A new method to detect event-related potentials based on Pearson\u2019s correlation

Event-related potentials (ERPs) are widely used in brain-computer interface applications and in neuroscience. Normal EEG activity is rich in background noise, and therefore, in order to detect ERPs, it is usually necessary to take the average from multiple trials to reduce the effects of this noise. The noise produced by EEG activity itself is not correlated with the ERP waveform and so, by calculating the average, the noise is decreased by a factor inversely proportional to the square root of N, where N is the number of averaged epochs. This is the easiest strategy currently used to detect ERPs, which is based on calculating the average of all ERP\u2019s waveform, these waveforms being time- and phase-locked. In this paper, a new method called GW6 is proposed, which calculates the ERP using a mathematical method based only on Pearson\u2019s correlation. The result is a graph with the same time resolution as the classical ERP and which shows only positive peaks representing the increase\u2014in consonance with the stimuli\u2014in EEG signal correlation over all channels. This new method is also useful for selectively identifying and highlighting some hidden components of the ERP response that are not phase-locked, and that are usually hidden in the standard and simple method based on the averaging of all the epochs. These hidden components seem to be caused by variations (between each successive stimulus) of the ERP\u2019s inherent phase latency period (jitter), although the same stimulus across all EEG channels produces a reasonably constant phase. For this reason, this new method could be very helpful to investigate these hidden components of the ERP response and to develop applications for scientific and medical purposes. Moreover, this new method is more resistant to EEG artifacts than the standard calculations of the average and could be very useful in research and neurology. The method we are proposing can be directly used in the form of a process written in the well-known Matlab programming language and can be easily and quickly written in any other software language

Advanced Signal Processing in Wearable Sensors for Health Monitoring

Smart, wearables devices on a miniature scale are becoming increasingly widely available, typically in the form of smart watches and other connected devices. Consequently, devices to assist in measurements such as electroencephalography (EEG), electrocardiogram (ECG), electromyography (EMG), blood pressure (BP), photoplethysmography (PPG), heart rhythm, respiration rate, apnoea, and motion detection are becoming more available, and play a significant role in healthcare monitoring. The industry is placing great emphasis on making these devices and technologies available on smart devices such as phones and watches. Such measurements are clinically and scientifically useful for real-time monitoring, long-term care, and diagnosis and therapeutic techniques. However, a pertaining issue is that recorded data are usually noisy, contain many artefacts, and are affected by external factors such as movements and physical conditions. In order to obtain accurate and meaningful indicators, the signal has to be processed and conditioned such that the measurements are accurate and free from noise and disturbances. In this context, many researchers have utilized recent technological advances in wearable sensors and signal processing to develop smart and accurate wearable devices for clinical applications. The processing and analysis of physiological signals is a key issue for these smart wearable devices. Consequently, ongoing work in this field of study includes research on filtration, quality checking, signal transformation and decomposition, feature extraction and, most recently, machine learning-based methods

Exploration of Computational Methods for Classification of Movement Intention During Human Voluntary Movement from Single Trial EEG

Objective: To explore effective combinations of computational methods for the prediction of movement intention preceding the production of self-paced right and left hand movements from single trial scalp electroencephalogram (EEG). Methods: Twelve naïve subjects performed self-paced movements consisting of three key strokes with either hand. EEG was recorded from 128 channels. The exploration was performed offline on single trial EEG data. We proposed that a successful computational procedure for classification would consist of spatial filtering, temporal filtering, feature selection, and pattern classification. A systematic investigation was performed with combinations of spatial filtering using principal component analysis (PCA), independent component analysis (ICA), common spatial patterns analysis (CSP), and surface Laplacian derivation (SLD); temporal filtering using power spectral density estimation (PSD) and discrete wavelet transform (DWT); pattern classification using linear Mahalanobis distance classifier (LMD), quadratic Mahalanobis distance classifier (QMD), Bayesian classifier (BSC), multi-layer perceptron neural network (MLP), probabilistic neural network (PNN), and support vector machine (SVM). A robust multivariate feature selection strategy using a genetic algorithm was employed. Results: The combinations of spatial filtering using ICA and SLD, temporal filtering using PSD and DWT, and classification methods using LMD, QMD, BSC and SVM provided higher performance than those of other combinations. Utilizing one of the better combinations of ICA, PSD and SVM, the discrimination accuracy was as high as 75%. Further feature analysis showed that beta band EEG activity of the channels over right sensorimotor cortex was most appropriate for discrimination of right and left hand movement intention. Conclusions: Effective combinations of computational methods provide possible classification of human movement intention from single trial EEG. Such a method could be the basis for a potential brain-computer interface based on human natural movement, which might reduce the requirement of long-term training. Significance: Effective combinations of computational methods can classify human movement intention from single trial EEG with reasonable accuracy

Comparing EEG-neurofeedback visual modalities between screen-based and immersive head-mounted VR

Tese de Mestrado Integrado, Engenharia Biomédica e Biofísica (Sinais e Imagens Médicas), 2022, Universidade de Lisboa, Faculdade de CiênciasNeurofeedback (NF) can be defined as a form of biofeedback that trains subjects to have self-control over brain their functions, by providing real-time feedback of their own cerebral activity. This activity can be presented in various forms, with auditory and visual feedback being the most common. Recently, NF has been investigated as a potential treatment for various clinical conditions associated with abnormal brain activity or cognitive capacities. However, the greater research focus is not discussing how the feedback should be presented. The chosen modality for any NF training system may strongly influence the training protocol and consequently the outcome of the experiment. In this thesis, a systematical comparison between two different type of visual modalities (ScreenBased vs. immersive-virtual reality (VR) ) was performed with the goal to evaluate the effectiveness of each modality on the NF training results. Data from two previous studies, recorded on healthy participants, in protocols that targeted the increase in the upper alpha (UA) band power measured at the EEG electrode Cz was used. This was then divided into two modality groups: Screen-Based modality group (N = 8) and the Immersive-VR group (N = 4). An extensive data processing and cleaning protocol was applied to both groups and the training effectiveness was measured through band power calculation, the definition of learning ability indexes and the application of statistical tests. Results showed that, both groups had a generally positive training effect within sessions, however data regarding different sessions is inconclusive and does not show clear evidence of up-regulation of the target feature. Additionally, when only considering within-session evolution, only the Immersive-VR modality group was able to maintain an increasing trend in all sessions. One of the main limitations of this study was the sample size, which was too small to determine the precise effect of NF training. Future work requires, not only an increase in sample size but also, the definition and incorporation of learning predictors that allow the pre-selection of subjects before the training sessions, in order to prevent high number of non-learners

Electroencephalography-Based Brain–Machine Interfaces in Older Adults: A Literature Review

The aging process is a multifaceted phenomenon that affects cognitive-affective and physical functioning as well as interactions with the environment. Although subjective cognitive decline may be part of normal aging, negative changes objectified as cognitive impairment are present in neurocognitive disorders and functional abilities are most impaired in patients with dementia. Electroencephalography-based brain–machine interfaces (BMI) are being used to assist older people in their daily activities and to improve their quality of life with neuro-rehabilitative applications. This paper provides an overview of BMI used to assist older adults. Both technical issues (detection of signals, extraction of features, classification) and application-related aspects with respect to the users’ needs are considered

Abnormal ECG Classification using Empirical Mode Decomposition and Entropy

Heart disease is one of the leading causes of death in the world. Early detection followed by therapy is one of the efforts to reduce the mortality rate of this disease. One of the leading medical instruments for diagnosing heart disorders is the electrocardiogram (ECG). The shape of the ECG signal represents normal or abnormal heart conditions. Some of the most common heart defects are atrial fibrillation and left bundle branch block. Detection or classification can be difficult if performed visually. Therefore in this study, we propose a method for the automatic classification of ECG signals. This method generally consists of feature extraction and classification. The feature extraction used is based on information theory, namely Fuzzy entropy and Shannon entropy, which is calculated on the decomposed signal. The simulated ECG signals are of three types: normal sinus rhythm, atrial fibrillation, and left bundle branch block. Support vector machine and k-Nearest Neighbor algorithms were employed for the validation performance of the proposed method. From the test results obtained, the highest accuracy is 81.1%. With specificity and sensitivity of 79.4% and 89.8%, respectively. It is hoped that this proposed method can be further developed to assist clinical diagnosis

A Study of recent classification algorithms and a novel approach for biosignal data classification

Analyzing and understanding human biosignals have been important research areas that have many practical applications in everyday life. For example, Brain Computer Interface is a research area that studies the connection between the human brain and external systems by processing and learning the brain signals called Electroencephalography (EEG) signals. Similarly, various assistive robotics applications are being developed to interpret eye or muscle signals in humans in order to provide control inputs for external devices. The efficiency for all of these applications depends heavily on being able to process and classify human biosignals. Therefore many techniques from Signal Processing and Machine Learning fields are applied in order to understand human biosignals better and increase the efficiency and success of these applications. This thesis proposes a new classifier for biosignal data classification utilizing Particle Swarm Optimization Clustering and Radial Basis Function Networks (RBFN). The performance of the proposed classifier together with several variations in the technique is analyzed by utilizing comparisons with the state of the art classifiers such as Fuzzy Functions Support Vector Machines (FFSVM), Improved Fuzzy Functions Support Vector Machines (IFFSVM). These classifiers are implemented on the classification of same biological signals in order to evaluate the proposed technique. Several clustering algorithms, which are used in these classifiers, such as K-means, Fuzzy c-means, and Particle Swarm Optimization (PSO), are studied and compared with each other based on clustering abilities. The effects of the analyzed clustering algorithms in the performance of Radial Basis Functions Networks classifier are investigated. Strengths and weaknesses are analyzed on various standard and EEG datasets. Results show that the proposed classifier that combines PSO clustering with RBFN classifier can reach or exceed the performance of these state of the art classifiers. Finally, the proposed classification technique is applied to a real-time system application where a mobile robot is controlled based on person\u27s EEG signal