Miniaturized Transistors

What is the future of CMOS? Sustaining increased transistor densities along the path of Moore's Law has become increasingly challenging with limited power budgets, interconnect bandwidths, and fabrication capabilities. In the last decade alone, transistors have undergone significant design makeovers; from planar transistors of ten years ago, technological advancements have accelerated to today's FinFETs, which hardly resemble their bulky ancestors. FinFETs could potentially take us to the 5-nm node, but what comes after it? From gate-all-around devices to single electron transistors and two-dimensional semiconductors, a torrent of research is being carried out in order to design the next transistor generation, engineer the optimal materials, improve the fabrication technology, and properly model future devices. We invite insight from investigators and scientists in the field to showcase their work in this Special Issue with research papers, short communications, and review articles that focus on trends in micro- and nanotechnology from fundamental research to applications

L'incontinence urinaire chez des survivantes d'un cancer de l'endomètre : effets d'un programme de réadaptation à distance

Il existe une forte prévalence d'incontinence urinaire (IU) chez les femmes ayant été traitées pour un cancer de l'endomètre (CE). Les connaissances actuelles sur les effets d'un programme de réadaptation pour réduire la sévérité de l'IU pour cette population sont rares. L'objectif principal de cette thèse était de vérifier les effets d'un programme de réadaptation à distance, comprenant l'utilisation d'une technologie mobile, pour réduire la sévérité de l'IU chez des survivantes d'un CE. Les objectifs secondaires visés par les travaux de cette thèse étaient de 1) décrire l'étendue des connaissances actuelles concernant l'utilisation des technologies mobiles pour le traitement de l'IU, 2) faire une synthèse des évidences sur les indices de sensibilité au changement des questionnaires auto-administrés qui mesurent l'impact de l'IU sur la qualité de vie lors d'une intervention conservatrice, et 3) déterminer la fidélité intra et inter-évaluateurs des mesures échographiques pour des mesures morphologiques et fonctionnelles de la vessie, de l'urètre et des muscles du plancher pelvien (MPPs) chez des femmes ayant été traitées avec de la radiothérapie pelvienne. Quatre études ont été réalisées pour rencontrer ces objectifs. La première étude était un examen systématique de la portée des connaissances sur l'utilisation des technologies mobiles pour le traitement conservateur de l'IU. Les résultats ont permis de démontrer que les technologies mobiles étudiées pour le traitement de l'IU présentent plusieurs fonctionnalités et paramètres recommandés pour les soins de santé. Également, les évidences recensées indiquent que l'utilisation des technologies mobiles peut être bénéfique en matière de réduction de la sévérité de l'IU, de satisfaction, de l'adhérence au traitement et des coûts. La deuxième étude était une revue systématique dans laquelle ont été recensées les évidences sur les indices de sensibilité au changement des questionnaires auto-administrés qui mesurent l'impact de l'IU sur la qualité de vie dans un contexte d'intervention conservatrice. Les résultats ont permis de mettre en lumière que le questionnaire bref International Consultation on Incontinence pour l'IU (ICIQ-UI SF) présente la sensibilité interne au changement la plus élevée dans un contexte d'intervention conservatrice. Les résultats indiquent également que l'étude avec la plus haute qualité méthodologique démontrait que c'est le questionnaire PRAFAB qui avait l'indice de sensibilité au changement externe le plus élevé. La troisième étude réalisée a permis de déterminer la fidélité des mesures échographiques transpérinéales de morphologie et de fonction des muscles du plancher pelvien auprès de femmes ayant eu de la radiothérapie pour traiter un cancer pelvien. Les résultats démontrent qu'il existe une très bonne fidélité intra-évaluateur pour mesurer la longueur de la plaque des releveurs au repos (LP-R), lors d'une contraction maximale des MPPs (LP-MVC) et lors d'une manœuvre maximale de Valsalva (LP-MVM), ainsi que pour la longueur de l'urètre (UL). La fidélité inter-évaluateurs est jugée très bonne pour LP-R, et bonne pour LP-MVC, LP-MVM et UL. Cependant, la fidélité intra- et inter-évaluateurs est jugée pauvre pour la mesure de l'épaisseur du mur de la vessie (BWT). Enfin, la quatrième étude était une étude d'intervention qui a été réalisée à l'aide d'un devis expérimental à cas unique avec réplications. Le programme de réadaptation comprenait des exercices des MPPs effectués avec la technologie mobile Elvie, une rééducation vésicale et de l'éducation sur les habitudes de vie favorisant la continence urinaire. Le programme s'est déroulé à distance et était supervisé téléphoniquement par une physiothérapeute. Les résultats indiquent que 7 femmes sur 8 ont amélioré la sévérité de leur IU à la suite du programme de réadaptation selon la mesure principale, le Pad Test d'une heure. De plus, les résultats découlant de l'analyse de groupe démontrent une réduction significative du nombre de fuites urinaires et d'urgences urinaires au journal urinaire de trois jours, ainsi que du score au ICIQ-UI SF. Ainsi, les résultats présentés dans cette thèse soutiennent qu'une approche de réadaptation à domicile, comprenant l'utilisation d'une technologie mobile et une supervision à distance par une physiothérapeute, peut réduire l'IU chez les survivantes d'un CE.There is a high prevalence of urinary incontinence (UI) in women who have been treated for endometrial cancer (CE). Current knowledge on the effects of a rehabilitation program to reduce the severity of UI for this population is scarce. The main objective of this thesis was to verify the effects of an in-home rehabilitation program, including the use of a mobile technology, in reducing the severity of UI in CE survivors. The secondary objectives of the works of this thesis were to 1) describe the extent of current knowledge on the use of mobile technologies for the treatment of UI, 2) to synthesize the evidence on the responsiveness of patient-reported outcome measures (PROMs) questionnaires that measure the impact of UI on quality of life in the context of a conservative intervention, and 3) to determine the intra and inter-rater reliability of ultrasound measurements for morphological and functional measurements of the bladder, urethra, and pelvic floor muscles (PFMs) in women who have been treated with pelvic radiotherapy. Four studies were carried out to meet these objectives. The first study was a systematic scoping review on the use of mobile technologies for the conservative management of UI. The results demonstrated that the mobile technologies studied for the treatment of UI have several important features that are recommended for healthcare. Evidence also indicates that the use of mobile technologies can be beneficial in reducing UI severity, for satisfaction, for treatment adherence and for treatment-related costs. The second study was a systematic review that synthesized the responsiveness indices from recommended PROMs questionnaires that measure the impact of UI on quality of life in the context of conservative intervention. The results established that the International Consultation on Incontinence for UI (ICIQ-UI SF) questionnaire presented the highest internal responsiveness index in a conservative intervention setting. In addition, the results established that the study with the highest methodological quality indicated that the PRAFAB-Q questionnaire was the one with the highest external responsiveness index. The third study carried out made it possible to determine the reliability of transperineal ultrasound measurements of the morphology and function of the pelvic floor muscles in women who have been treated with pelvic radiotherapy. The results demonstrate that there is very good intra-rater reliability for measuring the length of the levator plate at rest (LP-R), during maximal contraction of the PFMs (LP-MVC) during a maximal Valsalva maneuver (LP-MVM), as well as for the length of the urethra (UL). Results established that inter-rater reliability is very good for LP-R, and good for LP-MVC, LP-MVM and UL. However, intra- and inter-rater reliability are considered poor for the measurement of bladder wall thickness (BWT). Finally, the fourth study was an interventional study which was carried out using a single-case experimental design with replications. The rehabilitation program included PFM exercises performed with the Elvie mobile technology, bladder training and education on lifestyle to favor urinary continence. The program was conducted remotely (in-home) and was supervised by a physiotherapist through telephone follow-ups. The results indicate that 7 out of 8 women improved the severity of their UI measured by the main outcome, the one-hour Pad Test, after the rehabilitation program. In addition, the results from the group analysis demonstrate a significant reduction in the number of urine leaks and urinary urgency episodes on a three day bladder diary, as well as in the ICIQ-UI SF score, were found after the rehabilitation program. Thus, the results presented in this thesis support that an in-home rehabilitation program, including the use of a mobile technology and remote supervision by a physiotherapist, can reduce UI in CE survivors

Design and Code Optimization for Systems with Next-generation Racetrack Memories

With the rise of computationally expensive application domains such as machine learning, genomics, and fluids simulation, the quest for performance and energy-efficient computing has gained unprecedented momentum. The significant increase in computing and memory devices in modern systems has resulted in an unsustainable surge in energy consumption, a substantial portion of which is attributed to the memory system. The scaling of conventional memory technologies and their suitability for the next-generation system is also questionable. This has led to the emergence and rise of nonvolatile memory ( NVM ) technologies. Today, in different development stages, several NVM technologies are competing for their rapid access to the market. Racetrack memory ( RTM ) is one such nonvolatile memory technology that promises SRAM -comparable latency, reduced energy consumption, and unprecedented density compared to other technologies. However, racetrack memory ( RTM ) is sequential in nature, i.e., data in an RTM cell needs to be shifted to an access port before it can be accessed. These shift operations incur performance and energy penalties. An ideal RTM , requiring at most one shift per access, can easily outperform SRAM . However, in the worst-cast shifting scenario, RTM can be an order of magnitude slower than SRAM . This thesis presents an overview of the RTM device physics, its evolution, strengths and challenges, and its application in the memory subsystem. We develop tools that allow the programmability and modeling of RTM -based systems. For shifts minimization, we propose a set of techniques including optimal, near-optimal, and evolutionary algorithms for efficient scalar and instruction placement in RTMs . For array accesses, we explore schedule and layout transformations that eliminate the longer overhead shifts in RTMs . We present an automatic compilation framework that analyzes static control flow programs and transforms the loop traversal order and memory layout to maximize accesses to consecutive RTM locations and minimize shifts. We develop a simulation framework called RTSim that models various RTM parameters and enables accurate architectural level simulation. Finally, to demonstrate the RTM potential in non-Von-Neumann in-memory computing paradigms, we exploit its device attributes to implement logic and arithmetic operations. As a concrete use-case, we implement an entire hyperdimensional computing framework in RTM to accelerate the language recognition problem. Our evaluation shows considerable performance and energy improvements compared to conventional Von-Neumann models and state-of-the-art accelerators

Cross-Layer Rapid Prototyping and Synthesis of Application-Specific and Reconfigurable Many-accelerator Platforms

Technological advances of recent years laid the foundation consolidation of informatisationof society, impacting on economic, political, cultural and socialdimensions. At the peak of this realization, today, more and more everydaydevices are connected to the web, giving the term ”Internet of Things”. The futureholds the full connection and interaction of IT and communications systemsto the natural world, delimiting the transition to natural cyber systems and offeringmeta-services in the physical world, such as personalized medical care, autonomoustransportation, smart energy cities etc. . Outlining the necessities of this dynamicallyevolving market, computer engineers are required to implement computingplatforms that incorporate both increased systemic complexity and also cover awide range of meta-characteristics, such as the cost and design time, reliabilityand reuse, which are prescribed by a conflicting set of functional, technical andconstruction constraints. This thesis aims to address these design challenges bydeveloping methodologies and hardware/software co-design tools that enable therapid implementation and efficient synthesis of architectural solutions, which specifyoperating meta-features required by the modern market. Specifically, this thesispresents a) methodologies to accelerate the design flow for both reconfigurableand application-specific architectures, b) coarse-grain heterogeneous architecturaltemplates for processing and communication acceleration and c) efficient multiobjectivesynthesis techniques both at high abstraction level of programming andphysical silicon level.Regarding to the acceleration of the design flow, the proposed methodologyemploys virtual platforms in order to hide architectural details and drastically reducesimulation time. An extension of this framework introduces the systemicco-simulation using reconfigurable acceleration platforms as co-emulation intermediateplatforms. Thus, the development cycle of a hardware/software productis accelerated by moving from a vertical serial flow to a circular interactive loop.Moreover the simulation capabilities are enriched with efficient detection and correctiontechniques of design errors, as well as control methods of performancemetrics of the system according to the desired specifications, during all phasesof the system development. In orthogonal correlation with the aforementionedmethodological framework, a new architectural template is proposed, aiming atbridging the gap between design complexity and technological productivity usingspecialized hardware accelerators in heterogeneous systems-on-chip and networkon-chip platforms. It is presented a novel co-design methodology for the hardwareaccelerators and their respective programming software, including the tasks allocationto the available resources of the system/network. The introduced frameworkprovides implementation techniques for the accelerators, using either conventionalprogramming flows with hardware description language or abstract programmingmodel flows, using techniques from high-level synthesis. In any case, it is providedthe option of systemic measures optimization, such as the processing speed,the throughput, the reliability, the power consumption and the design silicon area.Finally, on addressing the increased complexity in design tools of reconfigurablesystems, there are proposed novel multi-objective optimization evolutionary algo-rithms which exploit the modern multicore processors and the coarse-grain natureof multithreaded programming environments (e.g. OpenMP) in order to reduce theplacement time, while by simultaneously grouping the applications based on theirintrinsic characteristics, the effectively explore the design space effectively.The efficiency of the proposed architectural templates, design tools and methodologyflows is evaluated in relation to the existing edge solutions with applicationsfrom typical computing domains, such as digital signal processing, multimedia andarithmetic complexity, as well as from systemic heterogeneous environments, suchas a computer vision system for autonomous robotic space navigation and manyacceleratorsystems for HPC and workstations/datacenters. The results strengthenthe belief of the author, that this thesis provides competitive expertise to addresscomplex modern - and projected future - design challenges.Οι τεχνολογικές εξελίξεις των τελευταίων ετών έθεσαν τα θεμέλια εδραίωσης της πληροφοριοποίησης της κοινωνίας, επιδρώντας σε οικονομικές,πολιτικές, πολιτιστικές και κοινωνικές διαστάσεις. Στο απόγειο αυτής τη ςπραγμάτωσης, σήμερα, ολοένα και περισσότερες καθημερινές συσκευές συνδέονται στο παγκόσμιο ιστό, αποδίδοντας τον όρο «Ίντερνετ των πραγμάτων».Το μέλλον επιφυλάσσει την πλήρη σύνδεση και αλληλεπίδραση των συστημάτων πληροφορικής και επικοινωνιών με τον φυσικό κόσμο, οριοθετώντας τη μετάβαση στα συστήματα φυσικού κυβερνοχώρου και προσφέροντας μεταυπηρεσίες στον φυσικό κόσμο όπως προσωποποιημένη ιατρική περίθαλψη, αυτόνομες μετακινήσεις, έξυπνες ενεργειακά πόλεις κ.α. . Σκιαγραφώντας τις ανάγκες αυτής της δυναμικά εξελισσόμενης αγοράς, οι μηχανικοί υπολογιστών καλούνται να υλοποιήσουν υπολογιστικές πλατφόρμες που αφενός ενσωματώνουν αυξημένη συστημική πολυπλοκότητα και αφετέρου καλύπτουν ένα ευρύ φάσμα μεταχαρακτηριστικών, όπως λ.χ. το κόστος σχεδιασμού, ο χρόνος σχεδιασμού, η αξιοπιστία και η επαναχρησιμοποίηση, τα οποία προδιαγράφονται από ένα αντικρουόμενο σύνολο λειτουργικών, τεχνολογικών και κατασκευαστικών περιορισμών. Η παρούσα διατριβή στοχεύει στην αντιμετώπιση των παραπάνω σχεδιαστικών προκλήσεων, μέσω της ανάπτυξης μεθοδολογιών και εργαλείων συνσχεδίασης υλικού/λογισμικού που επιτρέπουν την ταχεία υλοποίηση καθώς και την αποδοτική σύνθεση αρχιτεκτονικών λύσεων, οι οποίες προδιαγράφουν τα μετα-χαρακτηριστικά λειτουργίας που απαιτεί η σύγχρονη αγορά. Συγκεκριμένα, στα πλαίσια αυτής της διατριβής, παρουσιάζονται α) μεθοδολογίες επιτάχυνσης της ροής σχεδιασμού τόσο για επαναδιαμορφούμενες όσο και για εξειδικευμένες αρχιτεκτονικές, β) ετερογενή αδρομερή αρχιτεκτονικά πρότυπα επιτάχυνσης επεξεργασίας και επικοινωνίας και γ) αποδοτικές τεχνικές πολυκριτηριακής σύνθεσης τόσο σε υψηλό αφαιρετικό επίπεδο προγραμματισμού,όσο και σε φυσικό επίπεδο πυριτίου.Αναφορικά προς την επιτάχυνση της ροής σχεδιασμού, προτείνεται μια μεθοδολογία που χρησιμοποιεί εικονικές πλατφόρμες, οι οποίες αφαιρώντας τις αρχιτεκτονικές λεπτομέρειες καταφέρνουν να μειώσουν σημαντικά το χρόνο εξομοίωσης. Παράλληλα, εισηγείται η συστημική συν-εξομοίωση με τη χρήση επαναδιαμορφούμενων πλατφορμών, ως μέσων επιτάχυνσης. Με αυτόν τον τρόπο, ο κύκλος ανάπτυξης ενός προϊόντος υλικού, μετατεθειμένος από την κάθετη σειριακή ροή σε έναν κυκλικό αλληλεπιδραστικό βρόγχο, καθίσταται ταχύτερος, ενώ οι δυνατότητες προσομοίωσης εμπλουτίζονται με αποδοτικότερες μεθόδους εντοπισμού και διόρθωσης σχεδιαστικών σφαλμάτων, καθώς και μεθόδους ελέγχου των μετρικών απόδοσης του συστήματος σε σχέση με τις επιθυμητές προδιαγραφές, σε όλες τις φάσεις ανάπτυξης του συστήματος. Σε ορθογώνια συνάφεια με το προαναφερθέν μεθοδολογικό πλαίσιο, προτείνονται νέα αρχιτεκτονικά πρότυπα που στοχεύουν στη γεφύρωση του χάσματος μεταξύ της σχεδιαστικής πολυπλοκότητας και της τεχνολογικής παραγωγικότητας, με τη χρήση συστημάτων εξειδικευμένων επιταχυντών υλικού σε ετερογενή συστήματα-σε-ψηφίδα καθώς και δίκτυα-σε-ψηφίδα. Παρουσιάζεται κατάλληλη μεθοδολογία συν-σχεδίασης των επιταχυντών υλικού και του λογισμικού προκειμένου να αποφασισθεί η κατανομή των εργασιών στους διαθέσιμους πόρους του συστήματος/δικτύου. Το μεθοδολογικό πλαίσιο προβλέπει την υλοποίηση των επιταχυντών είτε με συμβατικές μεθόδους προγραμματισμού σε γλώσσα περιγραφής υλικού είτε με αφαιρετικό προγραμματιστικό μοντέλο με τη χρήση τεχνικών υψηλού επιπέδου σύνθεσης. Σε κάθε περίπτωση, δίδεται η δυνατότητα στο σχεδιαστή για βελτιστοποίηση συστημικών μετρικών, όπως η ταχύτητα επεξεργασίας, η ρυθμαπόδοση, η αξιοπιστία, η κατανάλωση ενέργειας και η επιφάνεια πυριτίου του σχεδιασμού. Τέλος, προκειμένου να αντιμετωπισθεί η αυξημένη πολυπλοκότητα στα σχεδιαστικά εργαλεία επαναδιαμορφούμενων συστημάτων, προτείνονται νέοι εξελικτικοί αλγόριθμοι πολυκριτηριακής βελτιστοποίησης, οι οποίοι εκμεταλλευόμενοι τους σύγχρονους πολυπύρηνους επεξεργαστές και την αδρομερή φύση των πολυνηματικών περιβαλλόντων προγραμματισμού (π.χ. OpenMP), μειώνουν το χρόνο επίλυσης του προβλήματος της τοποθέτησης των λογικών πόρων σε φυσικούς,ενώ ταυτόχρονα, ομαδοποιώντας τις εφαρμογές βάση των εγγενών χαρακτηριστικών τους, διερευνούν αποτελεσματικότερα το χώρο σχεδίασης.Η αποδοτικότητά των προτεινόμενων αρχιτεκτονικών προτύπων και μεθοδολογιών επαληθεύτηκε σε σχέση με τις υφιστάμενες λύσεις αιχμής τόσο σε αυτοτελής εφαρμογές, όπως η ψηφιακή επεξεργασία σήματος, τα πολυμέσα και τα προβλήματα αριθμητικής πολυπλοκότητας, καθώς και σε συστημικά ετερογενή περιβάλλοντα, όπως ένα σύστημα όρασης υπολογιστών για αυτόνομα διαστημικά ρομποτικά οχήματα και ένα σύστημα πολλαπλών επιταχυντών υλικού για σταθμούς εργασίας και κέντρα δεδομένων, στοχεύοντας εφαρμογές υψηλής υπολογιστικής απόδοσης (HPC). Τα αποτελέσματα ενισχύουν την πεποίθηση του γράφοντα, ότι η παρούσα διατριβή παρέχει ανταγωνιστική τεχνογνωσία για την αντιμετώπιση των πολύπλοκων σύγχρονων και προβλεπόμενα μελλοντικών σχεδιαστικών προκλήσεων

Exploiting task-based programming models for resilience

Hardware errors become more common as silicon technologies shrink and become more vulnerable, especially in memory cells, which are the most exposed to errors. Permanent and intermittent faults are caused by manufacturing variability and circuits ageing. While these can be mitigated once they are identified, their continuous rate of appearance throughout the lifetime of memory devices will always cause unexpected errors. In addition, transient faults are caused by effects such as radiation or small voltage/frequency margins, and there is no efficient way to shield against these events. Other constraints related to the diminishing sizes of transistors, such as power consumption and memory latency have caused the microprocessor industry to turn to increasingly complex processor architectures. To solve the difficulties arising from programming such architectures, programming models have emerged that rely on runtime systems. These systems form a new intermediate layer on the hardware-software abstraction stack, that performs tasks such as distributing work across computing resources: processor cores, accelerators, etc. These runtime systems dispose of a lot of information, both from the hardware and the applications, and offer thus many possibilities for optimisations. This thesis proposes solutions to the increasing fault rates in memory, across multiple resilience disciplines, from algorithm-based fault tolerance to hardware error correcting codes, through OS reliability strategies. These solutions rely for their efficiency on the opportunities presented by runtime systems. The first contribution of this thesis is an algorithmic-based resilience technique, allowing to tolerate detected errors in memory. This technique allows to recover data that is lost by performing computations that rely on simple redundancy relations identified in the program. The recovery is demonstrated for a family of iterative solvers, the Krylov subspace methods, and evaluated for the conjugate gradient solver. The runtime can transparently overlap the recovery with the computations of the algorithm, which allows to mask the already low overheads of this technique. The second part of this thesis proposes a metric to characterise the impact of faults in memory, which outperforms state-of-the-art metrics in precision and assurances on the error rate. This metric reveals a key insight into data that is not relevant to the program, and we propose an OS-level strategy to ignore errors in such data, by delaying the reporting of detected errors. This allows to reduce failure rates of running programs, by ignoring errors that have no impact. The architectural-level contribution of this thesis is a dynamically adaptable Error Correcting Code (ECC) scheme, that can increase protection of memory regions where the impact of errors is highest. A runtime methodology is presented to estimate the fault rate at runtime using our metric, through performance monitoring tools of current commodity processors. Guiding the dynamic ECC scheme online using the methodology's vulnerability estimates allows to decrease error rates of programs at a fraction of the redundancy cost required for a uniformly stronger ECC. This provides a useful and wide range of trade-offs between redundancy and error rates. The work presented in this thesis demonstrates that runtime systems allow to make the most of redundancy stored in memory, to help tackle increasing error rates in DRAM. This exploited redundancy can be an inherent part of algorithms that allows to tolerate higher fault rates, or in the form of dead data stored in memory. Redundancy can also be added to a program, in the form of ECC. In all cases, the runtime allows to decrease failure rates efficiently, by diminishing recovery costs, identifying redundant data, or targeting critical data. It is thus a very valuable tool for the future computing systems, as it can perform optimisations across different layers of abstractions.Los errores en memoria se vuelven más comunes a medida que las tecnologías de silicio reducen su tamaño. La variabilidad de fabricación y el envejecimiento de los circuitos causan fallos permanentes e intermitentes. Aunque se pueden mitigar una vez identificados, su continua tasa de aparición siempre causa errores inesperados. Además, la memoria también sufre de fallos transitorios contra los cuales no se puede proteger eficientemente. Estos fallos están causados por efectos como la radiación o los reducidos márgenes de voltaje y frecuencia. Otras restricciones coetáneas, como el consumo de energía y la latencia de la memoria, obligaron a las arquitecturas de computadores a volverse cada vez más complejas. Para programar tales procesadores, se desarrollaron modelos de programación basados en entornos de ejecución. Estos sistemas forman una nueva abstracción entre hardware y software, realizando tareas como la distribución del trabajo entre recursos informáticos: núcleos de procesadores, aceleradores, etc. Estos entornos de ejecución disponen de mucha información tanto sobre el hardware como sobre las aplicaciones, y ofrecen así muchas posibilidades de optimización. Esta tesis propone soluciones a los fallos en memoria entre múltiples disciplinas de resiliencia, desde la tolerancia a fallos basada en algoritmos, hasta los códigos de corrección de errores en hardware, incluyendo estrategias de resiliencia del sistema operativo. La eficiencia de estas soluciones depende de las oportunidades que presentan los entornos de ejecución. La primera contribución de esta tesis es una técnica a nivel algorítmico que permite corregir fallos encontrados mientras el programa su ejecuta. Para corregir fallos se han identificado redundancias simples en los datos del programa para toda una clase de algoritmos, los métodos del subespacio de Krylov (gradiente conjugado, GMRES, etc). La estrategia de recuperación de datos desarrollada permite corregir errores sin tener que reinicializar el algoritmo, y aprovecha el modelo de programación para superponer las computaciones del algoritmo y de la recuperación de datos. La segunda parte de esta tesis propone una métrica para caracterizar el impacto de los fallos en la memoria. Esta métrica supera en precisión a las métricas de vanguardia y permite identificar datos que son menos relevantes para el programa. Se propone una estrategia a nivel del sistema operativo retrasando la notificación de los errores detectados, que permite ignorar fallos en estos datos y reducir la tasa de fracaso del programa. Por último, la contribución a nivel arquitectónico de esta tesis es un esquema de Código de Corrección de Errores (ECC por sus siglas en inglés) adaptable dinámicamente. Este esquema puede aumentar la protección de las regiones de memoria donde el impacto de los errores es mayor. Se presenta una metodología para estimar el riesgo de fallo en tiempo de ejecución utilizando nuestra métrica, a través de las herramientas de monitorización del rendimiento disponibles en los procesadores actuales. El esquema de ECC guiado dinámicamente con estas estimaciones de vulnerabilidad permite disminuir la tasa de fracaso de los programas a una fracción del coste de redundancia requerido para un ECC uniformemente más fuerte. El trabajo presentado en esta tesis demuestra que los entornos de ejecución permiten aprovechar al máximo la redundancia contenida en la memoria, para contener el aumento de los errores en ella. Esta redundancia explotada puede ser una parte inherente de los algoritmos que permite tolerar más fallos, en forma de datos inutilizados almacenados en la memoria, o agregada a la memoria de un programa en forma de ECC. En todos los casos, el entorno de ejecución permite disminuir los efectos de los fallos de manera eficiente, disminuyendo los costes de recuperación, identificando datos redundantes, o focalizando esfuerzos de protección en los datos críticos.Postprint (published version

Proceedings of the 5th International Workshop on Reconfigurable Communication-centric Systems on Chip 2010 - ReCoSoC\u2710 - May 17-19, 2010 Karlsruhe, Germany. (KIT Scientific Reports ; 7551)

ReCoSoC is intended to be a periodic annual meeting to expose and discuss gathered expertise as well as state of the art research around SoC related topics through plenary invited papers and posters. The workshop aims to provide a prospective view of tomorrow\u27s challenges in the multibillion transistor era, taking into account the emerging techniques and architectures exploring the synergy between flexible on-chip communication and system reconfigurability

The impact of arterial input function determination variations on prostate dynamic contrast-enhanced magnetic resonance imaging pharmacokinetic modeling: a multicenter data analysis challenge, part II

This multicenter study evaluated the effect of variations in arterial input function (AIF) determination on pharmacokinetic (PK) analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data using the shutter-speed model (SSM). Data acquired from eleven prostate cancer patients were shared among nine centers. Each center used a site-specific method to measure the individual AIF from each data set and submitted the results to the managing center. These AIFs, their reference tissue-adjusted variants, and a literature population-averaged AIF, were used by the managing center to perform SSM PK analysis to estimate Ktrans (volume transfer rate constant), ve (extravascular, extracellular volume fraction), kep (efflux rate constant), and τi (mean intracellular water lifetime). All other variables, including the definition of the tumor region of interest and precontrast T1 values, were kept the same to evaluate parameter variations caused by variations in only the AIF. Considerable PK parameter variations were observed with within-subject coefficient of variation (wCV) values of 0.58, 0.27, 0.42, and 0.24 for Ktrans, ve, kep, and τi, respectively, using the unadjusted AIFs. Use of the reference tissue-adjusted AIFs reduced variations in Ktrans and ve (wCV = 0.50 and 0.10, respectively), but had smaller effects on kep and τi (wCV = 0.39 and 0.22, respectively). kep is less sensitive to AIF variation than Ktrans, suggesting it may be a more robust imaging biomarker of prostate microvasculature. With low sensitivity to AIF uncertainty, the SSM-unique τi parameter may have advantages over the conventional PK parameters in a longitudinal study

Exploiting task-based programming models for resilience

Hardware errors become more common as silicon technologies shrink and become more vulnerable, especially in memory cells, which are the most exposed to errors. Permanent and intermittent faults are caused by manufacturing variability and circuits ageing. While these can be mitigated once they are identified, their continuous rate of appearance throughout the lifetime of memory devices will always cause unexpected errors. In addition, transient faults are caused by effects such as radiation or small voltage/frequency margins, and there is no efficient way to shield against these events. Other constraints related to the diminishing sizes of transistors, such as power consumption and memory latency have caused the microprocessor industry to turn to increasingly complex processor architectures. To solve the difficulties arising from programming such architectures, programming models have emerged that rely on runtime systems. These systems form a new intermediate layer on the hardware-software abstraction stack, that performs tasks such as distributing work across computing resources: processor cores, accelerators, etc. These runtime systems dispose of a lot of information, both from the hardware and the applications, and offer thus many possibilities for optimisations. This thesis proposes solutions to the increasing fault rates in memory, across multiple resilience disciplines, from algorithm-based fault tolerance to hardware error correcting codes, through OS reliability strategies. These solutions rely for their efficiency on the opportunities presented by runtime systems. The first contribution of this thesis is an algorithmic-based resilience technique, allowing to tolerate detected errors in memory. This technique allows to recover data that is lost by performing computations that rely on simple redundancy relations identified in the program. The recovery is demonstrated for a family of iterative solvers, the Krylov subspace methods, and evaluated for the conjugate gradient solver. The runtime can transparently overlap the recovery with the computations of the algorithm, which allows to mask the already low overheads of this technique. The second part of this thesis proposes a metric to characterise the impact of faults in memory, which outperforms state-of-the-art metrics in precision and assurances on the error rate. This metric reveals a key insight into data that is not relevant to the program, and we propose an OS-level strategy to ignore errors in such data, by delaying the reporting of detected errors. This allows to reduce failure rates of running programs, by ignoring errors that have no impact. The architectural-level contribution of this thesis is a dynamically adaptable Error Correcting Code (ECC) scheme, that can increase protection of memory regions where the impact of errors is highest. A runtime methodology is presented to estimate the fault rate at runtime using our metric, through performance monitoring tools of current commodity processors. Guiding the dynamic ECC scheme online using the methodology's vulnerability estimates allows to decrease error rates of programs at a fraction of the redundancy cost required for a uniformly stronger ECC. This provides a useful and wide range of trade-offs between redundancy and error rates. The work presented in this thesis demonstrates that runtime systems allow to make the most of redundancy stored in memory, to help tackle increasing error rates in DRAM. This exploited redundancy can be an inherent part of algorithms that allows to tolerate higher fault rates, or in the form of dead data stored in memory. Redundancy can also be added to a program, in the form of ECC. In all cases, the runtime allows to decrease failure rates efficiently, by diminishing recovery costs, identifying redundant data, or targeting critical data. It is thus a very valuable tool for the future computing systems, as it can perform optimisations across different layers of abstractions.Los errores en memoria se vuelven más comunes a medida que las tecnologías de silicio reducen su tamaño. La variabilidad de fabricación y el envejecimiento de los circuitos causan fallos permanentes e intermitentes. Aunque se pueden mitigar una vez identificados, su continua tasa de aparición siempre causa errores inesperados. Además, la memoria también sufre de fallos transitorios contra los cuales no se puede proteger eficientemente. Estos fallos están causados por efectos como la radiación o los reducidos márgenes de voltaje y frecuencia. Otras restricciones coetáneas, como el consumo de energía y la latencia de la memoria, obligaron a las arquitecturas de computadores a volverse cada vez más complejas. Para programar tales procesadores, se desarrollaron modelos de programación basados en entornos de ejecución. Estos sistemas forman una nueva abstracción entre hardware y software, realizando tareas como la distribución del trabajo entre recursos informáticos: núcleos de procesadores, aceleradores, etc. Estos entornos de ejecución disponen de mucha información tanto sobre el hardware como sobre las aplicaciones, y ofrecen así muchas posibilidades de optimización. Esta tesis propone soluciones a los fallos en memoria entre múltiples disciplinas de resiliencia, desde la tolerancia a fallos basada en algoritmos, hasta los códigos de corrección de errores en hardware, incluyendo estrategias de resiliencia del sistema operativo. La eficiencia de estas soluciones depende de las oportunidades que presentan los entornos de ejecución. La primera contribución de esta tesis es una técnica a nivel algorítmico que permite corregir fallos encontrados mientras el programa su ejecuta. Para corregir fallos se han identificado redundancias simples en los datos del programa para toda una clase de algoritmos, los métodos del subespacio de Krylov (gradiente conjugado, GMRES, etc). La estrategia de recuperación de datos desarrollada permite corregir errores sin tener que reinicializar el algoritmo, y aprovecha el modelo de programación para superponer las computaciones del algoritmo y de la recuperación de datos. La segunda parte de esta tesis propone una métrica para caracterizar el impacto de los fallos en la memoria. Esta métrica supera en precisión a las métricas de vanguardia y permite identificar datos que son menos relevantes para el programa. Se propone una estrategia a nivel del sistema operativo retrasando la notificación de los errores detectados, que permite ignorar fallos en estos datos y reducir la tasa de fracaso del programa. Por último, la contribución a nivel arquitectónico de esta tesis es un esquema de Código de Corrección de Errores (ECC por sus siglas en inglés) adaptable dinámicamente. Este esquema puede aumentar la protección de las regiones de memoria donde el impacto de los errores es mayor. Se presenta una metodología para estimar el riesgo de fallo en tiempo de ejecución utilizando nuestra métrica, a través de las herramientas de monitorización del rendimiento disponibles en los procesadores actuales. El esquema de ECC guiado dinámicamente con estas estimaciones de vulnerabilidad permite disminuir la tasa de fracaso de los programas a una fracción del coste de redundancia requerido para un ECC uniformemente más fuerte. El trabajo presentado en esta tesis demuestra que los entornos de ejecución permiten aprovechar al máximo la redundancia contenida en la memoria, para contener el aumento de los errores en ella. Esta redundancia explotada puede ser una parte inherente de los algoritmos que permite tolerar más fallos, en forma de datos inutilizados almacenados en la memoria, o agregada a la memoria de un programa en forma de ECC. En todos los casos, el entorno de ejecución permite disminuir los efectos de los fallos de manera eficiente, disminuyendo los costes de recuperación, identificando datos redundantes, o focalizando esfuerzos de protección en los datos críticos