4,485 research outputs found
Modeling sparse connectivity between underlying brain sources for EEG/MEG
We propose a novel technique to assess functional brain connectivity in
EEG/MEG signals. Our method, called Sparsely-Connected Sources Analysis (SCSA),
can overcome the problem of volume conduction by modeling neural data
innovatively with the following ingredients: (a) the EEG is assumed to be a
linear mixture of correlated sources following a multivariate autoregressive
(MVAR) model, (b) the demixing is estimated jointly with the source MVAR
parameters, (c) overfitting is avoided by using the Group Lasso penalty. This
approach allows to extract the appropriate level cross-talk between the
extracted sources and in this manner we obtain a sparse data-driven model of
functional connectivity. We demonstrate the usefulness of SCSA with simulated
data, and compare to a number of existing algorithms with excellent results.Comment: 9 pages, 6 figure
Disentangling causal webs in the brain using functional Magnetic Resonance Imaging: A review of current approaches
In the past two decades, functional Magnetic Resonance Imaging has been used
to relate neuronal network activity to cognitive processing and behaviour.
Recently this approach has been augmented by algorithms that allow us to infer
causal links between component populations of neuronal networks. Multiple
inference procedures have been proposed to approach this research question but
so far, each method has limitations when it comes to establishing whole-brain
connectivity patterns. In this work, we discuss eight ways to infer causality
in fMRI research: Bayesian Nets, Dynamical Causal Modelling, Granger Causality,
Likelihood Ratios, LiNGAM, Patel's Tau, Structural Equation Modelling, and
Transfer Entropy. We finish with formulating some recommendations for the
future directions in this area
Markov models for fMRI correlation structure: is brain functional connectivity small world, or decomposable into networks?
Correlations in the signal observed via functional Magnetic Resonance Imaging
(fMRI), are expected to reveal the interactions in the underlying neural
populations through hemodynamic response. In particular, they highlight
distributed set of mutually correlated regions that correspond to brain
networks related to different cognitive functions. Yet graph-theoretical
studies of neural connections give a different picture: that of a highly
integrated system with small-world properties: local clustering but with short
pathways across the complete structure. We examine the conditional independence
properties of the fMRI signal, i.e. its Markov structure, to find realistic
assumptions on the connectivity structure that are required to explain the
observed functional connectivity. In particular we seek a decomposition of the
Markov structure into segregated functional networks using decomposable graphs:
a set of strongly-connected and partially overlapping cliques. We introduce a
new method to efficiently extract such cliques on a large, strongly-connected
graph. We compare methods learning different graph structures from functional
connectivity by testing the goodness of fit of the model they learn on new
data. We find that summarizing the structure as strongly-connected networks can
give a good description only for very large and overlapping networks. These
results highlight that Markov models are good tools to identify the structure
of brain connectivity from fMRI signals, but for this purpose they must reflect
the small-world properties of the underlying neural systems
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