150,948 research outputs found
Low-frequency oscillatory correlates of auditory predictive processing in cortical-subcortical networks: a MEG-study
Emerging evidence supports the role of neural oscillations as a mechanism for predictive information processing across large-scale networks. However, the oscillatory signatures underlying auditory mismatch detection and information flow between brain regions remain unclear. To address this issue, we examined the contribution of oscillatory activity at theta/alpha-bands (4–8/8–13 Hz) and assessed directed connectivity in magnetoencephalographic data while 17 human participants were presented with sound sequences containing predictable repetitions and order manipulations that elicited prediction-error responses. We characterized the spectro-temporal properties of neural generators using a minimum-norm approach and assessed directed connectivity using Granger Causality analysis. Mismatching sequences elicited increased theta power and phase-locking in auditory, hippocampal and prefrontal cortices, suggesting that theta-band oscillations underlie prediction-error generation in cortical-subcortical networks. Furthermore, enhanced feedforward theta/alpha-band connectivity was observed in auditory-prefrontal networks during mismatching sequences, while increased feedback connectivity in the alpha-band was observed between hippocampus and auditory regions during predictable sounds. Our findings highlight the involvement of hippocampal theta/alpha-band oscillations towards auditory prediction-error generation and suggest a spectral dissociation between inter-areal feedforward vs. feedback signalling, thus providing novel insights into the oscillatory mechanisms underlying auditory predictive processing
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Healthcare Event and Activity Logging.
The health of patients in the intensive care unit (ICU) can change frequently and inexplicably. Crucial events and activities responsible for these changes often go unnoticed. This paper introduces healthcare event and action logging (HEAL) which automatically and unobtrusively monitors and reports on events and activities that occur in a medical ICU room. HEAL uses a multimodal distributed camera network to monitor and identify ICU activities and estimate sanitation-event qualifiers. At the core is a novel approach to infer person roles based on semantic interactions, a critical requirement in many healthcare settings where individuals' identities must not be identified. The proposed approach for activity representation identifies contextual aspects basis and estimates aspect weights for proper action representation and reconstruction. The flexibility of the proposed algorithms enables the identification of people roles by associating them with inferred interactions and detected activities. A fully working prototype system is developed, tested in a mock ICU room and then deployed in two ICU rooms at a community hospital, thus offering unique capabilities for data gathering and analytics. The proposed method achieves a role identification accuracy of 84% and a backtracking role identification of 79% for obscured roles using interaction and appearance features on real ICU data. Detailed experimental results are provided in the context of four event-sanitation qualifiers: clean, transmission, contamination, and unclean
Structure emerges faster during cultural transmission in children than in adults
How does children’s limited processing capacity affect cultural transmission of complex information? We show that over the course of iterated reproduction of two-dimensional random dot patterns transmission accuracy increased to a similar extent in 5- to 8-year-old children and adults whereas algorithmic complexity decreased faster in children. Thus, children require more structure to render complex inputs learnable. In line with the Less-Is-More hypothesis, we interpret this as evidence that children’s processing limitations affecting working memory capacity and executive control constrain the ability to represent and generate complexity, which, in turn, facilitates emergence of structure. This underscores the importance of investigating the role of children in the transmission of complex cultural traits
Coding of details in very low bit-rate video systems
In this paper, the importance of including small image features at the initial levels of a progressive second generation video coding scheme is presented. It is shown that a number of meaningful small features called details should be coded, even at very low data bit-rates, in order to match their perceptual significance to the human visual system. We propose a method for extracting, perceptually selecting and coding of visual details in a video sequence using morphological techniques. Its application in the framework of a multiresolution segmentation-based coding algorithm yields better results than pure segmentation techniques at higher compression ratios, if the selection step fits some main subjective requirements. Details are extracted and coded separately from the region structure and included in the reconstructed images in a later stage. The bet of considering the local background of a given detail for its perceptual selection breaks the concept ofPeer ReviewedPostprint (published version
Nonlinear brain dynamics as macroscopic manifestation of underlying many-body field dynamics
Neural activity patterns related to behavior occur at many scales in time and
space from the atomic and molecular to the whole brain. Here we explore the
feasibility of interpreting neurophysiological data in the context of many-body
physics by using tools that physicists have devised to analyze comparable
hierarchies in other fields of science. We focus on a mesoscopic level that
offers a multi-step pathway between the microscopic functions of neurons and
the macroscopic functions of brain systems revealed by hemodynamic imaging. We
use electroencephalographic (EEG) records collected from high-density electrode
arrays fixed on the epidural surfaces of primary sensory and limbic areas in
rabbits and cats trained to discriminate conditioned stimuli (CS) in the
various modalities. High temporal resolution of EEG signals with the Hilbert
transform gives evidence for diverse intermittent spatial patterns of amplitude
(AM) and phase modulations (PM) of carrier waves that repeatedly re-synchronize
in the beta and gamma ranges at near zero time lags over long distances. The
dominant mechanism for neural interactions by axodendritic synaptic
transmission should impose distance-dependent delays on the EEG oscillations
owing to finite propagation velocities. It does not. EEGs instead show evidence
for anomalous dispersion: the existence in neural populations of a low velocity
range of information and energy transfers, and a high velocity range of the
spread of phase transitions. This distinction labels the phenomenon but does
not explain it. In this report we explore the analysis of these phenomena using
concepts of energy dissipation, the maintenance by cortex of multiple ground
states corresponding to AM patterns, and the exclusive selection by spontaneous
breakdown of symmetry (SBS) of single states in sequences.Comment: 31 page
De Novo Occurrence of a Variant in ARL3 and Apparent Autosomal Dominant Transmission of Retinitis Pigmentosa.
BackgroundRetinitis pigmentosa is a phenotype with diverse genetic causes. Due to this genetic heterogeneity, genome-wide identification and analysis of protein-altering DNA variants by exome sequencing is a powerful tool for novel variant and disease gene discovery. In this study, exome sequencing analysis was used to search for potentially causal DNA variants in a two-generation pedigree with apparent dominant retinitis pigmentosa.MethodsVariant identification and analysis of three affected members (mother and two affected offspring) was performed via exome sequencing. Parental samples of the index case were used to establish inheritance. Follow-up testing of 94 additional retinitis pigmentosa pedigrees was performed via retrospective analysis or Sanger sequencing.Results and conclusionsA total of 136 high quality coding variants in 123 genes were identified which are consistent with autosomal dominant disease. Of these, one of the strongest genetic and functional candidates is a c.269A>G (p.Tyr90Cys) variant in ARL3. Follow-up testing established that this variant occurred de novo in the index case. No additional putative causal variants in ARL3 were identified in the follow-up cohort, suggesting that if ARL3 variants can cause adRP it is an extremely rare phenomenon
Evidence for Information Processing in the Brain
Many cognitive and neuroscientists attempt to assign biological functions to brain structures. To achieve this end, scientists perform experiments that relate the physical properties of brain structures to organism-level abilities, behaviors, and environmental stimuli. Researchers make use of various measuring instruments and methodological techniques to obtain this kind of relational evidence, ranging from single-unit electrophysiology and optogenetics to whole brain functional MRI. Each experiment is intended to identify brain function. However, seemingly independent of experimental evidence, many cognitive scientists, neuroscientists, and philosophers of science assume that the brain processes information as a scientific fact. In this work we analyze categories of relational evidence and find that although physical features of specific brain areas selectively covary with external stimuli and abilities, and that the brain shows reliable causal organization, there is no direct evidence supporting the claim that information processing is a natural function of the brain. We conclude that the belief in brain information processing adds little to the science of cognitive science and functions primarily as a metaphor for efficient communication of neuroscientific data
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Hearing through your eyes: neural basis of audiovisual cross-activation, revealed by transcranial alternating current stimulation
Some people experience auditory sensations when seeing visual flashes or movements. This prevalent synaesthesia-like ‘visual-evoked auditory response’ (vEAR) could result either from over-exuberant cross-activation between brain areas, and/or reduced inhibition of normally-occurring cross-activation. We have used transcranial alternating current stimulation (tACS) to test these theories. We applied tACS at 10Hz (alpha-band frequency) or 40Hz (gamma-band), bilaterally either to temporal or occipital sites, while measuring same/different discrimination of paired auditory (A) versus visual (V) 'Morse code' sequences. At debriefing, participants were classified as vEAR or non-vEAR depending on whether they reported 'hearing' the silent flashes.
In non-vEAR participants, temporal 10Hz tACS caused impairment of A performance, which correlated with improved V; conversely under occipital tACS, poorer V performance correlated with improved A. This reciprocal pattern suggests that sensory cortices are normally mutually inhibitory, and that alpha-frequency tACS may bias the balance of competition between them. vEAR participants showed no tACS effects, consistent with reduced inhibition, or enhanced cooperation between modalities. In addition, temporal 40Hz tACS impaired V performance, specifically in individuals who showed a performance advantage for V (relative to A). Gamma-frequency tACS may therefore modulate the ability of these individuals to benefit from recoding flashes into the auditory modality, possibly by disrupting cross-activation of auditory areas by visual stimulation.
Our results support both theories, suggesting that vEAR may depend on disinhibition of normally-occurring sensory cross-activation, which may be expressed more strongly in some individuals. Furthermore, endogenous alpha and gamma-frequency oscillations may function respectively to inhibit or promote this cross-activation
Characterization of the Community Structure of Large Scale Functional Brain Networks During Ketamine-Medetomidine Anesthetic Induction
One of the central questions in neuroscience is to understand the way
communication is organized in the brain, trying to comprehend how cognitive
capacities or physiological states of the organism are potentially related to
brain activities involving interactions of several brain areas. One important
characteristic of the functional brain networks is that they are modularly
structured, being this modular architecture regarded to account for a series of
properties and functional dynamics. In the neurobiological context, communities
may indicate brain regions that are involved in one same activity, representing
neural segregated processes. Several studies have demonstrated the modular
character of organization of brain activities. However, empirical evidences
regarding to its dynamics and relation to different levels of consciousness
have not been reported yet. Within this context, this research sought to
characterize the community structure of functional brain networks during an
anesthetic induction process. The experiment was based on intra-cranial
recordings of neural activities of an old world macaque of the species Macaca
fuscata during a Ketamine-Medetomidine anesthetic induction process. Networks
were serially estimated in time intervals of five seconds. Changes were
observed within about one and a half minutes after the administration of the
anesthetics, revealing the occurrence of a transition on the community
structure. The awake state was characterized by the presence of large clusters
involving frontal and parietal regions, while the anesthetized state by the
presence of communities in the primary visual and motor cortices, being the
areas of the secondary associative cortex most affected. The results report the
influence of general anesthesia on the structure of functional clusters,
contributing for understanding some new aspects of neural correlates of
consciousness.Comment: 24 pages, 8 figures. arXiv admin note: text overlap with
arXiv:1604.0000
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