Thermally induced magnetic relaxation in square artificial spin ice

The properties of natural and artificial assemblies of interacting elements, ranging from Quarks to Galaxies, are at the heart of Physics. The collective response and dynamics of such assemblies are dictated by the intrinsic dynamical properties of the building blocks, the nature of their interactions and topological constraints. Here we report on the relaxation dynamics of the magnetization of artificial assemblies of mesoscopic spins. In our model nano-magnetic system - square artificial spin ice - we are able to control the geometrical arrangement and interaction strength between the magnetically interacting building blocks by means of nano-lithography. Using time resolved magnetometry we show that the relaxation process can be described using the Kohlrausch law and that the extracted temperature dependent relaxation times of the assemblies follow the Vogel-Fulcher law. The results provide insight into the relaxation dynamics of mesoscopic nano-magnetic model systems, with adjustable energy and time scales, and demonstrates that these can serve as an ideal playground for the studies of collective dynamics and relaxations.Comment: 15 pages, 5 figure

Identification of prediagnostic metabolites associated with prostate cancer risk by untargeted mass spectrometry-based metabolomics: A case-control study nested in the Northern Sweden Health and Disease Study

Prostate cancer (PCa) is the most common cancer form in males in many European and American countries, but there are still open questions regarding its etiology. Untargeted metabolomics can produce an unbiased global metabolic profile, with the opportunity for uncovering new plasma metabolites prospectively associated with risk of PCa, providing insights into disease etiology. We conducted a prospective untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics analysis using prediagnostic fasting plasma samples from 752 PCa case-control pairs nested within the Northern Sweden Health and Disease Study (NSHDS). The pairs were matched by age, BMI, and sample storage time. Discriminating features were identified by a combination of orthogonal projection to latent structures-effect projections (OPLS-EP) and Wilcoxon signed-rank tests. Their prospective associations with PCa risk were investigated by conditional logistic regression. Subgroup analyses based on stratification by disease aggressiveness and baseline age were also conducted. Various free fatty acids and phospholipids were positively associated with overall risk of PCa and in various stratification subgroups. Aromatic amino acids were positively associated with overall risk of PCa. Uric acid was positively, and glucose negatively, associated with risk of PCa in the older subgroup. This is the largest untargeted LC-MS based metabolomics study to date on plasma metabolites prospectively associated with risk of developing PCa. Different subgroups of disease aggressiveness and baseline age showed different associations with metabolites. The findings suggest that shifts in plasma concentrations of metabolites in lipid, aromatic amino acid, and glucose metabolism are associated with risk of developing PCa during the following two decades

Expressions of agency within complex policy structures: science teachers’ experiences of education policy reforms in Sweden

We explore the experiences of school science teachers as they enact three linked national curriculum and assessment policy reforms in Sweden. Our goal is to understand teachers’ differing responses to these reforms. A sample of 13 teachers engaged in 2 interviews over a 6–9-month period. Interviews included exploration of professional background and school context, perceptions of the aims of the policy reforms and experiences of working with these reforms in the classroom. Analysis was guided by an individual-oriented sociocultural perspective on professional agency. Here teaching is conceptualised as an ongoing interplay between teachers’ knowledge, skills and personal goals, and the characteristics of the social, institutional and policy settings in which they work. Our analysis shows that navigating the ensuing continuities and contradictions results in many different expressions of teacher agency, e.g. loss of autonomy and trust, pushing back, subversion, transfer of authority, and creative tensions. Typically, an individual teacher’s enactment of these reforms involved several of these expressions of agency. We demonstrate that the sociocultural perspective provides insights into teachers’ responses to education policy reform likely to be missed by studies that focus largely on individual teacher knowledge/beliefs about reform or skills in ‘implementing’ reform practices

SN 2006oz: rise of a super-luminous supernova observed by the SDSS-II SN Survey

We study SN 2006oz, a newly-recognized member of the class of H-poor, super-luminous supernovae. We present multi-color light curves from the SDSS-II SN Survey, that cover the rise time, as well as an optical spectrum that shows that the explosion occurred at z~0.376. We fitted black body functions to estimate the temperature and radius evolution of the photosphere and used the parametrized code SYNOW to model the spectrum. We constructed a bolometric light curve and compared it with explosion models. The very early light curves show a dip in the g- and r-bands and a possible initial cooling phase in the u-band before rising to maximum light. The bolometric light curve shows a precursor plateau with a duration of 6-10 days in the rest-frame. A lower limit of M_u < -21.5 can be placed on the absolute peak luminosity of the SN, while the rise time is constrained to be at least 29 days. During our observations, the emitting sphere doubled its radius to 2x10^15 cm, while the temperature remained hot at 15000 K. As for other similar SNe, the spectrum is best modeled with elements including O II and Mg II, while we tentatively suggest that Fe III might be present. We suggest that the precursor plateau might be related to a recombination wave in a circumstellar medium (CSM) and discuss whether this is a common property of all similar explosions. The subsequent rise can be equally well described by input from a magnetar or by ejecta-CSM interaction, but the models are not well constrained owing to the lack of post-maximum observations, and CSM interaction has difficulties accounting for the precursor plateau self-consistently. Radioactive decay is less likely to be the mechanism that powers the luminosity. The host galaxy, detected in deep imaging with the 10 m GTC, is a moderately young and star-forming, but not a starburst, galaxy. It has an absolute magnitude of M_g = -16.9.Comment: Contains minor changes (of editorial nature) with respect to v1 in order to match the published version. The abstract has been modified to fit the arXiv space requirements. 11 pages, 8 figures, 3 table

Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-ß receptor tyrosine kinase signaling

The inhibitory reversible oxidation of protein tyrosine phosphatases (PTPs) is an important regulatory mechanism in growth factor signaling. Studies on PTP oxidation have focused on pathways that increase or decrease reactive oxygen species levels and thereby affect PTP oxidation. The processes involved in reactivation of oxidized PTPs remain largely unknown. Here the role of the thioredoxin (Trx) system in reactivation of oxidized PTPs was analyzed using a combination of in vitro and cell-based assays. Cells lacking the major Trx reductase TrxR1 (Txnrd1-/-) displayed increased oxidation of PTP1B, whereas SHP2 oxidation was unchanged. Furthermore, in vivo-oxidized PTP1B was reduced by exogenously added Trx system components, whereas SHP2 oxidation remained unchanged. Trx1 reduced oxidized PTP1B in vitro but failed to reactivate oxidized SHP2. Interestingly, the alternative TrxR1 substrate TRP14 also reactivated oxidized PTP1B, but not SHP2. Txnrd1-depleted cells displayed increased phosphorylation of PDGF-ß receptor, and an enhanced mitogenic response, after PDGF-BB stimulation. The TrxR inhibitor auranofin also increased PDGF-ß receptor phosphorylation. This effect was not observed in cells specifically lacking PTP1B. Together these results demonstrate that the Trx system, including both Trx1 and TRP14, impacts differentially on the oxidation of individual PTPs, with a preference of PTP1B over SHP2 activation. The studies demonstrate a previously unrecognized pathway for selective redox-regulated control of receptor tyrosine kinase signaling

On the future of Gamma-Ray Burst Cosmology

With the understanding that the enigmatic Gamma-Ray Burts (GRBs) are beamed explosions, and with the recently discovered ``Ghirlanda-relation'', the dream of using GRBs as cosmological yardsticks may have come a few steps closer to reality. Assuming the Ghirlanda-relation is real, we have investigated possible constraints on cosmological parameters using a simulated future sample of a large number of GRBs inspired by the ongoing SWIFT mission. Comparing with constraints from a future sample of Type Ia supernovae, we find that GRBs are not efficient in constraining the amount of dark energy or its equation of state. The main reason for this is that very few bursts are available at low redshifts.Comment: 5 pages, 2 figures, matches version accepted for publication in JCA

NTT and NOT spectroscopy of SDSS-II supernovae

Context. The SDSS-II Supernova Survey, conducted between 2005 and 2007, was designed to detect a large number of Type Ia supernovae (SNe Ia) around z~0.2, the redshift "gap" between low-z and high-z SN searches. The survey has provided multi-band photometric lightcurves for variable targets, and SN candidates were scheduled for spectroscopic observations, primarily to provide SN classification and accurate redshifts. We present SN spectra obtained in 2006 and 2007 using the NTT and the NOT. Aims. We provide an atlas of SN spectra in the range z =0.03-0.32 that complements the well-sampled lightcurves from SDSS-II in the forthcoming three-year SDSS SN cosmology analysis. The sample can, for example, be used for spectral studies of SNe Ia, which are critical for understanding potential systematic effects when SNe are used to determine cosmological distances. Methods. The spectra were reduced in a uniform manner, and special care was taken in estimating the uncertainties for the different processing steps. Host-galaxy light was subtracted when possible and the SN type fitted using the SuperNova IDentification code (SNID). We also present comparisons between spectral and photometric dating using SALT lightcurve fits to the photometry from SDSS-II, as well as the global distribution of our sample in terms of the lightcurve parameters: stretch and colour. Results. We report new spectroscopic data from 141 SNe Ia, mainly between -9 and +15 days from lightcurve maximum, including a few cases of multi-epoch observations. This homogeneous, host-galaxy subtracted, SN Ia spectroscopic sample is among the largest such data sets and unique in its redshift interval. The sample includes two potential SN 1991T-like SNe (SN 2006on and SN 2007ni) and one potential SN 2002cx-like SN (SN 2007ie). In addition, the new compilation includes spectra from 23 confirmed Type II and 8 Type Ib/c SNe.Comment: Accepted for publication in A&

A multi-instrument comparison of integrated water vapour measurements at a high latitude site

We compare measurements of integrated water vapour (IWV) over a subarctic site (Kiruna, Northern Sweden) from five different sensors and retrieval methods: Radiosondes, Global Positioning System (GPS), ground-based Fourier-transform infrared (FTIR) spectrometer, groundbased microwave radiometer, and satellite-based microwave radiometer (AMSU-B). Additionally, we compare also to ERA-Interim model reanalysis data. GPS-based IWV data have the highest temporal coverage and resolution and are chosen as reference data set. All datasets agree reasonably well, but the ground-based microwave instrument only if the data are cloud-filtered. We also address two issues that are general for such intercomparison studies, the impact of different lower altitude limits for the IWV integration, and the impact of representativeness error. We develop methods for correcting for the former, and estimating the random error contribution of the latter. A literature survey reveals that reported systematic differences between different techniques are study-dependent and show no overall consistent pattern. Further improving the absolute accuracy of IWV measurements and providing climate-quality time series therefore remain challenging problems

Why Are Male Social Relationships Complex in the Doubtful Sound Bottlenose Dolphin Population?

Copyright 2008 Elsevier B.V., All rights reserved.Peer reviewedPublisher PD

Spectra and Light Curves of Six Type Ia Supernovae at 0.511 < z < 1.12 and the Union2 Compilation

We report on work to increase the number of well-measured Type Ia supernovae (SNe Ia) at high redshifts. Light curves, including high signal-to-noise HST data, and spectra of six SNe Ia that were discovered during 2001 are presented. Additionally, for the two SNe with z>1, we present ground-based J-band photometry from Gemini and the VLT. These are among the most distant SNe Ia for which ground based near-IR observations have been obtained. We add these six SNe Ia together with other data sets that have recently become available in the literature to the Union compilation (Kowalski et al. 2008). We have made a number of refinements to the Union analysis chain, the most important ones being the refitting of all light curves with the SALT2 fitter and an improved handling of systematic errors. We call this new compilation, consisting of 557 supernovae, the Union2 compilation. The flat concordance LambdaCDM model remains an excellent fit to the Union2 data with the best fit constant equation of state parameter w=-0.997^{+0.050}_{-0.054} (stat) ^{+0.077}_{-0.082} (stat+sys\ together) for a flat universe, or w=-1.035^{+0.055}_{-0.059} (stat)^{+0.093}_{-0.097} (stat+sys together) with curvature. We also present improved constraints on w(z). While no significant change in w with redshift is detected, there is still considerable room for evolution in w. The strength of the constraints depend strongly on redshift. In particular, at z > 1, the existence and nature of dark energy are only weakly constrained by the data.Comment: 33 pages, 18 figures; accepted for publication in Astrophysical Journal. For data tables, code for cosmological analysis and full-resolution figures, see http://supernova.lbl.gov/Union