General features of the retinal connectome determine the computation of motion anticipation

Motion anticipation allows the visual system to compensate for the slow speed of phototransduction so that a moving object can be accurately located. This correction is already present in the signal that ganglion cells send from the retina but the biophysical mechanisms underlying this computation are not known. Here we demonstrate that motion anticipation is computed autonomously within the dendritic tree of each ganglion cell and relies on feedforward inhibition. The passive and non-linear interaction of excitatory and inhibitory synapses enables the somatic voltage to encode the actual position of a moving object instead of its delayed representation. General rather than specific features of the retinal connectome govern this computation: an excess of inhibitory inputs over excitatory, with both being randomly distributed, allows tracking of all directions of motion, while the average distance between inputs determines the object velocities that can be compensated for

Can my chip behave like my brain?

Many decades ago, Carver Mead established the foundations of neuromorphic systems. Neuromorphic systems are analog circuits that emulate biology. These circuits utilize subthreshold dynamics of CMOS transistors to mimic the behavior of neurons. The objective is to not only simulate the human brain, but also to build useful applications using these bio-inspired circuits for ultra low power speech processing, image processing, and robotics. This can be achieved using reconfigurable hardware, like field programmable analog arrays (FPAAs), which enable configuring different applications on a cross platform system. As digital systems saturate in terms of power efficiency, this alternate approach has the potential to improve computational efficiency by approximately eight orders of magnitude. These systems, which include analog, digital, and neuromorphic elements combine to result in a very powerful reconfigurable processing machine.Ph.D

Detecting and Estimating Signals in Noisy Cable Structures, II: Information Theoretical Analysis

This is the second in a series of articles that seek to recast classical single-neuron biophysics in information-theoretical terms. Classical cable theory focuses on analyzing the voltage or current attenuation of a synaptic signal as it propagates from its dendritic input location to the spike initiation zone. On the other hand, we are interested in analyzing the amount of information lost about the signal in this process due to the presence of various noise sources distributed throughout the neuronal membrane. We use a stochastic version of the linear one-dimensional cable equation to derive closed-form expressions for the second-order moments of the fluctuations of the membrane potential associated with different membrane current noise sources: thermal noise, noise due to the random opening and closing of sodium and potassium channels, and noise due to the presence of “spontaneous” synaptic input. We consider two different scenarios. In the signal estimation paradigm, the time course of the membrane potential at a location on the cable is used to reconstruct the detailed time course of a random, band-limited current injected some distance away. Estimation performance is characterized in terms of the coding fraction and the mutual information. In the signal detection paradigm, the membrane potential is used to determine whether a distant synaptic event occurred within a given observation interval. In the light of our analytical results, we speculate that the length of weakly active apical dendrites might be limited by the information loss due to the accumulated noise between distal synaptic input sites and the soma and that the presence of dendritic nonlinearities probably serves to increase dendritic information transfer

Memristors for the Curious Outsiders

We present both an overview and a perspective of recent experimental advances and proposed new approaches to performing computation using memristors. A memristor is a 2-terminal passive component with a dynamic resistance depending on an internal parameter. We provide an brief historical introduction, as well as an overview over the physical mechanism that lead to memristive behavior. This review is meant to guide nonpractitioners in the field of memristive circuits and their connection to machine learning and neural computation.Comment: Perpective paper for MDPI Technologies; 43 page

A Compact CMOS Memristor Emulator Circuit and its Applications

Conceptual memristors have recently gathered wider interest due to their diverse application in non-von Neumann computing, machine learning, neuromorphic computing, and chaotic circuits. We introduce a compact CMOS circuit that emulates idealized memristor characteristics and can bridge the gap between concepts to chip-scale realization by transcending device challenges. The CMOS memristor circuit embodies a two-terminal variable resistor whose resistance is controlled by the voltage applied across its terminals. The memristor 'state' is held in a capacitor that controls the resistor value. This work presents the design and simulation of the memristor emulation circuit, and applies it to a memcomputing application of maze solving using analog parallelism. Furthermore, the memristor emulator circuit can be designed and fabricated using standard commercial CMOS technologies and opens doors to interesting applications in neuromorphic and machine learning circuits.Comment: Submitted to International Symposium of Circuits and Systems (ISCAS) 201