Optimized Seamless Integration of Biomolecular Data

Today, scientific data is inevitably digitized, stored in a wide variety of heterogeneous formats, and is accessible over the Internet. Scientists need to access an integrated view of multiple remote or local heterogeneous data sources. They then integrate the results of complex queries and apply further analysis and visualization to support the task of scientific discovery. Building such a digital library for scientific discovery requires accessing and manipulating data extracted from flat files or databases, documents retrieved from the Web, as well as data that is locally materialized in warehouses or is generated by software. We consider several tasks to provide optimized and seamless integration of biomolecular data. Challenges to be addressed include capturing and representing source capabilities; developing a methodology to acquire and represent semantic knowledge and metadata about source contents, overlap in source contents, and access costs; and decision support to select sources and capabilities using cost based and semantic knowledge, and generating low cost query evaluation plans. (Also referenced as UMIACS-TR-2001-51

Federated Query Processing over Heterogeneous Data Sources in a Semantic Data Lake

Data provides the basis for emerging scientific and interdisciplinary data-centric applications with the potential of improving the quality of life for citizens. Big Data plays an important role in promoting both manufacturing and scientific development through industrial digitization and emerging interdisciplinary research. Open data initiatives have encouraged the publication of Big Data by exploiting the decentralized nature of the Web, allowing for the availability of heterogeneous data generated and maintained by autonomous data providers. Consequently, the growing volume of data consumed by different applications raise the need for effective data integration approaches able to process a large volume of data that is represented in different format, schema and model, which may also include sensitive data, e.g., financial transactions, medical procedures, or personal data. Data Lakes are composed of heterogeneous data sources in their original format, that reduce the overhead of materialized data integration. Query processing over Data Lakes require the semantic description of data collected from heterogeneous data sources. A Data Lake with such semantic annotations is referred to as a Semantic Data Lake. Transforming Big Data into actionable knowledge demands novel and scalable techniques for enabling not only Big Data ingestion and curation to the Semantic Data Lake, but also for efficient large-scale semantic data integration, exploration, and discovery. Federated query processing techniques utilize source descriptions to find relevant data sources and find efficient execution plan that minimize the total execution time and maximize the completeness of answers. Existing federated query processing engines employ a coarse-grained description model where the semantics encoded in data sources are ignored. Such descriptions may lead to the erroneous selection of data sources for a query and unnecessary retrieval of data, affecting thus the performance of query processing engine. In this thesis, we address the problem of federated query processing against heterogeneous data sources in a Semantic Data Lake. First, we tackle the challenge of knowledge representation and propose a novel source description model, RDF Molecule Templates, that describe knowledge available in a Semantic Data Lake. RDF Molecule Templates (RDF-MTs) describes data sources in terms of an abstract description of entities belonging to the same semantic concept. Then, we propose a technique for data source selection and query decomposition, the MULDER approach, and query planning and optimization techniques, Ontario, that exploit the characteristics of heterogeneous data sources described using RDF-MTs and provide a uniform access to heterogeneous data sources. We then address the challenge of enforcing privacy and access control requirements imposed by data providers. We introduce a privacy-aware federated query technique, BOUNCER, able to enforce privacy and access control regulations during query processing over data sources in a Semantic Data Lake. In particular, BOUNCER exploits RDF-MTs based source descriptions in order to express privacy and access control policies as well as their automatic enforcement during source selection, query decomposition, and planning. Furthermore, BOUNCER implements query decomposition and optimization techniques able to identify query plans over data sources that not only contain the relevant entities to answer a query, but also are regulated by policies that allow for accessing these relevant entities. Finally, we tackle the problem of interest based update propagation and co-evolution of data sources. We present a novel approach for interest-based RDF update propagation that consistently maintains a full or partial replication of large datasets and deal with co-evolution

INTEGRATION OF DATA FROM HETEROGENEOUS SOURCES USING ETL TECHNOLOGY.

Data integration is a crucial issue in environments of heterogeneous data sources. At present mentioned heterogeneity is becoming widespread. Whenever, based on various data sources, we want to gain useful information and knowledge we must solve data integration problem in order to apply appropriate analytical methods on comprehensive and uniform data. Such activity is known as knowledge discovery from data process. Therefore approaches to data integration problem are very interesting and bring us closer to the "age of information". The paper presents an architecture, which implements knowledge discovery from data process. The solution combines ETL technology and wrapper layer known from mediated systems. It also provides semantic integration through connections mechanism between data elements. The solution allows for integration of any data sources and implementation of analytical methods in one environment. The proposed environment is verified by applying it to data sources on the foundry industry

An ontology engineering approach for knowledge discovery from data in evolving domains

Knowledge discovery in evolving domains presents several challenges in information extraction and knowledge acquisition from heterogeneous, distributed, dynamic data sources. We define an evolving process if the process is developing, changing over time in a continuous manner. Examples of such domains include biological sciences, medical sciences, and social sciences, among others. This paper describes research in progress on a new methodology for leveraging the semantic content of ontologies to improve knowledge discovery in complex and dynamical domains. We consider in this initial stage the problem of how to acquire previous knowledge from data and then use this information in the context of ontology engineering

The Translational Medicine Ontology and Knowledge Base: driving personalized medicine by bridging the gap between bench and bedside

Background: Translational medicine requires the integration of knowledge using heterogeneous data from health care to the life sciences. Here, we describe a collaborative effort to produce a prototype Translational Medicine Knowledge Base (TMKB) capable of answering questions relating to clinical practice and pharmaceutical drug discovery. Results: We developed the Translational Medicine Ontology (TMO) as a unifying ontology to integrate chemical, genomic and proteomic data with disease, treatment, and electronic health records. We demonstrate the use of Semantic Web technologies in the integration of patient and biomedical data, and reveal how such a knowledge base can aid physicians in providing tailored patient care and facilitate the recruitment of patients into active clinical trials. Thus, patients, physicians and researchers may explore the knowledge base to better understand therapeutic options, efficacy, and mechanisms of action. Conclusions: This work takes an important step in using Semantic Web technologies to facilitate integration of relevant, distributed, external sources and progress towards a computational platform to support personalized medicine. Availability: TMO can be downloaded from http://code.google.com/p/translationalmedicineontology and TMKB can be accessed at http://tm.semanticscience.org/sparql

Scalable Data Integration for Linked Data

Linked Data describes an extensive set of structured but heterogeneous datasources where entities are connected by formal semantic descriptions. In thevision of the Semantic Web, these semantic links are extended towards theWorld Wide Web to provide as much machine-readable data as possible forsearch queries. The resulting connections allow an automatic evaluation to findnew insights into the data. Identifying these semantic connections betweentwo data sources with automatic approaches is called link discovery. We derivecommon requirements and a generic link discovery workflow based on similaritiesbetween entity properties and associated properties of ontology concepts. Mostof the existing link discovery approaches disregard the fact that in times ofBig Data, an increasing volume of data sources poses new demands on linkdiscovery. In particular, the problem of complex and time-consuming linkdetermination escalates with an increasing number of intersecting data sources.To overcome the restriction of pairwise linking of entities, holistic clusteringapproaches are needed to link equivalent entities of multiple data sources toconstruct integrated knowledge bases. In this context, the focus on efficiencyand scalability is essential. For example, reusing existing links or backgroundinformation can help to avoid redundant calculations. However, when dealingwith multiple data sources, additional data quality problems must also be dealtwith. This dissertation addresses these comprehensive challenges by designingholistic linking and clustering approaches that enable reuse of existing links.Unlike previous systems, we execute the complete data integration workflowvia a distributed processing system. At first, the LinkLion portal will beintroduced to provide existing links for new applications. These links act asa basis for a physical data integration process to create a unified representationfor equivalent entities from many data sources. We then propose a holisticclustering approach to form consolidated clusters for same real-world entitiesfrom many different sources. At the same time, we exploit the semantic typeof entities to improve the quality of the result. The process identifies errorsin existing links and can find numerous additional links. Additionally, theentity clustering has to react to the high dynamics of the data. In particular,this requires scalable approaches for continuously growing data sources withmany entities as well as additional new sources. Previous entity clusteringapproaches are mostly static, focusing on the one-time linking and clustering ofentities from few sources. Therefore, we propose and evaluate new approaches for incremental entity clustering that supports the continuous addition of newentities and data sources. To cope with the ever-increasing number of LinkedData sources, efficient and scalable methods based on distributed processingsystems are required. Thus we propose distributed holistic approaches to linkmany data sources based on a clustering of entities that represent the samereal-world object. The implementation is realized on Apache Flink. In contrastto previous approaches, we utilize efficiency-enhancing optimizations for bothdistributed static and dynamic clustering. An extensive comparative evaluationof the proposed approaches with various distributed clustering strategies showshigh effectiveness for datasets from multiple domains as well as scalability on amulti-machine Apache Flink cluster

Earth‐Observation Data Access: A Knowledge Discovery Concept for Payload Ground Segments

In recent years the ability to store large quantities of Earth Observation (EO) satellite images has greatly surpassed the ability to access and meaningfully extract information from it. The state-of-the-art of operational systems for Remote Sensing data access (in particular for images) allows queries by geographical location, time of acquisition or type of sensor. Nevertheless, this information is often less relevant than the content of the scene (e.g. specific scattering properties, structures, objects, etc.). Moreover, the continuous increase in the size of the archives and in the variety and complexity of EO sensors require new methodologies and tools - based on a shared knowledge - for information mining and management, in support of emerging applications (e.g.: change detection, global monitoring, disaster and risk management, image time series, etc.). In addition, the current Payload Ground Segments (PGS) are mainly designed for Long Term Data Preservation (LTDP), in this article we propose an alternative solution for enhancing the access to the data content. Our solution presents a knowledge discovery concept, whose intention is to implement a communication channel between the PGS (EO data sources) and the end-user who receives the content of the data sources coded in an understandable format associated with semantics and ready for the exploitation. The first implemented concepts were presented in Knowledge driven content based Image Information Mining (KIM) and Geospatial Information Retrieval and Indexing (GeoIRIS) system as examples of data mining systems. Our new concept is developed in a modular system composed of the following components 1) the data model generation implementing methods for extracting relevant descriptors (low-level features) of the sources (EO images), analyzing their metadata in order to complement the information, and combining with vector data sources coming from Geographical Information Systems. 2) A database management system, where the database structure supports the knowledge management, feature computation, and visualization tools because of the modules for analysis, indexing, training and retrieval are resolved into the database. 3) Data mining and knowledge discovery tools allowing the end-user to perform advanced queries and to assign semantic annotations to the image content. The low-level features are complemented with semantic annotations giving meaning to the image information. The semantic description is based on semi-supervised learning methods for spatio-temporal and contextual pattern discovery. 4) Scene understanding counting on annotation tools for helping the user to create scenarios using EO images as for example change detection analysis, etc. 5) Visual data mining providing Human-Machine Interfaces for navigating and browsing the archive using 2D or 3D representation. The visualization techniques perform an interactive loop in order to optimize the visual interaction with huge volumes of data of heterogeneous nature and the end-user

Computational and human-based methods for knowledge discovery over knowledge graphs

The modern world has evolved, accompanied by the huge exploitation of data and information. Daily, increasing volumes of data from various sources and formats are stored, resulting in a challenging strategy to manage and integrate them to discover new knowledge. The appropriate use of data in various sectors of society, such as education, healthcare, e-commerce, and industry, provides advantages for decision support in these areas. However, knowledge discovery becomes challenging since data may come from heterogeneous sources with important information hidden. Thus, new approaches that adapt to the new challenges of knowledge discovery in such heterogeneous data environments are required. The semantic web and knowledge graphs (KGs) are becoming increasingly relevant on the road to knowledge discovery. This thesis tackles the problem of knowledge discovery over KGs built from heterogeneous data sources. We provide a neuro-symbolic artificial intelligence system that integrates symbolic and sub-symbolic frameworks to exploit the semantics encoded in a KG and its structure. The symbolic system relies on existing approaches of deductive databases to make explicit, implicit knowledge encoded in a KG. The proposed deductive database $DS$ can derive new statements to ego networks given an abstract target prediction. Thus, $DS$ minimizes data sparsity in KGs. In addition, a sub-symbolic system relies on knowledge graph embedding (KGE) models. KGE models are commonly applied in the KG completion task to represent entities in a KG in a low-dimensional vector space. However, KGE models are known to suffer from data sparsity, and a symbolic system assists in overcoming this fact. The proposed approach discovers knowledge given a target prediction in a KG and extracts unknown implicit information related to the target prediction. As a proof of concept, we have implemented the neuro-symbolic system on top of a KG for lung cancer to predict polypharmacy treatment effectiveness. The symbolic system implements a deductive system to deduce pharmacokinetic drug-drug interactions encoded in a set of rules through the Datalog program. Additionally, the sub-symbolic system predicts treatment effectiveness using a KGE model, which preserves the KG structure. An ablation study on the components of our approach is conducted, considering state-of-the-art KGE methods. The observed results provide evidence for the benefits of the neuro-symbolic integration of our approach, where the neuro-symbolic system for an abstract target prediction exhibits improved results. The enhancement of the results occurs because the symbolic system increases the prediction capacity of the sub-symbolic system. Moreover, the proposed neuro-symbolic artificial intelligence system in Industry 4.0 (I4.0) is evaluated, demonstrating its effectiveness in determining relatedness among standards and analyzing their properties to detect unknown relations in the I4.0KG. The results achieved allow us to conclude that the proposed neuro-symbolic approach for an abstract target prediction improves the prediction capability of KGE models by minimizing data sparsity in KGs