738 research outputs found

    The relationship between therapist outcome, therapist language and reflexivity amongst clients experiencing major depressive disorder

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    The research not only identified particular language processes contributing to successful and less successful therapeutic outcomes; but, how therapists use language to enable clients to make meaningful changes to their lives. The research developed a new methodology to objectively assess therapeutic performance that was based upon an analysis of several thousand therapy sessions undertaken in the QUT Psychology Clinic in order to examine the language processes associated with more and less effective psychotherapy. The research makes a unique contribution to the field of psychotherapy research, practice, and training as evidenced by publications in leading journals. The findings have significant implications for the training of clinicians wishing to understand language processes and their contribution to optimal therapeutic outcomes, and for the ongoing development of evidence-based clinical training programs

    Application of the pMHC array to characterise tumour antigen specific T cell populations in leukaemia patients at disease diagnosis

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    Immunotherapy treatments for cancer are becoming increasingly successful, however to further improve our understanding of the T-cell recognition involved in effective responses and to encourage moves towards the development of personalised treatments for leukaemia immunotherapy, precise antigenic targets in individual patients have been identified. Cellular arrays using peptide-MHC (pMHC) tetramers allow the simultaneous detection of different antigen specific T-cell populations naturally circulating in patients and normal donors. We have developed the pMHC array to detect CD8+ T-cell populations in leukaemia patients that recognise epitopes within viral antigens (cytomegalovirus (CMV) and influenza (Flu)) and leukaemia antigens (including Per Arnt Sim domain 1 (PASD1), MelanA, Wilms’ Tumour (WT1) and tyrosinase). We show that the pMHC array is at least as sensitive as flow cytometry and has the potential to rapidly identify more than 40 specific T-cell populations in a small sample of T-cells (0.8–1.4 x 106). Fourteen of the twenty-six acute myeloid leukaemia (AML) patients analysed had T cells that recognised tumour antigen epitopes, and eight of these recognised PASD1 epitopes. Other tumour epitopes recognised were MelanA (n = 3), tyrosinase (n = 3) and WT1126-134 (n = 1). One of the seven acute lymphocytic leukaemia (ALL) patients analysed had T cells that recognised the MUC1950-958 epitope. In the future the pMHC array may be used provide point of care T-cell analyses, predict patient response to conventional therapy and direct personalised immunotherapy for patients

    Cancer data and Aboriginal disparities (CanDAD)-developing an Advanced Cancer Data System for Aboriginal people in South Australia: a mixed methods research protocol

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    Introduction: In Australia, Aboriginal and Torres Strait Islander People carry a greater burden of cancerrelated mortality than non-Aboriginal Australians. The Cancer Data and Aboriginal Disparities Project aims to develop and test an integrated, comprehensive cancer monitoring and surveillance system capable of incorporating epidemiological and narrative data to address disparities and advocate for clinical system change. Methods and analysis: The Advanced Cancer Data System will integrate routinely collected unit record data from the South Australian Population Cancer Registry and a range of other data sources for a retrospective cohort of indigenous people with cancers diagnosed from 1990 to 2010. A randomly drawn non- Aboriginal cohort will be matched by primary cancer site, sex, age and year at diagnosis. Cross-tabulations and regression analyses will examine the extent to which demographic attributes, cancer stage and survival vary between the cohorts. Narratives from Aboriginal people with cancer, their families, carers and service providers will be collected and analysed using patient pathway mapping and thematic analysis. Statements from the narratives will structure both a concept mapping process of rating, sorting and prioritising issues, focusing on issues of importance and feasibility, and the development of a real-time Aboriginal Cancer Measure of Experience for ongoing linkage with epidemiological data in the Advanced Cancer Data System. Aboriginal Community engagement underpins this Project. Ethics and dissemination: The research has been approved by relevant local and national ethics committees. Findings will be disseminated in local and international peer-reviewed journals and conference presentations. In addition, the research will provide data for knowledge translation activities across the partner organisations and feed directly into the Statewide Cancer Control Plan. It will provide a mechanism for monitoring and evaluating the implementation of the recommendations in these documents.Paul Henry Yerrell, David Roder, Margaret Cargo, Rachel Reilly, David Banham, Jasmine May Micklem, Kim Morey, Harold Bundamurra Stewart, Janet Stajic, Michael Norris, Alex Brown, On behalf of the CanDAD Aboriginal Community Reference Group and CanDAD Investigator

    The Stratigraphy of Central and Western Butte and the Greenheugh Pediment Contact

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    The Greenheugh pediment at the base of Aeolis Mons (Mt. Sharp), which may truncate units in the Murray formation and is capped by a thin sandstone unit, appears to represent a major shift in climate history within Gale crater. The pediment appears to be an erosional remnant of potentially a much more extensive feature. Curiositys traverse through the southern extent of Glen Torridon (south of Vera Rubin ridge) has brought the rover in contact with several new stratigraphic units that lie beneath the pediment. These strata were visited at two outcrop-forming buttes (Central and Western butte- both remnants of the retreating pediment) south of an orbitally defined boundary marking the transition from the Fractured Clay-bearing Unit (fCU) and the fractured Intermediate Unit (fIU). Here we present preliminary interpretations of the stratigraphy within Central and Western buttes and propose the Western butte cap rocks do not match the pediment capping unit

    A Lacustrine Paleoenvironment Recorded at Vera RubinRidge, Gale Crater: Overview of the Sedimentology and Stratigraphy Observed by the Mars ScienceLaboratory Curiosity Rover

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    For ~500 Martian solar days (sols), the Mars Science Laboratory team explored Vera Rubin ridge (VRR), a topographic feature on the northwest slope of Aeolis Mons. Here we review the sedimentary facies and stratigraphy observed during sols 1,800–2,300, covering more than 100 m of stratigraphic thickness. Curiosity's traverse includes two transects across the ridge, which enables investigation of lateral variability over a distance of ~300 m. Three informally named stratigraphic members of the Murray formation are described: Blunts Point, Pettegrove Point, and Jura, with the latter two exposed on VRR. The Blunts Point member, exposed just below the ridge, is characterized by a recessive, fine‐grained facies that exhibits extensive planar lamination and is crosscut by abundant curvi‐planar veins. The Pettegrove Point member is more resistant, fine‐grained, thinly planar laminated, and contains a higher abundance of diagenetic concretions. Conformable above the Pettegrove Point member is the Jura member, which is also fine‐grained and parallel stratified, but is marked by a distinct step in topography, which coincides with localized meter‐scale inclined strata, a thinly and thickly laminated facies, and occasional crystal molds. All members record low‐energy lacustrine deposition, consistent with prior observations of the Murray formation. Uncommon outcrops of low‐angle stratification suggest possible subaqueous currents, and steeply inclined beds may be the result of slumping. Collectively, the rocks exposed at VRR provide additional evidence for a long‐lived lacustrine environment (in excess of 106 years via comparison to terrestrial records of sedimentation), which extends our understanding of the duration of habitable conditions in Gale crater

    Spice and rice: Pepper, cloves and everyday cereal foods at the ancient port of Mantai, Sri Lanka

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    Lying on the north-west coast of Sri Lanka, the ancient port of Mantai was ideally situated as a 'hub' for trade between East and West from the first millennium BC onwards. Excavations at the site were interrupted by civil war in 1984, delaying publication of these results and leading to the underestimation of Mantai's importance in the development of Early Historic Indian Ocean trade. Renewed excavations in 2009-2010 yielded extensive archaeobotanical remains, which, alongside an improved understanding of the site's chronology, provide important new insights into the development of local and regional trade routes and direct evidence for early trade in the valuable spices upon which later empires were founded

    A tale of two rice varieties: Modelling the prehistoric dispersals of japonica and proto-indica rices

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    © The Author(s) 2018. We model the prehistoric dispersals of two rice varieties, japonica and proto-indica, across Asia using empirical evidence drawn from an archaeobotanical dataset of 400 sites from mainland East, Southeast and South Asia. The approach is based on regression modelling wherein goodness of fit is obtained from log–log quantile regressions of the archaeologically inferred age versus a least-cost distance from the origin(s) of dispersal. The Fast Marching method is used to estimate the least-cost distances based on simple geographical features. We explicitly test three hypotheses for the arrival of japonica rice to India where, it has been proposed, it hybridized with the indigenous proto-indica, subsequently spreading again throughout India. Model selection, based on information criteria, highlights the role of the Inner Asia Mountain Corridor in introducing japonica rice into northeast India, followed closely by a ‘mixed-route’ model, where japonica was also almost simultaneously introduced via Assam, Bangladesh and Myanmar. Finally, we estimate the impact of future archaeological work on model selection, further strengthening the importance of the Inner Asia Mountain Corridor
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