Eltrombopag for the treatment of immune thrombocytopenia: The aegean region of Turkey experience

Objective: Immune thrombocytopenia (ITP) is an immune-mediated disease characterized by transient or persistent decrease of the platelet count to less than 100x109/L. Although it is included in a benign disease group, bleeding complications may be mortal. With a better understanding of the pathophysiology of the disease, thrombopoietin receptor agonists, which came into use in recent years, seem to be an effective option in the treatment of resistant cases. This study aimed to retrospectively assess the efficacy, long-term safety, and tolerability of eltrombopag in Turkish patients with chronic ITP in the Aegean region of Turkey. Materials and Methods: Retrospective data of 40 patients with refractory ITP who were treated with eltrombopag in the Aegean region were examined and evaluated. Results: The total rate of response was 87%, and the median duration of response defined as the number of the platelets being over 50x109/L was 19.5 (interquartile range: 5-60) days. In one patient, venous sinus thrombosis was observed with no other additional risk factors due to or related to thrombosis. Another patient with complete response and irregular follow-up for 12 months was lost due to sudden death as the result of probable acute myocardial infarction. Conclusion: Although the responses to eltrombopag were satisfactory, patients need to be monitored closely for overshooting platelet counts as well as thromboembolic events. © 2015 Turkish Society of Hematology. All rights reserved

Collider aspects of flavour physics at high Q

This review presents flavour related issues in the production and decays of heavy states at LHC, both from the experimental side and from the theoretical side. We review top quark physics and discuss flavour aspects of several extensions of the Standard Model, such as supersymmetry, little Higgs model or models with extra dimensions. This includes discovery aspects as well as measurement of several properties of these heavy states. We also present public available computational tools related to this topic.Comment: Report of Working Group 1 of the CERN Workshop ``Flavour in the era of the LHC'', Geneva, Switzerland, November 2005 -- March 200

Effect of different concentrations of canola oil in diets on body chemical composition and growth performance of nile tilapia (Oreochromis niloticus, Linnaeus 1758)

The study was conducted in order to investigate the effect of supplementing various concentrations of canola oil on the growth performance and body chemical composition of Nile tilapia (Oreochromis niloticus, Linnaeus 1758). In the present study, five different experimental diets were used. Control group was fed 100% fish oil (FO) while other groups in triplicate, each of 25 fish, weighing 10 g each on the average were fed varying concentrations of canola oil viz., 25% (CO25), 50% (CO50), 75% (CO75) and 100% (CO100). There was no significant difference among the groups in terms of their growth performance at the end of the experiment (60 days). The better feed utilization was observed for the FO group (P0.05). The highest protein content in whole body was determined for CO50 and the lowest lipid content was determined for the CO75 group. Total saturated fatty acid (SFA) content was the highest in CO75 (33.51%). The monounsaturated fatty acid (MUFA) level was higher in canola-fed groups than in FO. The total n-3 polyunsaturated fatty acid (PUFA) level was higher in FO (11.21%) than that in the canola-fed groups (between 6.26% and 8.27%). The ratio of n-3/n-6 was highest in FO group (2.16), and in all groups it was greater than 1. Our findings confirmed that there was no adverse effect of canola oil on growth performance of Nile tilapia. Furthermore the whole body fatty acid composition was balanced in the canola-fed groups. Copyright 2015 Zoological Society of Pakistan

The effects of different cycles of starvation and re-feeding on growth and body composition in rainbow trout (Oncorhynchus mykiss, Walbaum, 1792)

This study was designed to investigate the effects of starvation and re-feeding cycles on the growth performance and body chemical composition of Oncorhynchus mykiss juveniles. A total of 360 juveniles with initial mean weights (IW) of 8.46 ± 0.07 g (n = 360) were stocked into 400-L tanks in triplicate for each group, with 30 juveniles per tanks. The control group received regular feed, as is the common practice. The three other groups were periodically starved: 1 day starvation followed by 6 days re-feeding (S1), 2 days starvation followed by 5 days re-feeding (S2) and 3 days starvation followed by 4 days re-feeding (S3). The experiment lasted for 10 weeks, over the course of which the water flow rate was 4 L min-1 and the water quality parameters determined as: temperature 14.4 ± 1.1°C, oxygen 8.2 ± 0.4 mg L-1 and pH 7.5 ± 0.2. At the end of the study, S1 had the best growth performance (final weight, specific growth rate, average daily growth) of all test groups (P < 0.05). The lowest daily feed intake (DFI) and growth performance parameters were observed in S3 (P < 0.05), while protein efficiency ratio (PER), net protein utilization (NPU) and lipid efficiency ratio (LER) were higher in the S3 fish group than in the other groups (P < 0.05). Whole body protein and lipid contents were highest in S1 fish. The hepatosomatic index (HSI) and viscerosomatic index (VSI) were significantly different among groups (P < 0.05). Feed conversion ratio (FCR) was significantly lower in starvation groups S1, S2 and S3 than in the control (P < 0.05). Compensation coefficient (CC) values were higher than 1 in all starvation groups. The concluding indicate that rainbow trout exposed to 1 and 2 days of starvation in week cycles could achieve over compensation compared to the control. Additionally, partial growth compensation and improved feed utilization could be achieved in a starvation group within 3 days in a week, by beginning with the juvenile size over a 10-week experimental period. © 2016 Blackwell Verlag GmbH