322,102 research outputs found

    Analysis of scale effects in peer-to-peer networks

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    In this paper, we study both positive and negative scale effects on the operations of peer-to-peer (P2P) file sharing networks and propose the optimal sizing (number of peers) and grouping (number of directory intermediary) decisions. Using analytical models and simulation, we evaluate various performance metrics to investigate the characteristics of a P2P network. Our results show that increasing network scale has a positive effect on the expected content availability and transmission cost, but a negative effect on the expected provision and search costs. We propose an explicit expression for the overall utility of a content sharing P2P community that incorporates tradeoffs among all of the performance measures. This utility function is maximized numerically to obtain the optimal network size (or scale). We also investigate the impact of various P2P network parameters on the performance measures as well as optimal scaling decisions. Furthermore, we extend the model to examine the grouping decision in networks with symmetric interconnection structures and compare the performance between random- and location-based grouping policies. © 2008 IEEE.published_or_final_versio

    Exercise Training and Functional Connectivity Changes in Mild Cognitive Empairment and Healthy Elders

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    Background: Effective interventions are needed to improve brain function in mild cognitive impairment (MCI), an early stage of Alzheimer’s disease (AD). The posterior cingulate cortex (PCC)/precuneus is a hub of the default mode network (DMN) and is preferentially vulnerable to disruption of functional connectivity in MCI and AD. Objective: We investigated whether 12 weeks of aerobic exercise could enhance functional connectivity of the PCC/precuneus in MCI and healthy elders. Methods: Sixteen MCI and 16 healthy elders (age range = 60–88) engaged in a supervised 12-week walking exercise intervention. Functional MRI was acquired at rest; the PCC/precuneus was used as a seed for correlated brain activity maps. Results: A linear mixed effects model revealed a significant interaction in the right parietal lobe: the MCI group showed increased connectivity while the healthy elders showed decreased connectivity. In addition, both groups showed increased connectivity with the left postcentral gyrus. Comparing pre to post intervention changes within each group, the MCI group showed increased connectivity in 10 regions spanning frontal, parietal, temporal and insular lobes, and the cerebellum. Healthy elders did not demonstrate any significant connectivity changes. Conclusion: The observed results show increased functional connectivity of the PCC/precuneus in individuals with MCI after 12 weeks of moderate intensity walking exercise training. The protective effects of exercise training on cognition may be realized through the enhancement of neural recruitment mechanisms, which may possibly increase cognitive reserve. Whether these effects of exercise training may delay further cognitive decline in patients diagnosed with MCI remains to be demonstrated

    Topics in social network analysis and network science

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    This chapter introduces statistical methods used in the analysis of social networks and in the rapidly evolving parallel-field of network science. Although several instances of social network analysis in health services research have appeared recently, the majority involve only the most basic methods and thus scratch the surface of what might be accomplished. Cutting-edge methods using relevant examples and illustrations in health services research are provided

    Peer-to-peer:is deviant behavior the norm on P2P file-sharing networks?

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    P2P file-sharing networks such as Kazaa, eDonkey, and Limewire boast millions of users. Because of scalability concerns and legal issues, such networks are moving away from the semicentralized approach that Napster typifies toward more scalable and anonymous decentralized P2P architectures. Because they lack any central authority, these networks provide a new, interesting context for the expression of human social behavior. However, the activities of P2P community members are sometimes at odds with what real-world authorities consider acceptable. One example is the use of P2P networks to distribute illegal pornography. To gauge the form and extent of P2P-based sharing of illegal pornography, we analyzed pornography-related resource-discovery traffic in the Gnutella P2P network. We found that a small yet significant proportion of Gnutella activity relates to illegal pornography: for example, 1.6 percent of searches and 2.4 percent of responses are for this type of material. But does this imply that such activity is widespread in the file-sharing population? On the contrary, our results show that a small yet particularly active subcommunity of users searches for and distributes illegal pornography, but it isn't a behavioral norm
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