“This is proof”? Forensic evidence and ambiguous material culture at Treblinka extermination camp

In recent years, a forensic archaeological project at Treblinka extermination camp has uncovered significance evidence relating to the mass murder that took place there. A number of questions emerged regarding the provenance and origins of objects discovered as part of this work, and why they had remained undiscovered for over seventy years. These discoveries led to an opportunity to confirm and challenge the history of the extermination camp, and demands (from the public) to view the objects. This paper will outline how archaeologists and artists came together to reflect on these issues, whilst simultaneously providing access to the new findings

Seasonal circulation over the Catalan inner-shelf (northwest Mediterranean Sea)

This study characterizes the seasonal cycle of the Catalan inner-shelf circulation using observations and complementary numerical results. The relation between seasonal circulation and forcing mechanisms is explored through the depth-averaged momentum balance, for the period between May 2010 and April 2011, when velocity observations were partially available. The monthly-mean along-shelf flow is mainly controlled by the along-shelf pressure gradient and by surface and bottom stresses. During summer, fall, and winter, the along-shelf momentum balance is dominated by the barotropic pressure gradient and local winds. During spring, both wind stress and pressure gradient act in the same direction and are compensated by bottom stress. In the cross-shelf direction the dominant forces are in geostrophic balance, consistent with dynamic altimetry data. Key Points A hydrodynamic model is implemented for the first time in Catalan inner-shelf. Frictional and pressure gradient are revealed as the main forcing mechanisms A clear seasonal pattern is found in the current velocity.Peer ReviewedPostprint (published version

Management Of Tizanidine Withdrawal Syndrome: A Case Report

Most drugs that act on the central nervous system (CNS) require dose titration to avoid withdrawal syndrome. Tizanidine withdrawal syndrome is caused by adrenergic discharge due to its alpha(2)-agonist mechanism and is characterized by hypertension, reflex tachycardia, hypertonicity, and anxiety. Although tizanidine withdrawal syndrome is mentioned as a potential side effect of cessation, it is not common and there have been few reports. We present the case of a 31-year-old woman with tizanidine withdrawal syndrome after discontinuing medication prescribed for a muscle contracture (tizanidine). She showed high adrenergic activity with nausea, vomiting, generalized tremor, dysthermia, hypertension, and tachycardia. Symptoms were reversed and successful reweaning was achieved by restarting tizanidine followed by slow downward titration. Withdrawal syndrome should be considered when drugs targeting the CNS are suddenly stopped. Weaning regimens should be closely monitored for acute withdrawal reactions

Temporal evolution of the momentum balance terms and frictional adjustment observed over the inner shelf during a storm

We investigate the rapidly changing equilibrium between the momentum sources and sinks during the passage of a single two-peak storm over the Catalan inner shelf (NW Mediterranean Sea). Velocity measurements at 24¿m water depth are taken as representative of the inner shelf, and the cross-shelf variability is explored with measurements at 50¿m water depth. During both wind pulses, the flow accelerated at 24¿m until shortly after the wind maxima, when the bottom stress was able to compensate for the wind stress. Concurrently, the sea level also responded, with the pressure-gradient force opposing the wind stress. Before, during and after the second wind pulse, there were velocity fluctuations with both super- and sub-inertial periods likely associated with transient coastal waves. Throughout the storm, the Coriolis force and wave radiation stresses were relatively unimportant in the along-shelf momentum balance. The frictional adjustment timescale was around 10¿h, consistent with the e-folding time obtained from bottom drag parameterizations. The momentum evolution at 50¿m showed a larger influence of the Coriolis force at the expense of a decreased frictional relevance, typical in the transition from the inner to the mid-shelf.Postprint (published version

Archaeological signatures of landscape and settlement change on the Isle of Harris

Between 2004 and 2011, a programme of archaeological investigation by the University of Birmingham on the Isle of Harris, a distinctive island forming part of the Western Isles of Scotland, has allowed the archaeological remains of this enigmatic place to be further characterised and understood. Despite intensive archaeological interest in the archipelago for a number of decades, the Isle of Harris has been overlooked and only now are we beginning to identify the archaeological resource and make comparisons to the wealth of published data from islands such as the Uists, Barra and Lewis. This paper highlights some generic overall patterns of archaeological signatures on the Isle which has been identified through a range of archaeological methods including field walking, intrusive excavation, aerial reconnaissance, geophysical and topographical survey, and documentary research. Several key case studies will be introduced including upland shieling complexes and mulitperiod settlement sites on the west coast machair systems. The purpose of the paper is not to present a gazetteer of the results of the work to date, but to highlight some of the key findings with a view to demonstrating that the Isle of Harris is directly comparable with the archaeologically rich landscapes of the other islands

Imaging leachate runoff from a landfill using magnetotellurics: The Garraf karst case

Electrical and active source electromagnetic geophysical methods have been traditionally employed to approach and tackle environmental problems, such as those caused by landfills. However, since these problems are more consequential and cover broader areas, it is necessary to use deeper penetration methods, such as magnetotellurics. In the Garraf Massif (Catalan Coastal Ranges, NE Spain), an urban waste disposal landfill had been in operation from 1974 to 2006, during which more than 26 million metric tons of garbage had been deposited. This landfill overlies karstic terrain, thus principally impacting groundwater circulation. Previous electrical resistivity tomography profiles had partially imaged the infill but were not able to penetrate below the base of the original landfill. During 2019 and 2020 we performed a magnetotelluric study over the landfill and its surrounding with the goals of characterizing the electrical resistivity of the infill and below it. The 2D and 3D resistivity models confirmed the highly conductive nature of the leachate and allowed us to identify its presence below the landfill base, which we quantified with maximum thicknesses of 90 m. This proved that landfill leachate had filtered through the original impermeable layer, enhanced by the karstic drainage structure

Euploidy rates in donor egg cycles significantly differ between fertility centers

STUDY QUESTION: Do external factors affect euploidy in egg donor cycles? SUMMARY ANSWER: The study demonstrates that during human assisted reproduction, embryonic chromosome abnormalities may be partly iatrogenic. WHAT IS KNOWN ALREADY: Chromosome abnormalities have been linked in the past to culture conditions such as temperature and Ph variations, as well as hormonal stimulation. Those reports were performed with older screening techniques (FISH), or ART methods no longer in use, and the subjects studied were not a homogeneous group. STUDY DESIGN, SIZE, DURATION: A total of 1645 donor oocyte cycles and 13 282 blastocyst biopsies from 42 fertility clinics were included in this retrospective cohort study. Samples from donor cycles with PGS attempted between September 2011 and July 2015 were included. PARTICIPANTS/MATERIALS, SETTING, METHODS: PGS cycles from multiple fertility clinics referred to Reprogenetics (Livingston, NJ) that involved only oocyte donation were included in this study. Testing was performed by array comparative genomic hybridization (aCGH). Ploidy data were analyzed using Generalized Linear Mixed Models with logistic regression using a logit link function considering a number of variables that represent fixed and random effects. MAIN RESULTS AND THE ROLE OF CHANCE: Euploidy rate was associated with the referring center and independent of almost all the parameters examined except donor age and testing technology. Average euploidy rate per center ranged from 39.5 to 82.5%. The mean expected rate of euploidy was 68.4%, but there are variations in this rate associated with the center effect. LIMITATIONS, REASONS FOR CAUTION: Data set does not include details of the donor selection process, donor race or ethnic origin, ovarian reserve or ovarian responsiveness. Due to the retrospective nature of the study, associations are apparent, however, causality cannot be established. Discrepancies in regard to completeness and homogeneity of data exist due to data collection from over 40 different clinics. WIDER IMPLICATIONS OF THE FINDINGS: This is the first study to show a strong association between center-specific ART treatment practices and the incidence of chromosome abnormality in human embryos, although the meiotic or mitotic origin of these abnormalities could not be determined using these technologies. Given the widespread applications of ART in both subfertile and fertile populations, our findings should be of interest to the medical community in general as well as the ART community in particular. STUDY FUNDING/COMPETING INTEREST(S): No external funds were used for this study. S. Munne is a founding principle of Reprogenetics/current employee of Cooper Genomics. M Alikani’s spouse is a founding principle of Reprogenetics/current consultant for Cooper Genomics. The remaining authors have no conflicts to declare

Polar body array CGH for prediction of the status of the corresponding oocyte. Part I: clinical results

Several randomized controlled trials have not shown a benefit from preimplantation genetic screening (PGS) biopsy of cleavage-stage embryos and assessment of up to 10 chromosomes for aneuploidy. Therefore, a proof-of-principle study was planned to determine the reliability of alternative form of PGS, i.e. PGS by polar body (PB) biopsy, with whole genome amplification and microarray-based comparative genomic hybridization (array CGH) analysis. In two centres, all mature metaphase II oocytes from patients who consented to the study were fertilized by ICSI. The first and second PBs (PB1and PB2) were biopsied and analysed separately for chromosome copy number by array CGH. If either or both of the PBs were found to be aneuploid, the corresponding zygote was then also processed by array CGH for concordance analysis. Both PBs were biopsied from a total of 226 zygotes from 42 cycles (average 5.5 per cycle; range 1-15) in 41 couples with an average maternal age of 40.0 years. Of these, the ploidy status of the zygote could be predicted in 195 (86%): 55 were euploid (28%) and 140 were aneuploid (72%). With only one exception, there was at least one predicted aneuploid zygote in each cycle and in 19 out of 42 cycles (45%), all zygotes were predicted to be aneuploid. Fresh embryos were transferred in the remaining 23 cycles (55%), and one frozen transfer was done. Eight patients had a clinical pregnancy of which seven were evolutive (ongoing pregnancy rates: 17% per cycle and 30% per transfer). The ploidy status of 156 zygotes was successfully analysed by array CGH: 38 (24%) were euploid and 118 (76%) were aneuploid. In 138 cases complete information was available on both PBs and the corresponding zygotes. In 130 (94%), the ploidy status of the zygote was concordant with the ploidy status of the PBs and in 8 (6%), the results were discordant. This proof-of-principle study indicates that the ploidy of the zygote can be predicted with acceptable accuracy by array CGH analysis of both PB

Early maternal mirroring predicts infant motor system activation during facial expression observation.

Processing facial expressions is an essential component of social interaction, especially for preverbal infants. In human adults and monkeys, this process involves the motor system, with a neural matching mechanism believed to couple self- and other-generated facial gestures. Here, we used electroencephalography to demonstrate recruitment of the human motor system during observation and execution of facial expressions in nine-month-old infants, implicating this system in facial expression processing from a very young age. Notably, examination of early video-recorded mother-infant interactions supported the common, but as yet untested, hypothesis that maternal mirroring of infant facial gestures is central to the development of a neural matching mechanism for these gestures. Specifically, the extent to which mothers mirrored infant facial expressions at two months postpartum predicted infant motor system activity during observation of the same expressions at nine months. This suggests that maternal mirroring strengthens mappings between visual and motor representations of facial gestures, which increases infant neural sensitivity to particularly relevant cues in the early social environment

Thermal Response Testing of Large Diameter Energy Piles

Energy piles are a novel form of ground heat exchanger (GHE) used in ground source heat pump systems. However, characterizing the pile and ground thermal properties is more challenging than for traditional GHEs. Routine in-situ thermal response testing (TRT) methods assume that steady state conditions in the GHE are achieved within a few hours, whereas larger diameter energy piles may take days or even weeks, thereby incurring significant costs. Previous work on pile TRTs has focused on small diameters up to 450 mm. This paper makes the first rigorous assessment of TRT methods for larger diameter piles using field and laboratory datasets, the application of numerical and analytical modelling, and detailed consideration of costs and program. Three-dimensional numerical simulation is shown to be effective for assessing the data gathered but is too computationally expensive for routine practice. Simpler fast run time steady state analytical models are shown to be a theoretically viable tool where sufficient duration test data is available. However, a new assessment of signal to noise ratio (SNR) in real field data shows how power fluctuations cause increased uncertainty in long duration tests. It is therefore recommended to apply transient models or instead to carry out faster and more cost-effective borehole in-situ tests for ground characterization with analytical approaches for pile characterization