Prevalencia de delirium en adultos mayores con fractura de cadera

Objetivo: Establecer la prevalencia de delirium en pacientes adultos mayores con fractura de cadera en el Servicio de Traumatología del Hospital Universitario Dr. José E. González de octubre del 2008 a mayo del 2009. Métodos: se realizó estudio descriptivo, transversal y prospectivo en la población de pacientes mayores de 60 años con diagnóstico de fractura de cadera en un periodo de ocho meses. Se evaluó delirium mediante el método del estado confusional agudo (CAM) y criterios DSM IV, durante el internamiento y al mes del egreso por vía telefónica. Resultados: Se analizó una población de 74 pacientes con una edad promedio de 79.47 años y primordialmente femenina (74.3%), el promedio de días de estancia fue de 14.68 días, observando prevalencia de delirium del 37.8% y una mortalidad final del 17.6%. No se encontraron diferencias entre ambos grupos, la edad es mayor en los pacientes con delirium y esta correlaciona con la patología (edad promedio: delirium= 84 años / sin delirium= 77 años / p = 0.0016; Rho= 0.347 / p = 0.002). Conclusiones: La prevalencia de delirium encontrada es similar a la reportada en otros estudios. Se observó menor tiempo de estancia hospitalaria, así como una mayor mortalidad en ambos grupos durante su hospitalización, de igual manera, un mes después del ingreso, en el grupo de pacientes que desarrollaron delirium

Modelado de la interacción de albúmina de suero de bovino (BSA) con diferentes combinatorias en la estructura de pirrol sintetizado por plasma (PPPy)

Se ha estudiado la interacción entre el polipirrol sintetizado por plasma (PPPy) con la proteína albúmina de suero bovino (BSA). Esta interacción es importante debido a que el PPPy presenta neuroprotección y mejora la actividad motora en lesiones traumáticas de médula espinal en roedores. Se realizaron estudios de acoplamiento molecular (docking) alrededor de la superficie de BSA con diferentes combinaciones de PPPy generados a partir de la estructura reportada por Kumar et al., (2003) y se evaluó la energía de unión de estos complejos. Los resultados obtenidos indicaron una clara contribución electrostática en los sitios de reconocimiento sobre la superficie de BSA debido a la combinación de tres grupos funcionales (CH3, OH y NH2) presentes en los confórmeros de PPPy. Es importante mencionar que estos resultados complementan evidencias experimentales y computacionales de nuestro grupo de investigación.The interaction between plasma synthesized polypyrrol (PPPy) with bovine serum albumin protein (BSA) has been studied. This interaction is important because PPPy exhibits neuroprotection and improves motor activity in traumatic spinal cord lesions in rodents. Docking studies were made around of surface of BSA with different combinations of PPPy generated from the structure reported by Kumar et al., (2003) and the binding energy of these complexes was evaluated. The results indicated a clear electrostatic contribution at the recognition sites on the surface of BSA due to the combination of three functional groups (CH3, OH and NH2) present in the PPPy conformers. It is important to mention that these results complement the experimental and computational evidence obtained in our research group

A New Water Governance Model Aimed at Supply-Demand Management for Irrigation and Land Development in the Mendoza River Basin, Argentina.

This study aimed at achieving an organizational solution for improving the governance of water and land use and, consequently, improving the supply-demand water balance. Related modeling applied to diverse scenarios focus on water and land use development in the Mendoza River basin. A strategic analysis of water organization was performed using causal analysis, producing a Strategic Map (SM) and designing a Balanced Scorecard (BS). To assess the basin's water resources supply and demand, the Water Evaluation and Planning (WEAP) model was applied to the Administrative Management Units existing in the basin, taking into consideration the water availability and the granted water rights. The application of the organizational and governance model to various scenarios referring to 2030 show that by reordering allocations and water use criteria, implementing a better farm irrigation water management, improving capacity building of existing human resources, and adopting more adequate hard- and software for dams and canal management, it will be possible to accommodate demand in 2030 better than at present despite climate change impacts on demand and supply. In addition, users' participation will be enhanced

Seminarios multimedia de implanto-prótesis y patología oclusal

Memoria ID-0116. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2014-2015

XLI Jornadas de teatro clásico

Jornadas organizadas por el Instituto Almagro de teatro clásico, dedicadas a la figura de Agustín Moreto

Genetic diversity of HLA system in four populations from Baja California, Mexico: Mexicali, La Paz, Tijuana and rural Baja California

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 250 Mexicans from the states of Baja California Norte and Baja California Sur living in Mexicali (N = 100), La Paz (N = 75), Tijuana (N = 25) and rural communities (N = 50) to obtain information regarding allelic and haplotypic frequencies. The most frequent haplotypes for the Baja California region include nine Native American and five European haplotypes. Admixture estimates revealed that the main genetic components are European (50.45 ± 1.84% by ML; 42.03% of European haplotypes) and Native American (43.72 ± 2.36% by ML; 40.24% of Native American haplotypes), while the African genetic component was less apparent (5.83 ± 0.98% by ML; 9.36% of African haplotypes)

The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) allele groups and alleles by PCR-SSP based typing in a total of 15,318 mixed ancestry Mexicans from all the states of the country divided into 78 sample sets, providing information regarding allelic and haplotypic frequencies and their linkage disequilibrium, as well as admixture estimates and genetic substructure. We identified the presence of 4268 unique HLA extended haplotypes across Mexico and find that the ten most frequent (HF > 1%) HLA haplotypes with significant linkage disequilibrium (Δ’≥0.1) in Mexico (accounting for 20% of the haplotypic diversity of the country) are of primarily Native American ancestry (A*02~B*39~DRB1*04~DQB1*03:02, A*02~B*35~DRB1*08~DQB1*04, A*68~B*39~DRB1*04~DQB1*03:02, A*02~B*35~DRB1*04~DQB1*03:02, A*24~B*39~DRB1*14~DQB1*03:01, A*24~B*35~DRB1*04~DQB1*03:02, A*24~B*39~DRB1*04~DQB1*03:02, A*02~B*40:02~DRB1*04~DQB1*03:02, A*68~B*35~DRB1*04~DQB1*03:02, A*02~B*15:01~DRB1*04~DQB1*03:02). Admixture estimates obtained by a maximum likelihood method using HLA-A/-B/-DRB1 as genetic estimators revealed that the main genetic components in Mexico as a whole are Native American (ranging from 37.8% in the northern part of the country to 81.5% in the southeastern region) and European (ranging from 11.5% in the southeast to 62.6% in northern Mexico). African admixture ranged from 0.0 to 12.7% not following any specific pattern. We were able to detect three major immunogenetic clusters correlating with genetic diversity and differential admixture within Mexico: North, Central and Southeast, which is in accordance with previous reports using genome-wide data. Our findings provide insights into the population immunogenetic substructure of the whole country and add to the knowledge of mixed ancestry Latin American population genetics, important for disease association studies, detection of demographic signatures on population variation and improved allocation of public health resources.Fil: Barquera, Rodrigo. Max Planck Institute For The Science Of Human History; Alemania. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Hernández Zaragoza, Diana Iraíz. Técnicas Genéticas Aplicadas A la Clínica (tgac); México. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Bravo Acevedo, Alicia. Instituto Mexicano del Seguro Social; MéxicoFil: Arrieta Bolaños, Esteban. Universitat Essen; AlemaniaFil: Clayton, Stephen. Max Planck Institute For The Science Of Human History; AlemaniaFil: Acuña Alonzo, Víctor. Instituto Nacional de Antropología E Historia, Mexico; MéxicoFil: Martínez Álvarez, Julio César. Instituto Mexicano del Seguro Social; MéxicoFil: López Gil, Concepción. Instituto Mexicano del Seguro Social; MéxicoFil: Adalid Sáinz, Carmen. Instituto Mexicano del Seguro Social; MéxicoFil: Vega Martínez, María del Rosario. Hospital Central Sur de Alta Especialidad; MéxicoFil: Escobedo Ruíz, Araceli. Instituto Mexicano del Seguro Social; MéxicoFil: Juárez Cortés, Eva Dolores. Instituto Mexicano del Seguro Social; MéxicoFil: Immel, Alexander. Max Planck Institute For The Science Of Human History; Alemania. Christian Albrechts Universitat Zu Kiel; AlemaniaFil: Pacheco Ubaldo, Hanna. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: González Medina, Liliana. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Lona Sánchez, Abraham. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Lara Riegos, Julio. Universidad Autónoma de Yucatán; MéxicoFil: Sánchez Fernández, María Guadalupe de Jesús. Instituto Mexicano del Seguro Social; MéxicoFil: Díaz López, Rosario. Hospital Central Militar, Mexico City; MéxicoFil: Guizar López, Gregorio Ulises. Hospital Central Militar, Mexico City; MéxicoFil: Medina Escobedo, Carolina Elizabeth. Instituto Mexicano del Seguro Social; MéxicoFil: Arrazola García, María Araceli. Instituto Mexicano del Seguro Social; MéxicoFil: Montiel Hernández, Gustavo Daniel. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Hernández Hernández, Ofelia. Técnicas Genéticas Aplicadas a la Clínica ; MéxicoFil: Ramos de la Cruz, Flor del Rocío. Instituto Mexicano del Seguro Social; MéxicoFil: Juárez Nicolás, Francisco. Instituto Nacional de Pediatría; MéxicoFil: Pantoja Torres, Jorge Arturo. Instituto Mexicano del Seguro Social; MéxicoFil: Rodríguez Munguía, Tirzo Jesús. Hospital General Norberto Treviño Zapata; MéxicoFil: Juárez Barreto, Vicencio. Hospital Infantil de Mexico Federico Gomez; MéxicoFil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentin

Symptom cluster analysis of long COVID-19 in patients discharged from the Temporary COVID-19 Hospital in Mexico City.

INTRODUCTION: Several reports have emerged describing the long-term consequences of COVID-19 and its effects on multiple systems. METHODS: As further research is needed, we conducted a longitudinal observational study to report the prevalence and associated risk factors of the long-term health consequences of COVID-19 by symptom clusters in patients discharged from the Temporary COVID-19 Hospital (TCH) in Mexico City. Self-reported clinical symptom data were collected via telephone calls over 90 days post-discharge. Among 4670 patients, we identified 45 symptoms across eight symptom clusters (neurological; mood disorders; systemic; respiratory; musculoskeletal; ear, nose, and throat; dermatological; and gastrointestinal). RESULTS: We observed that the neurological, dermatological, and mood disorder symptom clusters persisted in >30% of patients at 90 days post-discharge. Although most symptoms decreased in frequency between day 30 and 90, alopecia and the dermatological symptom cluster significantly increased (p < 0.00001). Women were more prone than men to develop long-term symptoms, and invasive mechanical ventilation also increased the frequency of symptoms at 30 days post-discharge. CONCLUSION: Overall, we observed that symptoms often persisted regardless of disease severity. We hope these findings will help promote public health strategies that ensure equity in the access to solutions focused on the long-term consequences of COVID-19

Creación de una web del Grupo de Investigación: avances en Salud Oral

Memoria ID-0135. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2015-2016