Lifecycle information for E-literature: an introduction to the second phase of the LIFE project

Introduction: The first phase of LIFE (Lifecycle Information For E-Literature) made a major contribution to understanding the long-term costs of digital preservation; an essential step in helping institutions plan for the future. The LIFE work models the digital lifecycle and calculates the costs of preserving digital information for future years. Organisations can apply this process in order to understand costs and plan effectively for the preservation of their digital collections The second phase of the LIFE Project, LIFE2, has refined the LIFE Model adding three new exemplar Case Studies to further build upon LIFE1. LIFE2 is an 18-month JISC-funded project between UCL (University College London) and The British Library (BL), supported by the LIBER Access and Preservation Divisions. LIFE1 was completed in April 2006. LIFE2 started in March 2007, and was completed in August 2008. This summary aims to give an overview of the LIFE Project, summarising some of the key outputs. There are four main areas discussed: 1 From LIFE1 to LIFE2 outlines some of the key findings from the first phase of the project as well as summarising the motivation behind this second phase. 2 The LIFE Model describes the current version of the model (version 2) which has been thoroughly updated from the first phase. 3 LIFE2 Case Studies describes the three new Case Studies for LIFE2. It does not include the results from the Case Studies (these are available in the overall LIFE2 Report), but offers some background on each of the studies as well as discussion of why they were chosen. 4 Findings and Conclusions outlines all of the findings and outputs from the entire project

PENYELENGGARAAN PEMILIHAN UMUM 1955

This journal is focus to the showing General Choices 1955. General choices is the solution to approaching have politics stability. The primary in this writes to have: first, how politics lifes before during general choces 1955. Second, how during showing general choices 1955. This observation have to assistmen with history methodes there are have four steps: heuristic, critical, interpretasion, n chronologhy. From two including that and than have the answerer there are: first, beforing during showing General Choices 1955 this peoples in Indonesian country faced didn’t stabillity “Gouverment” because of the chrisis cabinets. Second, showing General choices during two steps there are: choices to choose DPR Departmen that trying in 29 September 1955, and Departmen of Constituante that trying 15 December 1955. Keywords: History Methods, Politics life, General Choces 1955

Oxidative stress and life histories: unresolved issues and current needs

Life-history theory concerns the trade-offs that mold the patterns of investment by animals between reproduction, growth, and survival. It is widely recognized that physiology plays a role in the mediation of life-history trade-offs, but the details remain obscure. As life-history theory concerns aspects of investment in the soma that influence survival, understanding the physiological basis of life histories is related, but not identical, to understanding the process of aging. One idea from the field of aging that has gained considerable traction in the area of life histories is that life-history trade-offs may be mediated by free radical production and oxidative stress. We outline here developments in this field and summarize a number of important unresolved issues that may guide future research efforts. The issues are as follows. First, different tissues and macromolecular targets of oxidative stress respond differently during reproduction. The functional significance of these changes, however, remains uncertain. Consequently there is a need for studies that link oxidative stress measurements to functional outcomes, such as survival. Second, measurements of oxidative stress are often highly invasive or terminal. Terminal studies of oxidative stress in wild animals, where detailed life-history information is available, cannot generally be performed without compromising the aims of the studies that generated the life-history data. There is a need therefore for novel non-invasive measurements of multi-tissue oxidative stress. Third, laboratory studies provide unrivaled opportunities for experimental manipulation but may fail to expose the physiology underpinning life-history effects, because of the benign laboratory environment. Fourth, the idea that oxidative stress might underlie life-history trade-offs does not make specific enough predictions that are amenable to testing. Moreover, there is a paucity of good alternative theoretical models on which contrasting predictions might be based. Fifth, there is an enormous diversity of life-history variation to test the idea that oxidative stress may be a key mediator. So far we have only scratched the surface. Broadening the scope may reveal new strategies linked to the processes of oxidative damage and repair. Finally, understanding the trade-offs in life histories and understanding the process of aging are related but not identical questions. Scientists inhabiting these two spheres of activity seldom collide, yet they have much to learn from each other

Physiotherapy for Parkinson's disease: a comparison of techniques (Review)

Background: Despite medical therapies and surgical interventions for Parkinson's disease (PD), patients develop progressive disability. The role of physiotherapy is to maximise functional ability and minimise secondary complications through movement rehabilitation within a context of education and support for the whole person. The overall aim is to optimise independence, safety and wellbeing, thereby enhancing quality of life. Trials have shown that physiotherapy has short-term benefits in PD. However, which physiotherapy intervention is most effective remains unclear. Objectives: To assess the effectiveness of one physiotherapy intervention compared with a second approach in patients with PD. Search methods: Relevant trials were identified by electronic searches of numerous literature databases (for example MEDLINE, EMBASE) and trial registers, plus handsearching of major journals, abstract books, conference proceedings and reference lists of retrieved publications. The literature search included trials published up to the end of January 2012. Selection criteria: Randomised controlled trials of one physiotherapy intervention versus another physiotherapy intervention in patients with PD. Data collection and analysis: Data were abstracted independently from each paper by two authors. Trials were classified into the following intervention comparisons: general physiotherapy, exercise, treadmill training, cueing, dance and martial arts. Main results: A total of 43 trials were identified with 1673 participants. All trials used small patient numbers (average trial size of 39 participants); the methods of randomisation and concealment of allocation were poor or not stated in most trials. Blinded assessors were used in just over half of the trials and only 10 stated that they used intention-to-treat analysis.A wide variety of validated and customised outcome measures were used to assess the effectiveness of physiotherapy interventions. The most frequently reported physiotherapy outcomes were gait speed and timed up and go, in 19 and 15 trials respectively. Only five of the 43 trials reported data on falls (12%). The motor subscales of the Unified Parkinson?s Disease Rating Scale and Parkinson?s Disease Questionnaire-39 were the most commonly reported clinician-rated disability and patient-rated quality of life outcome measures, used in 22 and 13 trials respectively. The content and delivery of the physiotherapy interventions varied widely in the trials included within this review, so no quantitative meta-analysis could be performed. Authors' conclusions: Considering the small number of participants examined, the methodological flaws in many of the studies, the possibility of publication bias, and the variety of interventions, formal comparison of the different physiotherapy techniques could not be performed. There is insufficient evidence to support or refute the effectiveness of one physiotherapy intervention over another in PD.This review shows that a wide range of physiotherapy interventions to treat PD have been tested . There is a need for more specific trials with improved treatment strategies to underpin the most appropriate choice of physiotherapy intervention and the outcomes measured

Oxidative stress and life histories: unresolved issues and current needs.

Life-history theory concerns the trade-offs that mold the patterns of investment by animals between reproduction, growth, and survival. It is widely recognized that physiology plays a role in the mediation of life-history trade-offs, but the details remain obscure. As life-history theory concerns aspects of investment in the soma that influence survival, understanding the physiological basis of life histories is related, but not identical, to understanding the process of aging. One idea from the field of aging that has gained considerable traction in the area of life histories is that life-history trade-offs may be mediated by free radical production and oxidative stress. We outline here developments in this field and summarize a number of important unresolved issues that may guide future research efforts. The issues are as follows. First, different tissues and macromolecular targets of oxidative stress respond differently during reproduction. The functional significance of these changes, however, remains uncertain. Consequently there is a need for studies that link oxidative stress measurements to functional outcomes, such as survival. Second, measurements of oxidative stress are often highly invasive or terminal. Terminal studies of oxidative stress in wild animals, where detailed life-history information is available, cannot generally be performed without compromising the aims of the studies that generated the life-history data. There is a need therefore for novel non-invasive measurements of multi-tissue oxidative stress. Third, laboratory studies provide unrivaled opportunities for experimental manipulation but may fail to expose the physiology underpinning life-history effects, because of the benign laboratory environment. Fourth, the idea that oxidative stress might underlie life-history trade-offs does not make specific enough predictions that are amenable to testing. Moreover, there is a paucity of good alternative theoretical models on which contrasting predictions might be based. Fifth, there is an enormous diversity of life-history variation to test the idea that oxidative stress may be a key mediator. So far we have only scratched the surface. Broadening the scope may reveal new strategies linked to the processes of oxidative damage and repair. Finally, understanding the trade-offs in life histories and understanding the process of aging are related but not identical questions. Scientists inhabiting these two spheres of activity seldom collide, yet they have much to learn from each other

François Jullien: The Double Transit of Human Life

François Jullien finds the “unthinkable” in our philosophical tradition in his journey to the Chinese world. One of these ideas is precisely that of understanding nature as a process, not formulated in terms of continuity but of transit. In this transit human life is inscribed, like all lives. But in Jullien there is also an ethical commitment to understand this human life as open to the possibility of another transit, that of a second life. These are interesting ideas to pick up even seeing the limitations of the Chinese approach. As François Cheng points out, the ideas of subject and right are missing. We could go further and say that the idea of freedom is missing. But Jullien overcomes these limitations by pointing out this lack and overcoming it in his proposal. But as he also underlines, it is precisely this idea of transit as a way out of our dualisms and polarities that can teach us the most, as Westerners

The geographical concentration of hotels in Switzerland and the industry life cycle

Empirical studies of numerous products and industries have shown that the evolution of variables such as the market price of a product, output and the number of competitors in an industry are non-monotonic and follow a typical pattern over the life span of that industry. The Swiss hotel industry has been experiencing stagnation, even decline, for a period of over 20 years. This can be measured in terms of arrivals, overnight stays and, perhaps most importantly, the number of firms. Thus the number of hotels in Switzerland has declined by over 10 per cent in the past decade. This decline is forecast by the life-cycle model. These models, however, tell us little about where geographically the decline would take place. The aim of this paper is, first, to verify if the evolution of the Swiss hotel industry fits some of the stylized facts of the industry life cycle. The second aim is to verify if there is evidence of geographical clustering of the hotel industry, and, by extension, of tourism. The third aim is to verify a hypothesis that the decline or final phases of the industry life cycle will lead to greater concentration of an industry; in other words that the decline manifests itself mainly in decentralized locations

Inter-industry contagion and the competitive effects of financial distress announcements: evidence from commercial banks and life insurance companies

Contagion usually refers to the spillover of the effects of shocks from one or more firms to other firms. Most studies of contagion limit their analysis to how shock affect firms in the same industry, or "intra-industry" contagion. The purpose of this paper is to explore and document the likely magnitude of "inter-industry" contagion. In their comprehensive study of intra-industry contagion using many individual industries Lang and Stulz (1992) argue that if contagion is not simply an informational effect it will impose a social cost on our economic system. If this is true for intra-industry contagion, then the same argument must hold for inter-industry contagion as well. We focus on inter-industry contagion effects in this paper because the vast majority of the extant literature about contagion has neglected its important potential cost to shareholders. Most of the studies on contagion attempts to differentiate between a "pure" contagion effect and a signaling or information-based contagion effect. An example of a pure contagion effect would be the negative effects of a bank failure spilling over to other banks regardless of the cause of the bank failure. And, an example of a signaling contagion effect would be if a bank failure is caused by problems whose revelation is correlated across banks, and the correlated banks are impacted negatively. We conduct our investigation of contagion by examining three separate announcements involving adverse information about commercial real estate portfolios. The first announcement is by a large commercial bank (the Bank of New England), the second announcement consists of a series of events--from several large banking organizations and a regulatory agency (the Office of the Comptroller of the Currency), and the third announcement is by a large life insurance company (Travelers). There are two reasons we chose these particular events. First, the events seemed to be very unusual and very significant indicators of future (and present) financial distress. Second, the events shared a common theme of financial distress caused by problems with commercial real estate portfolios. We first establish that the commercial bank announcements negatively impact the equity values of life insurance companies (and vice versa). Next, we demonstrate that the bank regulatory agency announcement negatively impacts the equity values of life insurance companies as well as commercial banks. We then explicitly test if the shareholder wealth effects are linked to a set of specific firm characteristics. Consistent with previous contagion studies, our results provide strong evidence of "intra-industry" contagion related wealth effects. We also find that these contagion effects, to a significant degree, can be explained by firm specific variables. This implies that the intra-industry spillover effects associated with our three events are not of the totally "pure" contagion variety, but have an informational component as well. We also find very strong evidence of significant "inter-industry" contagion-based shareholder wealth effects. Again, these contagion-based wealth effects do not appear to be purely contagion-based. Wealth effects can also be explained by such factors as geographic proximity, asset composition, liability composition, leverage, size, and regulatory expectations.Insurance ; Bank failures ; Stocks

The association between healthy beverage index and quality of life among overweight and obese women: a cross-sectional study

BACKGROUND: Although several studies have evaluated the association between patterns of beverage consumption with different components of quality of life separately, the findings are controversial. In addition, none have examined all components of quality of life together in relation to patterns of beverage consumption. Therefore, this study was conducted to identify the association between healthy beverage index (HBI) and quality of life among overweight and obese women. METHODS: For this cross-sectional study, 210 obese and overweight women were recruited from health centers in Tehran, Iran. Using reliable and verified standard protocols, data on beverage intake, socio-demographic, physical activity, and anthropometric variables were assessed. Based on past studies, the predetermined HBI was estimated. Serum samples were used to determine biochemical characteristics, and quality of life was assessed using SF-36 questionnaires. RESULTS: There was a significant association between total QoL score with T2 tertile of HBI in the adjusted model (β: 13.11, 95% CI: 1.52, 24.69, p-value = 0.027). General health had a significant negative association with T2 (β: -5.83; 95% CI: − 11.48, − 0.18; p-value = 0.043) and T3 (β: -6.20; 95% CI: − 12.37, − 0.03; p-value = 0.049). Women with greater adherence to the HBI had a higher physical functioning score, and there was a significant upward trend from the second to the third tertile (7.74 vs 0.62) (−trend = 0.036). There was a significant positive association between mental health with T3 of HBI (β: 4.26; 95% CI: 1.51, 5.98; p-value = 0.015) and a significant increasing trend was observed with increasing tertiles (P-trend = 0.045). CONCLUSION: In conclusion, there is a significant association between total QoL score, and its components, with HBI among overweight and obese women. However, additional well-designed studies are needed to confirm these findings