A Hierachical Evolutionary Algorithm for Multiobjective Optimization in IMRT

Purpose: Current inverse planning methods for IMRT are limited because they are not designed to explore the trade-offs between the competing objectives between the tumor and normal tissues. Our goal was to develop an efficient multiobjective optimization algorithm that was flexible enough to handle any form of objective function and that resulted in a set of Pareto optimal plans. Methods: We developed a hierarchical evolutionary multiobjective algorithm designed to quickly generate a diverse Pareto optimal set of IMRT plans that meet all clinical constraints and reflect the trade-offs in the plans. The top level of the hierarchical algorithm is a multiobjective evolutionary algorithm (MOEA). The genes of the individuals generated in the MOEA are the parameters that define the penalty function minimized during an accelerated deterministic IMRT optimization that represents the bottom level of the hierarchy. The MOEA incorporates clinical criteria to restrict the search space through protocol objectives and then uses Pareto optimality among the fitness objectives to select individuals. Results: Acceleration techniques implemented on both levels of the hierarchical algorithm resulted in short, practical runtimes for optimizations. The MOEA improvements were evaluated for example prostate cases with one target and two OARs. The modified MOEA dominated 11.3% of plans using a standard genetic algorithm package. By implementing domination advantage and protocol objectives, small diverse populations of clinically acceptable plans that were only dominated 0.2% by the Pareto front could be generated in a fraction of an hour. Conclusions: Our MOEA produces a diverse Pareto optimal set of plans that meet all dosimetric protocol criteria in a feasible amount of time. It optimizes not only beamlet intensities but also objective function parameters on a patient-specific basis

Effective and efficient algorithm for multiobjective optimization of hydrologic models

Practical experience with the calibration of hydrologic models suggests that any single-objective function, no matter how carefully chosen, is often inadequate to properly measure all of the characteristics of the observed data deemed to be important. One strategy to circumvent this problem is to define several optimization criteria (objective functions) that measure different (complementary) aspects of the system behavior and to use multicriteria optimization to identify the set of nondominated, efficient, or Pareto optimal solutions. In this paper, we present an efficient and effective Markov Chain Monte Carlo sampler, entitled the Multiobjective Shuffled Complex Evolution Metropolis (MOSCEM) algorithm, which is capable of solving the multiobjective optimization problem for hydrologic models. MOSCEM is an improvement over the Shuffled Complex Evolution Metropolis (SCEM-UA) global optimization algorithm, using the concept of Pareto dominance (rather than direct single-objective function evaluation) to evolve the initial population of points toward a set of solutions stemming from a stable distribution (Pareto set). The efficacy of the MOSCEM-UA algorithm is compared with the original MOCOM-UA algorithm for three hydrologic modeling case studies of increasing complexity

The influence of mutation on population dynamics in multiobjective genetic programming

Using multiobjective genetic programming with a complexity objective to overcome tree bloat is usually very successful but can sometimes lead to undesirable collapse of the population to all single-node trees. In this paper we report a detailed examination of why and when collapse occurs. We have used different types of crossover and mutation operators (depth-fair and sub-tree), different evolutionary approaches (generational and steady-state), and different datasets (6-parity Boolean and a range of benchmark machine learning problems) to strengthen our conclusion. We conclude that mutation has a vital role in preventing population collapse by counterbalancing parsimony pressure and preserving population diversity. Also, mutation controls the size of the generated individuals which tends to dominate the time needed for fitness evaluation and therefore the whole evolutionary process. Further, the average size of the individuals in a GP population depends on the evolutionary approach employed. We also demonstrate that mutation has a wider role than merely culling single-node individuals from the population; even within a diversity-preserving algorithm such as SPEA2 mutation has a role in preserving diversity

Improved dynamical particle swarm optimization method for structural dynamics

A methodology to the multiobjective structural design of buildings based on an improved particle swarm optimization algorithm is presented, which has proved to be very efficient and robust in nonlinear problems and when the optimization objectives are in conflict. In particular, the behaviour of the particle swarm optimization (PSO) classical algorithm is improved by dynamically adding autoadaptive mechanisms that enhance the exploration/exploitation trade-off and diversity of the proposed algorithm, avoiding getting trapped in local minima. A novel integrated optimization system was developed, called DI-PSO, to solve this problem which is able to control and even improve the structural behaviour under seismic excitations. In order to demonstrate the effectiveness of the proposed approach, the methodology is tested against some benchmark problems. Then a 3-story-building model is optimized under different objective cases, concluding that the improved multiobjective optimization methodology using DI-PSO is more efficient as compared with those designs obtained using single optimization.Peer ReviewedPostprint (published version

Strategies for multiobjective genetic algorithm development: Application to optimal batch plant design in process systems engineering

This work deals with multiobjective optimization problems using Genetic Algorithms (GA). A MultiObjective GA (MOGA) is proposed to solve multiobjective problems combining both continuous and discrete variables. This kind of problem is commonly found in chemical engineering since process design and operability involve structural and decisional choices as well as the determination of operating conditions. In this paper, a design of a basic MOGA which copes successfully with a range of typical chemical engineering optimization problems is considered and the key points of its architecture described in detail. Several performance tests are presented, based on the influence of bit ranging encoding in a chromosome. Four mathematical functions were used as a test bench. The MOGA was able to find the optimal solution for each objective function, as well as an important number of Pareto optimal solutions. Then, the results of two multiobjective case studies in batch plant design and retrofit were presented, showing the flexibility and adaptability of the MOGA to deal with various engineering problems

A nature-inspired multi-objective optimisation strategy based on a new reduced space searching algorithm for the design of alloy steels

In this paper, a salient search and optimisation algorithm based on a new reduced space searching strategy, is presented. This algorithm originates from an idea which relates to a simple experience when humans search for an optimal solution to a ‘real-life’ problem, i.e. when humans search for a candidate solution given a certain objective, a large area tends to be scanned first; should one succeed in finding clues in relation to the predefined objective, then the search space is greatly reduced for a more detailed search. Furthermore, this new algorithm is extended to the multi-objective optimisation case. Simulation results of optimising some challenging benchmark problems suggest that both the proposed single objective and multi-objective optimisation algorithms outperform some of the other well-known Evolutionary Algorithms (EAs). The proposed algorithms are further applied successfully to the optimal design problem of alloy steels, which aims at determining the optimal heat treatment regime and the required weight percentages for chemical composites to obtain the desired mechanical properties of steel hence minimising production costs and achieving the overarching aim of ‘right-first-time production’ of metals

ETEA: A euclidean minimum spanning tree-Based evolutionary algorithm for multiobjective optimization

© the Massachusetts Institute of TechnologyAbstract The Euclidean minimum spanning tree (EMST), widely used in a variety of domains, is a minimum spanning tree of a set of points in the space, where the edge weight between each pair of points is their Euclidean distance. Since the generation of an EMST is entirely determined by the Euclidean distance between solutions (points), the properties of EMSTs have a close relation with the distribution and position information of solutions. This paper explores the properties of EMSTs and proposes an EMST-based Evolutionary Algorithm (ETEA) to solve multiobjective optimization problems (MOPs). Unlike most EMO algorithms that focus on the Pareto dominance relation, the proposed algorithm mainly considers distance-based measures to evaluate and compare individuals during the evolutionary search. Specifically in ETEA, four strategies are introduced: 1) An EMST-based crowding distance (ETCD) is presented to estimate the density of individuals in the population; 2) A distance comparison approach incorporating ETCD is used to assign the fitness value for individuals; 3) A fitness adjustment technique is designed to avoid the partial overcrowding in environmental selection; 4) Three diversity indicators-the minimum edge, degree, and ETCD-with regard to EMSTs are applied to determine the survival of individuals in archive truncation. From a series of extensive experiments on 32 test instances with different characteristics, ETEA is found to be competitive against five state-of-the-art algorithms and its predecessor in providing a good balance among convergence, uniformity, and spread.Engineering and Physical Sciences Research Council (EPSRC) of the United Kingdom under Grant EP/K001310/1, and the National Natural Science Foundation of China under Grant 61070088

A test problem for visual investigation of high-dimensional multi-objective search

An inherent problem in multiobjective optimization is that the visual observation of solution vectors with four or more objectives is infeasible, which brings major difficulties for algorithmic design, examination, and development. This paper presents a test problem, called the Rectangle problem, to aid the visual investigation of high-dimensional multiobjective search. Key features of the Rectangle problem are that the Pareto optimal solutions 1) lie in a rectangle in the two-variable decision space and 2) are similar (in the sense of Euclidean geometry) to their images in the four-dimensional objective space. In this case, it is easy to examine the behavior of objective vectors in terms of both convergence and diversity, by observing their proximity to the optimal rectangle and their distribution in the rectangle, respectively, in the decision space. Fifteen algorithms are investigated. Underperformance of Pareto-based algorithms as well as most state-of-the-art many-objective algorithms indicates that the proposed problem not only is a good tool to help visually understand the behavior of multiobjective search in a high-dimensional objective space but also can be used as a challenging benchmark function to test algorithms' ability in balancing the convergence and diversity of solutions