Pancreas and islet cell transplantation

Currently, for the patient with type 1 diabetes, a definitive treatment without resorting to the use of exogenous insulin can be achieved only with pancreas or islet cell transplantation. These means of restoring β-cell mass can completely maintain essentially normal long-term glucose homeostasis, although the need for powerful immunosuppressive regimens limits their application to only a subgroup of adult patients. Apart from the shortage of donors that has limited all kinds of transplantation, however, the widespread use of β-cell replacement has been precluded until recently by the drawbacks associated with both organ and islet cell transplantation. Although the study of recurrence of diabetes has generated attention, the fundamental obstacle to pancreas and islet transplantation has been, and remains, the alloimmune response. With a better elucidation of the mechanisms of alloengraftment achieved during the last 3 years, the stage has been set for further advances

Hare-lip surgery in the history of traditional Chinese medicine

There have been a few articles published in Chinese and English on hare-lip surgery in the history of traditional Chinese medicine. They are brief and some of them are inaccurate, although two recent English articles on this subject have presented an adequate picture on some aspects.' This article offers unreported information and evidence of both congenital and traumatic hare-lip surgery in the history of traditional Chinese medicine and also clarifies and corrects some of the facts and mistakes that have appeared in works previously published either in Chinese or English

"Rotterdam econometrics": publications of the econometric institute 1956-2005

This paper contains a list of all publications over the period 1956-2005, as reported in the Rotterdam Econometric Institute Reprint series during 1957-2005.

Computability and analysis: the legacy of Alan Turing

We discuss the legacy of Alan Turing and his impact on computability and analysis.Comment: 49 page

Rapid design of tool-wear condition monitoring systems for turning processes using novelty detection

Condition monitoring systems of manufacturing processes have been recognised in recent years as one of the key technologies that provide the competitive advantage in many manufacturing environments. It is capable of providing an essential means to reduce cost, increase productivity, improve quality and prevent damage to the machine or workpiece. Turning operations are considered one of the most common manufacturing processes in industry. It is used to manufacture different round objects such as shafts, spindles and pins. Despite recent development and intensive engineering research, the development of tool wear monitoring systems in turning is still ongoing challenge. In this paper, force signals are used for monitoring tool-wear in a feature fusion model. A novel approach for the design of condition monitoring systems for turning operations using novelty detection algorithm is presented. The results found prove that the developed system can be used for rapid design of condition monitoring systems for turning operations to predict tool-wear