The Product Mapping and the Market Segmentation to Determine the Strategy to Enhance the Business Competition of the Medan Students

The result of this research showed that the business activities carried out by the college students were grouped into five clusters. They were: a) agriculture, b) livestock, c) fashion, d) handicraft, and e) culinary. Referring to the clusters, the businessmen among college students did some important steps to get advantages. One of the important steps was mapping the conditions in each of the categories. The mapping is directed on the particular segments based on lifestyles, such as: business enterprising types, resident types, social types, and entertainer types. The strategic steps were in the form of series of the stages of the program or activity which were determined by SWOT analysis. Through this analysis, it is expected that the businessmen could hold and determine the competitive advantage so that they could be the leader in the market. Moreover, it also occurred on the businesses which were implemented by young businessmen from the educational institution. By involving the micro, small enterprise businessmen, the experts, and the local government officials, this research obtained someimportant data or input in formulating marketing strategies to enhance the competition of the businesses of the micro, small enterprise. This research used qualitative and quantitative approaches. The data collecting techniques were filling the questionnaire, conducting depth interview, and doing FGD. The businessmenamong the college students had strengths on the non-physical aspects such as motivation and independence. In addition, the problems on the relationship which had existed so far between suppliers and customers or consumers could also be the strength forthe businessmen among the college students. However, the college students also hadweaknesses. The weaknesseswere in the form of the minimal capital, the simple business management issues, and the current infrastructures to process the production. The college students felt that the campus wasavery potential market. Moreover, their market shareon products was also relatively high compared to the competitors in the market insidethe campus. In addition, the opportunities which were seen by the businessmen were: a) competition at campus couldrelatively be overcome by them, b) the support of government agencies and the campus itself, and c) the consultancy assistance of the campus due to the businesses which was carried out. Furthermore, the conditionwhich complicates their business development was about the problem of competitionon condition that the products would be soldespecially in markets outside the campus.KEY WORDSClusters, Segmentation, Strategy, Competition

Analisis Pelaksanaan Program Pengelolaan Teknologi Tepat Guna (Ttg) Oleh Badan Pemberdayaan Masyarakat Dan Desa (Bapermades) Provinsi Jawa Tengah

This research was arranged to analyze the implementation of TTG managerial program from Bapermades of Central Java Province and the constraints that may affect the TTG's program implementation. Bapermades of Central Java province has not implement guidance and facilitation of optimal thus giving rise to problems in implementation. This research is kind of descriptive- qualitative research where the data was collected through interviews, observation, and literature study. Informants were taken by author is the head of SDA and TTG sub division, TTG's sub division staff, Posyantek officials, and representatives of community groups. The Author used the indicators of TTG's program implementation guides from Minister of Home Affairs Regulation and Central Java Governor Regulation then it compared accordingly with problems in the field. Based on the research, the results obtained that needs mapping of TTG are still in manual. Socialization, information media, IT knowledge and training are still in deficiency. Posyantek formation is still uneven and regulatory in Regents Regulation level as well as a special institution for TTG has not yet been established. The Number of human resources and budget limitation is the kind of obstacles for conducting the program. Based on the results, this study concludes that the implementation of TTG managial program have conducted in accordingly with the applicable guidelines of regulation, but it still encountered some obstacles so it can't be implemented to the fullest. The advice given by the author is this program needs to be socialized and assisted to the community,it needs to improve the information media, training and developing in the IT field as well as increasing the cooperation with various stakeholders

Perancangan Public Service Announcement Anti Rokok Bagi Remaja Usia 15 – 19 Tahun

Indonesia merupakan Negara konsumen tembakau terbesar nomor 5 di Dunia. Di Surabaya, sebanyak 23% remajanya merupakan perokok aktif dengan motivasi merokok dikarenakan oleh pengaruh lingkungan dan kebiasaan interaksi dengan perokok. 28% remaja mengaku tetap merokok karena kurangnya media yang mampu memotivasi mereka untuk berhenti merokok, oleh karena itu dirancanglah sebuah kampanye Public Service Announcement (PSA) yang mampu memotivasi mereka untuk berhenti merokok. PSA adalah proses penyampaian pesan sosial yang bertujuan untuk membangkitkan kepedulian masyarakat terhadap sejumlah masalah yang harus mereka hadapi. Metodologi riset yang digunakan berawal dari proses penggalian data mengenai fenomena, identifikasi masalah, rumusan masalah serta solusi yang dipelajari melalui studi eksisting, literatur, penggalian data secara primer dan sekunder. Setelah proses pencarian data, langkah selanjutnya adalah menentukan ide kampanye yang akan di turunkan pada konsep komunikasi, visual dan media. Proses perancangan PSA ini memiliki konsep mengajak remaja untuk berhenti merokok dengan tagline “Mandheg Yok Rek!”. Konsep yang dimiliki di dapatkan dari pengamatan perilaku target audiens. Tagline menggunakan bahasa khas daerah Surabaya dengan maksud untuk dapat mendekatkan diri dengan target audiens yang merupakan remaja – remaja Surabaya. Diharapkan kampanye ini dapat menumbuhkan motivasi remaja perokok untuk dapat mengurangi angka perokok aktif di Surabaya

Hakikat Supervisi Pendidikan

The purpose of this article is to find out about the nature of educational supervision, the role of supervision, the purpose of supervision, principles of supervision, types (styles) of educational supervision. The research was carried out at the base school of the flagship presidential instruction of Putri Taman Sari. In this study using a descriptive literature method, from various sources, namely books, articles, journals, and other reading sources. The objective of creating this interactive media is to facilitate and simplify the process of delivering educational. The result of the evaluation, namely Education Supervision, is a method carried out by school supervisors or school heads with the aim of improving the quality of learning in each educational institution, and includes various interrelated aspects, such as monitoring, guidance, evaluation, and development of teacher professionalism. With the aim of providing assistance and providing convenience to educators in improving their teaching abilities, it aims to realize the learning goals of students to be achieved

Administrasi Hubungan Kerjasama Sekolah dan Masyarakat

A strong school-community partnership is the foundation for realizing quality education. This colaboration will benefit students, teaching staff, and the wider community. This research aims to learn more about the process, purpose and benefits of community and school collaboration. With a literature approach, this research uses qualitative methods. As a result, to achieve its goals and vision and mission, the school needs a good working relationship with the community. Harmonized school and community collaboration will provide benefits to the community, especially parents. School perfomance determines the level of community trust the school. The community will feel the need to involve themselves in school programs, when all data and information from the school has been delivered and can be understood by the community as a whole. This is obtained through the administrative process of a good and harmonius working relationshi

Efficacy of Continuous Interleukin 1 Blockade in Mevalonate Kinase Deficiency: A Multicenter Retrospective Study in 13 Adult Patients and Literature Review

OBJECTIVE: To report efficacy and tolerance of interleukin 1 blockade in adult patients with mevalonate kinase deficiency (MKD). METHODS: We retrospectively collected data on 13 patients with MKD who had received anakinra (n = 10) and canakinumab (n = 7). RESULTS: Anakinra resulted in complete or partial remission in 3/10 and 5/10 patients, respectively, and no efficacy in 2/10, but a switch to canakinumab led to partial remission. Canakinumab resulted in complete or partial remission in 3/7 and 4/7 patients, respectively. CONCLUSION: These data support frequent partial responses, showing a better response with canakinumab. The genotype and therapeutic outcomes correlation should help in the personalization of treatment

Genetic variation of macronutrient tolerance in Drosophila melanogaster

Carbohydrates, proteins and lipids are essential nutrients to all animals; however, closely related species, populations, and individuals can display dramatic variation in diet. Here we explore the variation in macronutrient tolerance in Drosophila melanogaster using the Drosophila genetic reference panel, a collection of similar to 200 strains derived from a single natural population. Our study demonstrates that D. melanogaster, often considered a "dietary generalist", displays marked genetic variation in survival on different diets, notably on high-sugar diet. Our genetic analysis and functional validation identify several regulators of macronutrient tolerance, including CG10960/GLUT8, Pkn and Eip75B. We also demonstrate a role for the JNK pathway in sugar tolerance and de novo lipogenesis. Finally, we report a role for tailless, a conserved orphan nuclear hormone receptor, in regulating sugar metabolism via insulin-like peptide secretion and sugar-responsive CCHamide-2 expression. Our study provides support for the use of nutrigenomics in the development of personalized nutrition.Peer reviewe

The 10th Biennial Hatter Cardiovascular Institute workshop: cellular protection—evaluating new directions in the setting of myocardial infarction, ischaemic stroke, and cardio-oncology

Due to its poor capacity for regeneration, the heart is particularly sensitive to the loss of contractile cardiomyocytes. The onslaught of damage caused by ischaemia and reperfusion, occurring during an acute myocardial infarction and the subsequent reperfusion therapy, can wipe out upwards of a billion cardiomyocytes. A similar program of cell death can cause the irreversible loss of neurons in ischaemic stroke. Similar pathways of lethal cell injury can contribute to other pathologies such as left ventricular dysfunction and heart failure caused by cancer therapy. Consequently, strategies designed to protect the heart from lethal cell injury have the potential to be applicable across all three pathologies. The investigators meeting at the 10th Hatter Cardiovascular Institute workshop examined the parallels between ST-segment elevation myocardial infarction (STEMI), ischaemic stroke, and other pathologies that cause the loss of cardiomyocytes including cancer therapeutic cardiotoxicity. They examined the prospects for protection by remote ischaemic conditioning (RIC) in each scenario, and evaluated impasses and novel opportunities for cellular protection, with the future landscape for RIC in the clinical setting to be determined by the outcome of the large ERIC-PPCI/CONDI2 study. It was agreed that the way forward must include measures to improve experimental methodologies, such that they better reflect the clinical scenario and to judiciously select combinations of therapies targeting specific pathways of cellular death and injury

Polymorphic variants of genes involved in homocysteine metabolism in celiac disease

Celiac disease (CD) is a polygenic chronic enteropathy conferring an increased risk for various nutrient deficiency states. Hyperhomocysteinemia is a frequent finding in CD and may be related to the development of venous thrombosis, cardiovascular disease, and stroke in untreated CD patients. Recently, a possible excess in the frequency of the MTHFR c.677C>T (rs1801133) gene variant in CD patients was reported. The purpose of this study was to determine if there exist differences in the distribution of polymorphic variants of genes involved in homocysteine/methyl group metabolism between CD patients and the general population. A set of 10 gene polymorphisms (MTHFR rs1801133, MTR rs1805087, MTHFD1 rs2236225, MTRR rs1801394, CBS 844ins68, BHMT1 rs7356530 and rs3733890, BHMT2 rs526264 and rs625879, and TCN2 rs1801198) was tested in 134 patients with CD and 160 matched healthy controls. The frequency of the MTR rs1805087 GG genotype in CD patients was lower than in controls (0.01 and 0.06, respectively), although statistical significance was not achieved (P = 0.06). For the other analyzed polymorphisms, there was no evidence of difference in both allelic and genotypic distribution between cases and controls. The exhaustive Multifactor Dimensionality Reduction analysis revealed no combination of interactive polymorphisms predicting the incidence of CD. In contrast to the well-documented clinical observations of increased risks of vascular disease in patients with longstanding untreated CD, in our group of patients no significant association with CD was found for all tested polymorphic variants of genes involved in homocysteine metabolism. These findings should be replicated in studies with a larger sample size