177 research outputs found
Экономический эффект реализации проекта "Комплексный подход решения проблем сепарационного оборудования объектов подготовки и компримирования газа"
Stokes imaging, Doppler mapping and Roche tomography of the AM Her system V834 Cen
We report on new simultaneous phase resolved spectroscopic and polarimetric
observations of the polar (AM Herculis star) V834 Cen during a high state of
accretion. Strong emission lines and high levels of variable circular and
linear polarization are observed over the orbital period. The polarization data
is modelled using the Stokes imaging technique of Potter et al. The
spectroscopic emission lines are investigated using the Doppler tomography
technique of Marsh and Horne and the Roche tomography technique of Dhillon and
Watson. Up to now all three techniques have been used separately to investigate
the geometry and accretion dynamics in Cataclysmic Variables. For the first
time, we apply all three techniques to simultaneous data for a single system.
This allows us to compare and test each of the techniques against each other
and hence derive a better understanding of the geometry, dynamics and system
parameters of V834 Cen.Comment: 10 pages, 8 figures; Accepted for publication in MNRA
The second flight of the SUNRISE balloon-borne solar observatory: overview of instrument updates, the flight, the data and first results
The SUNRISE balloon-borne solar observatory, consisting of a 1~m aperture
telescope that provided a stabilized image to a UV filter imager and an imaging
vector polarimeter, carried out its second science flight in June 2013. It
provided observations of parts of active regions at high spatial resolution,
including the first high-resolution images in the Mg~{\sc ii}~k line. The
obtained data are of very high quality, with the best UV images reaching the
diffraction limit of the telescope at 3000~\AA\ after Multi-Frame Blind
Deconvolution reconstruction accounting for phase-diversity information. Here a
brief update is given of the instruments and the data reduction techniques,
which includes an inversion of the polarimetric data. Mainly those aspects that
evolved compared with the first flight are described. A tabular overview of the
observations is given. In addition, an example time series of a part of the
emerging active region NOAA AR~11768 observed relatively close to disk centre
is described and discussed in some detail. The observations cover the pores in
the trailing polarity of the active region, as well as the polarity inversion
line where flux emergence was ongoing and a small flare-like brightening
occurred in the course of the time series. The pores are found to contain
magnetic field strengths ranging up to 2500~G and, while large pores are
clearly darker and cooler than the quiet Sun in all layers of the photosphere,
the temperature and brightness of small pores approach or even exceed those of
the quiet Sun in the upper photosphere.Comment: Accepted for publication in The Astrophysical Journa
Treatment patterns and clinical outcomes
BACKGROUND: Treatment resistant depression (TRD) characterizes a subgroup of 10-30% of patients with major depressive disorder, and is associated with considerable morbidity and mortality. A consensus treatment for TRD does not exist, which often leads to wide variations in treatment strategies. Real-world studies on treatment patterns and outcomes in TRD patients in Europe are lacking and could help elucidate current treatment strategies and their efficacy. METHODS: This non-interventional cohort study of patients with TRD (defined as treatment failure on ≥2 oral antidepressants given at adequate dose and duration) with moderate to severe depression collected real-world data on treatment patterns and outcomes in several European countries. Patients were started on a new treatment for depression according to routine clinical practice. RESULTS: Among 411 patients enrolled, after 6 months, only 16.7% achieved remission and 73.5% showed no response. At Month 12, while 19.2% achieved remission and 69.2% showed no response, 33.3% of those in remission at Month 6 were no longer in remission. Pharmacological treatments employed were heterogenous; 54 different drugs were recorded at baseline, and the top 5 treatment types according to drug classes accounted for 40.0% of patients. Even though remission rates were very low, at Month 12, 60.0% of patients had not changed treatment since enrolment. CONCLUSIONS: The heterogeneity of treatments highlights a lack of consensus. Moreover, despite low response rates, patients often remained on treatments for substantial periods of time. These data further support existence of an unmet treatment need for TRD patients in Europe.publishersversionpublishe
Healthcare resource utilization
Background: Treatment resistant depression (TRD) is diagnosed when patients experiencing a major depressive episode fail to respond to ≥2 treatments. Along with substantial indirect costs, patients with TRD have higher healthcare resource utilization (HCRU) than other patients with depression. However, research on the economic impact of this HCRU, and differences according to response to treatment, is lacking. Methods: This multicenter, observational study documented HCRU among patients with TRD in European clinical practice initiating new antidepressant treatments. Data regarding access to outpatient consultations and other healthcare resources for the first 6 months, collected using a questionnaire, were analyzed qualitatively according to response and remission status. The economic impact of HCRU, estimated using European costing data, was analyzed quantitatively. Results: Among 411 patients, average HCRU was higher in non-responders, attending five times more general practitioner (GP) consultations and spending longer in hospital (1.7 versus 1.1 days) than responders. Greater differences were observed according to remission status, with non-remitters attending seven times more GP consultations and spending approximately three times longer in hospital (1.7 versus 0.6 days) than remitters. Consequently, the estimated economic impacts of non-responders and non-remitters were significantly greater than those of responders and remitters, respectively. Limitations: Key limitations are small cohort size, absence of control groups and generalizability to different healthcare systems. Conclusion: Patients with TRD, particularly those not achieving remission, have considerable HCRU, with associated economic impact. The costs of unmet TRD treatment needs are thus substantial, and treatment success is fundamental to reduce individual needs and societal costs.publishersversionpublishe
The Sunrise Mission
The first science flight of the balloon-borne \Sunrise telescope took place
in June 2009 from ESRANGE (near Kiruna/Sweden) to Somerset Island in northern
Canada. We describe the scientific aims and mission concept of the project and
give an overview and a description of the various hardware components: the 1-m
main telescope with its postfocus science instruments (the UV filter imager
SuFI and the imaging vector magnetograph IMaX) and support instruments (image
stabilizing and light distribution system ISLiD and correlating wavefront
sensor CWS), the optomechanical support structure and the instrument mounting
concept, the gondola structure and the power, pointing, and telemetry systems,
and the general electronics architecture. We also explain the optimization of
the structural and thermal design of the complete payload. The preparations for
the science flight are described, including AIV and ground calibration of the
instruments. The course of events during the science flight is outlined, up to
the recovery activities. Finally, the in-flight performance of the
instrumentation is briefly summarized.Comment: 35 pages, 17 figure
A model for the optical high state light curve of AM Herculis
We present a simple quantitative model that can describe the photometric B
and V band light curves of AM Herculis obtained during a high state. The
double-humped shape of the V band light curve is dominated by cyclotron
emission from a region at the main accreting pole with an area of ~5x10e16 cm^2
and sustaining an inflow of ~0.06 g/cm^2/s. The almost unmodulated B band is
dominated by emission from the accretion stream. The contribution of the heated
white dwarf to the optical emission is small in the B band, but comparable to
that of the accretion stream in the V band. The emission of the secondary star
is negligible both in B and in V.Comment: 6 pages A&A-Latex, 6 Figures, accepted for publication in A&
XMM-Newton observations of the eclipsing polar EP Dra
We present XMM-Newton observations of the eclipsing polar EP Dra which cover
nearly 3 binary orbital cycles. The X-ray and UV data show evidence for a
prominent dip before the eclipse which is due to the accretion stream obscuring
the accretion region. The dip ingress is rapid in hard X-rays suggesting there
is a highly collimated core of absorption. We find that a different level of
absorption column density is required to match the observed count rates in
different energy bands. We propose that this is due to the fact that different
absorption components should be used to model the reprocessed X-rays, the
shocked X-ray component and the UV emission and explore the affect that this
has on the resulting fits to the spectrum. Further, there is evidence that
absorption starts to obscure the softer X-rays shortly after the onset of the
bright phase. This suggests that material is threaded by an unusually wide
range of magnetic field lines, consistent with the suggestion of Bridge et al.
We find that the period is slightly greater than that determined by Schwope &
Mengel.Comment: Accepted for publication MNRAS, 6 page
Roche tomography of cataclysmic variables - II. Images of the secondary stars in AM Her, QQ Vul, IP Peg and HU Aqr
We present a set of Roche tomography reconstructions of the secondary stars in the cataclysmic variables AM Her, QQ Vul, IP Peg and HU Aqr. The image reconstructions show distinct asymmetries in the irradiation pattern for all four systems that can be attributed to shielding of the secondary star by the accretion stream/column in AM Her, QQ Vul and HU Aqr, and increased irradiation by the bright-spot in IP Peg. We use the entropy landscape technique to derive accurate system parameters (M1, M2, i and γ) for the four binaries. In principle, this technique should provide the most reliable mass determinations available, since the intensity distribution across the secondary star is known. We also find that the intensity distribution can systematically affect the value of γ derived from circular orbit fits to radial velocity variations
Multicenter evaluation of blood-based biomarkers for the detection of endometriosis and adenomyosis: A prospective non-interventional study.
OBJECTIVE
To evaluate blood-based biomarkers to detect endometriosis and/or adenomyosis across nine European centers (June 2014-April 2018).
METHODS
This prospective, non-interventional study assessed the diagnostic accuracy of 54 blood-based biomarker immunoassays in samples from 919 women (aged 18-45 years) with suspicion of endometriosis and/or adenomyosis versus symptomatic controls. Endometriosis was stratified by revised American Society for Reproductive Medicine stage. Symptomatic controls were "pathologic symptomatic controls" or "pathology-free symptomatic controls". The main outcome measure was receiver operating characteristic-area under the curve (ROC-AUC) and Wilcoxon P values corrected for multiple testing (q values).
RESULTS
CA-125 performed best in "all endometriosis cases" versus "all symptomatic controls" (AUC 0.645, 95% confidence interval [CI] 0.600-0.690, q < 0.001) and increased (P < 0.001) with disease stage. In "all endometriosis cases" versus "pathology-free symptomatic controls", S100-A12 performed best (AUC 0.692, 95% CI 0.614-0.769, q = 0.001) followed by CA-125 (AUC 0.649, 95% CI 0.569-0.729, q = 0.021). In "adenomyosis only cases" versus "symptomatic controls" or "pathology-free symptomatic controls", respectively, the top-performing biomarkers were sFRP-4 (AUC 0.615, 95% CI 0.551-0.678, q = 0.045) and S100-A12 (AUC 0.701, 95% CI 0.611-0.792, q = 0.004).
CONCLUSION
This study concluded that no biomarkers tested could diagnose or rule out endometriosis/adenomyosis with high certainty
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