Applications of Deep Learning and Machine Learning in Healthcare Domain – A Literature Review

In recent years, Artificial Intelligence (AI) has advanced rapidly in terms of software algorithms, hardware implementation, and implementations in a wide range of fields. The latest advances in AI applications in biomedicine, such as disease diagnostics, living assistance, biomedical information processing, and biomedical science, are summarised in this study. Brain-Computer Interfaces (BCIs), Arterial Spin Labeling (ASL) imaging, ASL-MRI, biomarkers, Natural Language Processing (NLP), and various algorithms all help to reduce errors and monitor disease progression. Computer-assisted diagnosis, decision support systems, expert systems, and software implementation can help doctors reduce intra- and inter-observer variability. In this paper, numerous researchers conduct a systematic literature review on the application and implementation of Machine Learning, Deep Learning, and Artificial Intelligence in the healthcare industry

Application of infrared thermography in computer aided diagnosis

The invention of thermography, in the 1950s, posed a formidable problem to the research community: What is the relationship between disease and heat radiation captured with Infrared (IR) cameras? The research community responded with a continuous effort to find this crucial relationship. This effort was aided by advances in processing techniques, improved sensitivity and spatial resolution of thermal sensors. However, despite this progress fundamental issues with this imaging modality still remain. The main problem is that the link between disease and heat radiation is complex and in many cases even non-linear. Furthermore, the change in heat radiation as well as the change in radiation pattern, which indicate disease, is minute. On a technical level, this poses high requirements on image capturing and processing. On a more abstract level, these problems lead to inter-observer variability and on an even more abstract level they lead to a lack of trust in this imaging modality. In this review, we adopt the position that these problems can only be solved through a strict application of scientific principles and objective performance assessment. Computing machinery is inherently objective; this helps us to apply scientific principles in a transparent way and to assess the performance results. As a consequence, we aim to promote thermography based Computer-Aided Diagnosis (CAD) systems. Another benefit of CAD systems comes from the fact that the diagnostic accuracy is linked to the capability of the computing machinery and, in general, computers become ever more potent. We predict that a pervasive application of computers and networking technology in medicine will help us to overcome the shortcomings of any single imaging modality and this will pave the way for integrated health care systems which maximize the quality of patient care

Data fusion by using machine learning and computational intelligence techniques for medical image analysis and classification

Data fusion is the process of integrating information from multiple sources to produce specific, comprehensive, unified data about an entity. Data fusion is categorized as low level, feature level and decision level. This research is focused on both investigating and developing feature- and decision-level data fusion for automated image analysis and classification. The common procedure for solving these problems can be described as: 1) process image for region of interest\u27 detection, 2) extract features from the region of interest and 3) create learning model based on the feature data. Image processing techniques were performed using edge detection, a histogram threshold and a color drop algorithm to determine the region of interest. The extracted features were low-level features, including textual, color and symmetrical features. For image analysis and classification, feature- and decision-level data fusion techniques are investigated for model learning using and integrating computational intelligence and machine learning techniques. These techniques include artificial neural networks, evolutionary algorithms, particle swarm optimization, decision tree, clustering algorithms, fuzzy logic inference, and voting algorithms. This work presents both the investigation and development of data fusion techniques for the application areas of dermoscopy skin lesion discrimination, content-based image retrieval, and graphic image type classification --Abstract, page v

Improved Alzheimer’s disease detection by MRI using multimodal machine learning algorithms

Dementia is one of the huge medical problems that have challenged the public health sector around the world. Moreover, it generally occurred in older adults (age > 60). Shockingly, there are no legitimate drugs to fix this sickness, and once in a while it will directly influence individual memory abilities and diminish the human capacity to perform day by day exercises. Many health experts and computing scientists were performing research works on this issue for the most recent twenty years. All things considered, there is an immediate requirement for finding the relative characteristics that can figure out the identification of dementia. The motive behind the works presented in this thesis is to propose the sophisticated supervised machine learning model in the prediction and classification of AD in elder people. For that, we conducted different experiments on open access brain image information including demographic MRI data of 373 scan sessions of 150 patients. In the first two works, we applied single ML models called support vectors and pruned decision trees for the prediction of dementia on the same dataset. In the first experiment with SVM, we achieved 70% of the prediction accuracy of late-stage dementia. Classification of true dementia subjects (precision) is calculated as 75%. Similarly, in the second experiment with J48 pruned decision trees, the accuracy was improved to the value of 88.73%. Classification of true dementia cases with this model was comprehensively done and achieved 92.4% of precision. To enhance this work, rather than single modelling we employed multi-modelling approaches. In the comparative analysis of the machine learning study, we applied the feature reduction technique called principal component analysis. This approach identifies the high correlated features in the dataset that are closely associated with dementia type. By doing the simultaneous application of three models such as KNN, LR, and SVM, it has been possible to identify an ideal model for the classification of dementia subjects. When compared with support vectors, KNN and LR models comprehensively classified AD subjects with 97.6% and 98.3% of accuracy respectively. These values are relatively higher than the previous experiments. However, because of the AD severity in older adults, it should be mandatory to not leave true AD positives. For the classification of true AD subjects among total subjects, we enhanced the model accuracy by introducing three independent experiments. In this work, we incorporated two new models called Naïve Bayes and Artificial Neural Networks along support vectors and KNN. In the first experiment, models were independently developed with manual feature selection. The experimental outcome suggested that KNN 3 is the optimal model solution because of 91.32% of classification accuracy. In the second experiment, the same models were tested with limited features (with high correlation). SVM was produced a high 96.12% of classification accuracy and NB produced a 98.21% classification rate of true AD subjects. Ultimately, in the third experiment, we mixed these four models and created a new model called hybrid type modelling. Hybrid model performance is validated AU-ROC curve value which is 0.991 (i.e., 99.1% of classification accuracy) has achieved. All these experimental results suggested that the ensemble modelling approach with wrapping is an optimal solution in the classification of AD subjects

WEATHER LORE VALIDATION TOOL USING FUZZY COGNITIVE MAPS BASED ON COMPUTER VISION

Published ThesisThe creation of scientific weather forecasts is troubled by many technological challenges (Stern & Easterling, 1999) while their utilization is generally dismal. Consequently, the majority of small-scale farmers in Africa continue to consult some forms of weather lore to reach various cropping decisions (Baliscan, 2001). Weather lore is a body of informal folklore (Enock, 2013), associated with the prediction of the weather, and based on indigenous knowledge and human observation of the environment. As such, it tends to be more holistic, and more localized to the farmers’ context. However, weather lore has limitations; for instance, it has an inability to offer forecasts beyond a season. Different types of weather lore exist, utilizing almost all available human senses (feel, smell, sight and hearing). Out of all the types of weather lore in existence, it is the visual or observed weather lore that is mostly used by indigenous societies, to come up with weather predictions. On the other hand, meteorologists continue to treat this knowledge as superstition, partly because there is no means to scientifically evaluate and validate it. The visualization and characterization of visual sky objects (such as moon, clouds, stars, and rainbows) in forecasting weather are significant subjects of research. To realize the integration of visual weather lore in modern weather forecasting systems, there is a need to represent and scientifically substantiate this form of knowledge. This research was aimed at developing a method for verifying visual weather lore that is used by traditional communities to predict weather conditions. To realize this verification, fuzzy cognitive mapping was used to model and represent causal relationships between selected visual weather lore concepts and weather conditions. The traditional knowledge used to produce these maps was attained through case studies of two communities (in Kenya and South Africa).These case studies were aimed at understanding the weather lore domain as well as the causal effects between metrological and visual weather lore. In this study, common astronomical weather lore factors related to cloud physics were identified as: bright stars, dispersed clouds, dry weather, dull stars, feathery clouds, gathering clouds, grey clouds, high clouds, layered clouds, low clouds, stars, medium clouds, and rounded clouds. Relationships between the concepts were also identified and formally represented using fuzzy cognitive maps. On implementing the verification tool, machine vision was used to recognize sky objects captured using a sky camera, while pattern recognition was employed in benchmarking and scoring the objects. A wireless weather station was used to capture real-time weather parameters. The visualization tool was then designed and realized in a form of software artefact, which integrated both computer vision and fuzzy cognitive mapping for experimenting visual weather lore, and verification using various statistical forecast skills and metrics. The tool consists of four main sub-components: (1) Machine vision that recognizes sky objects using support vector machine classifiers using shape-based feature descriptors; (2) Pattern recognition–to benchmark and score objects using pixel orientations, Euclidean distance, canny and grey-level concurrence matrix; (3) Fuzzy cognitive mapping that was used to represent knowledge (i.e. active hebbian learning algorithm was used to learn until convergence); and (4) A statistical computing component was used for verifications and forecast skills including brier score and contingency tables for deterministic forecasts. Rigorous evaluation of the verification tool was carried out using independent (not used in the training and testing phases) real-time images from Bloemfontein, South Africa, and Voi-Kenya. The real-time images were captured using a sky camera with GPS location services. The results of the implementation were tested for the selected weather conditions (for example, rain, heat, cold, and dry conditions), and found to be acceptable (the verified prediction accuracies were over 80%). The recommendation in this study is to apply the implemented method for processing tasks, towards verifying all other types of visual weather lore. In addition, the use of the method developed also requires the implementation of modules for processing and verifying other types of weather lore, such as sounds, and symbols of nature. Since time immemorial, from Australia to Asia, Africa to Latin America, local communities have continued to rely on weather lore observations to predict seasonal weather as well as its effects on their livelihoods (Alcock, 2014). This is mainly based on many years of personal experiences in observing weather conditions. However, when it comes to predictions for longer lead-times (i.e. over a season), weather lore is uncertain (Hornidge & Antweiler, 2012). This uncertainty has partly contributed to the current status where meteorologists and other scientists continue to treat weather lore as superstition (United-Nations, 2004), and not capable of predicting weather. One of the problems in testing the confidence in weather lore in predicting weather is due to wide varieties of weather lore that are found in the details of indigenous sayings, which are tightly coupled to locality and pattern variations(Oviedo et al., 2008). This traditional knowledge is entrenched within the day-to-day socio-economic activities of the communities using it and is not globally available for comparison and validation (Huntington, Callaghan, Fox, & Krupnik, 2004). Further, this knowledge is based on local experience that lacks benchmarking techniques; so that harmonizing and integrating it within the science-based weather forecasting systems is a daunting task (Hornidge & Antweiler, 2012). It is partly for this reason that the question of validation of weather lore has not yet been substantially investigated. Sufficient expanded processes of gathering weather observations, combined with comparison and validation, can produce some useful information. Since forecasting weather accurately is a challenge even with the latest supercomputers (BBC News Magazine, 2013), validated weather lore can be useful if it is incorporated into modern weather prediction systems. Validation of traditional knowledge is a necessary step in the management of building integrated knowledge-based systems. Traditional knowledge incorporated into knowledge-based systems has to be verified for enhancing systems’ reliability. Weather lore knowledge exists in different forms as identified by traditional communities; hence it needs to be tied together for comparison and validation. The development of a weather lore validation tool that can integrate a framework for acquiring weather data and methods of representing the weather lore in verifiable forms can be a significant step in the validation of weather lore against actual weather records using conventional weather-observing instruments. The success of validating weather lore could stimulate the opportunity for integrating acceptable weather lore with modern systems of weather prediction to improve actionable information for decision making that relies on seasonal weather prediction. In this study a hybrid method is developed that includes computer vision and fuzzy cognitive mapping techniques for verifying visual weather lore. The verification tool was designed with forecasting based on mimicking visual perception, and fuzzy thinking based on the cognitive knowledge of humans. The method provides meaning to humanly perceivable sky objects so that computers can understand, interpret, and approximate visual weather outcomes. Questionnaires were administered in two case study locations (KwaZulu-Natal province in South Africa, and Taita-Taveta County in Kenya), between the months of March and July 2015. The two case studies were conducted by interviewing respondents on how visual astronomical and meteorological weather concepts cause weather outcomes. The two case studies were used to identify causal effects of visual astronomical and meteorological objects to weather conditions. This was followed by finding variations and comparisons, between the visual weather lore knowledge in the two case studies. The results from the two case studies were aggregated in terms of seasonal knowledge. The causal links between visual weather concepts were investigated using these two case studies; results were compared and aggregated to build up common knowledge. The joint averages of the majority of responses from the case studies were determined for each set of interacting concepts. The modelling of the weather lore verification tool consists of input, processing components and output. The input data to the system are sky image scenes and actual weather observations from wireless weather sensors. The image recognition component performs three sub-tasks, including: detection of objects (concepts) from image scenes, extraction of detected objects, and approximation of the presence of the concepts by comparing extracted objects to ideal objects. The prediction process involves the use of approximated concepts generated in the recognition component to simulate scenarios using the knowledge represented in the fuzzy cognitive maps. The verification component evaluates the variation between the predictions and actual weather observations to determine prediction errors and accuracy. To evaluate the tool, daily system simulations were run to predict and record probabilities of weather outcomes (i.e. rain, heat index/hotness, dry, cold index). Weather observations were captured periodically using a wireless weather station. This process was repeated several times until there was sufficient data to use for the verification process. To match the range of the predicted weather outcomes, the actual weather observations (measurement) were transformed and normalized to a range [0, 1].In the verification process, comparisons were made between the actual observations and weather outcome prediction values by computing residuals (error values) from the observations. The error values and the squared error were used to compute the Mean Squared Error (MSE), and the Root Mean Squared Error (RMSE), for each predicted weather outcome. Finally, the validity of the visual weather lore verification model was assessed using data from a different geographical location. Actual data in the form of daily sky scenes and weather parameters were acquired from Voi, Kenya, from December 2015 to January 2016.The results on the use of hybrid techniques for verification of weather lore is expected to provide an incentive in integrating indigenous knowledge on weather with modern numerical weather prediction systems for accurate and downscaled weather forecasts

Intelligent Systems

This book is dedicated to intelligent systems of broad-spectrum application, such as personal and social biosafety or use of intelligent sensory micro-nanosystems such as "e-nose", "e-tongue" and "e-eye". In addition to that, effective acquiring information, knowledge management and improved knowledge transfer in any media, as well as modeling its information content using meta-and hyper heuristics and semantic reasoning all benefit from the systems covered in this book. Intelligent systems can also be applied in education and generating the intelligent distributed eLearning architecture, as well as in a large number of technical fields, such as industrial design, manufacturing and utilization, e.g., in precision agriculture, cartography, electric power distribution systems, intelligent building management systems, drilling operations etc. Furthermore, decision making using fuzzy logic models, computational recognition of comprehension uncertainty and the joint synthesis of goals and means of intelligent behavior biosystems, as well as diagnostic and human support in the healthcare environment have also been made easier

Computational models and approaches for lung cancer diagnosis

The success of treatment of patients with cancer depends on establishing an accurate diagnosis. To this end, the aim of this study is to developed novel lung cancer diagnostic models. New algorithms are proposed to analyse the biological data and extract knowledge that assists in achieving accurate diagnosis results