Vida y obra de Juan López de Zamora, O. P. : un intelectual castellano del siglo XV : antología de textos

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2012-201

Evaluación de tres herbicidas en el control pre emergente de arvenses en caña de azúcar (Original)

During the period february-june 2017, a trial was established in plots of commercial areas, in shoot stock, applied before the outbreak of the foliage on a Fluvisol soil (Alluvial). The experiment was carried out in a random block design, with 4 treatments and 4 replications, the area of ​​the plot of 0.009 ha (90 m2) per treatment in the Agricultural Production Cooperative (CPA) "Omar Rivero Fonseca", of the Base Business Unit (UEB) Bartolomé Masó, located in the town of Vuelta del Caño, municipality of Manzanillo, Granma province, with the objective of evaluating the effect of three herbicides on the variety of sugarcane CP 52-43, suckers. The herbicides evaluated were the Mayoral LS 35 at 0,600 L / ha p.c applied in pre-emergence before germination irrigation; Herbicide MerlinGD 75 at 0.270 kg / ha p.c; In addition, the total Merlin 60 SC was used at 0.250 L / ha p.c and finally a Control A (absolute) was used where the effectiveness of each herbicide treated in the cover of weeds could be compared. The product was applied with Matabi backpack hand sprayer five days after the cut (5 DDC), under dry soil conditions, where the results were obtained at the beginning of 2018.Durante el período febrero-junio 2017, se estableció un ensayo en parcelas de áreas comerciales, en cepa de retoño, aplicadas antes del brote del follaje sobre un Fluvisol. El experimento se realizó en un diseño de bloque al azar, con cuatro tratamientos y cuatro réplicas, el área de la parcela de 0,009 ha (90m2) por tratamento en la Cooperativa de Producción Agropecuaria (CPA) “Omar Rivero Fonseca”, de la Unidad Empresarial de Base (UEB) Bartolomé Masó, ubicada en el poblado Vuelta del Caño, municipio de Manzanillo, provincia Granma, con el objetivo de evaluar el efecto de tres herbicidas en la variedad de caña de azúcar CP 52-43, retoños. Los herbicidas evaluados fueron El Mayoral LS 35a 0,600 L/ha p. c aplicado en preemergencia antes del riego de germinación; el herbicida Merlin GD 75 a 0.270 kg/ha p.c; además se utilizó el Merlin total 60 SC a 0.250 L/ha p.c y por último se utilizó un Testigo A (absoluto) donde se pudiera comparar la eficacia de cada herbicida tratado en la cobertura de arvenses. El producto se aplicó con asperjadora manual Mochila Matabia los cincodías después del corte (5 DDC), en condiciones de suelo seco, donde se obtuvieron los resultados a principios del año 2018

Efficacy and safety outcomes of recanalization procedures in patients with acute symptomatic pulmonary embolism: systematic review and network meta-analysis.

Background We aimed to review the efficacy and safety of recanalisation procedures for the treatment of PE. Methods We searched PubMed, the Cochrane Library, EMBASE, EBSCO, Web of Science and CINAHL databases from inception through 31 July 2015 and included randomised clinical trials that compared the effect of a recanalisation procedure versus each other or anticoagulant therapy in patients diagnosed with PE. We used network meta-analysis and multivariate randomeffects meta-regression to estimate pooled differences between each intervention and meta-regression to assess the association between trial characteristics and the reported effects of recanalisation procedures versus anticoagulation. Results For all-cause mortality, there were no significant differences in event rates between any of the recanalisation procedures and anticoagulant treatment (full-dose thrombolysis: OR 0.60; 95% CI0.36 to 1.01; low-dose thrombolysis: 0.47; 95%CI 0.14 to 1.59; and catheter-associated thrombolysis: 0.31; 95%CI 0.01 to 7.96). Full-dose thrombolysis increased the risk of major bleeding (2.00; 95%CI 1.06 to 3.78) compared with anticoagulation. Catheter-directed thrombolysis was associated with the lowest probability of dying (surface under the cumulative ranking curve (SUCRA), 0.67), followed by low-dose thrombolysis (SUCRA, 0.66) and full-dose thrombolysis (SUCRA, 0.55). Similarly, low-dose thrombolysis was associated with the lowest probability of major bleeding (SUCRA, 0.61), followed by catheterdirected thrombolysis (SUCRA, 0.54) and full-dose thrombolysis (SUCRA, 0.17). The results were similar in sensitivity analyses based on restricting only to studies in haemodynamically stable patients with PE. Conclusions In the treatment of PE, recanalisation procedures do not seem to offer a clear advantage compared with standard anticoagulation. Low-dose thrombolysis was associated with the lowest probability of dying and bleedingpre-print549 K

Structural and magnetic properties study of nd16fe76-xnixb8 alloys with low ni contents

In this work we report a magnetic and structural study of Nd16Fe76-xNixB8 (x = 0, 2.5, 5, 7.5 and 10) alloys. This system was investigated by means of x-ray diffraction, Mössbauer spectrometry, and magnetization. The samples were melted in an arc furnace and then annealed during three days at 1000 oC. The results show the majority formation of the hard Nd2Fe14B tetragonal phase with lattice parameters a = 8.810 Å and c = 12.210 Å; these parameters do not vary substantially with the addition of Ni. Mössbauer results show a ferromagnetic contribution with six sites of iron associated to the Nd2Fe14B phase and a paramagnetic contribution as a doublet attributed to the Nd1,1Fe4B4 phase. The hysteresis cycles show that all the samples present a hard magnetic behavior, and the addition of Ni decreases this property.En este trabajo reportamos las propiedades magnéticas y estructurales de las aleaciones Nd16Fe76-xNixB8 (x=0, 2.5, 5, 7.5 y 10). Este sistema fue investigado por medio de difracción de rayos-x, espectrometría Mössbauer y magnetización. Las muestras fueron fundidas en un horno a arco y luego recocidas a 1000 oC durante tres días. Los resultados muestran la formación mayoritaria de la fase tetragonal dura Nd2Fe14B con parámetros de red a=8.810 Å y c=12.210 Å; estos parámetros no varían sustancialmente al agregar Ni. Los resultados Mössbauer muestran una contribución ferromagnética constituida por seis sitios de hierro asociados a la fase Nd2Fe14B y una contribución paramagnética en forma de doblete atribuida a la fase Nd1,1Fe4B4. Los ciclos de histéresis muestran que todas las muestras presentan un comportamiento magnético duro, y al agregar Ni esta propiedad disminuye

Osmotic stress tolerance in forage oat varieties (Avena Sativa L.) based on osmotic potential trials

Received: April 1st, 2022 ; Accepted: December 12th, 2022 ; Published: February 7th, 2023 ; Correspondence: [email protected]; [email protected] oats (Avena sativa L.) are globally important for milk and meat production, and, to a lesser extent, for the human diet. In Mexico, oats are a strategic crop, occupying the fourth place in cultivated area, only after maize for grain, bean, and sorghum for grain. Droughts are the main problem for oat production in Mexico. This study evaluated the germination and seedling growth of several oat varieties in response to drought stress simulated by PEG-6000 treatments of different osmotic pressure in order to identify drought-resistant genotypes. The Teporaca genotype was the most outstanding in the three levels of OP compared to its control with 0.0 of Osmotic Potential (OP). The Teporaca genotype showed the largest root length and the lowest diminishment of root length under osmotic stress conditions. This genotype also had the largest shoot length in the three osmotic stress levels. Regarding root fresh weight, Babicora stands out with 98.5% and Teporaca with 43% in the most severe level. Teporaca, Menonita, and Babicora showed the outstanding root dry weights of 346.5%, 327.2%, and 251.2%, respectively. These varieties had higher root dry weight than their own controls in water in the most severe level of OP. In conclusion, the Teporaca, Menonita, and Karma genotypes showed the highest osmotic stress tolerance and could be used as sources of favorable alleles to improve oat drought tolerance

¿Se asocia el consumo de refrescos azucarados con la composición corporal? Estudio transversal en adolescentes españoles

Objectives: Published data about the association between the consumption of sweetened soft-drinks (SSD) and obesity in childhood are controversial and still inconsistent. In addition, data are lacking in the Spanish population. The purpose of this study was therefore, to explore the cross-sectional association between body composition- related parameters and SSD consumption in Spanish adolescents. Subjects and methods: A representative sample of 1,523 adolescents (768 boys and 755 girls), with complete dietary data as well as anthropometric measurements, were included in this study. Weight, height, waist circumferences, and 6 skinfolds were measured, and BMI and percentage body fat were calculated. From a 24h dietary recall the subjects were grouped in 3 groups according to their SSD consumption: 1) Non-consumers (0 g of SSD consumption); 2) Moderate consumption (< 336 g/day of SSD, equivalent to the average SSD portion size); and 3) High consumption (> 336 g/day of SSD). Results: 67% males and 75% females did not consume any SSD the day before the dietary recall interview. Males consumed more SSD than females. Regarding the association between SSD consumption and measures of obesity, no difference was observed between the three groups of SSD consumption in any of the anthropometric measurement, BMI or body fat. Conclusion: As no association was present between SSD consumption and obesity in our cross-sectional study we suggest that dietary patterns and habits as well as lifestyle factors such as physical activity should be present when examining cross-sectional or longitudinal relationships with obesity. Multidisciplinary intervention studies are crucial when trying to develop solutions against the increasing obesity epidemic.Objetivos: Los datos publicados sobre la asociación entre el consumo de refrescos azucarados (SSD) y la obesidad en la infancia son controvertidos y todavía inconsistentes. Además, estos datos son muy escasos en la población española. Por ello, el propósito de este estudio ha sido estudiar la asociación entre los parámetros relacionados con la composición corporal y el consumo de SSD en adolescentes españoles. Sujetos y métodos: Se ha realizado el estudio en una muestra de 1.523 adolescentes (768 chicos y 755 chicas) que tenían cumplimentados los datos dietéticos y los parámetros antropométricos (peso, altura, circunferencias de cintura, y 6 pliegues). Se calculó el IMC y el porcentaje de grasa corporal. La dieta ha sido calculada a partir de un recordatorio de 24h. Los sujetos fueron divididos en grupos dependiendo de la cantidad de SSD que consumían: 1) No consumidores (0 g de consumo SSD); 2) Consumo moderado (< 336 g/día de SSD, equivalente a una bebida al día de SSD); y 3) Consumo alto (> 336 g/día de SSD). Resultados: El 67% de los varones y el 75% de las mujeres indican no consumir este tipo de bebidas el día anterior a la encuesta. Los varones en general consumieron más SSD que las mujeres. En cuanto a la asociación entre consumo SSD y medidas antropométricas y de composición corporal, no se encontraron diferencias significativas entre los tres grupos de estudio en los parámetros antropométricos, IMC o grasa corporal. Conclusión: Dado que no se ha encontrado en este estudio ninguna asociación entre el consumo de SSD y la obesidad, sugerimos que los patrones y hábitos dietarios así como los factores del estilo de vida, y la actividad física, deberían tenerse en cuenta al examinar las relaciones transversales o longitudinales con la obesidad, y que los estudios de intervención multidisciplinar son cruciales cuando se trata de desarrollar soluciones contra el incremento de una epidemia como la obesidad.The AVENA study was supported by Spanish Ministry of Health (00/0015) and by grants from the Spanish Higher Sports Council (05/UPB32/01, 09/UPB31/03 and 13/UPB20/04), the Spanish Ministry of Education (AP2003-2128 and AP2004-2745), Coca-Cola, Panrico SA, Madaus SA and Procter & Gamble SA

DD04107-Derived neuronal exocytosis inhibitor peptides: Evidences for synaptotagmin-1 as a putative target

The analgesic peptide DD04107 (Pal-EEMQRR-NH2) and its acetylated analogue inhibit a-calcitonin gene-related peptide (a-CGRP) exocytotic release from primary sensory neurons. Examining the crystal structure of the SNARE-Synaptotagmin-1(Syt1) complex, we hypothesized that these peptides could inhibit neuronal exocytosis by binding to Syt1, hampering at least partially its interaction with the SNARE complex. To address this hypothesis, we first interrogate the role of individual side-chains on the inhibition of a-CGRP release, finding that E1, M3, Q4 and R6 residues were crucial for activity. CD and NMR conformational analysis showed that linear peptides have tendency to adopt a-helical conformations, but the results with cyclic analogues indicated that this secondary structure is not needed for activity. Isothermal titration calorimetry (ITC) measurements demonstrate a direct interaction of some of these peptides with Syt1-C2B domain, but not with Syt7-C2B region, indicating selectivity. As expected for a compound able to inhibit a-CGRP release, cyclic peptide derivative Pal-E-cyclo[EMQK]R-NH2 showed potent in vivo analgesic activity, in a model of inflammatory pain. Molecular dynamics simulations provided a model consistent with KD values for the interaction of peptides with Syt1-C2B domain, and with their biological activity. Altogether, these results identify Syt1 as a potential new analgesic target. © 202