NEU screen shows high accuracy in detecting cognitive impairment in older persons living with HIV

The NEUrocognitive (NEU) Screen is a practical tool proposed to screen for HIV-associated cognitive impairment in the clinical setting. This is a pencil-and-paper method that can be applied rapidly (<=10 minutes for administration) and has no copyright limitations. In this study, we aimed at investigating its diagnostic accuracy in an older population of persons living with HIV (PLWH), with cutoffs set at 30, 40, 50, and 60 years. Data were collected from a sample of 368 PLWH who underwent a comprehensive neuropsychological tests battery (gold standard). Results of statistical tests showed that accuracy of the NEU Screen increased with age of the participants. The highest degree of precision, with a sensitivity of 91% and specificity of 92%, was obtained for people ages 60 years or older (correct classification: 91%). These optimal results point to the great potential of the NEU Screen as a tool for detecting cognitive disorders in older PLWH

Diagnosis and Molecular Characterization of Chikungunya Virus Infections

In recent years, large-scale outbreaks of chikungunya arbovirus (CHIKV), which is transmitted by the Aedes mosquito, have enabled the rapid propagation of the virus across the world. After acute infection phase with commonly fever, joint pain, headache, or rash, chronic rheumatism (arthralgia or myalgia, anorexia, and concentration disorders) up to 40% of cases is observed. The chronic form is defined by symptoms persisting for more than 3 months, and up to years, after initial diagnosis. Chronic discomfort has been linked to one of the four genotypes described. These genotypes represent different geographic lineages (classification based on partial sequence of viral E1 glycoprotein): West African, East-Central-South-African (ECSA), ECSA-diverged or Indian Ocean Lineage (IOL), and Asian. The first marker detected in CHIK infection is the viral RNA, usually by reverse transcription-polymerase chain reaction (RT-PCR). This marker can be identified in samples within 8 days of symptom onset. The infection can also be diagnosed with serological testing to detect CHIKV-specific immunoglobulin IgG and/or IgM. Sequencing studies can determine the infecting genotype

The importance of atmospheric correction for airborne hyperspectral remote sensing of shallow waters: application to depth estimation

Accurate determination of water depth is indispensable in multiple aspects of civil engineering (dock construction, dikes, submarines outfalls, trench control, etc.). To determine the type of atmospheric correction most appropriate for the depth estimation, different accuracies are required. Accuracy in bathymetric information is highly dependent on the atmospheric correction made to the imagery. The reduction of effects such as glint and cross-track illumination in homogeneous shallow-water areas improves the results of the depth estimations. The aim of this work is to assess the best atmospheric correction method for the estimation of depth in shallow waters, considering that reflectance values cannot be greater than 1.5% because otherwise the background would not be seen. This paper addresses the use of hyperspectral imagery to quantitative bathymetric mapping and explores one of the most common problems when attempting to extract depth information in conditions of variable water types and bottom reflectances. The current work assesses the accuracy of some classical bathymetric algorithms (Polcyn? Lyzenga, Philpot, Benny?Dawson, Hamilton, principal component analysis) when four different atmospheric correction methods are applied and water depth is derived. No atmospheric correction is valid for all type of coastal waters, but in heterogeneous shallow water the model of atmospheric correction 6S offers good results

Emergency surgery in chronic intestinal pseudo-obstruction due to mitochondrial neurogastrointestinal encephalomyopathy: case reports

Chronic intestinal pseudo-obstruction (CIPO) is a syndrome characterized by recurrent clinical episodes of intestinal obstruction in the absence of any mechanical cause occluding the gut. There are multiple causes related to this rare syndrome. Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is one of the causes related to primary CIPO. MNGIE is caused by mutations in the gene encoding thymidine phosphorylase. These mutations lead to an accumulation of thymidine and deoxyuridine in blood and tissues of these patients. Toxic levels of these nucleosides induce mitochondrial DNA abnormalities leading to an abnormal intestinal motility

Conditioning factors of linearized wood's function lactation curve shape parameters, milk yield, fat and protein content in murciano-granadina primiparous does

Research Areas: Agriculture ; Veterinary Sciences ; ZoologyA total of 137,927 controls of 22,932 Murciano-Granadina first lactation goats (measured between 1996–2016) were evaluated to determine the influence of the number of kids, season, year and farm on total milk yield, daily milk yield, lactation length, total production of fat and protein and percentages of fat and protein. All factors analyzed had a significant effect on the variables studied, except for the influence of the number of kids on the percentages of fat and protein, where the variation was very small. Goats with two offspring produced nearly 15% more milk, fat and protein per lactation compared to goats with simple kids. Kiddings occurring in summer–autumn resulted in average milk, fat and protein yields nearly 14, 19 and 23% higher when compared to winter–spring kiddings. Lactation curves were evaluated to determine the effects of the number of kids and season, using the linearized version of the model of Wood in random regression analyses. Peak Yield increased by about 0.3 kg per additional offspring at kidding, but persistence was higher in goats with single offspring. The kidding season significantly influenced the lactation curve shape. Hence summer-kidding goats were more productive, and peak occurred earlier, while a higher persistence was observed in goats kidding during autumn.info:eu-repo/semantics/publishedVersio

Fitness as mediator between weight status and dimensions of health-related quality of life

FUNDAMENTOS: Hay pruebas de que el sobrepeso y la obesidad en los niños se asocia con una mala condición física y, por consiguiente, con una menor calidad de vida relacionada con la salud (HRQoL). Sin embargo, esta relación lineal-causal entre el Estado de Peso → Aptitud Física → CVRS no es suficiente para comprender plenamente este fenómeno. Por lo tanto, es necesario saber, a través de un análisis de mediación, cómo funciona la Aptitud Física entre el estado de peso y las dimensiones de la CVRS. PROPÓSITO: El objetivo de este estudio fue determinar qué dimensiones de CVRS están mediadas por la Aptitud Física en niños obesos (incluyendo el sobrepeso) y de peso normal. El estudio también examinó la asociación entre la Aptitud Física, el Índice de Masa Corporal (IMC) y la CVRS. MÉTODOS: Un total de 233 niños obesos o con sobrepeso y 105 niños con peso normal participaron en el estudio. Los niños fueron reclutados en centros educativos públicos y en un programa público de pérdida de peso. Se midió el IMC, la aptitud física (fuerza de las extremidades superiores, centrales e inferiores; agilidad y rango de movimiento) y la CVRS (PedsQL y VAS). Se realizaron análisis simples de mediación por género, a través de la macro de PROCESO desarrollada por Predicador y Hayes, para analizar si la Aptitud Física computada como z-score, es un mediador en la relación entre el estado de peso (peso normal o sobrepeso/obesidad) y las dimensiones de CVRS. \N - Tradicionalmente, las estadísticas de desigual-varianzas t se ejecutaron para conocer las diferencias en el IMC, los componentes de Aptitud Física y las dimensiones de CVRS entre los grupos, y las correlaciones para conocer las asociaciones entre el estado de peso, el puntaje z de Aptitud Física y la CVRS. RESULTADOS: Nuestros resultados, indicaron la asociación entre el puntaje z de Aptitud Física y las dimensiones de CVRS en niños con sobrepeso/obesos. Con respecto al análisis de mediación, los resultados mostraron que la asociación negativa entre el sobrepeso/obesidad y la CVRS se suaviza por el nivel de Aptitud Física. Por lo tanto, la aptitud física es un mediador en la relación entre los niños con sobrepeso y obesidad y la mayoría de las dimensiones de la CVRS, excepto el funcionamiento de la escuela en los niños y el funcionamiento de la escuela y las emociones en las niñas. CONCLUSIONES: El efecto negativo del sobrepeso u obesidad en la CVRS de los niños, es mitigado por la Condición Física. Por consiguiente, la Aptitud Física es un mediador de la CVRS en la mayoría de las dimensiones, especialmente en la vida diaria, en los escolares.BACKGROUND: There is evidence that overweight and obesity in children is associated with poor Physical Fitness and consequently lower Health-related Quality of Life (HRQoL). However, this linear-causal relationship between Weight Status → Physical Fitness → HRQoL is not enough to fully understand this phenomenon. Therefore, need to know, through mediation analysis, how operate the Physical Fitness between weight status and HRQoL dimensions. PURPOSE: The aim of this study was to determine which HRQoL dimensions are mediated through Physical Fitness in obese (including overweight) and normal weight children. The study also examined the association between Physical Fitness, Body Mass Index (BMI) and HRQoL. METHODS: A total of 233 overweight/obese children and 105 normal-weight children participated in the study. Children were recruited from public educational centers and a public weight loss program. BMI, Physical Fitness (upper limb, central body and lower limb strength; agility and range of motion) and HRQoL (PedsQL and VAS) were measured. Simple mediation analyses by gender, through PROCESS macro developed by Preacher and Hayes, were performed in order to analyze whether Physical Fitness computed as z-score, is a mediator in the relation between weight status (normal weight or overweight/obesity) and HRQoL dimensions. \itionally, unequal-variances t statistics were executed to know differences in BMI, Physical Fitness components and HRQoL dimensions between groups, and correlations to know the associations between weight status, Physical Fitness z-score and HRQoL. RESULTS: Our results, indicated association between the Physical Fitness z-score and HRQoL dimensions in overweight/obese children. Regarding to mediation analysis, the results showed that the negative association between overweight/obesity and HRQoL is softened by the level of Physical Fitness. Therefore Physical Fitness is a mediator in the relationship between overweight/obesity children and the most of dimensions of HRQoL, except the School functioning in boys and the School and Emotional functioning in girls. CONCLUSIONS: The negative effect of overweight or obesity on HRQoL inn children, is mitigated by Physical Fitness. Consequently, the Physical Fitness is a mediator on HRQoL in most dimensions, especially daily living, in schoolchildren.• Junta de Junta de Extremadura. Beca de Salud y Dependencia ref. 118/06peerReviewe

Modelling the vertical distribution of canopy fuel load using national forest inventory and low-density airbone laser scanning data

The fuel complex variables canopy bulk density and canopy base height are often used to predict crown fire initiation and spread. Direct measurement of these variables is impractical, and they are usually estimated indirectly by modelling. Recent advances in predicting crown fire behaviour require accurate estimates of the complete vertical distribution of canopy fuels. The objectives of the present study were to model the vertical profile of available canopy fuel in pine stands by using data from the Spanish national forest inventory plus lowdensity airborne laser scanning (ALS) metrics. In a first step, the vertical distribution of the canopy fuel load was modelled using the Weibull probability density function. In a second step, two different systems of models were fitted to estimate the canopy variables defining the vertical distributions; the first system related these variables to stand variables obtained in a field inventory, and the second system related the canopy variables to airborne laser scanning metrics. The models of each system were fitted simultaneously to compensate the effects of the inherent cross-model correlation between the canopy variables. Heteroscedasticity was also analyzed, but no correction in the fitting process was necessary. The estimated canopy fuel load profiles from field variables explained 84% and 86% of the variation in canopy fuel load for maritime pine and radiata pine respectively; whereas the estimated canopy fuel load profiles from ALS metrics explained 52% and 49% of the variation for the same species. The proposed models can be used to assess the effectiveness of different forest management alternatives for reducing crown fire hazardWe are grateful to the Galician Government and European Social Fund (Official Journal of Galicia—DOG n° 52, 17/03/2014, p. 11343, exp: POS-A/2013/049) for financing the postdoctoral research stays of Dr Eduardo González-Ferreiro at different institutions. Copyright of LiDAR data, Instituto Geográfico Nacional-Xunta de GaliciaS

Classification Models for Neurocognitive Impairment in HIV Infection Based on Demographic and Clinical Variables

Objective: We used demographic and clinical data to design practical classification models for prediction of neurocognitive impairment (NCI) in people with HIV infection. Methods: The study population comprised 331 HIV-infected patients with available demographic, clinical, and neurocognitive data collected using a comprehensive battery of neuropsychological tests. Classification and regression trees (CART) were developed to obtain detailed and reliable models to predict NCI. Following a practical clinical approach, NCI was considered the main variable for study outcomes, and analyses were performed separately in treatment-naı¨ve and treatment-experienced patients. Results: The study sample comprised 52 treatment-naı¨ve and 279 experienced patients. In the first group, the variables identified as better predictors of NCI were CD4 cell count and age (correct classification [CC]: 79.6%, 3 final nodes). In treatment-experienced patients, the variables most closely related to NCI were years of education, nadir CD4 cell count, central nervous system penetration-effectiveness score, age, employment status, and confounding comorbidities (CC: 82.1%, 7 final nodes). In patients with an undetectable viral load and no comorbidities, we obtained a fairly accurate model in which the main variables were nadir CD4 cell count, current CD4 cell count, time on current treatment, and past highest viral load (CC: 88%, 6 final nodes). Conclusion: Practical classification models to predict NCI in HIV infection can be obtained using demographic and clinical variables. An approach based on CART analyses may facilitate screening for HIV-associated neurocognitive disorders and complement clinical information about risk and protective factors for NCI in HIV-infected patients

Escalera Mecánica

Escalera mecánica, que comprende un sinfín de peldaños (1) que van montados sobre dos cadenas laterales de arrastre (2-3) y guías conductoras (4-5) y quedan limitados entre balaustradas laterales fijas. Cada peldaño está soportado por dos brazos (7-8) no alineados, que son perpendiculares a la dirección de desplazamiento de dichos peldaños y paralelos a las superficies pisables de los mismos. Estos brazos sobresalen de los peldaños, uno por cada lado, para su conexión a puntos de articulación (9- 10) de las cadenas, coincidentes con el peldaño