Applicable Solutions in Non-Linear Dynamical Systems

From Preface: The 15th International Conference „Dynamical Systems - Theory and Applications” (DSTA 2019, 2-5 December, 2019, Lodz, Poland) gathered a numerous group of outstanding scientists and engineers who deal with widely understood problems of theoretical and applied dynamics. Organization of the conference would not have been possible without great effort of the staff of the Department of Automation, Biomechanics and Mechatronics of the Lodz University of Technology. The patronage over the conference has been taken by the Committee of Mechanics of the Polish Academy of Sciences and Ministry of Science and Higher Education of Poland. It is a great pleasure that our event was attended by over 180 researchers from 35 countries all over the world, who decided to share the results of their research and experience in different fields related to dynamical systems. This year, the DSTA Conference Proceedings were split into two volumes entitled „Theoretical Approaches in Non-Linear Dynamical Systems” and „Applicable Solutions in Non-Linear Dynamical Systems”. In addition, DSTA 2019 resulted in three volumes of Springer Proceedings in Mathematics and Statistics entitled „Control and Stability of Dynamical Systems”, „Mathematical and Numerical Approaches in Dynamical Systems” and „Dynamical Systems in Mechatronics and Life Sciences”. Also, many outstanding papers will be recommended to special issues of renowned scientific journals.Cover design: Kaźmierczak, MarekTechnical editor: Kaźmierczak, Mare

12th International Conference on Vibrations in Rotating Machinery

Since 1976, the Vibrations in Rotating Machinery conferences have successfully brought industry and academia together to advance state-of-the-art research in dynamics of rotating machinery. 12th International Conference on Vibrations in Rotating Machinery contains contributions presented at the 12th edition of the conference, from industrial and academic experts from different countries. The book discusses the challenges in rotor-dynamics, rub, whirl, instability and more. The topics addressed include: - Active, smart vibration control - Rotor balancing, dynamics, and smart rotors - Bearings and seals - Noise vibration and harshness - Active and passive damping - Applications: wind turbines, steam turbines, gas turbines, compressors - Joints and couplings - Challenging performance boundaries of rotating machines - High power density machines - Electrical machines for aerospace - Management of extreme events - Active machines - Electric supercharging - Blades and bladed assemblies (forced response, flutter, mistuning) - Fault detection and condition monitoring - Rub, whirl and instability - Torsional vibration Providing the latest research and useful guidance, 12th International Conference on Vibrations in Rotating Machinery aims at those from industry or academia that are involved in transport, power, process, medical engineering, manufacturing or construction

12th International Conference on Vibrations in Rotating Machinery

Since 1976, the Vibrations in Rotating Machinery conferences have successfully brought industry and academia together to advance state-of-the-art research in dynamics of rotating machinery. 12th International Conference on Vibrations in Rotating Machinery contains contributions presented at the 12th edition of the conference, from industrial and academic experts from different countries. The book discusses the challenges in rotor-dynamics, rub, whirl, instability and more. The topics addressed include: - Active, smart vibration control - Rotor balancing, dynamics, and smart rotors - Bearings and seals - Noise vibration and harshness - Active and passive damping - Applications: wind turbines, steam turbines, gas turbines, compressors - Joints and couplings - Challenging performance boundaries of rotating machines - High power density machines - Electrical machines for aerospace - Management of extreme events - Active machines - Electric supercharging - Blades and bladed assemblies (forced response, flutter, mistuning) - Fault detection and condition monitoring - Rub, whirl and instability - Torsional vibration Providing the latest research and useful guidance, 12th International Conference on Vibrations in Rotating Machinery aims at those from industry or academia that are involved in transport, power, process, medical engineering, manufacturing or construction

New lipid-based formulation approaches and characterization tools for hot-melt extrusion

Amorphous solid dispersions (SDs) are considered as one of the most effective strategies for the formulation of poorly water-soluble compounds. The active compound is dispersed in an inert carrier composed of a polymer and active excipients. Since the drug is amorphous, there is typically an increase in apparent solubility as well as dissolution rate. Various methods are employed for manufacturing of SDs, nevertheless, hot-melt extrusion (HME) has become one of the most common process techniques. Indeed, as a solvent-free, one-step continuous process allowing the production of a wide variety of solid dosage forms, HME has emerged as an attractive method. Among the excipients that can be used for SD development, lipid-based excipients are particularly interesting for the formulation of lipophilic compounds. They act as drug solubilizers and stabilizers by improving the chemical and physical stability of drugs. Among poorly water-soluble compounds those exhibiting both high crystallinity and lipophilicity are particularly challenging and require specific formulation considerations. A simple polymeric system might not be sufficient to obtain amorphous SDs. This can lead to sophisticated systems in structure and composition, which are hence rather complex to characterize by means of conventional analysis methods. The present thesis consists of four studies that aim at developing novel lipid-based formulations for crystalline lipophilic compounds by means of HME and that introduce new characterization methods. For this purpose, β-carotene (BC) was selected as a high melting point, poorly water-soluble model compound. The objective of the first study was to compare the ability of state-of-the-art methods to detect the presence of low-dose crystalline compounds in lipid matrices. Sensitivity issues were encountered using conventional methods, therefore a new analytical tool was introduced. The novel flow-through cross-polarized imaging combined the advantages of analyzing large sample sizes and the high sensitivity of a microscopic technique. Small amounts of crystalline materials could easily be detected and an upper limit of the kinetic solubility of the model compound could be estimated. The second study aimed at designing lipid microdomains for drug delivery systems produced by HME. A polymer, a solid fatty acid and an inorganic adsorbent were combined. The acidic lipid was meant to adsorb onto the inorganic carrier to create so called designed lipid microdomains (DLMs) to host an active compound. The employed analytical methods supported the assumption of specific molecular interactions between the fatty acid and the adsorbent. These interactions fostered the amorphization and stabilization of the acidic lipid and lead to the targeted DLM. The novel delivery system appeared to be promising for inclusion of a crystalline lipophilic compound. In the third study, hot-melt extrudates composed of a polymer, a liquid lipid and different kinds of silica-based adsorbents were produced. Such formulations exhibited a complex microstructure. Since the microstructure can influence the final dosage form quality attributes, the aim was to introduce a mathematical tool for structural analysis of extrudates. This work introduced the multifractal formalism in the field of pharmaceutics and showed that the adsorbent concentration, the type of adsorbent as well as the screw speed had an influence on the microstructure. This study was complemented by self-dispersion analysis since it can condition release of any active compound. We showed that the self-dispersion ability of extrudates can be modified by the lipophilic or hydrophilic nature of the adsorbent. The multifractal and self-dispersion studies appeared to be complementary to better understand complex formulations and future work should evaluate specific effects on drug formulation microstructure. Finally, in the fourth study a polymer, a liquid lipid and two types of adsorbents were employed as excipients for HME. Using these ingredients, amorphous SDs of BC were produced. The influence of the adsorbent type as well as the presence of amorphous substance on the microstructure was assessed by multifractal analysis. This structural analysis was complemented by mechanical analysis of extrudates. Our results suggested that the type of adsorbent and the presence of amorphous compound had an impact on the extrudate microstructure and thus on the mechanical performance. These findings evidenced the complementarity of the two methods, which could further be used in the development of dosage forms that require knowledge on mechanical properties. This thesis introduced new lipid-based delivery systems for poorly-water soluble compounds. Novel excipient combinations, involving polymer matrices, lipid-based excipients and inorganic adsorbents, have been suggested for HME and state-of-the-art characterization methods were complemented by new analytical tools to better understand complex formulations. A flow-through cross polarized imaging technique allowed overcoming sensitivity issues encountered otherwise with conventional methods. Moreover, multifractal formalism complemented by self-dispersion imaging provided key insights into pharmaceutical dosage form microstructure that is hardly accessible using conventional methods. These new approaches for HME bear much potential in pharmaceutical technology to tailor dosage form performance

Proceedings of the 2018 Canadian Society for Mechanical Engineering (CSME) International Congress

Published proceedings of the 2018 Canadian Society for Mechanical Engineering (CSME) International Congress, hosted by York University, 27-30 May 2018

Advanced Automation for Space Missions

The feasibility of using machine intelligence, including automation and robotics, in future space missions was studied

Queensland Institute of Technology: Handbook 1971

The Queensland Institute of Technology handbook gives an outline of the faculties and subject offerings available that were offered by QIT

Social work with airports passengers

Social work at the airport is in to offer to passengers social services. The main methodological position is that people are under stress, which characterized by a particular set of characteristics in appearance and behavior. In such circumstances passenger attracts in his actions some attention. Only person whom he trusts can help him with the documents or psychologically

List of Bureau of Mines publications and articles, January 1, 1965, to December 31, 1969, with subject and author index

"This compilation supplements the 50-year list of Bureau publications issued from July 1, 1910, to January 1, 1960; the 50-year list of articles by Bureau authors published outside the Bureau from July 1, 1910, to January 1, 1960; and the 5-year list of Bureau publications and articles published from January 1, 1960, to December 31, 1964. It includes all the material in the four annual lists of Bureau publications and articles for January 1, 1965, to December 31, 1968, as well as the Bureau publications and articles for 1969. More than 2,500 publications by Bureau authors published in the regular Bureau of Mines series, in scientific, technical, or trade journals, or in other media are listed and summarized; those available from the Bureau of Mines are indicated. Libraries which maintain files of Bureau publications are listed. Cooperative publications issued by organizations with which the Bureau conducted joint research are described. Patents issued to Bureau personnel are also listed, and instructions are given on how to apply for permission to use them. One of the outstanding features of this special publication is an exhaustive subject and author index." - NIOSHTIC-2NIOSHTIC no. 1000888719701171