A Review of the Teaching and Learning on Power Electronics Course

—In this review, we describe various kinds of problem and solution related teaching and learning on power electronics course all around the world. The method was used the study of literature on journal articles and proceedings published by reputable international organizations. Thirtynine papers were obtained using Boolean operators, according to the specified criteria. The results of the problems generally established that student learning motivation was low, teaching approaches that are still teacher-centered, the scope of the curriculum extends, and the physical limitations of laboratory equipment. The solutions offered are very diverse ranging from models, strategies, methods and learning techniques supported by information and communication technology

Analysis of contrast-enhanced medical images.

Early detection of human organ diseases is of great importance for the accurate diagnosis and institution of appropriate therapies. This can potentially prevent progression to end-stage disease by detecting precursors that evaluate organ functionality. In addition, it also assists the clinicians for therapy evaluation, tracking diseases progression, and surgery operations. Advances in functional and contrast-enhanced (CE) medical images enabled accurate noninvasive evaluation of organ functionality due to their ability to provide superior anatomical and functional information about the tissue-of-interest. The main objective of this dissertation is to develop a computer-aided diagnostic (CAD) system for analyzing complex data from CE magnetic resonance imaging (MRI). The developed CAD system has been tested in three case studies: (i) early detection of acute renal transplant rejection, (ii) evaluation of myocardial perfusion in patients with ischemic heart disease after heart attack; and (iii), early detection of prostate cancer. However, developing a noninvasive CAD system for the analysis of CE medical images is subject to multiple challenges, including, but are not limited to, image noise and inhomogeneity, nonlinear signal intensity changes of the images over the time course of data acquisition, appearances and shape changes (deformations) of the organ-of-interest during data acquisition, determination of the best features (indexes) that describe the perfusion of a contrast agent (CA) into the tissue. To address these challenges, this dissertation focuses on building new mathematical models and learning techniques that facilitate accurate analysis of CAs perfusion in living organs and include: (i) accurate mathematical models for the segmentation of the object-of-interest, which integrate object shape and appearance features in terms of pixel/voxel-wise image intensities and their spatial interactions; (ii) motion correction techniques that combine both global and local models, which exploit geometric features, rather than image intensities to avoid problems associated with nonlinear intensity variations of the CE images; (iii) fusion of multiple features using the genetic algorithm. The proposed techniques have been integrated into CAD systems that have been tested in, but not limited to, three clinical studies. First, a noninvasive CAD system is proposed for the early and accurate diagnosis of acute renal transplant rejection using dynamic contrast-enhanced MRI (DCE-MRI). Acute rejection–the immunological response of the human immune system to a foreign kidney–is the most sever cause of renal dysfunction among other diagnostic possibilities, including acute tubular necrosis and immune drug toxicity. In the U.S., approximately 17,736 renal transplants are performed annually, and given the limited number of donors, transplanted kidney salvage is an important medical concern. Thus far, biopsy remains the gold standard for the assessment of renal transplant dysfunction, but only as the last resort because of its invasive nature, high cost, and potential morbidity rates. The diagnostic results of the proposed CAD system, based on the analysis of 50 independent in-vivo cases were 96% with a 95% confidence interval. These results clearly demonstrate the promise of the proposed image-based diagnostic CAD system as a supplement to the current technologies, such as nuclear imaging and ultrasonography, to determine the type of kidney dysfunction. Second, a comprehensive CAD system is developed for the characterization of myocardial perfusion and clinical status in heart failure and novel myoregeneration therapy using cardiac first-pass MRI (FP-MRI). Heart failure is considered the most important cause of morbidity and mortality in cardiovascular disease, which affects approximately 6 million U.S. patients annually. Ischemic heart disease is considered the most common underlying cause of heart failure. Therefore, the detection of the heart failure in its earliest forms is essential to prevent its relentless progression to premature death. While current medical studies focus on detecting pathological tissue and assessing contractile function of the diseased heart, this dissertation address the key issue of the effects of the myoregeneration therapy on the associated blood nutrient supply. Quantitative and qualitative assessment in a cohort of 24 perfusion data sets demonstrated the ability of the proposed framework to reveal regional perfusion improvements with therapy, and transmural perfusion differences across the myocardial wall; thus, it can aid in follow-up on treatment for patients undergoing the myoregeneration therapy. Finally, an image-based CAD system for early detection of prostate cancer using DCE-MRI is introduced. Prostate cancer is the most frequently diagnosed malignancy among men and remains the second leading cause of cancer-related death in the USA with more than 238,000 new cases and a mortality rate of about 30,000 in 2013. Therefore, early diagnosis of prostate cancer can improve the effectiveness of treatment and increase the patient’s chance of survival. Currently, needle biopsy is the gold standard for the diagnosis of prostate cancer. However, it is an invasive procedure with high costs and potential morbidity rates. Additionally, it has a higher possibility of producing false positive diagnosis due to relatively small needle biopsy samples. Application of the proposed CAD yield promising results in a cohort of 30 patients that would, in the near future, represent a supplement of the current technologies to determine prostate cancer type. The developed techniques have been compared to the state-of-the-art methods and demonstrated higher accuracy as shown in this dissertation. The proposed models (higher-order spatial interaction models, shape models, motion correction models, and perfusion analysis models) can be used in many of today’s CAD applications for early detection of a variety of diseases and medical conditions, and are expected to notably amplify the accuracy of CAD decisions based on the automated analysis of CE images

Phenomenological modeling of image irradiance for non-Lambertian surfaces under natural illumination.

Various vision tasks are usually confronted by appearance variations due to changes of illumination. For instance, in a recognition system, it has been shown that the variability in human face appearance is owed to changes to lighting conditions rather than person\u27s identity. Theoretically, due to the arbitrariness of the lighting function, the space of all possible images of a fixed-pose object under all possible illumination conditions is infinite dimensional. Nonetheless, it has been proven that the set of images of a convex Lambertian surface under distant illumination lies near a low dimensional linear subspace. This result was also extended to include non-Lambertian objects with non-convex geometry. As such, vision applications, concerned with the recovery of illumination, reflectance or surface geometry from images, would benefit from a low-dimensional generative model which captures appearance variations w.r.t. illumination conditions and surface reflectance properties. This enables the formulation of such inverse problems as parameter estimation. Typically, subspace construction boils to performing a dimensionality reduction scheme, e.g. Principal Component Analysis (PCA), on a large set of (real/synthesized) images of object(s) of interest with fixed pose but different illumination conditions. However, this approach has two major problems. First, the acquired/rendered image ensemble should be statistically significant vis-a-vis capturing the full behavior of the sources of variations that is of interest, in particular illumination and reflectance. Second, the curse of dimensionality hinders numerical methods such as Singular Value Decomposition (SVD) which becomes intractable especially with large number of large-sized realizations in the image ensemble. One way to bypass the need of large image ensemble is to construct appearance subspaces using phenomenological models which capture appearance variations through mathematical abstraction of the reflection process. In particular, the harmonic expansion of the image irradiance equation can be used to derive an analytic subspace to represent images under fixed pose but different illumination conditions where the image irradiance equation has been formulated in a convolution framework. Due to their low-frequency nature, irradiance signals can be represented using low-order basis functions, where Spherical Harmonics (SH) has been extensively adopted. Typically, an ideal solution to the image irradiance (appearance) modeling problem should be able to incorporate complex illumination, cast shadows as well as realistic surface reflectance properties, while moving away from the simplifying assumptions of Lambertian reflectance and single-source distant illumination. By handling arbitrary complex illumination and non-Lambertian reflectance, the appearance model proposed in this dissertation moves the state of the art closer to the ideal solution. This work primarily addresses the geometrical compliance of the hemispherical basis for representing surface reflectance while presenting a compact, yet accurate representation for arbitrary materials. To maintain the plausibility of the resulting appearance, the proposed basis is constructed in a manner that satisfies the Helmholtz reciprocity property while avoiding high computational complexity. It is believed that having the illumination and surface reflectance represented in the spherical and hemispherical domains respectively, while complying with the physical properties of the surface reflectance would provide better approximation accuracy of image irradiance when compared to the representation in the spherical domain. Discounting subsurface scattering and surface emittance, this work proposes a surface reflectance basis, based on hemispherical harmonics (HSH), defined on the Cartesian product of the incoming and outgoing local hemispheres (i.e. w.r.t. surface points). This basis obeys physical properties of surface reflectance involving reciprocity and energy conservation. The basis functions are validated using analytical reflectance models as well as scattered reflectance measurements which might violate the Helmholtz reciprocity property (this can be filtered out through the process of projecting them on the subspace spanned by the proposed basis, where the reciprocity property is preserved in the least-squares sense). The image formation process of isotropic surfaces under arbitrary distant illumination is also formulated in the frequency space where the orthogonality relation between illumination and reflectance bases is encoded in what is termed as irradiance harmonics. Such harmonics decouple the effect of illumination and reflectance from the underlying pose and geometry. Further, a bilinear approach to analytically construct irradiance subspace is proposed in order to tackle the inherent problem of small-sample-size and curse of dimensionality. The process of finding the analytic subspace is posed as establishing a relation between its principal components and that of the irradiance harmonics basis functions. It is also shown how to incorporate prior information about natural illumination and real-world surface reflectance characteristics in order to capture the full behavior of complex illumination and non-Lambertian reflectance. The use of the presented theoretical framework to develop practical algorithms for shape recovery is further presented where the hitherto assumed Lambertian assumption is relaxed. With a single image of unknown general illumination, the underlying geometrical structure can be recovered while accounting explicitly for object reflectance characteristics (e.g. human skin types for facial images and teeth reflectance for human jaw reconstruction) as well as complex illumination conditions. Experiments on synthetic and real images illustrate the robustness of the proposed appearance model vis-a-vis illumination variation. Keywords: computer vision, computer graphics, shading, illumination modeling, reflectance representation, image irradiance, frequency space representations, {hemi)spherical harmonics, analytic bilinear PCA, model-based bilinear PCA, 3D shape reconstruction, statistical shape from shading

Aerospace medicine and biology: A continuing bibliography with indexes, supplement 204

This bibliography lists 140 reports, articles, and other documents introduced into the NASA scientific and technical information system in February 1980

Models and Analysis of Vocal Emissions for Biomedical Applications

The MAVEBA Workshop proceedings, held on a biannual basis, collect the scientific papers presented both as oral and poster contributions, during the conference. The main subjects are: development of theoretical and mechanical models as an aid to the study of main phonatory dysfunctions, as well as the biomedical engineering methods for the analysis of voice signals and images, as a support to clinical diagnosis and classification of vocal pathologies

Simulation of the spatial structure and cellular organization evolution of cell aggregates arranged in various simple geometries, using a kinetic monte carlo method applied to a lattice model

ilustraciones, graficasEsta tesis trata los modelos de morfogénesis, en particular los modelos de evolución guiada por contacto que son coherentes con la hipótesis de la adhesión diferencial. Se presenta una revisión de algunos modelos, sus principios biológicos subyacentes, la relevancia y aplicaciones en el marco de la bioimpresión, la ingeniería de tejidos y la bioconvergencia. Luego, se presentan los detalles de los modelos basados en métodos de Monte Carlo para profundizar más adelante en el modelo basados en algoritmos Kinetic Monte Carlo (KMC) , más específicamente, se describe en detalle un modelo KMC de autoaprendizaje (SL-KMC). Se presenta y explica la estructura algorítmica del código implementado, se evalúa el rendimiento del modelo y se compara con un modelo KMC tradicional. Finalmente, se realizan los procesos de calibración y validación, se observó que el modelo es capaz de replicar la evolución del sistema multicelular cuando las condiciones de energía interfacial del sistema simulado son similares a las del sistema de calibraciones. (Texto tomado de la fuente)This thesis treats the models for morphogenesis, in particular the contact-guided evolution models that are coherent with the differential adhesion hypothesis. A review of some models, their biological underpinning principles, the relevance and applications in the framework of bioprinting, tissue engineering and bioconvergence are presented. Then the details for the Monte Carlo methods-based models are presented to later deep dive into the Kinetic Monte Carlo (KMC) based model, and more specifically a Self-Learning KMC (SL-KMC) model is described to detail. The algorithmic structure of the implemented code is presented and explained, the model performance is assessed and compared with a traditional KMC model. Finally, the calibration and validation processes have been carried out, it was observed that the model is able to replicate the multicellular system evolution when the interfacial energy conditions of the simulated system are similar to those of the calibrations system.MaestríaMagíster en Ingeniería - Ingeniería Químic

Segmentation and quantification of spinal cord gray matter–white matter structures in magnetic resonance images

This thesis focuses on finding ways to differentiate the gray matter (GM) and white matter (WM) in magnetic resonance (MR) images of the human spinal cord (SC). The aim of this project is to quantify tissue loss in these compartments to study their implications on the progression of multiple sclerosis (MS). To this end, we propose segmentation algorithms that we evaluated on MR images of healthy volunteers. Segmentation of GM and WM in MR images can be done manually by human experts, but manual segmentation is tedious and prone to intra- and inter-rater variability. Therefore, a deterministic automation of this task is necessary. On axial 2D images acquired with a recently proposed MR sequence, called AMIRA, we experiment with various automatic segmentation algorithms. We first use variational model-based segmentation approaches combined with appearance models and later directly apply supervised deep learning to train segmentation networks. Evaluation of the proposed methods shows accurate and precise results, which are on par with manual segmentations. We test the developed deep learning approach on images of conventional MR sequences in the context of a GM segmentation challenge, resulting in superior performance compared to the other competing methods. To further assess the quality of the AMIRA sequence, we apply an already published GM segmentation algorithm to our data, yielding higher accuracy than the same algorithm achieves on images of conventional MR sequences. On a different topic, but related to segmentation, we develop a high-order slice interpolation method to address the large slice distances of images acquired with the AMIRA protocol at different vertebral levels, enabling us to resample our data to intermediate slice positions. From the methodical point of view, this work provides an introduction to computer vision, a mathematically focused perspective on variational segmentation approaches and supervised deep learning, as well as a brief overview of the underlying project's anatomical and medical background