10.1787/9789264257108-en .Ortiz-Miranda, D., Moragues-Faus, A.M., 2014. Governing fair trade coffee supply: dynamics and challenges in small farmers’ organizations. Sustainable Development, https://doi.org/10.1002/sd.1570 .Oxfam and Church Action. (2013). Walking the breadline: The scandal of food poverty in 21st-century Britain. http://policy-practice.oxfam.org.uk/publications/walking-the-breadline-the-scandal-of-food-poverty-in-21st-century-britain-292978 . Accessed 19 August 2014.Padel, S., & Foster, C. (2005). Exploring the gap between attitudes and behaviour: Understandingwhy consumers buy or do not buy organic food. British Food Journal, 107, 606–625. https://doi.org/10.1108/00070700510611002 .Radhika Ch., Hemantha U., 2017. Research study on nutrition security and equity in its access in watershed development programmes. Research reports series 107. National Institute of Rural Development & Panchayati Raj. ISBN 978-93-84503-81-9.Renting, H., Marsden, T. K., & Banks, J. (2003). Understanding alternative food networks: Exploring the role of short food supply chains in rural development. Environment and Planning, 35, 393–411. https://doi.org/10.1068/a3510 .Renting, H., Schermer, M., & Rossi, A. (2012). Building food democracy: Exploring civic food networks and newly emerging forms of food citizenship. International Journal of Sociology of Agriculture and Food, 19, 289–307.Romero, J., & Francés, M. (Eds.). (2012). La Huerta de Valencia. Un paisaje cultural con futuro incierto. Valencia: Publicaciones de la Universitat de València.Sage, C. (2003). Social embeddedness and relations of regard: Alternative “good food” networks in south-West Ireland. Journal of Rural Studies, 19, 47–60. https://doi.org/10.1016/S0743-0167(02)00044-X .Sonnino, R., & Marsden, T. (2006). Beyond the divide: Rethinking relationships between alternative and conventional food networks in Europe. Journal of Economic Geography, 6, 181–199. https://doi.org/10.1093/jeg/lbi006 .Sonnino, R., Marsden, T., & Moragues-Faus, A. (2016). Relationalities and convergences in food security narratives: Towards a place-based approach. Transactions of the Institute of British Geographers, 41, 477–489. https://doi.org/10.1111/tran.12137 .Soriano i Piqueras, V. (2015). La huerta de Valencia un paisaje menguante. Amazon. ISBN-13: 978-1512009231.Stanners, D., & Bourdeau, P. (1995). Europe’s environment: The Dobris assessment. Copenhagen: European Environmental Agency.Tregear, A. (2011). Progressing knowledge in alternative and local food networks: Critical reflections and a research agenda. Journal of Rural Studies, 27, 419–430. https://doi.org/10.1016/j.jrurstud.2011.06.003 .Valencia City Council. (2016). Department of Agricultura and Huerta (ongoing review). Pla d’Acció Integral per a la promoció de l’activitat i el territori agrícola municipal. https://hortaipoblesvalencia.org/es/agricultura-y-huerta/ . Accessed Jan 2018.Van Gameren, V., Ruwet, C., & Bauler, T. (2015). Towards a governance of sustainable consumption transitions: How institutional factors influence emerging local food systems in Belgium. Local Environment: The international journal of justice and sustainability, https://doi.org/10.1080/13549839.2013.872090 .Venn, L., Kneafsey, M., Holloway, L., Cox, R., Dowler, E., & Tuomainen, H. (2006). Researching European “alternative” food networks: Some methodological considerations. Area, 38, 248–258. https://doi.org/10.1111/j.1475-4762.2006.00694.x .Vervoort, J., Thornton, P. K., Kristjanson, P., et al. (2014). Challenges to scenario-guided adaptive action on food security under climate change. Global Environmental Change, 28, 383–394. https://doi.org/10.1016/j.gloenvcha.2014.03.001 .Weingartner L. (2005). Paper I. The concept of food and nutrition security. In: Klennert K, editor. Achieving food and nutrition security: Actions to meet the global challenge: A training course reader. Feldafing: German Society for International Cooperation; p. 3–28. ISBN 3-937235 -71-X.Whatmore, S., Stassart, P., & Renting, H. (2003). What’s alternative about alternative food networks? Environment and Planning, 35, 389–391. https://doi.org/10.1068/a3621 .Zwart, T. A., Mathijs, E., Avermaete, T. (2016). Can alternative food networks contribute to a transition towards sustainability in Flanders: Assessing the marketing functions of Voedselteams. Report available at http://ageconsearch.umn.edu/record/245069/files/BioeconWP_2016_04_submitted.pdf . Accessed Sept 2017

Crohn's disease adherent-invasive Escherichia coli colonize and induce strong gut inflammation in transgenic mice expressing human CEACAM

Abnormal expression of CEACAM6 is observed at the apical surface of the ileal epithelium in Crohn's disease (CD) patients, and CD ileal lesions are colonized by pathogenic adherent-invasive Escherichia coli (AIEC). We investigated the ability of AIEC reference strain LF82 to colonize the intestinal mucosa and to induce inflammation in CEABAC10 transgenic mice expressing human CEACAMs. AIEC LF82 virulent bacteria, but not nonpathogenic E. coli K-12, were able to persist in the gut of CEABAC10 transgenic mice and to induce severe colitis with reduced survival rate, marked weight loss, increased rectal bleeding, presence of erosive lesions, mucosal inflammation, and increased proinflammatory cytokine expression. The colitis depended on type 1 pili expression by AIEC bacteria and on intestinal CEACAM expression because no sign of colitis was observed in transgenic mice infected with type 1 pili–negative LF82-ΔfimH isogenic mutant or in wild-type mice infected with AIEC LF82 bacteria. These findings strongly support the hypothesis that in CD patients having an abnormal intestinal expression of CEACAM6, AIEC bacteria via type 1 pili expression can colonize the intestinal mucosa and induce gut inflammation. Thus, targeting AIEC adhesion to gut mucosa represents a new strategy for clinicians to prevent and/or to treat ileal CD

Masked suffix priming and morpheme positional constraints

Although masked stem priming (e.g., dealer\u2013DEAL) is one of the most established effects in visual word identification (e.g., Grainger et al., 1991), it is less clear whether primes and targets sharing a suffix (e.g., kindness\u2013WILDNESS) also yield facilitation (Giraudo & Grainger, 2003; Du\uf1abeitia et al., 2008). In a new take on this issue, we show that prime nonwords facilitate lexical decisions to target words ending with the same suffix (sheeter\uac\u2013TEACHER) compared to a condition where the critical suffix was substituted by another one (sheetal\u2013TEACHER) or by an unrelated non\u2013morphological ending (sheetub\u2013 TEACHER). We also show that this effect is genuinely morphological, as no priming emerged in non\u2013complex items with the same orthographic characteristics (sportel\u2013BROTHEL vs. sportic\u2013BROTHEL vs. sportur\u2013BROTHEL). In a further experiment, we took advantage of these results to assess whether suffixes are recognized in a position\u2013specific fashion. Masked suffix priming did not emerge when the relative order of stems and suffixes was reversed in the prime nonwords\u2014ersheet did not yield any time saving in the identification of teacher as compared to either alsheet or obsheet. We take these results to show that \u2013er was not identified as a morpheme in ersheet, thus indicating that suffix identification is position specific. This conclusion is in line with data on interference effects in nonword rejection (Crepaldi, Rastle, & Davis, 2010), and strongly constrains theoretical proposals on how complex words are identified. In particular, because these findings were reported in a masked priming paradigm, they suggest that positional constraints operate early, most likely at a pre\u2013lexical level of morpho\u2013orthographic analysi