13,640 research outputs found
Impact of Indirect Contacts in Emerging Infectious Disease on Social Networks
Interaction patterns among individuals play vital roles in spreading
infectious diseases. Understanding these patterns and integrating their impact
in modeling diffusion dynamics of infectious diseases are important for
epidemiological studies. Current network-based diffusion models assume that
diseases transmit through interactions where both infected and susceptible
individuals are co-located at the same time. However, there are several
infectious diseases that can transmit when a susceptible individual visits a
location after an infected individual has left. Recently, we introduced a
diffusion model called same place different time (SPDT) transmission to capture
the indirect transmissions that happen when an infected individual leaves
before a susceptible individual's arrival along with direct transmissions. In
this paper, we demonstrate how these indirect transmission links significantly
enhance the emergence of infectious diseases simulating airborne disease
spreading on a synthetic social contact network. We denote individuals having
indirect links but no direct links during their infectious periods as hidden
spreaders. Our simulation shows that indirect links play similar roles of
direct links and a single hidden spreader can cause large outbreak in the SPDT
model which causes no infection in the current model based on direct link. Our
work opens new direction in modeling infectious diseases.Comment: Workshop on Big Data Analytics for Social Computing,201
Simulation of an SEIR infectious disease model on the dynamic contact network of conference attendees
The spread of infectious diseases crucially depends on the pattern of
contacts among individuals. Knowledge of these patterns is thus essential to
inform models and computational efforts. Few empirical studies are however
available that provide estimates of the number and duration of contacts among
social groups. Moreover, their space and time resolution are limited, so that
data is not explicit at the person-to-person level, and the dynamical aspect of
the contacts is disregarded. Here, we want to assess the role of data-driven
dynamic contact patterns among individuals, and in particular of their temporal
aspects, in shaping the spread of a simulated epidemic in the population.
We consider high resolution data of face-to-face interactions between the
attendees of a conference, obtained from the deployment of an infrastructure
based on Radio Frequency Identification (RFID) devices that assess mutual
face-to-face proximity. The spread of epidemics along these interactions is
simulated through an SEIR model, using both the dynamical network of contacts
defined by the collected data, and two aggregated versions of such network, in
order to assess the role of the data temporal aspects.
We show that, on the timescales considered, an aggregated network taking into
account the daily duration of contacts is a good approximation to the full
resolution network, whereas a homogeneous representation which retains only the
topology of the contact network fails in reproducing the size of the epidemic.
These results have important implications in understanding the level of
detail needed to correctly inform computational models for the study and
management of real epidemics
A Comparative Analysis of Influenza Vaccination Programs
The threat of avian influenza and the 2004-2005 influenza vaccine supply
shortage in the United States has sparked a debate about optimal vaccination
strategies to reduce the burden of morbidity and mortality caused by the
influenza virus. We present a comparative analysis of two classes of suggested
vaccination strategies: mortality-based strategies that target high risk
populations and morbidity-based that target high prevalence populations.
Applying the methods of contact network epidemiology to a model of disease
transmission in a large urban population, we evaluate the efficacy of these
strategies across a wide range of viral transmission rates and for two
different age-specific mortality distributions. We find that the optimal
strategy depends critically on the viral transmission level (reproductive rate)
of the virus: morbidity-based strategies outperform mortality-based strategies
for moderately transmissible strains, while the reverse is true for highly
transmissible strains. These results hold for a range of mortality rates
reported for prior influenza epidemics and pandemics. Furthermore, we show that
vaccination delays and multiple introductions of disease into the community
have a more detrimental impact on morbidity-based strategies than
mortality-based strategies. If public health officials have reasonable
estimates of the viral transmission rate and the frequency of new introductions
into the community prior to an outbreak, then these methods can guide the
design of optimal vaccination priorities. When such information is unreliable
or not available, as is often the case, this study recommends mortality-based
vaccination priorities
Efficient detection of contagious outbreaks in massive metropolitan encounter networks
Physical contact remains difficult to trace in large metropolitan networks,
though it is a key vehicle for the transmission of contagious outbreaks.
Co-presence encounters during daily transit use provide us with a city-scale
time-resolved physical contact network, consisting of 1 billion contacts among
3 million transit users. Here, we study the advantage that knowledge of such
co-presence structures may provide for early detection of contagious outbreaks.
We first examine the "friend sensor" scheme --- a simple, but universal
strategy requiring only local information --- and demonstrate that it provides
significant early detection of simulated outbreaks. Taking advantage of the
full network structure, we then identify advanced "global sensor sets",
obtaining substantial early warning times savings over the friends sensor
scheme. Individuals with highest number of encounters are the most efficient
sensors, with performance comparable to individuals with the highest travel
frequency, exploratory behavior and structural centrality. An efficiency
balance emerges when testing the dependency on sensor size and evaluating
sensor reliability; we find that substantial and reliable lead-time could be
attained by monitoring only 0.01% of the population with the highest degree.Comment: 4 figure
Zoonosis emergence linked to agricultural intensification and environmental change
A systematic review was conducted by a multidisciplinary team to analyze qualitatively best available scientific evidence on the effect of agricultural intensification and environmental changes on the risk of zoonoses for which there are epidemiological interactions between wildlife and livestock. The study found several examples in which agricultural intensification and/or environmental change were associated with an increased risk of zoonotic disease emergence, driven by the impact of an expanding human population and changing human behavior on the environment. We conclude that the rate of future zoonotic disease emergence or reemergence will be closely linked to the evolution of the agriculture–environment nexus. However, available research inadequately addresses the complexity and interrelatedness of environmental, biological, economic, and social dimensions of zoonotic pathogen emergence, which significantly limits our ability to predict, prevent, and respond to zoonotic disease emergence
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