2,831 research outputs found
Design of a Simulator for Neonatal Multichannel EEG: Application to Time-Frequency Approaches for Automatic Artifact Removal and Seizure Detection
The electroencephalogram (EEG) is used to noninvasively monitor brain activities; it is the most utilized tool to detect abnormalities such as seizures.
In recent studies, detection of neonatal EEG seizures has been automated to assist neurophysiologists in diagnosing EEG as manual detection is time consuming and subjective; however it still lacks the necessary robustness that is required for clinical implementation. Moreover, as EEG is intended to record the cerebral activities, extra-cerebral activities external to the brain are also recorded; these are called “artifacts” and can seriously degrade the accuracy of seizure detection.
Seizures are one of the most common neurologic problems managed by hospitals occurring in 0.1%-0.5% livebirths. Neonates with seizures are at higher risk for mortality and are reported to be 55-70 times more likely to have severe cerebral-palsy. Therefore, early and accurate detection of neonatal seizures is important to prevent long-term neurological damage.
Several attempts in modelling the neonatal EEG and artifacts have been done, but most did not consider the multichannel case. Furthermore, these models were used to test artifact or seizure detection separately, but not together. This study aims to design synthetic models that generate clean or corrupted multichannel EEG to test the accuracy of available artifact and seizure detection algorithms in a controlled environment.
In this thesis, synthetic neonatal EEG model is constructed by using; single-channel EEG simulators, head model, 21-electrodes, and propagation equations, to produce clean multichannel EEG. Furthermore, neonatal EEG artifact model is designed using synthetic signals to corrupt EEG waveforms. After that, an automated EEG artifact detection and removal system is designed in both time and time-frequency domains. Artifact detection is optimised and removal performance is evaluated. Finally, an automated seizure detection technique is developed, utilising fused and extended multichannel features along a cross-validated SVM classifier.
Results show that the synthetic EEG model mimics real neonatal EEG with 0.62 average correlation, and corrupted-EEG can degrade seizure detection average accuracy from 100% to 70.9%. They also show that using artifact detection and removal enhances the average accuracy to 89.6%, and utilising the extended features enhances it to 97.4% and strengthened its robustness.لمراقبة ورصد أنشطة واشارات المخ، دون الحاجة لأي عملیات (EEG) یستخدم الرسم أو التخطیط الكھربائي للدماغ
للدماغجراحیة، وھي تعد الأداة الأكثر استخداما في الكشف عن أي شذوذأو نوبات غیر طبیعیة مثل نوبات الصرع. وقد أظھرت دراسات حدیثة، أن الكشف الآلي لنوبات حدیثي الولادة، ساعد علماء الفسیولوجیا العصبیة في تشخیص الاشارات الدماغیة بشكل أكبر من الكشف الیدوي، حیث أن الكشف الیدوي یحتاج إلى وقت وجھد أكبر وھوذو فعالیة أقل بكثیر، إلا أنھ لا یزال یفتقر إلى المتانة الضروریة والمطلوبة للتطبیق السریري.علاوة على ذلك؛ فكما یقوم الرسم الكھربائي بتسجیل الأنشطة والإشارات الدماغیة الداخلیة، فھو یسجل أیضا أي نشاط أو اشارات خارجیة، مما یؤدي إلى -(artifacts) :حدوث خلل في مدى دقة وفعالیة الكشف عن النوبات الدماغیة الداخلیة، ویطلق على تلك الاشارات مسمى (نتاج صنعي) . 0.5٪ولادة حدیثة في -٪تعد نوبات الصرع من أكثر المشكلات العصبیة انتشارا،ً وھي تصیب ما یقارب 0.1المستشفیات. حیث أن حدیثي الولادة المصابین بنوبات الصرع ھم أكثر عرضة للوفاة، وكما تشیر التقاریر الى أنھم 70مرة أكثر. لذا یعد الكشف المبكر والدقیق للنوبات الدماغیة -معرضین للإصابة بالشلل الدماغي الشدید بما یقارب 55لحدیثي الولادة مھم جدا لمنع الضرر العصبي على المدى الطویل. لقد تم القیام بالعدید من المحاولات التي كانتتھدف الى تصمیم نموذج التخطیط الكھربائي والنتاج الصنعي لدماغ حدیثي الولادة, إلا أن معظمھا لم یعر أي اھتمام الى قضیة تعدد القنوات. إضافة الى ذلك, استخدمت ھذه النماذج , كل على حدة, أو نوبات الصرع. تھدف ھذه الدراسة الى تصمیم نماذج مصطنعة من شأنھا (artifact) لإختبار كاشفات النتاج الصنعيأن تولد اشارات دماغیة متعددة القنوات سلیمة أو معطلة وذلك لفحص مدى دقة فعالیة خوارزمیات الكشف عن نوبات ضمن بیئة یمكن السیطرة علیھا. (artifact) الصرع و النتاج الصنعي في ھذه الأطروحة, یتكون نموذج الرسم الكھربائي المصطنع لحدیثي الولادة من : قناة محاكاة واحده للرسم الكھربائي, نموذج رأس, 21قطب كھربائي و معادلات إنتشار. حیث تھدف جمیعھا لإنتاج إشاراة سلیمة متعدده القنوات للتخطیط عن طریق استخدام اشارات مصطنعة (artifact) الكھربائي للدماغ.علاوة على ذلك, لقد تم تصمیم نموذجالنتاج الصنعيفي نطاقالوقت و (artifact) لإتلاف الرسم الكھربائي للدماغ. بعد ذلك تم انشاء برنامج لكشف و إزالةالنتاج الصناعينطاقالوقت و التردد المشترك. تم تحسین برنامج الكشف النتاج الصناعيالى ابعد ما یمكن بینما تمت عملیة تقییم أداء الإزالة. وفي الختام تم التمكن من تطویر تقنیة الكشف الآلي عن نوبات الصرع, وذلك بتوظیف صفات مدمجة و صفات الذي تم التأكد من صحتھ. (SVM) جدیدة للقنوات المتعددة لإستخدامھا للمصنفلقد أظھرت النتائج أن نموذج الرسم الكھربائي المصطنع لحدیثي الولادة یحاكي الرسمالكھربائي الحقیقي لحدیثي الولادة بمتوسط ترابط 0.62, و أنالرسم الكھربائي المتضرر للدماغ قد یؤدي الى حدوث ھبوطفي مدى دقة متوسط الكشف عن نوبات الصرع من 100%الى 70.9%. وقد أشارت أیضا الى أن استخدام الكشف والإزالة عن النتاج الصنعي (artifact) یؤدي الى تحسن مستوى الدقة الى نسبة 89.6 %, وأن توظیف الصفات الجدیدة للقنوات المتعددة یزید من
تحسنھا لتصل الى نسبة 94.4 % مما یعمل على دعم متانتھا
System Identification with Applications in Speech Enhancement
As the increasing popularity of integrating hands-free telephony on mobile portable devices
and the rapid development of voice over internet protocol, identification of acoustic
systems has become desirable for compensating distortions introduced to speech signals
during transmission, and hence enhancing the speech quality. The objective of this research
is to develop system identification algorithms for speech enhancement applications
including network echo cancellation and speech dereverberation.
A supervised adaptive algorithm for sparse system identification is developed for
network echo cancellation. Based on the framework of selective-tap updating scheme
on the normalized least mean squares algorithm, the MMax and sparse partial update
tap-selection strategies are exploited in the frequency domain to achieve fast convergence
performance with low computational complexity. Through demonstrating how
the sparseness of the network impulse response varies in the transformed domain, the
multidelay filtering structure is incorporated to reduce the algorithmic delay.
Blind identification of SIMO acoustic systems for speech dereverberation in the
presence of common zeros is then investigated. First, the problem of common zeros is
defined and extended to include the presence of near-common zeros. Two clustering algorithms
are developed to quantify the number of these zeros so as to facilitate the study
of their effect on blind system identification and speech dereverberation. To mitigate such
effect, two algorithms are developed where the two-stage algorithm based on channel
decomposition identifies common and non-common zeros sequentially; and the forced
spectral diversity approach combines spectral shaping filters and channel undermodelling
for deriving a modified system that leads to an improved dereverberation performance.
Additionally, a solution to the scale factor ambiguity problem in subband-based blind system identification is developed, which motivates further research on subbandbased
dereverberation techniques. Comprehensive simulations and discussions demonstrate
the effectiveness of the aforementioned algorithms. A discussion on possible directions
of prospective research on system identification techniques concludes this thesis
Sound Source Separation
This is the author's accepted pre-print of the article, first published as G. Evangelista, S. Marchand, M. D. Plumbley and E. Vincent. Sound source separation. In U. Zölzer (ed.), DAFX: Digital Audio Effects, 2nd edition, Chapter 14, pp. 551-588. John Wiley & Sons, March 2011. ISBN 9781119991298. DOI: 10.1002/9781119991298.ch14file: Proof:e\EvangelistaMarchandPlumbleyV11-sound.pdf:PDF owner: markp timestamp: 2011.04.26file: Proof:e\EvangelistaMarchandPlumbleyV11-sound.pdf:PDF owner: markp timestamp: 2011.04.2
Advanced signal processing methods in dynamic contrast enhanced magnetic resonance imaging
Tato dizertační práce představuje metodu zobrazování perfúze magnetickou rezonancí, jež je výkonným nástrojem v diagnostice, především v onkologii. Po ukončení sběru časové sekvence T1-váhovaných obrazů zaznamenávajících distribuci kontrastní látky v těle začíná fáze zpracování dat, která je předmětem této dizertace. Je zde představen teoretický základ fyziologických modelů a modelů akvizice pomocí magnetické rezonance a celý řetězec potřebný k vytvoření obrazů odhadu parametrů perfúze a mikrocirkulace v tkáni. Tato dizertační práce je souborem uveřejněných prací autora přispívajícím k rozvoji metodologie perfúzního zobrazování a zmíněného potřebného teoretického rozboru.This dissertation describes quantitative dynamic contrast enhanced magnetic resonance imaging (DCE-MRI), which is a powerful tool in diagnostics, mainly in oncology. After a time series of T1-weighted images recording contrast-agent distribution in the body has been acquired, data processing phase follows. It is presented step by step in this dissertation. The theoretical background in physiological and MRI-acquisition modeling is described together with the estimation process leading to parametric maps describing perfusion and microcirculation properties of the investigated tissue on a voxel-by-voxel basis. The dissertation is divided into this theoretical analysis and a set of publications representing particular contributions of the author to DCE-MRI.
Convolutive Blind Source Separation Methods
In this chapter, we provide an overview of existing algorithms for blind source separation of convolutive audio mixtures. We provide a taxonomy, wherein many of the existing algorithms can be organized, and we present published results from those algorithms that have been applied to real-world audio separation tasks
Instrumental and perceptual evaluation of dereverberation techniques based on robust acoustic multichannel equalization
Speech signals recorded in an enclosed space by microphones at a distance from the speaker are often corrupted by reverberation, which arises from the superposition of many delayed and attenuated copies of the source signal. Because reverberation degrades the signal, removing reverberation would enhance quality. Dereverberation techniques based on acoustic multichannel equalization are known to be sensitive to room impulse response perturbations. In order to increase robustness, several methods have been proposed, as for example, using a shorter reshaping filter length, incorporating regularization, or applying a sparsity-promoting penalty function. This paper focuses on evaluating the performance of these methods for single-source multi-microphone scenarios, using instrumental performance measures as well as using subjective listening tests. By analyzing the correlation between the instrumental and the perceptual results, it is shown that signal-based performance measures are more advantageous than channel-based performance measures to evaluate the perceptual speech quality of signals that were dereverberated by equalization techniques. Furthermore, this analysis also demonstrates the need to develop more reliable instrumental performance measures
Efficient Multiband Algorithms for Blind Source Separation
The problem of blind separation refers to recovering original signals, called source signals, from the mixed signals, called observation signals, in a reverberant environment. The mixture is a function of a sequence of original speech signals mixed in a reverberant room. The objective is to separate mixed signals to obtain the original signals without degradation and without prior information of the features of the sources. The strategy used to achieve this objective is to use multiple bands that work at a lower rate, have less computational cost and a quicker convergence than the conventional scheme. Our motivation is the competitive results of unequal-passbands scheme applications, in terms of the convergence speed. The objective of this research is to improve unequal-passbands schemes by improving the speed of convergence and reducing the computational cost. The first proposed work is a novel maximally decimated unequal-passbands scheme.This scheme uses multiple bands that make it work at a reduced sampling rate, and low computational cost. An adaptation approach is derived with an adaptation step that improved the convergence speed. The performance of the proposed scheme was measured in different ways. First, the mean square errors of various bands are measured and the results are compared to a maximally decimated equal-passbands scheme, which is currently the best performing method. The results show that the proposed scheme has a faster convergence rate than the maximally decimated equal-passbands scheme. Second, when the scheme is tested for white and coloured inputs using a low number of bands, it does not yield good results; but when the number of bands is increased, the speed of convergence is enhanced. Third, the scheme is tested for quick changes. It is shown that the performance of the proposed scheme is similar to that of the equal-passbands scheme. Fourth, the scheme is also tested in a stationary state. The experimental results confirm the theoretical work. For more challenging scenarios, an unequal-passbands scheme with over-sampled decimation is proposed; the greater number of bands, the more efficient the separation. The results are compared to the currently best performing method. Second, an experimental comparison is made between the proposed multiband scheme and the conventional scheme. The results show that the convergence speed and the signal-to-interference ratio of the proposed scheme are higher than that of the conventional scheme, and the computation cost is lower than that of the conventional scheme
Space-time processing for wireless mobile communications
Intersymbol interference (ISI) and co-channel interference (CCI) are two major
obstacles to high speed data transmission in wireless cellular communications
systems. Unlike thermal noise, their effects cannot be removed by
increasing the signal power and are time-varying due to the relative motion
between the transmitters and receivers. Space-time processing offers a signal
processing framework to optimally integrate the spatial and temporal properties
of the signal for maximal signal reception and at the same time, mitigate
the ISI and CCI impairments. In this thesis, we focus on the development of
this emerging technology to combat the undesirable effects of ISI and CCL
We first develop a convenient mathematical model to parameterize the
space-time multipath channel based on signal path power, directions and
times of arrival. Starting from the continuous time-domain, we derive compact
expressions of the vector space-time channel model that lead to the
notion of block space-time manifold, Under certain identifiability conditions,
the noiseless vector-channel outputs will lie on a subspace constructed from
a set. of basis belonging to the block space-time manifold. This is an important
observation as many high resolution array processing algorithms Can be
applied directly to estimate the multi path channel parameters.
Next we focus on the development of semi-blind channel identification
and equalization algorithms for fast time-varying multi path channels. Specifically.
we develop space-time processing algorithms for wireless TDMA networks that use short burst data formats with extremely short training data.
sequences. Due to the latter, the estimated channel parameters are extremely
unreliable for equalization with conventional adaptive methods. We approach
the channel acquisition, tracking and equalization problems jointly, and exploit
the richness of the inherent structural relationship between the channel
parameters and the data sequence by repeated use of available data through a forward- backward optimization procedure. This enables the fuller exploitation
of the available data. Our simulation studies show that significant performance
gains are achieved over conventional methods.
In the final part of this thesis, we address the problem identifying and
equalizing multi path communication channels in the presence of strong CCl.
By considering CCI as stochasic processes, we find that temporal diversity
can be gained by observing the channel outputs from a tapped delay line. Together with the assertion that the finite alphabet property of the information
sequences can offer additional information about the channel parameters and
the noise-plus-covariance matrix, we develop a spatial temporal algorithm,
iterative reweighting alternating minimization, to estimate the channel parameters
and information sequence in a weighted least squares framework.
The proposed algorithm is robust as it does not require knowledge of the
number of CCI nor their structural information. Simulation studies demonstrate
its efficacy over many reported methods
Data-driven multivariate and multiscale methods for brain computer interface
This thesis focuses on the development of data-driven multivariate and multiscale methods
for brain computer interface (BCI) systems. The electroencephalogram (EEG), the
most convenient means to measure neurophysiological activity due to its noninvasive nature,
is mainly considered. The nonlinearity and nonstationarity inherent in EEG and its
multichannel recording nature require a new set of data-driven multivariate techniques to
estimate more accurately features for enhanced BCI operation. Also, a long term goal
is to enable an alternative EEG recording strategy for achieving long-term and portable
monitoring.
Empirical mode decomposition (EMD) and local mean decomposition (LMD), fully
data-driven adaptive tools, are considered to decompose the nonlinear and nonstationary
EEG signal into a set of components which are highly localised in time and frequency. It
is shown that the complex and multivariate extensions of EMD, which can exploit common
oscillatory modes within multivariate (multichannel) data, can be used to accurately
estimate and compare the amplitude and phase information among multiple sources, a
key for the feature extraction of BCI system. A complex extension of local mean decomposition
is also introduced and its operation is illustrated on two channel neuronal
spike streams. Common spatial pattern (CSP), a standard feature extraction technique
for BCI application, is also extended to complex domain using the augmented complex
statistics. Depending on the circularity/noncircularity of a complex signal, one of the
complex CSP algorithms can be chosen to produce the best classification performance
between two different EEG classes.
Using these complex and multivariate algorithms, two cognitive brain studies are
investigated for more natural and intuitive design of advanced BCI systems. Firstly, a Yarbus-style auditory selective attention experiment is introduced to measure the user
attention to a sound source among a mixture of sound stimuli, which is aimed at improving
the usefulness of hearing instruments such as hearing aid. Secondly, emotion experiments
elicited by taste and taste recall are examined to determine the pleasure and displeasure
of a food for the implementation of affective computing. The separation between two
emotional responses is examined using real and complex-valued common spatial pattern
methods.
Finally, we introduce a novel approach to brain monitoring based on EEG recordings
from within the ear canal, embedded on a custom made hearing aid earplug. The new
platform promises the possibility of both short- and long-term continuous use for standard
brain monitoring and interfacing applications
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