31,621 research outputs found
An overview of current approaches and future challenges in physiological monitoring
Sufficient evidence exists from laboratory studies to suggest that physiological measures can be useful as an adjunct to behavioral and subjective measures of human performance and capabilities. Thus it is reasonable to address the conceptual and engineering challenges that arise in applying this technology in operational settings. Issues reviewed include the advantages and disadvantages of constructs such as mental states, the need for physiological measures of performance, areas of application for physiological measures in operational settings, which measures appear to be most useful, problem areas that arise in the use of these measures in operational settings, and directions for future development
Information and communication technology solutions for outdoor navigation in dementia
INTRODUCTION:
Information and communication technology (ICT) is potentially mature enough to empower outdoor and social activities in dementia. However, actual ICT-based devices have limited functionality and impact, mainly limited to safety. What is an ideal operational framework to enhance this field to support outdoor and social activities?
METHODS:
Review of literature and cross-disciplinary expert discussion.
RESULTS:
A situation-aware ICT requires a flexible fine-tuning by stakeholders of system usability and complexity of function, and of user safety and autonomy. It should operate by artificial intelligence/machine learning and should reflect harmonized stakeholder values, social context, and user residual cognitive functions. ICT services should be proposed at the prodromal stage of dementia and should be carefully validated within the life space of users in terms of quality of life, social activities, and costs.
DISCUSSION:
The operational framework has the potential to produce ICT and services with high clinical impact but requires substantial investment
Everything should be as simple as possible, but no simpler : towards a protocol for accumulating evidence regarding the active content of health behaviour change interventions
Supplemental data for this article can be accessed here: 10.1080/17437199.2013.848409Peer reviewedPublisher PD
The impact of board governance on director compensation in West African IPO firms
This paper undertakes a unique study of the determinants of corporate governance in the West African developing region and their impact on director compensation. A new measure of director total remuneration is constructed providing a conservative estimate of expropriation of private benefits of control. Using a hand-collected sample of 51 West African IPO firms from 2000 and 2011 we find evidence that increased presence of true independent nonexecutives that are unconnected to CEO or dominant insider groups within firm and nominally independent board level committees are highly associated with expropriation inferring that firm’s with directors engaging in this behavior are more likely to adopt measures indicative of governance best practic
Likelihood-Based Inference for Discretely Observed Birth-Death-Shift Processes, with Applications to Evolution of Mobile Genetic Elements
Continuous-time birth-death-shift (BDS) processes are frequently used in
stochastic modeling, with many applications in ecology and epidemiology. In
particular, such processes can model evolutionary dynamics of transposable
elements - important genetic markers in molecular epidemiology. Estimation of
the effects of individual covariates on the birth, death, and shift rates of
the process can be accomplished by analyzing patient data, but inferring these
rates in a discretely and unevenly observed setting presents computational
challenges. We propose a mutli-type branching process approximation to BDS
processes and develop a corresponding expectation maximization (EM) algorithm,
where we use spectral techniques to reduce calculation of expected sufficient
statistics to low dimensional integration. These techniques yield an efficient
and robust optimization routine for inferring the rates of the BDS process, and
apply more broadly to multi-type branching processes where rates can depend on
many covariates. After rigorously testing our methodology in simulation
studies, we apply our method to study intrapatient time evolution of IS6110
transposable element, a frequently used element during estimation of
epidemiological clusters of Mycobacterium tuberculosis infections.Comment: 31 pages, 7 figures, 1 tabl
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