Ultra-low power mixed-signal frontend for wearable EEGs

Electronics circuits are ubiquitous in daily life, aided by advancements in the chip design industry, leading to miniaturised solutions for typical day to day problems. One of the critical healthcare areas helped by this advancement in technology is electroencephalography (EEG). EEG is a non-invasive method of tracking a person's brain waves, and a crucial tool in several healthcare contexts, including epilepsy and sleep disorders. Current ambulatory EEG systems still suffer from limitations that affect their usability. Furthermore, many patients admitted to emergency departments (ED) for a neurological disorder like altered mental status or seizures, would remain undiagnosed hours to days after admission, which leads to an elevated rate of death compared to other conditions. Conducting a thorough EEG monitoring in early-stage could prevent further damage to the brain and avoid high mortality. But lack of portability and ease of access results in a long wait time for the prescribed patients. All real signals are analogue in nature, including brainwaves sensed by EEG systems. For converting the EEG signal into digital for further processing, a truly wearable EEG has to have an analogue mixed-signal front-end (AFE). This research aims to define the specifications for building a custom AFE for the EEG recording and use that to review the suitability of the architectures available in the literature. Another critical task is to provide new architectures that can meet the developed specifications for EEG monitoring and can be used in epilepsy diagnosis, sleep monitoring, drowsiness detection and depression study. The thesis starts with a preview on EEG technology and available methods of brainwaves recording. It further expands to design requirements for the AFE, with a discussion about critical issues that need resolving. Three new continuous-time capacitive feedback chopped amplifier designs are proposed. A novel calibration loop for setting the accurate value for a pseudo-resistor, which is a crucial block in the proposed topology, is also discussed. This pseudoresistor calibration loop achieved the resistor variation of under 8.25%. The thesis also presents a new design of a curvature corrected bandgap, as well as a novel DDA based fourth-order Sallen-Key filter. A modified sensor frontend architecture is then proposed, along with a detailed analysis of its implementation. Measurement results of the AFE are finally presented. The AFE consumed a total power of 3.2A (including ADC, amplifier, filter, and current generation circuitry) with the overall integrated input-referred noise of 0.87V-rms in the frequency band of 0.5-50Hz. Measurement results confirmed that only the proposed AFE achieved all defined specifications for the wearable EEG system with the smallest power consumption than state-of-art architectures that meet few but not all specifications. The AFE also achieved a CMRR of 131.62dB, which is higher than any studied architectures.Open Acces

Transistor mismatch effect on common-mode gain of cross-coupled amplifie

In this paper, the analytical approach of MOS transistor mismatch effect on common-mode gain of cross-coupled amplifier is presented. Transconductance (MOS transistor parameter) mismatch effect on common-mode gain of cross-coupled amplifier was analyzed. This study was started with mathematical derivation for representing the mismatch effect of transconductance between 2 differential pairs of crosscoupled amplifier due to common-mode voltage. The derivation result was simulated based on Monte Carlo simulation with random transconductance mismatch rate from 0.05% until 1%. The common-mode gain increases 36.9 dB and average common-mode gain is -81.1 dB. The transconductance mismatch rate increases followed by increase in common-mode gain. The results can be used by circuit designers to design analog circuits, especially operational amplifier used for biosignals processing to minimize the common-mode gain of their circuits. This research presents aid to circuit designers to improve their circuits performance

A True 0.4-V Delta-Sigma Modulator Using a Mixed DDA Integrator Without Clock Boosted Switches

This brief proposes a delta-sigma modulator that operates at extremely low voltage without using a clock boosting technique. To maintain the advantages of a discrete-time integrator in oversampled data converters, a mixed differential difference amplifier (DDA) integrator is developed that removes the input sampling switch in a switched-capacitor integrator. Conventionally, many low-voltage delta-sigma modulators have used high-voltage generating circuits to boost the clock voltage levels. A mixed DDA integrator with both a switched-resistor and a switched-capacitor technique is developed to implement a discrete-time integrator without clock boosted switches. The proposed mixed DDA integrator is demonstrated by a third-order delta-sigma modulator with a feedforward topology. The fabricated modulator shows a 68-dB signal-to-noise-plus-distortion ratio for a 20-kHz signal bandwidth with an oversampling ratio of 80. The chip consumes 140 mu W of power at a true 0.4-V power supply, which is the lowest voltage without a clock boosting technique among the state-of-the-art modulators in this signal band.This work was supported by the Ministry of Knowledge Economy, Korea, under the University Information Technology Research Center Support Program supervised by the National IT Industry Promotion Agency (NIPA-2013-H0301-13-1007). This brief was recommended by Associate Editor P. Rombouts

Electronic bidirectional interfaces to the peripheral nervous system for prosthetic applications

The research presented in this thesis concerns the field of bioelectronics, in particular the work has been focused on the development of special electronic devices for neural signal acquisition and Peripheral Nervous System (PNS) stimulation. The final aim of the project in which this work is involved is in fact the realization of a prosthetic hand controlled using neural signals. The commercially available prosthesis are based on Electromyographic (EMG) signals, their use implies unnatural movements for the patient that needs a special training to develop the control capabilities over the mechanical limb. The proposed approach offers a number of advantages compared to the traditional prosthesis, first because the signals used are the same used to control the biologic limb, allowing a more comfortable solution for the patient that gets closer to feel the robotic hand as a natural extension of his/her body. Secondly, placing temperature and pressure sensors on the limb surface, it is possible to trasduce such information in an electrical current that, injected into the PNS, can restore the sensory feedback in amputees. The final goal of this research is the development of a fully implantable device able to perform a bidirectional communication between the robotic hand and the patient. Due to small area, low noise and low power constraints, the only possible way to reach this aim is the design of a full custom Integrated Circuit (IC). However a preliminary evaluation of the key design features, such as neural signal amplitudes and frequencies as well as stimulation shape parameters, is necessary in order to define clearly and precisely the design specifications. A low-cost and short implementation time device is then needed for this aim, the Components Off The Shelf (COTS) approach seems to be the best solution for this purpose. A Printed Circuit Board (PCB) with discrete components has been designed, developed and tested, the information extracted by the test results have been used to guide the IC design. The generation of electrical signals in biological cells, such as neural spikes, is possible thanks to ions that move across the cell membrane. In many applications it is important, not only to record the spikes, but also to measure these small currents in order to understand which electro-chemical processes are involved in the signal generation and to have a direct measurement of the ion channels involved in the reaction. Ion currents, in fact, play a key role in several physiological processes, in neural signal generation, but also in the maintenance of heartbeat and in muscle contraction. For this purpose, a system level implementation of a Read out circuit for ion channel current detection has been developed

Electronic bidirectional interfaces to the peripheral nervous system for prosthetic applications

The research presented in this thesis concerns the field of bioelectronics, in particular the work has been focused on the development of special electronic devices for neural signal acquisition and Peripheral Nervous System (PNS) stimulation. The final aim of the project in which this work is involved is in fact the realization of a prosthetic hand controlled using neural signals. The commercially available prosthesis are based on Electromyographic (EMG) signals, their use implies unnatural movements for the patient that needs a special training to develop the control capabilities over the mechanical limb. The proposed approach offers a number of advantages compared to the traditional prosthesis, first because the signals used are the same used to control the biologic limb, allowing a more comfortable solution for the patient that gets closer to feel the robotic hand as a natural extension of his/her body. Secondly, placing temperature and pressure sensors on the limb surface, it is possible to trasduce such information in an electrical current that, injected into the PNS, can restore the sensory feedback in amputees. The final goal of this research is the development of a fully implantable device able to perform a bidirectional communication between the robotic hand and the patient. Due to small area, low noise and low power constraints, the only possible way to reach this aim is the design of a full custom Integrated Circuit (IC). However a preliminary evaluation of the key design features, such as neural signal amplitudes and frequencies as well as stimulation shape parameters, is necessary in order to define clearly and precisely the design specifications. A low-cost and short implementation time device is then needed for this aim, the Components Off The Shelf (COTS) approach seems to be the best solution for this purpose. A Printed Circuit Board (PCB) with discrete components has been designed, developed and tested, the information extracted by the test results have been used to guide the IC design. The generation of electrical signals in biological cells, such as neural spikes, is possible thanks to ions that move across the cell membrane. In many applications it is important, not only to record the spikes, but also to measure these small currents in order to understand which electro-chemical processes are involved in the signal generation and to have a direct measurement of the ion channels involved in the reaction. Ion currents, in fact, play a key role in several physiological processes, in neural signal generation, but also in the maintenance of heartbeat and in muscle contraction. For this purpose, a system level implementation of a Read out circuit for ion channel current detection has been developed

Interface Circuits for Microsensor Integrated Systems

ca. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms. [Recent advances in sensing technologies, especially those for Microsensor Integrated Systems, have led to several new commercial applications. Among these, low voltage and low power circuit architectures have gained growing attention, being suitable for portable long battery life devices. The aim is to improve the performances of actual interface circuits and systems, both in terms of voltage mode and current mode, in order to overcome the potential problems due to technology scaling and different technology integrations. Related problems, especially those concerning parasitics, lead to a severe interface design attention, especially concerning the analog front-end and novel and smart architecture must be explored and tested, both at simulation and prototype level. Moreover, the growing demand for autonomous systems gets even harder the interface design due to the need of energy-aware cost-effective circuit interfaces integrating, where possible, energy harvesting solutions. The objective of this Special Issue is to explore the potential solutions to overcome actual limitations in sensor interface circuits and systems, especially those for low voltage and low power Microsensor Integrated Systems. The present Special Issue aims to present and highlight the advances and the latest novel and emergent results on this topic, showing best practices, implementations and applications. The Guest Editors invite to submit original research contributions dealing with sensor interfacing related to this specific topic. Additionally, application oriented and review papers are encouraged.

An implantable micro-system for neural prosthesis control and sensory feedback restoration in amputees

In this work, the prototype of an electronic bi-directional interface between the Peripheral Nervous System (PNS) and a neuro-controlled hand prosthesis is presented. The system is composed of two Integrated Circuits (ICs): a standard CMOS device for neural recording and a High Voltage (HV) CMOS device for neural stimulation. The integrated circuits have been realized in two different 0.35μm CMOS processes available fromAustriaMicroSystem(AMS). The recoding IC incorporates 8 channels each including the analog front-end and the A/D conversion based on a sigma delta architecture. It has a total area of 16.8mm2 and exhibits an overall power consumption of 27.2mW. The neural stimulation IC is able to provide biphasic current pulses to stimulate 8 electrodes independently. A voltage booster generates a 17V voltage supply in order to guarantee the programmed stimulation current even in case of high impedances at the electrode-tissue interface in the order of tens of k­. The stimulation patterns, generated by a 5-bit current DAC, are programmable in terms of amplitude, frequency and pulse width. Due to the huge capacitors of the implemented voltage boosters, the stimulation IC has a wider area of 18.6mm2. In addition, a maximum power consumption of 29mW was measured. Successful in-vivo experiments with rats having a TIME electrode implanted in the sciatic nerve were carried out, showing the capability of recording neural signals in the tens of microvolts, with a global noise of 7μVrms , and to selectively elicit the tibial and plantarmuscles using different active sites of the electrode. In order to get a completely implantable interface, a biocompatible and biostable package was designed. It hosts the developed ICs with the minimal electronics required for their proper operation. The package consists of an alumina tube closed at both extremities by two ceramic caps hermetically sealed on it. Moreover, the two caps serve as substrate for the hermetic feedthroughs to enable the device powering and data exchange with the external digital controller implemented on a Field-Programmable Gate Array (FPGA) board. The package has an outer diameter of 7mm and a total length of 26mm. In addition, a humidity and temperature sensor was also included inside the package to allow future hermeticity and life-time estimation tests. Moreover, a wireless, wearable and non-invasive EEG recording system is proposed in order to improve the control over the artificial limb,by integrating the neural signals recorded from the PNS with those directly acquired from the brain. To first investigate the system requirements, a Component-Off-The-Shelf (COTS) device was designed. It includes a low-power 8- channel acquisition module and a Bluetooth (BT) transceiver to transmit the acquired data to a remote platform. It was designed with the aimof creating a cheap and user-friendly system that can be easily interfaced with the nowadays widely spread smartphones or tablets by means of a mobile-based application. The presented system, validated through in-vivo experiments, allows EEG signals recording at different sample rates and with a maximum bandwidth of 524Hz. It was realized on a 19cm2 custom PCB with a maximum power consumption of 270mW

Design and Implementation of Switching Voltage Integrated Circuits Based on Sliding Mode Control

The need for high performance circuits in systems with low-voltage and low-power requirements has exponentially increased during the few last years due to the sophistication and miniaturization of electronic components. Most of these circuits are required to have a very good efficiency behavior in order to extend the battery life of the device. This dissertation addresses two important topics concerning very high efficiency circuits with very high performance specifications. The first topic is the design and implementation of class D audio power amplifiers, keeping their inherent high efficiency characteristic while improving their linearity performance, reducing their quiescent power consumption, and minimizing the silicon area. The second topic is the design and implementation of switching voltage regulators and their controllers, to provide a low-cost, compact, high efficient and reliable power conversion for integrated circuits. The first part of this dissertation includes a short, although deep, analysis on class D amplifiers, their history, principles of operation, architectures, performance metrics, practical design considerations, and their present and future market distribution. Moreover, the harmonic distortion of open-loop class D amplifiers based on pulse-width modulation (PWM) is analyzed by applying the duty cycle variation technique for the most popular carrier waveforms giving an easy and practical analytic method to evaluate the class D amplifier distortion and determine its specifications for a given linearity requirement. Additionally, three class D amplifiers, with an architecture based on sliding mode control, are proposed, designed, fabricated and tested. The amplifiers make use of a hysteretic controller to avoid the need of complex overhead circuitry typically needed in other architectures to compensate non-idealities of practical implementations. The design of the amplifiers based on this technique is compact, small, reliable, and provides a performance comparable to the state-of-the-art class D amplifiers, but consumes only one tenth of quiescent power. This characteristic gives to the proposed amplifiers an advantage for applications with minimal power consumption and very high performance requirements. The second part of this dissertation presents the design, implementation, and testing of switching voltage regulators. It starts with a description and brief analysis on the power converters architectures. It outlines the advantages and drawbacks of the main topologies, discusses practical design considerations, and compares their current and future market distribution. Then, two different buck converters are proposed to overcome the most critical issue in switching voltage regulators: to provide a stable voltage supply for electronic devices, with good regulation voltage, high efficiency performance, and, most important, a minimum number of components. The first buck converter, which has been designed, fabricated and tested, is an integrated dual-output voltage regulator based on sliding mode control that provides a power efficiency comparable to the conventional solutions, but potentially saves silicon area and input filter components. The design is based on the idea of stacking traditional buck converters to provide multiple output voltages with the minimum number of switches. Finally, a fully integrated buck converter based on sliding mode control is proposed. The architecture integrates the external passive components to deliver a complete monolithic solution with minimal silicon area. The buck converter employs a poly-phase structure to minimize the output current ripple and a hysteretic controller to avoid the generation of an additional high frequency carrier waveform needed in conventional solutions. The simulated results are comparable to the state-of-the-art works even with no additional post-fabrication process to improve the converter performance