8 research outputs found
Cybersickness in People with Multiple Sclerosis Exposed to Immersive Virtual Reality
Together with the wide range of possible benefits for the rehabilitation/training of people with multiple sclerosis (pwMS) and other neurologic conditions, exposure to immersive virtual reality (VR) has often been associated with unpleasant symptoms, such as transient dizziness, headache, nausea, disorientation and impaired postural control (i.e., cybersickness). Since these symptoms can significantly impact the safety and tolerability of the treatment, it appears important to correctly estimate their presence and magnitude. Given the existing data scarcity, this study aims to assess the existence and severity of possible adverse effects associated with exposure to immersive VR in a cohort of pwMS using both objective measurements of postural control effectiveness and subjective evaluations of perceived symptoms. To this aim, postural sway under upright quiet posture (in the presence and absence of visual input) of 56 pwMS with an Expanded Disability Status Scale score (EDSS) in the range of 0â6.5 (mean EDSS 2.3) and 33 unaffected individuals was measured before and after a 10-min immersive VR session and at 10 min follow-up on the basis of center of pressure (COP) trajectories. The severity of cybersickness symptoms associated with VR exposure was also self-rated by the participants using the Italian version of the Simulator Sickness Questionnaire (SSQ). Temporary impairments of postural control in terms of significantly increased sway area were observed after the VR session only in pwMS with mildâmoderate disability (i.e., EDSS in the range of 2.5â6.5) in the presence of visual input. No changes were observed in pwMS with low disability (EDSS 0â2) and unaffected individuals. In contrast, when the visual input was removed, there was a decrease in sway area (pwMS with mildâmoderate disability) and COP path length relating to the use of VR (pwMS with mildâmoderate disability and unaffected individuals), thus suggesting a sort of âbalance training effectâ. Even in this case, the baseline values were restored at follow-up. All participants, regardless of their status, experienced significant post-VR side effects, especially in terms of blurred vision and nausea. Taken together, the findings of the present study suggest that a short immersive VR session negatively (eyes open) and positively (eyes closed) impacts the postural control of pwMS and causes significant disorientation. However, such effects are of limited duration. While it is reasonable to state that immersive VR is sufficiently safe and tolerable to not be contraindicated in the rehabilitation/training of pwMS, in order to reduce possible negative effects and maximize the efficacy, safety and comfort of the treatment, it appears necessary to develop specific guidelines that consider important factors like individual susceptibility, maximum exposure time according to the specific features of the simulation, posture to adopt and protocols to assess objective and perceived effects on participants
How immersive virtual reality methods may meet the criteria of the National Academy of Neuropsychology and American Academy of Clinical Neuropsychology:A software review of the Virtual Reality Everyday Assessment Lab (VR-EAL)
International audienceClinical tools involving immersive virtual reality (VR) may bring several advantages to cognitive neuroscience and neuropsychology. However, there are some technical and methodological pitfalls. The American Academy of Clinical Neuropsychology (AACN) and the National Academy of Neuropsychology (NAN) raised 8 key issues pertaining to Computerized Neuropsychological Assessment Devices. These issues pertain to: (1) the safety and effectivity; (2) the identity of the end-user; (3) the technical hardware and software features; (4) privacy and data security; (5) the psychometric properties; (6) examinee issues; (7) the use of reporting services; and (8) the reliability of the responses and results. The VR Everyday Assessment Lab (VR-EAL) is the first immersive VR neuropsychological battery with enhanced ecological validity for the assessment of everyday cognitive functions by offering a pleasant testing experience without inducing cybersickness. The VR-EAL meets the criteria of the NAN and AACN, addresses the methodological pitfalls, and brings advantages for neuropsychological testing. However, there are still shortcomings of the VR-EAL, which should be addressed. Future iterations should strive to improve the embodiment illusion in VR-EAL and the creation of an open access VR software library should be attempted. The discussed studies demonstrate the utility of VR methods in cognitive neuroscience and neuropsychology
Technological competence is a precondition for effective implementation of virtual reality head mounted displays in human neuroscience:A technological review and meta-analysis
International audienceImmersive virtual reality (VR) emerges as a promising research and clinical tool. However, several studies suggest that VR induced adverse symptoms and effects (VRISE) may undermine the health and safety standards, and the reliability of the scientific results. In the current literature review, the technical reasons for the adverse symptomatology are investigated to provide suggestions and technological knowledge for the implementation of VR head-mounted display (HMD) systems in cognitive neuroscience. The technological systematic literature indicated features pertinent to display, sound, motion tracking, navigation, ergonomic interactions, user experience, and computer hardware that should be considered by the researchers. Subsequently, a meta-analysis of 44 neuroscientific or neuropsychological studies involving VR HMD systems was performed. The meta-analysis of the VR studies demonstrated that new generation HMDs induced significantly less VRISE and marginally fewer dropouts. Importantly, the commercial versions of the new generation HMDs with ergonomic interactions had zero incidents of adverse symptomatology and dropouts. HMDs equivalent to or greater than the commercial versions of contemporary HMDs accompanied with ergonomic interactions are suitable for implementation in cognitive neuroscience. In conclusion, researchers' technological competency, along with meticulous methods and reports pertinent to software, hardware, and VRISE, are paramount to ensure the health and safety standards and the reliability of neuroscientific results
The Effects of Primary and Secondary Task Workloads on Cybersickness in Immersive Virtual Active Exploration Experiences
Virtual reality (VR) technology promises to transform humanity. The technology enables users to explore and interact with computer-generated environments that can be simulated to approximate or deviate from reality. This creates an endless number of ways to propitiously apply the technology in our lives. It follows that large technological conglomerates are pushing for the widespread adoption of VR, financing the creation of the Metaverse - a hypothetical representation of the next iteration of the internet.
Even with VR technology\u27s continuous growth, its widespread adoption remains long overdue. This can largely be attributed to an affliction called cybersickness, an analog to motion sickness, which often manifests in users as an undesirable side-effect of VR experiences, inhibiting its sustained usage. This makes it highly important to study factors related to the malady.
The tasks performed in a simulated environment provide context, purpose, and meaning to the experience. Active exploration experiences afford users control over their motion, primarily allowing them to navigate through an environment. While navigating, users may also have to engage in secondary tasks that can be distracting. These navigation and distraction tasks differ in terms of the source and magnitude of attentional demands involved, potentially influencing how cyber-sickening a simulation can be. Given the sparse literature in this area, this dissertation sets out to investigate how the interplay between these factors impacts the onset and severity of sickness, thereby contributing to the knowledge base on how the attentional demands associated with the tasks performed during navigation affect cybersickness in virtual reality
Immersive virtual reality methods in cognitive neuroscience and neuropsychology: the Virtual Reality Everyday Assessment Lab (VR-EAL).an immersive neuropsychological test battery of everyday cognitive functions
In cognitive neuroscience and neuropsychology, the collection of cognitive and
behavioural data is predominantly achieved by implementing paper-and-pencil and
computerized (i.e., 2D and 3D applications) assessments. However, these
psychometric tools in clinics and/or laboratories display several limitations and
discrepancies between the observed performance in the laboratory/clinic and the actual
performance of individuals in everyday life. The functional and predictive association
between an individual's performance on a set of neuropsychological tests and the
individual's performance in various everyday life settings is called ecological validity.
Ecological validity is considered an important issue that cannot be resolved by the
currently available assessment tools. Virtual reality head-mounted displays (HMD)
appear to be effective research tools, which may address the problem of ecological
validity in neuropsychological testing. However, their widespread implementation is
hindered by virtual reality induced symptoms and effects (VRISE) and the lack of
skills in virtual reality software development.
In this PhD, a technological systematic literature review of the reasons for adverse
symptomatology was conducted and suggestions and technological knowledge for the
implementation of virtual reality HMD systems in cognitive neuroscience provided.
The review indicated features pertinent to display, sound, motion tracking, navigation,
ergonomic interactions, user experience, and computer hardware that should be
considered by researchers. Subsequently, a meta-analysis of 44 neuroscientific or
neuropsychological studies involving virtual reality HMD systems was performed.
The meta-analysis of the virtual reality studies demonstrated that new generation
HMDs induce significantly less VRISE and marginally fewer dropouts. Importantly, the commercial versions of the new generation HMDs with ergonomic interactions had
zero incidents of adverse symptomatology and dropouts. HMDs equivalent to or
greater than the commercial versions of contemporary HMDs accompanied with
ergonomic interactions are suitable for implementation in cognitive neuroscience.
Another aim of this PhD was to devise a brief tool to appraise and report both the
quality of software features and VRISE intensity quantitatively; such a tool does not
currently exist. The Virtual Reality Neuroscience Questionnaire (VRNQ; Kourtesis et
al., 2019) was developed to assess the quality of virtual reality software in terms of
user experience, game mechanics, in-game assistance, and VRISE. Forty participants
aged between 28 and 43 years were recruited (18 gamers and 22 non-gamers) for the
study. They participated in 3 different virtual reality sessions until they felt weary or
discomfort and subsequently filled in the VRNQ. The results demonstrated that VRNQ
is a valid tool for assessing virtual reality software as it has good convergent,
discriminant, and construct validity. The maximum duration of virtual reality sessions
should be between 55 and 70 min when the virtual reality software meets or exceeds
the parsimonious cut-offs of the VRNQ, and the users are familiarized with the virtual
reality system. Also, gaming experience does not affect how long virtual reality
sessions should last. Furthermore, while the quality of virtual reality software
substantially modulates the maximum duration of virtual reality sessions, age and
education do not. Finally, deeper immersion, better quality of graphics and sound, and
more helpful in-game instructions and prompts were found to reduce VRISE intensity.
The VRNQ facilitates the brief assessment and reporting of the quality of virtual reality
software features and/or the intensity of VRISE, while its minimum and parsimonious
cut-offs may appraise the suitability of virtual reality software for implementation in research and clinical settings. However, the development of virtual reality software is
predominantly dependent on third parties (e.g., freelancers or companies) with
programming and software development skills. A solution that will promote the
adoption of immersive virtual reality as a research and clinical tool might be the in-house development of virtual reality research/clinical software by computer science
literate cognitive scientists or research software engineers.
In Chapter 4, guidelines are offered for the development of virtual reality software in
cognitive neuroscience and neuropsychology, by describing and discussing the stages
of the development of Virtual Reality Everyday Assessment Lab (VR-EAL), the first
neuropsychological battery in immersive virtual reality. Techniques for evaluating
cognitive functions within a realistic storyline are discussed. The utility of various
assets in Unity, software development kits, and other software are described so that
cognitive scientists can overcome challenges pertinent to VRISE and the quality of the
virtual reality software. In addition, VR-EAL is evaluated in accordance with the
necessary criteria for virtual reality software for research purposes. The virtual reality
neuroscience questionnaire (VRNQ) was implemented to appraise the quality of the
three versions of VR-EAL in terms of user experience, game mechanics, in-game
assistance, and VRISE. Twenty-five participants aged between 20 and 45 years with
12â16 years of full-time education evaluated various versions of VR-EAL. The final
version of VR-EAL achieved high scores in every sub-score of the VRNQ and
exceeded its parsimonious cut-offs. It also appeared to have better in-game assistance
and game mechanics, while its improved graphics substantially increased the quality
of the user experience and almost eradicated VRISE. The results substantially support the feasibility of the development of effective virtual reality research and clinical
software without the presence of VRISE during a 60-min virtual reality session.
In Chapter 5, validation of VR-EAL as an assessment of prospective memory, episodic
memory, attention, and executive functions using an ecologically valid approach is
examined. Performance on the VR-EAL, an immersive virtual reality
neuropsychological battery, is examined against an extensive paper-and-pencil
neuropsychological battery. Forty-one participants (21 females) were recruited: 18
gamers and 23 non-gamers who attended both an immersive virtual reality and a paper-and-pencil testing session. Bayesian Pearson correlation analyses were conducted to
assess construct and convergent validity of the VR-EAL. Bayesian t-tests were
performed to compare virtual reality and paper-and-pencil testing in terms of
administration time, similarity to real life tasks (i.e., ecological validity), and
pleasantness. VR-EAL scores were significantly correlated with their equivalent
scores on the paper-and-pencil tests. The participantsâ reports indicated that the VR-EAL tasks were considered significantly more ecologically valid and pleasant than the
paper-and-pencil neuropsychological battery. The VR-EAL battery also had a shorter
administration time. The VR-EAL appears to be an effective neuropsychological tool
for the assessment of everyday cognitive functions, and has enhanced ecological
validity, a highly pleasant testing experience, and does not induce cybersickness.
In the final part of this thesis, the preparatory attentional and memory (PAM) and the
multiprocess theories of prospective memory are examined by attempting to identify
the cognitive functions which may predict the individualâs performance on
ecologically valid prospective memory tasks in the same group of participants
described in Chapter 5. Bayesian t-tests were conducted to explore the differences among different prospective memory tasks (e.g., event-based and time-based) and
prospective memory tasks with varying delays between encoding and the recall of the
intended action (e.g., short-delay versus long-delay). Bayesian linear regression
analyses were performed to examine the predictors of VR-EAL scores. The results
revealed that the type of prospective memory task does not play a significant role in
everyday prospective memory functioning, but instead the length of delay between
encoding and retrieving the prospective memory intention plays a central role. Support
for the PAM and MP frameworks was found in non-focal and focal event-based tasks
respectively. However, the findings, inferring a dynamic interplay between automatic
and intentional monitoring and retrieval processes, agree with the inclusive approach
of the multiprocess framework. Also, the role of executive functions appears crucial
in everyday PM. Finally, everyday PM is predominantly facilitated by episodic
memory, visuospatial attention, auditory attention, and executive functions.
In conclusion, this PhD thesis attempted to show how immersive virtual reality
research methods may be implemented efficiently without the confounding effect of
cybersickness symptomatology in order to enhance the ecological validity of
neuropsychological testing and contribute to our understanding of everyday cognitive
ability
Proceedings of the 7th international conference on disability, virtual reality and associated technologies, with ArtAbilitation (ICDVRAT 2008)
The proceedings of the conferenc
Life Sciences Program Tasks and Bibliography for FY 1997
This document includes information on all peer reviewed projects funded by the Office of Life and Microgravity Sciences and Applications, Life Sciences Division during fiscal year 1997. This document will be published annually and made available to scientists in the space life sciences field both as a hard copy and as an interactive internet web page