3,391 research outputs found
Computerized Analysis of Magnetic Resonance Images to Study Cerebral Anatomy in Developing Neonates
The study of cerebral anatomy in developing neonates is of great importance for
the understanding of brain development during the early period of life. This
dissertation therefore focuses on three challenges in the modelling of cerebral
anatomy in neonates during brain development. The methods that have been
developed all use Magnetic Resonance Images (MRI) as source data.
To facilitate study of vascular development in the neonatal period, a set of image
analysis algorithms are developed to automatically extract and model cerebral
vessel trees. The whole process consists of cerebral vessel tracking from
automatically placed seed points, vessel tree generation, and vasculature
registration and matching. These algorithms have been tested on clinical Time-of-
Flight (TOF) MR angiographic datasets.
To facilitate study of the neonatal cortex a complete cerebral cortex segmentation
and reconstruction pipeline has been developed. Segmentation of the neonatal
cortex is not effectively done by existing algorithms designed for the adult brain
because the contrast between grey and white matter is reversed. This causes pixels
containing tissue mixtures to be incorrectly labelled by conventional methods. The
neonatal cortical segmentation method that has been developed is based on a novel
expectation-maximization (EM) method with explicit correction for mislabelled
partial volume voxels. Based on the resulting cortical segmentation, an implicit
surface evolution technique is adopted for the reconstruction of the cortex in
neonates. The performance of the method is investigated by performing a detailed
landmark study.
To facilitate study of cortical development, a cortical surface registration algorithm
for aligning the cortical surface is developed. The method first inflates extracted
cortical surfaces and then performs a non-rigid surface registration using free-form
deformations (FFDs) to remove residual alignment. Validation experiments using
data labelled by an expert observer demonstrate that the method can capture local
changes and follow the growth of specific sulcus
Recommended from our members
A normative spatiotemporal MRI atlas of the fetal brain for automatic segmentation and analysis of early brain growth.
Longitudinal characterization of early brain growth in-utero has been limited by a number of challenges in fetal imaging, the rapid change in size, shape and volume of the developing brain, and the consequent lack of suitable algorithms for fetal brain image analysis. There is a need for an improved digital brain atlas of the spatiotemporal maturation of the fetal brain extending over the key developmental periods. We have developed an algorithm for construction of an unbiased four-dimensional atlas of the developing fetal brain by integrating symmetric diffeomorphic deformable registration in space with kernel regression in age. We applied this new algorithm to construct a spatiotemporal atlas from MRI of 81 normal fetuses scanned between 19 and 39 weeks of gestation and labeled the structures of the developing brain. We evaluated the use of this atlas and additional individual fetal brain MRI atlases for completely automatic multi-atlas segmentation of fetal brain MRI. The atlas is available online as a reference for anatomy and for registration and segmentation, to aid in connectivity analysis, and for groupwise and longitudinal analysis of early brain growth
Evaluation of rigid registration methods for whole head imaging in diffuse optical tomography
Functional brain imaging has become an important neuroimaging technique for the study of brain organization and development. Compared to other imaging techniques, diffuse optical tomography (DOT) is a portable and low-cost technique that can be applied to infants and hospitalized patients using an atlas-based light model. For DOT imaging, the accuracy of the forward model has a direct effect on the resulting recovered brain function within a field of view and so the accuracy of the spatially normalized atlas-based forward models must be evaluated. Herein, the accuracy of atlas-based DOT is evaluated on models that are spatially normalized via a number of different rigid registration methods on 24 subjects. A multileveled approach is developed to evaluate the correlation of the geometrical and sensitivity accuracies across the full field of view as well as within specific functional subregions. Results demonstrate that different registration methods are optimal for recovery of different sets of functional brain regions. However, the “nearest point to point” registration method, based on the EEG 19 landmark system, is shown to be the most appropriate registration method for image quality throughout the field of view of the high-density cap that covers the whole of the optically accessible cortex
The development and application of structural priors for diffuse optical imaging in infants from newborn to two years of age
This thesis describes the development and application of age-appropriate structural priors to improve the localisation accuracy of diffuse optical tomography (DOT) approaches in infants aged from birth to two years of age. Knowledge of the target cranial anatomy, known as a structural prior, is required to produce three-dimensional images localising concentration changes to the cortex. A structural prior would ideally be subject-specific, i.e. derived from structural magnetic resonance imaging (MRI) data from each specific subject. Requiring a structural scan from every infant participant, however, is not feasible and undermines many of the benefits of DOT.
A review was conducted to catalogue available infant structural MRI data, and selected data was then used to produce structural priors for infants aged 1- to 24-months. Conventional analyses using functional near-infrared spectroscopy (fNIRS) implicitly assume that head size and array position are constant across infants. Using DOT, the validity of assuming these parameters constant in a longitudinal infant cohort was investigated. The results show that this assumption is reasonable at the group-level in infants aged 5- to 12-months but becomes less valid for smaller group sizes. A DOT approach was determined to illicit more subtle effects of activation, particularly for smaller group sizes and expected responses.
Using state-of-the-art MRI data from the Developing Human Connectome Project, a database of structural priors of the neonatal head was produced for infants aged pre-term to term-equivalent age. A leave-one-out approach was used to determine how best to find a match between a given infant and a model from the database, and how best to spatially register the model to minimise the anatomical and localisation errors relative to subject-specific anatomy. Model selection based on the 10/20 scalp positions was determined to be the best method (of those based on external features of the head) to minimise these errors
Comprehensive Brain MRI Segmentation in High Risk Preterm Newborns
Most extremely preterm newborns exhibit cerebral atrophy/growth disturbances and white matter signal abnormalities on MRI at term-equivalent age. MRI brain volumes could serve as biomarkers for evaluating the effects of neonatal intensive care and predicting neurodevelopmental outcomes. This requires detailed, accurate, and reliable brain MRI segmentation methods. We describe our efforts to develop such methods in high risk newborns using a combination of manual and automated segmentation tools. After intensive efforts to accurately define structural boundaries, two trained raters independently performed manual segmentation of nine subcortical structures using axial T2-weighted MRI scans from 20 randomly selected extremely preterm infants. All scans were re-segmented by both raters to assess reliability. High intra-rater reliability was achieved, as assessed by repeatability and intra-class correlation coefficients (ICC range: 0.97 to 0.99) for all manually segmented regions. Inter-rater reliability was slightly lower (ICC range: 0.93 to 0.99). A semi-automated segmentation approach was developed that combined the parametric strengths of the Hidden Markov Random Field Expectation Maximization algorithm with non-parametric Parzen window classifier resulting in accurate white matter, gray matter, and CSF segmentation. Final manual correction of misclassification errors improved accuracy (similarity index range: 0.87 to 0.89) and facilitated objective quantification of white matter signal abnormalities. The semi-automated and manual methods were seamlessly integrated to generate full brain segmentation within two hours. This comprehensive approach can facilitate the evaluation of large cohorts to rigorously evaluate the utility of regional brain volumes as biomarkers of neonatal care and surrogate endpoints for neurodevelopmental outcomes
SEGMA: an automatic SEGMentation Approach for human brain MRI using sliding window and random forests
Quantitative volumes from brain magnetic resonance imaging (MRI) acquired across the life course may be useful for investigating long term effects of risk and resilience factors for brain development and healthy aging, and for understanding early life determinants of adult brain structure. Therefore, there is an increasing need for automated segmentation tools that can be applied to images acquired at different life stages. We developed an automatic segmentation method for human brain MRI, where a sliding window approach and a multi-class random forest classifier were applied to high-dimensional feature vectors for accurate segmentation. The method performed well on brain MRI data acquired from 179 individuals, analyzed in three age groups: newborns (38–42 weeks gestational age), children and adolescents (4–17 years) and adults (35–71 years). As the method can learn from partially labeled datasets, it can be used to segment large-scale datasets efficiently. It could also be applied to different populations and imaging modalities across the life course
Structural subnetwork evolution across the life-span: rich-club, feeder, seeder
The impact of developmental and aging processes on brain connectivity and the
connectome has been widely studied. Network theoretical measures and certain
topological principles are computed from the entire brain, however there is a
need to separate and understand the underlying subnetworks which contribute
towards these observed holistic connectomic alterations. One organizational
principle is the rich-club - a core subnetwork of brain regions that are
strongly connected, forming a high-cost, high-capacity backbone that is
critical for effective communication in the network. Investigations primarily
focus on its alterations with disease and age. Here, we present a systematic
analysis of not only the rich-club, but also other subnetworks derived from
this backbone - namely feeder and seeder subnetworks. Our analysis is applied
to structural connectomes in a normal cohort from a large, publicly available
lifespan study. We demonstrate changes in rich-club membership with age
alongside a shift in importance from 'peripheral' seeder to feeder subnetworks.
Our results show a refinement within the rich-club structure (increase in
transitivity and betweenness centrality), as well as increased efficiency in
the feeder subnetwork and decreased measures of network integration and
segregation in the seeder subnetwork. These results demonstrate the different
developmental patterns when analyzing the connectome stratified according to
its rich-club and the potential of utilizing this subnetwork analysis to reveal
the evolution of brain architectural alterations across the life-span
Segmentation of brain MRI during early childhood
The objective of this thesis is the development of automatic methods to measure the changes in
volume and growth of brain structures in prematurely born infants. Automatic tools for accurate
tissue quantification from magnetic resonance images can provide means for understanding
how the neurodevelopmental effects of the premature birth, such as cognitive, neurological or
behavioural impairment, are related to underlying changes in brain anatomy. Understanding
these changes forms a basis for development of suitable treatments to improve the outcomes of
premature birth.
In this thesis we focus on the segmentation of brain structures from magnetic resonance images
during early childhood. Most of the current brain segmentation techniques have been focused
on the segmentation of adult or neonatal brains. As a result of rapid development, the brain
anatomy during early childhood differs from anatomy of both adult and neonatal brains and
therefore requires adaptations of available techniques to produce good results.
To address the issue of anatomical differences of the brain during early childhood compared
to other age-groups, population-specific deformable and probabilistic atlases are introduced. A
method for generation of population-specific prior information in form of a probabilistic atlas
is proposed and used to enhance existing segmentation algorithms.
The evaluation of registration-based and intensity-based approaches shows the techniques to
be complementary in the quality of automatic segmentation in different parts of the brain. We
propose a novel robust segmentation method combining the advantages of both approaches. The
method is based on multiple label propagation using B-spline non-rigid registration followed by
EM segmentation.
Intensity inhomogeneity is a shading artefact resulting from the acquisition process, which
significantly affects modern high resolution MR data acquired at higher magnetic field strengths.
A novel template based method focused on correcting the intensity inhomogeneity in data
acquired at higher magnetic field strengths is therefore proposed.
The proposed segmentation method combined with proposed intensity inhomogeneity correction
method offers a robust tool for quantification of volumes and growth of brain structures during
early childhood. The tool have been applied to 67 T1-weigted images of subject at one and two years of age
- …