Mobile Health Technologies

Mobile Health Technologies, also known as mHealth technologies, have emerged, amongst healthcare providers, as the ultimate Technologies-of-Choice for the 21st century in delivering not only transformative change in healthcare delivery, but also critical health information to different communities of practice in integrated healthcare information systems. mHealth technologies nurture seamless platforms and pragmatic tools for managing pertinent health information across the continuum of different healthcare providers. mHealth technologies commonly utilize mobile medical devices, monitoring and wireless devices, and/or telemedicine in healthcare delivery and health research. Today, mHealth technologies provide opportunities to record and monitor conditions of patients with chronic diseases such as asthma, Chronic Obstructive Pulmonary Diseases (COPD) and diabetes mellitus. The intent of this book is to enlighten readers about the theories and applications of mHealth technologies in the healthcare domain

Automotive applications of high precision GNSS

This thesis aims to show that Global Navigation Satellite Systems (GNSS) positioning can play a significant role in the positioning systems of future automotive applications. This is through the adoption of state-of-the-art GNSS positioning technology and techniques, and the exploitation of the rapidly developing vehicle-to-vehicle concept. The merging together of these two developments creates greater performance than can be achieved separately. The original contribution of this thesis comes from this combination: Through the introduction of the Pseudo-VRS concept. Pseudo-VRS uses the princples of Network Real Time Kinematic (N-RTK) positioning to share GNSS information between vehicles, which enables absolute vehicle positioning. Pseudo-VRS is shown to improve the performance of high precision GNSS positioning for road vehicles, through the increased availability of GNSS correction messages and the rapid resolution of the N-RTK fixed solution. Positioning systems in the automotive sector are dominated by satellite-based solutions provided by GNSS. This has been the case since May 2001, when the United States Department of Defense switched off Selective Availability, enabling significantly improved positioning performance for civilian users. The average person most frequently encounters GNSS when using electronic personal navigation devices. The Sat Nav or GPS Navigator is ubiquitous in modern societies, where versions can be found on nomadic devices such as smartphones and dedicated personal navigation devices, or built in to the dashboards of vehicles. Such devices have been hugely successful due to their intrinsic ability to provide position information anywhere in the world with an accuracy of approximately 10 metres, which has proved ideal for general navigation applications. There are a few well known limitations of GNSS positioning, including anecdotal evidence of incorrect navigation advice for personal navigation devices, but these are minor compared to the overall positioning performance. Through steady development of GNSS positioning devices, including the integration of other low cost sensors (for instance, wheel speed or odometer sensors in vehicles), and the development of robust map matching algorithms, the performance of these devices for navigation applications is truly incredible. However, when tested for advanced automotive applications, the performance of GNSS positioning devices is found to be inadequate. In particular, in the most advanced fields of research such as autonomous vehicle technology, GNSS positioning devices are relegated to a secondary role, or often not used at all. They are replaced by terrestrial sensors that provide greater situational awareness, such as radar and lidar. This is due to the high performance demand of such applications, including high positioning accuracy (sub-decimetre), high availability and continuity of solutions (100%), and high integrity of the position information. Low-cost GNSS receivers generally do not meet such requirements. This could be considered an enormous oversight, as modern GNSS positioning technology and techniques have significantly improved satellite-based positioning performance. Other non-GNSS techniques also have their limitations that GNSS devices can minimise or eliminate. For instance, systems that rely on situational awareness require accurate digital maps of their surroundings as a reference. GNSS positioning can help to gather this data, provide an input, and act as a fail-safe in the event of digital map errors. It is apparent that in order to deliver advanced automotive applications - such as semi- or fully-autonomous vehicles - there must be an element of absolute positioning capability. Positioning systems will work alongside situational awareness systems to enable the autonomous vehicles to navigate through the real world. A strong candidate for the positioning system is GNSS positioning. This thesis builds on work already started by researchers at the University of Nottingham, to show that N-RTK positioning is one such technique. N-RTK can provide sub-decimetre accuracy absolute positioning solutions, with high availability, continuity, and integrity. A key component of N-RTK is the availability of real-time GNSS correction data. This is typically delivered to the GNSS receiver via mobile internet (for a roving receiver). This can be a significant limitation, as it relies on the performance of the mobile communications network, which can suffer from performance degradation during dynamic operation. Mobile communications systems are expected to improve significantly over the next few years, as consumers demand faster download speeds and wider availability. Mobile communications coverage already covers a high percentage of the population, but this does not translate into a high percentage of a country's geography. Pockets of poor coverage, often referred to as notspots, are widespread. Many of these notspots include the transportation infrastructure. The vehicle-to-vehicle concept has made significant forward steps in the last few years. Traditionally promoted as a key component of future automotive safety applications, it is now driven primarily by increased demand for in-vehicle infotainment. The concept, which shares similarities with the Internet of Things and Mobile Ad-hoc Networks, relies on communication between road vehicles and other road agents (such as pedestrians and road infrastructure). N-RTK positioning can take advantage of this communication link to minimise its own communications-related limitations. Sharing GNSS information between local GNSS receivers enables better performance of GNSS positioning, based on the principles of differential GNSS and N-RTK positioning techniques. This advanced concept is introduced and tested in this thesis. The Pseudo VRS concept follows the protocols and format of sharing GNSS data used in N-RTK positioning. The technique utilises the latest GNSS receiver design, including multiple frequency measurements and high quality antennas

Automotive applications of high precision GNSS

This thesis aims to show that Global Navigation Satellite Systems (GNSS) positioning can play a significant role in the positioning systems of future automotive applications. This is through the adoption of state-of-the-art GNSS positioning technology and techniques, and the exploitation of the rapidly developing vehicle-to-vehicle concept. The merging together of these two developments creates greater performance than can be achieved separately. The original contribution of this thesis comes from this combination: Through the introduction of the Pseudo-VRS concept. Pseudo-VRS uses the princples of Network Real Time Kinematic (N-RTK) positioning to share GNSS information between vehicles, which enables absolute vehicle positioning. Pseudo-VRS is shown to improve the performance of high precision GNSS positioning for road vehicles, through the increased availability of GNSS correction messages and the rapid resolution of the N-RTK fixed solution. Positioning systems in the automotive sector are dominated by satellite-based solutions provided by GNSS. This has been the case since May 2001, when the United States Department of Defense switched off Selective Availability, enabling significantly improved positioning performance for civilian users. The average person most frequently encounters GNSS when using electronic personal navigation devices. The Sat Nav or GPS Navigator is ubiquitous in modern societies, where versions can be found on nomadic devices such as smartphones and dedicated personal navigation devices, or built in to the dashboards of vehicles. Such devices have been hugely successful due to their intrinsic ability to provide position information anywhere in the world with an accuracy of approximately 10 metres, which has proved ideal for general navigation applications. There are a few well known limitations of GNSS positioning, including anecdotal evidence of incorrect navigation advice for personal navigation devices, but these are minor compared to the overall positioning performance. Through steady development of GNSS positioning devices, including the integration of other low cost sensors (for instance, wheel speed or odometer sensors in vehicles), and the development of robust map matching algorithms, the performance of these devices for navigation applications is truly incredible. However, when tested for advanced automotive applications, the performance of GNSS positioning devices is found to be inadequate. In particular, in the most advanced fields of research such as autonomous vehicle technology, GNSS positioning devices are relegated to a secondary role, or often not used at all. They are replaced by terrestrial sensors that provide greater situational awareness, such as radar and lidar. This is due to the high performance demand of such applications, including high positioning accuracy (sub-decimetre), high availability and continuity of solutions (100%), and high integrity of the position information. Low-cost GNSS receivers generally do not meet such requirements. This could be considered an enormous oversight, as modern GNSS positioning technology and techniques have significantly improved satellite-based positioning performance. Other non-GNSS techniques also have their limitations that GNSS devices can minimise or eliminate. For instance, systems that rely on situational awareness require accurate digital maps of their surroundings as a reference. GNSS positioning can help to gather this data, provide an input, and act as a fail-safe in the event of digital map errors. It is apparent that in order to deliver advanced automotive applications - such as semi- or fully-autonomous vehicles - there must be an element of absolute positioning capability. Positioning systems will work alongside situational awareness systems to enable the autonomous vehicles to navigate through the real world. A strong candidate for the positioning system is GNSS positioning. This thesis builds on work already started by researchers at the University of Nottingham, to show that N-RTK positioning is one such technique. N-RTK can provide sub-decimetre accuracy absolute positioning solutions, with high availability, continuity, and integrity. A key component of N-RTK is the availability of real-time GNSS correction data. This is typically delivered to the GNSS receiver via mobile internet (for a roving receiver). This can be a significant limitation, as it relies on the performance of the mobile communications network, which can suffer from performance degradation during dynamic operation. Mobile communications systems are expected to improve significantly over the next few years, as consumers demand faster download speeds and wider availability. Mobile communications coverage already covers a high percentage of the population, but this does not translate into a high percentage of a country's geography. Pockets of poor coverage, often referred to as notspots, are widespread. Many of these notspots include the transportation infrastructure. The vehicle-to-vehicle concept has made significant forward steps in the last few years. Traditionally promoted as a key component of future automotive safety applications, it is now driven primarily by increased demand for in-vehicle infotainment. The concept, which shares similarities with the Internet of Things and Mobile Ad-hoc Networks, relies on communication between road vehicles and other road agents (such as pedestrians and road infrastructure). N-RTK positioning can take advantage of this communication link to minimise its own communications-related limitations. Sharing GNSS information between local GNSS receivers enables better performance of GNSS positioning, based on the principles of differential GNSS and N-RTK positioning techniques. This advanced concept is introduced and tested in this thesis. The Pseudo VRS concept follows the protocols and format of sharing GNSS data used in N-RTK positioning. The technique utilises the latest GNSS receiver design, including multiple frequency measurements and high quality antennas

Personalized data analytics for internet-of-things-based health monitoring

The Internet-of-Things (IoT) has great potential to fundamentally alter the delivery of modern healthcare, enabling healthcare solutions outside the limits of conventional clinical settings. It can offer ubiquitous monitoring to at-risk population groups and allow diagnostic care, preventive care, and early intervention in everyday life. These services can have profound impacts on many aspects of health and well-being. However, this field is still at an infancy stage, and the use of IoT-based systems in real-world healthcare applications introduces new challenges. Healthcare applications necessitate satisfactory quality attributes such as reliability and accuracy due to their mission-critical nature, while at the same time, IoT-based systems mostly operate over constrained shared sensing, communication, and computing resources. There is a need to investigate this synergy between the IoT technologies and healthcare applications from a user-centered perspective. Such a study should examine the role and requirements of IoT-based systems in real-world health monitoring applications. Moreover, conventional computing architecture and data analytic approaches introduced for IoT systems are insufficient when used to target health and well-being purposes, as they are unable to overcome the limitations of IoT systems while fulfilling the needs of healthcare applications. This thesis aims to address these issues by proposing an intelligent use of data and computing resources in IoT-based systems, which can lead to a high-level performance and satisfy the stringent requirements. For this purpose, this thesis first delves into the state-of-the-art IoT-enabled healthcare systems proposed for in-home and in-hospital monitoring. The findings are analyzed and categorized into different domains from a user-centered perspective. The selection of home-based applications is focused on the monitoring of the elderly who require more remote care and support compared to other groups of people. In contrast, the hospital-based applications include the role of existing IoT in patient monitoring and hospital management systems. Then, the objectives and requirements of each domain are investigated and discussed. This thesis proposes personalized data analytic approaches to fulfill the requirements and meet the objectives of IoT-based healthcare systems. In this regard, a new computing architecture is introduced, using computing resources in different layers of IoT to provide a high level of availability and accuracy for healthcare services. This architecture allows the hierarchical partitioning of machine learning algorithms in these systems and enables an adaptive system behavior with respect to the user's condition. In addition, personalized data fusion and modeling techniques are presented, exploiting multivariate and longitudinal data in IoT systems to improve the quality attributes of healthcare applications. First, a real-time missing data resilient decision-making technique is proposed for health monitoring systems. The technique tailors various data resources in IoT systems to accurately estimate health decisions despite missing data in the monitoring. Second, a personalized model is presented, enabling variations and event detection in long-term monitoring systems. The model evaluates the sleep quality of users according to their own historical data. Finally, the performance of the computing architecture and the techniques are evaluated in this thesis using two case studies. The first case study consists of real-time arrhythmia detection in electrocardiography signals collected from patients suffering from cardiovascular diseases. The second case study is continuous maternal health monitoring during pregnancy and postpartum. It includes a real human subject trial carried out with twenty pregnant women for seven months

Personalized ambient parameters monitoring: design and implementing of a wrist-worn prototype for hazardous gases and sound level detection

The concentration is on “3D space utilization” as the concept and infrastructure of designing of a wearable in ambient parameters monitoring. This strategy is implemented according to “multi-layer” approach. In this approach, each group of parameters from the same category is monitored by a modular physical layer enriched with the respected sensors. Depending on the number of parameters and layers, each physical layer is located on top of another. The intention is to implement a device for “everyone in everywhere for everything”

Strategic Intelligence Monitor on Personal Health Systems (SIMPHS): Report on Typology/Segmentation of the PHS Market

This market segmentation reports for Personal Health Systems (PHS) describes the methodological background and illustrates the principles of classification and typology regarding different fragments forming this market. It discusses different aspects of the market for PHS and highlights challenges towards a stringent and clear-cut typology or defining market segmentation. Based on these findings a preliminary hybrid typology and indications and insights are created in order to be used in the continuation of the SIMPHS project. It concludes with an annex containing examples and cases studies.JRC.DDG.J.4-Information Societ

Fall prevention strategy for an active orthotic system

Dissertação de mestrado integrado em Engenharia Biomédica (especialização em Eletrónica Médica)Todos os anos, são reportadas cerca de 684,000 quedas fatais e 37.3 milhões de quedas não fatais que requerem atenção médica, afetando principalmente a população idosa. Assim, é necessário identificar eficientemente indivíduos com alto risco de queda, a partir da população alvo idosa, e prepará los para superar perturbações da marcha inesperadas. Uma estratégia de prevenção de queda capaz de eficientemente e atempadamente detetar e contrariar os eventos de perdas de equilíbrio (PDE) mais frequentes pode reduzir o risco de queda. Como slips foram identificados como a causa mais prevalente de quedas, estes eventos devem ser abordados como foco principal da estratégia. No entanto, há falta de estratégias de prevenção de quedas por slip. Esta dissertação tem como objetivo o design de uma estratégia de prevenção de quedas de slips baseada na conceção das etapas de atuação e deteção. A estratégia de atuação foi delineada com base na resposta biomecânica humana a slips, onde o joelho da perna perturbada (leading) apresenta um papel proeminente para contrariar LOBs induzidas por slips. Quando uma slip é detetada, a estratégia destaca uma ortótese de joelho que providencia um torque assisstivo para prevenir a queda. A estratégia de deteção considerou as propriedades atrativas dos controladores Central Pattern Generator (CPG) para prever parâmetros da marcha. Algoritmos baseados em threshold monitorizam o erro de previsão do CPG, que aumenta após uma perturbação inesperada na marcha, para a deteção de slips. O ângulo do joelho e a velocidade angular da canela foram selecionados como os parâmetros de monitorização da marcha. Um protocolo experimental concebido para provocar perturbações de slip a sujeitos humanos permitiu a recolha de dados destas variáveis para posteriormente validar o algoritmo de deteção de perturbações. Algoritmos CPG foram capazes de produzir aproximações aceitáveis dos sinais de marcha em estado estacionário do ângulo do joelho e da velocidade angular da canela com sucesso. Além disso, o algoritmo de threshold adaptativo detetou LOBs induzidas por slips eficientemente. A melhor performance global foi obtida usando este algoritmo para monitorizar o ângulo do joelho, que detetou quase 80% (78.261%) do total de perturbações com um tempo médio de deteção (TMD) de 250 ms. Além disso, uma média de 0.652 falsas perturbações foram detetadas por cada perturbação corretamente identificada. Estes resultados sugerem uma performance aceitável de deteção de perturbações do algoritmo, de acordo com os requisitos especificados para a deteção.Every year, an estimated 684,000 fatal falls and 37.3 million non-fatal falls requiring medical attention are reported, mostly affecting the older population. Thus, it is necessary to effectively screen high fall risk individuals from targeted elderly populations and prepare them to successfully overcome unexpected gait perturbations. A fall prevention strategy capable of effectively and timely detect and counteract the most frequent loss of balance (LOB) events may reduce the fall risk. Since slips were identified as the main contributors to falls, these events should be addressed as a main focus of the strategy. Nonetheless, there is a lack of slip-induced fall prevention strategies. This dissertation aims the design of a slip-related fall prevention strategy based on the conception of an actuation and a detection stage. The actuation strategy was delineated based on the human biomechanical reactions to slips, where the perturbed (leading) leg’s knee joint presents a prominent role to counteract slip-induced LOBs. Thereby, upon the detection of a slip, this strategy highlighted a knee orthotic device that provides an assistive torque to prevent the falls. The detection strategy considered the attractive properties of biological-inspired Central Pattern Generator (CPG) controllers to predict gait parameters. Threshold-based algorithms monitored the CPG’s prediction error produced, which increases upon an unexpected gait perturbation, to perform slip detection. The knee angle and shank angular velocity were selected as the monitoring gait parameters. An experimental protocol designed to provoke slip perturbations to human subjects allowed to collect data from these variables to further validate the perturbation detection algorithm. CPG algorithms were able to successfully produce acceptable estimations of the knee angle and shank angular velocity signals during steady-state walking. Furthermore, an adaptive threshold algorithm effectively detected slip-induced LOBs. The best overall performance was obtained using this algorithm to monitor the knee angle from the perturbed leg, which detected almost 80% (78.261%) of the total perturbations with a mean detection time (MDT) of 250 ms. In addition, a mean of 0.652 false perturbations were detected for each correct perturbation identified. These results suggest an acceptable perturbation detection performance of the algorithm implemented in light of the detection requirements specified

Challenges and Solutions on Assistive Technologies: Electronic systems design for people with disabilities

This work of PhD Thesis focuses on technology dedicated to persons with disabilities. This category of devices is known in the academic field and also on the market with the term of Assistive Technology. This name in fact indicates a series of technological solutions that can assist people with disabilities during everyday life and often return to the user one or more skills such as walk, talk, play or trivially change channels when watching television. In the elaborate some of the major contributions made by the candidate to the field of Assistive Technology are presented. However, to better understand the dynamics and the scene of the Assistive Technology worldwide, also the most important and current issues of this field, both technological and economics, are described

SUSTAINABLE AND MOBILITY TECHNOLOGIES FOR ASSISTIVE HEALTHCARE AND MONITORING

Ph.DDOCTOR OF PHILOSOPH