Parallel Pairwise Epistasis Detection on Heterogeneous Computing Architectures

This is a post-peer-review, pre-copyedit version of an article published in IEEE Transactions on Parallel and Distributed Systems. The final authenticated version is available online at: http://dx.doi.org/10.1109/TPDS.2015.2460247.[Abstract] Development of new methods to detect pairwise epistasis, such as SNP-SNP interactions, in Genome-Wide Association Studies is an important task in bioinformatics as they can help to explain genetic influences on diseases. As these studies are time consuming operations, some tools exploit the characteristics of different hardware accelerators (such as GPUs and Xeon Phi coprocessors) to reduce the runtime. Nevertheless, all these approaches are not able to efficiently exploit the whole computational capacity of modern clusters that contain both GPUs and Xeon Phi coprocessors. In this paper we investigate approaches to map pairwise epistasic detection on heterogeneous clusters using both types of accelerators. The runtimes to analyze the well-known WTCCC dataset consisting of about 500 K SNPs and 5 K samples on one and two NVIDIA K20m are reduced by 27 percent thanks to the use of a hybrid approach with one additional single Xeon Phi coprocessor.Wellcome Trust; 076113Wellcome Trust; 085475Ministerio de Ecnomía y Competitividad; TIN2013-42148-

Contributions to the efficient use of general purpose coprocessors: kernel density estimation as case study

142 p.The high performance computing landscape is shifting from assemblies of homogeneous nodes towards heterogeneous systems, in which nodes consist of a combination of traditional out-of-order execution cores and accelerator devices. Accelerators provide greater theoretical performance compared to traditional multi-core CPUs, but exploiting their computing power remains as a challenging task.This dissertation discusses the issues that arise when trying to efficiently use general purpose accelerators. As a contribution to aid in this task, we present a thorough survey of performance modeling techniques and tools for general purpose coprocessors. Then we use as case study the statistical technique Kernel Density Estimation (KDE). KDE is a memory bound application that poses several challenges for its adaptation to the accelerator-based model. We present a novel algorithm for the computation of KDE that reduces considerably its computational complexity, called S-KDE. Furthermore, we have carried out two parallel implementations of S-KDE, one for multi and many-core processors, and another one for accelerators. The latter has been implemented in OpenCL in order to make it portable across a wide range of devices. We have evaluated the performance of each implementation of S-KDE in a variety of architectures, trying to highlight the bottlenecks and the limits that the code reaches in each device. Finally, we present an application of our S-KDE algorithm in the field of climatology: a novel methodology for the evaluation of environmental models

Generalized database index structures on massively parallel processor architectures

Height-balanced search trees are ubiquitous in database management systems as well as in other applications that require efficient access methods in order to identify entries in large data volumes. They can be configured with various strategies for structuring the search space for a given data set and for pruning it when different kinds of search queries are answered. In order to facilitate the development of application-specific tree variants, index frameworks, such as GiST, exist that provide a reusable library of commonly shared tree management functionality. By specializing internal data organization strategies, the framework can be customized to create an index that is efficient for an application's data access characteristics. Because the majority of the framework's code can be reused development and testing efforts are significantly lower, compared to an implementation from scratch. However, none of the existing frameworks supports the execution of index operations on massively parallel processor architectures, such as GPUs. Enabling the use of such processors for generalized index frameworks is the goal of this thesis. By compiling state-of-the-art techniques from a wide range of CPU- and GPU-optimized indexes, a GiST extension is developed that abstracts the physical execution aspect of generic, tree-based search queries. Tree traversals are broken-down into vectorized processing primitives that can be scheduled to one of the available (co-)processors for execution. Further, a CPU-based implementation is provided as well as a new GPU-based algorithm that, unlike prior art in this area, does not require that the index is fully stored inside a GPU's main memory buffer. The applicability of the extended framework is assessed for image rendering engines and, based on microbenchmarks, the parallelized algorithm performance is compared for different CPU and GPU generations. It will be shown that cases exist, where the GPU clearly outperforms the CPU and vice versa. In order to leverage the strengths of each processor type, an adaptive scheduler is presented that can be calibrated to schedule index operations to the best-fitting device in a hybrid system. With the help of a tree traversal simulation different scheduling strategies are evaluated and it will be shown that the adaptive scheduler can be used to make near-optimal decisions.Suchbäume sind allgegenwärtig in Datenbanksystemen und anderen Anwendungen, die eine effiziente Möglichkeit benötigen um in großen Datensätzen nach Einträgen zu suchen, die bestimmte Suchkriterien erfüllen. Sie können mit verschiedenen Strategien konfiguriert werden um den Suchraum zu strukturieren und die für ein Suchergebnis irrelevante Bereiche von der Bearbeitung auszuschließen. Die Entwicklung von anwendungsspezifischen Indexen wird durch Frameworks wie GiST unterstützt. Jedoch unterstützt keines der heute bereits existierenden Frameworks die Verwendung von hochgradig parallelen Prozessorarchitekturen wie GPUs. Solche Prozessoren für generische Index Frameworks nutzbar zu machen, ist Ziel dieser Arbeit. Dazu werden Techniken aus verschiedensten CPU- und GPU-optimierten Indexen analysiert und für die Entwicklung einer GiST-Erweiterung verwendet, welche die für eine Suche in Suchbäumen nötigen Berechnungen abstrahiert. Traversierungsoperationen werden dabei auf vektorisierte Primitive abgebildet, die auf parallelen Prozessoren implementiert werden können. Die Verwendung dieser Erweiterung wird beispielhaft an einem CPU Algorithmus demonstriert. Weiterhin wird ein neuer GPU-basierter Algorithmus vorgestellt, der im Vergleich zu bisherigen Verfahren, ein dynamisches Nachladen der Index Daten in den Hauptspeicher der GPU unterstützt. Die Praktikabilität des erweiterten Frameworks wird am Beispiel von Anwendungen aus der Computergrafik untersucht und die Performanz der verwendeten Algorithmen mit Hilfe eines Benchmarks auf verschiedenen CPU- und GPU-Modellen analysiert. Dabei wird gezeigt, unter welchen Bedingungen die parallele GPU-basierte Ausführung schneller ist als die CPU-basierte Variante - und umgekehrt. Um die Stärken beider Prozessortypen in einem hybriden System ausnutzen zu können, wird ein Scheduler entwickelt, der nach einer Kalibrierungsphase für eine gegebene Operation den geeignetsten Prozessor wählen kann. Mit Hilfe eines Simulators für Baumtraversierungen werden verschiedenste Scheduling Strategien verglichen. Dabei wird gezeigt, dass die Entscheidungen des Schedulers kaum vom Optimum abweichen und, abhängig von der simulierten Last, die erzielbaren Durchsätze für die parallele Ausführung mehrerer Suchoperationen durch hybrides Scheduling um eine Größenordnung und mehr erhöht werden können

Neurostream: Scalable and Energy Efficient Deep Learning with Smart Memory Cubes

open4siHigh-performance computing systems are moving towards 2.5D and 3D memory hierarchies, based on High Bandwidth Memory (HBM) and Hybrid Memory Cube (HMC) to mitigate the main memory bottlenecks. This trend is also creating new opportunities to revisit near-memory computation. In this paper, we propose a flexible processor-in-memory (PIM) solution for scalable and energy-efficient execution of deep convolutional networks (ConvNets), one of the fastest-growing workloads for servers and high-end embedded systems. Our co-design approach consists of a network of Smart Memory Cubes (modular extensions to the standard HMC) each augmented with a many-core PIM platform called NeuroCluster. NeuroClusters have a modular design based on NeuroStream coprocessors (for Convolution-intensive computations) and general-purpose RISC-V cores. In addition, a DRAM-friendly tiling mechanism and a scalable computation paradigm are presented to efficiently harness this computational capability with a very low programming effort. NeuroCluster occupies only 8 percent of the total logic-base (LoB) die area in a standard HMC and achieves an average performance of 240 GFLOPS for complete execution of full-featured state-of-the-art (SoA) ConvNets within a power budget of 2.5 W. Overall 11 W is consumed in a single SMC device, with 22.5 GFLOPS/W energy-efficiency which is 3.5X better than the best GPU implementations in similar technologies. The minor increase in system-level power and the negligible area increase make our PIM system a cost-effective and energy efficient solution, easily scalable to 955 GFLOPS with a small network of just four SMCs.openAzarkhish, Erfan*; Rossi, Davide; Loi, Igor; Benini, LucaAzarkhish, Erfan*; Rossi, Davide; Loi, Igor; Benini, Luc

REAL-TIME ADAPTIVE PULSE COMPRESSION ON RECONFIGURABLE, SYSTEM-ON-CHIP (SOC) PLATFORMS

New radar applications need to perform complex algorithms and process a large quantity of data to generate useful information for the users. This situation has motivated the search for better processing solutions that include low-power high-performance processors, efficient algorithms, and high-speed interfaces. In this work, hardware implementation of adaptive pulse compression algorithms for real-time transceiver optimization is presented, and is based on a System-on-Chip architecture for reconfigurable hardware devices. This study also evaluates the performance of dedicated coprocessors as hardware accelerator units to speed up and improve the computation of computing-intensive tasks such matrix multiplication and matrix inversion, which are essential units to solve the covariance matrix. The tradeoffs between latency and hardware utilization are also presented. Moreover, the system architecture takes advantage of the embedded processor, which is interconnected with the logic resources through high-performance buses, to perform floating-point operations, control the processing blocks, and communicate with an external PC through a customized software interface. The overall system functionality is demonstrated and tested for real-time operations using a Ku-band testbed together with a low-cost channel emulator for different types of waveforms

A computing origami: Optimized code generation for emerging parallel platforms

Ph.DDOCTOR OF PHILOSOPH

Reconfigurable computing for large-scale graph traversal algorithms

This thesis proposes a reconfigurable computing approach for supporting parallel processing in large-scale graph traversal algorithms. Our approach is based on a reconfigurable hardware architecture which exploits the capabilities of both FPGAs (Field-Programmable Gate Arrays) and a multi-bank parallel memory subsystem. The proposed methodology to accelerate graph traversal algorithms has been applied to three case studies, revealing that application-specific hardware customisations can benefit performance. A summary of our four contributions is as follows. First, a reconfigurable computing approach to accelerate large-scale graph traversal algorithms. We propose a reconfigurable hardware architecture which decouples computation and communication while keeping multiple memory requests in flight at any given time, taking advantage of the high bandwidth of multi-bank memory subsystems. Second, a demonstration of the effectiveness of our approach through two case studies: the breadth-first search algorithm, and a graphlet counting algorithm from bioinformatics. Both case studies involve graph traversal, but each of them adopts a different graph data representation. Third, a method for using on-chip memory resources in FPGAs to reduce off-chip memory accesses for accelerating graph traversal algorithms, through a case-study of the All-Pairs Shortest-Paths algorithm. This case study has been applied to process human brain network data. Fourth, an evaluation of an approach based on instruction-set extension for FPGA design against many-core GPUs (Graphics Processing Units), based on a set of benchmarks with different memory access characteristics. It is shown that while GPUs excel at streaming applications, the proposed approach can outperform GPUs in applications with poor locality characteristics, such as graph traversal problems.Open Acces

High-performance and hardware-aware computing: proceedings of the second International Workshop on New Frontiers in High-performance and Hardware-aware Computing (HipHaC\u2711), San Antonio, Texas, USA, February 2011 ; (in conjunction with HPCA-17)

High-performance system architectures are increasingly exploiting heterogeneity. The HipHaC workshop aims at combining new aspects of parallel, heterogeneous, and reconfigurable microprocessor technologies with concepts of high-performance computing and, particularly, numerical solution methods. Compute- and memory-intensive applications can only benefit from the full hardware potential if all features on all levels are taken into account in a holistic approach