Discovery and Cross-Section Measurement of Neutron-Rich Isotopes in the Element Range from Neodymium to Platinum at the FRS

With a new detector setup and the high-resolution performance of the fragment separator FRS at GSI we discovered 57 new isotopes in the atomic number range of 60$\leq Z \leq 78$: \nuc{159-161}{Nb}, \nuc{160-163}{Pm}, \nuc{163-166}Sm, \nuc{167-168}{Eu}, \nuc{167-171}{Gd}, \nuc{169-171}{Tb}, \nuc{171-174}{Dy}, \nuc{173-176}{Ho}, \nuc{176-178}{Er}, \nuc{178-181}{Tm}, \nuc{183-185}{Yb}, \nuc{187-188}{Lu}, \nuc{191}{Hf}, \nuc{193-194}{Ta}, \nuc{196-197}{W}, \nuc{199-200}{Re}, \nuc{201-203}{Os}, \nuc{204-205}{Ir} and \nuc{206-209}{Pt}. The new isotopes have been unambiguously identified in reactions with a $^{238}$U beam impinging on a Be target at 1 GeV/u. The isotopic production cross-section for the new isotopes have been measured and compared with predictions of different model calculations. In general, the ABRABLA and COFRA models agree better than a factor of two with the new data, whereas the semiempirical EPAX model deviates much more. Projectile fragmentation is the dominant reaction creating the new isotopes, whereas fission contributes significantly only up to about the element holmium.Comment: 9 pages, 4 figure

The initial conditions of stellar protocluster formation. II. A catalogue of starless and protostellar clumps embedded in IRDCs in the Galactic longitude range 15<l<55

We present a catalogue of starless and protostellar clumps associated with infrared dark clouds (IRDCs) in a 40 degrees wide region of the inner Galactic Plane (b<1). We have extracted the far-infrared (FIR) counterparts of 3493 IRDCs with known distance in the Galactic longitude range 15<l<55 and searched for the young clumps using Hi-GAL, the survey of the Galactic Plane carried out with the Herschel satellite. Each clump is identified as a compact source detected at 160, 250 and 350 mum. The clumps have been classified as protostellar or starless, based on their emission (or lack of emission) at 70 mum. We identify 1723 clumps, 1056 (61%) of which are protostellar and 667 (39%) starless. These clumps are found within 764 different IRDCs, 375 (49%) of which are only associated with protostellar clumps, 178 (23%) only with starless clumps, and 211 (28%) with both categories of clumps. The clumps have a median mass of 250 M_sun and range up to >10^4$ M_sun in mass and up to 10^5 L_sun in luminosity. The mass-radius distribution shows that almost 30% of the starless clumps identified in this survey could form high-mass stars, however these massive clumps are confined in only ~4% of the IRDCs. Assuming a minimum mass surface density threshold for the formation of high-mass stars, the comparison of the numbers of massive starless clumps and those already containing embedded sources suggests an upper limit lifetime for the starless phase of 10^5 years for clumps with a mass M>500 M_sun.Comment: accepted for publication in MNRAS. Online catalogues available soon, please contact the authors if intereste

Analisis Keterampilan Membuka Kelas Pada Guru Pjok Di Mi Plus Ja –Alhaq Kota Bengkulu

This study aims to determine the level of skill in opening class for PJOK teachers at Mi Plus Ja - Alhaq Bengkulu City. Descriptive Qualitative research type with research informants pjok teachers, teachers, principals and students. The results of research on the skills of opening the class of pjok teachers at MI Plus Ja-Alhaq are good as evidenced by the results of interviews and observations in this study. In the observation technique, class 1 obtained a score of 160 with a percentage of 80%, class 2 obtained a score of 161 with a percentage of 81%, class 3 obtained a score of 172 with a percentage of 86%, class 4 obtained a score of 173 with a percentage of 87%, class 5 obtained a score of 177 with a percentage of 89%, and class 6 obtained a score of 178 with a percentage of 89%. There are several aspects of the pjok teacher's skills in opening the class such as; lining up students, counting / attendance, leading prayers, giving greetings, giving apperceptions, conveying learning objectives, leading warm-ups, preparing places, preparing tools and preparing media

Königliche Technische Hochschule Stuttgart. Liste der Studierenden vom Wintersemester 1906/07

KÖNIGLICHE TECHNISCHE HOCHSCHULE STUTTGART. LISTE DER STUDIERENDEN VOM WINTERSEMESTER 1906/07 Personal- und Studierendenverzeichnisse (-) Königliche Technische Hochschule Stuttgart. Liste der Studierenden vom Wintersemester 1906/07 (1906/1907) (-) Einband (-) Verzeichnis der Vorlesungen an der Königlichen Technischen Hochschule in Stuttgart für das Wintersemester 1906-1907 mit möglichst vollständiger Stunden-Angabe der einzelnen Fächer. (-) [1. Studierende] (1) A. (1) B. (4-5) C. (22-23) D. (24-25) E. (30-31) F. (34-35) G. (42-43) H. (50-51) J. (64-65) K. (66-67) L. (84-85) M. (94-95) N. (104-105) O. (106-107) P. (110-111) Q. (114-115) R. (114-115) S. (128-129) T. (160-161) U. (162-163) V. (162-163) W. (166-167) Z. (178-179) [2. Abrechnungen von Unterrichtsgeld und Gebühren] (182-183) Leerseite (-) Farbinformation (-) Einband (-

Field Performance of a Rapid Test to Detect Progressive, Regressive, and Abortive Feline Leukemia Virus Infections in Domestic Cats in Australia and Germany

Different feline leukemia virus (FeLV) infection outcomes are possible in cats following natural exposure, such as progressive infections (persistent viremia), regressive infections (transient or no viremia followed by proviral persistence) and abortive infections (presence of only antibodies). Laboratory-based testing is currently required for categorization of infection outcomes in cats. The aim of this study was to evaluate the field performance of a novel, rapid, combination point-of-care (PoC) test kit commercially available in Europe (v-RetroFel®Ag/Ab; 2020–2021 version) to determine different FeLV infection outcomes by concurrent detection of FeLV antigen (p27) and antibodies against FeLV transmembrane envelope protein (p15E). A secondary aim was to evaluate the performance of the same test kit (v-RetroFel®FIV) to determine positive/negative feline immunodeficiency virus (FIV) infection status by the detection of antibodies to FIV capsid protein (p24) and transmembrane glycoprotein (gp40). Two cohorts of domestic cats were recruited and tested with v-RetroFel® using plasma or serum, including cats in Australia (n = 200) and cats in Germany (n = 170). Results from p27 antigen PoC testing, proviral DNA PCR, and neutralizing antibody testing or testing for antibodies against non-glycosylated surface unit envelope protein (p45) were used to assign cats to groups according to different FeLV infection outcomes. Testing with a laboratory-based FeLV p15E antibody ELISA was also performed for comparison. In the first cohort, v-RetroFel®Ag/Ab correctly identified 89% (109/122) FeLV-unexposed cats and 91% (21/23) progressive infections, but no regressive (0/23) or abortive (0/32) infections. In the second cohort, v-RetroFel®Ag/Ab correctly identified 94% (148/158) FeLV-unexposed cats and 100% (4/4) progressive infections, but no regressive (0/2) and only 17% (1/6) abortive infections. There was test agreement between v-RetroFel®Ab and the p15E laboratory ELISA in 58.9% of samples. As a secondary outcome of this study, the sensitivity and specificity of v-RetroFel®FIV testing in cohort 1 were 94.7% (18/19) and 98.3% (178/181), and in cohort 2, 30.0% (3/10) and 100.0% (160/160), respectively. Prior history of FIV vaccination did not produce any false-positive FIV results. In conclusion, v-RetroFel®Ag/Ab (2020–2021 version) was unable to accurately determine different FeLV infection outcomes in the field. Improvements of the test prior to application to field samples are required

A gene-expression profiling score for prediction of outcome in patients with follicular lymphoma: a retrospective training and validation analysis in three international cohorts

Patients with follicular lymphoma (FL) have heterogeneous outcomes. Predictor models able to distinguish, at diagnosis, patients at high versus low risk of progression are still needed. A training set of fresh-frozen tumour biopsies was prospectively obtained from 160 untreated patients with high-tumour-burden follicular lymphoma enrolled in the phase 3 randomised PRIMA trial, in which rituximab maintenance was evaluated after rituximab plus chemotherapy induction (median follow-up 6·6 years [IQR 6·0-7·0]). RNA of sufficient quality was obtained for 149 of 160 cases, and Affymetrix U133 Plus 2.0 microarrays were used for gene-expression profiling. We did a multivariate Cox regression analysis to identify genes with expression levels associated with progression-free survival independently of maintenance treatment in a subgroup of 134 randomised patients. Expression levels from 95 curated genes were then determined by digital expression profiling (NanoString technology) in 53 formalin-fixed paraffin-embedded samples of the training set to compare the technical reproducibility of expression levels for each gene between technologies. Genes with high correlation (>0·75) were included in an L2-penalised Cox model adjusted on rituximab maintenance to build a predictive score for progression-free survival. The model was validated using NanoString technology to digitally quantify gene expression in 488 formalin-fixed, paraffin-embedded samples from three independent international patient cohorts from the PRIMA trial (n=178; distinct from the training cohort), the University of Iowa/Mayo Clinic Lymphoma SPORE project (n=201), and the Barcelona Hospital Clinic (n=109). All tissue samples consisted of pretreatment diagnostic biopsies and were confirmed as follicular lymphoma grade 1-3a. The patients were all treated with regimens containing rituximab and chemotherapy, possibly followed by either rituximab maintenance or ibritumomab-tiuxetan consolidation. We determined an optimum threshold on the score to predict patients at low risk and high risk of progression. The model, including the multigene score and the threshold, was initially evaluated in the three validation cohorts separately. The sensitivity and specificity of the score for the prediction of the risk of lymphoma progression at 2 years were assessed on the combined validation cohorts. FINDINGS: In the training cohort, the expression levels of 395 genes were associated with a risk of progression. 23 genes reflecting both B-cell biology and tumour microenvironment with correlation coefficients greater than 0·75 between the two technologies and sample types were retained to build a predictive model that identified a population at an increased risk of progression (p<0·0001). In a multivariate Cox model for progression-free survival adjusted on rituximab maintenance treatment and Follicular Lymphoma International Prognostic Index 1 (FLIPI-1) score, this predictor independently predicted progression (adjusted hazard ratio [aHR] of the high-risk group compared with the low-risk group 3·68, 95% CI 2·19-6·17 [p<0·0001]). The 5-year progression-free survival was 26% (95% CI 16-43) in the high-risk group and 73% (64-83) in the low-risk group. The predictor performances were confirmed in each of the individual validation cohorts (aHR comparing high-risk to low-risk groups 2·57 [95% CI 1·65-4·01] in cohort 1; 2·12 [1·32-3·39] in cohort 2; and 2·11 [1·01-4·41] in cohort 3). In the combined validation cohort, the median progression-free survival was 3·1 years (95% CI 2·4-4·8) in the high-risk group and 10·8 years (10·1-not reached) in the low-risk group (p<0·0001). The risk of lymphoma progression at 2 years was 38% (95% CI 29-46) in the high-risk group and 19% (15-24) in the low-risk group. In a multivariate analysis, the score predicted progression-free survival independently of anti-CD20 maintenance treatment and of the FLIPI score (aHR for the combined cohort 2·30, 95% CI 1·72-3·07). INTERPRETATION: We developed and validated a robust 23-gene expression-based predictor of progression-free survival that is applicable to routinely available formalin-fixed, paraffin-embedded tumour biopsies from patients with follicular lymphoma at time of diagnosis. Applying this score could allow individualised therapy for patients according to their risk category

Introducing Critical Pedagogy to English Language Teachers at Tertiary Education in Oman: Attitudes, Potentialities and Challenges

Based on critical theory and postmodernist paradigms, the aim of this study is to introduce Critical Pedagogy (CP) to English language teachers in four higher education institutions in Oman via an action research methodology. Eventually, the ultimate purpose of this study is to create a change by raising teachers' awareness of CP. Although CP cannot be reduced to a monolithic body of discourse, through a review of literature, unified principles have been put forward by various critical educators that shape this study: (1) the political nature of education, (2) the nature of knowledge, (3) education for empowerment, (4) education for transformation, (5) integrating the world into the classroom, and (6) the meaning of ‘critical’ within CP framework. Five data collection tools are utilized during the four phases of the study. In the first phase, 178 teachers complete a five-point Likert scale questionnaire. In the second phase, an article is sent to teachers and a workshop on CP is conducted for 160 English language teachers in the four colleges. Then, documents (102 workshop evaluation forms and 25 lesson plans) and semi-structured interviews with 20 teachers are analysed to elicit teachers' attitudes towards CP and its potentialities and challenges in teaching English. Lastly, in the fourth phase, eight classroom observations are conducted to obtain a deeper insight of the feasibilities and challenges of implementing CP. The findings show teachers’ initial lack of awareness of CP as a possible approach to teaching English. After the intervention, the findings reveal that teachers have various attitudes towards applying CP, ranging from caution to full support. Some teachers resist some of CP’s premises while others are in-between. Although the findings of the study indicate the great potential of CP, the participants acknowledge the existence of many challenges to its implementation; these challenges are related to students, teachers and the college system. These findings are discussed in light of the existing literature and the Omani context. Implications for teachers, pre-service and in-service teacher education programmes and policy makers are drawn based on the study's findings

Resultados cardiotocográficos en gestantes con diagnóstico de trabajo de parto y distocia funicular de circular de cordón atendidas en el Hospital Sergio E. Bernales, 2019

Resultados cardiotocográficos en gestantes con diagnóstico de trabajo de parto y distocia funicular de circular de cordón atendidas en el Hospital Sergio E. Bernales, 2019. OBJETIVO: determinar los resultados cardiotocográficos en gestantes con diagnóstico de trabajo de parto y distocia funicular circular de cordón atendidas en el Hospital Sergio E. Bernales, 2019. MATERIAL Y MÉTODO: estudio descriptivo, transversal, retrospectivo, realizado en 178 gestantes con diagnóstico de trabajo de parto y distocia funicular. Se empleó como instrumento una ficha de recolección de datos. RESULTADOS: el rango de edades que predominó en el estudio fue de 20 a 29 años (47,8% /n=85), entre las características obstétricas se resaltaron las de 2 a 3 gestaciones (53,3% /n=95), la edad gestacional predominante fue de 37 semanas (33,3% / n=59). La línea de base entre 120 a 160 lpm (98,3% /n=175) y de 100 a 119 lpm (1,7% /n=3). La variabilidad de 5 a 9 o >25 (50,6% /n=90), de 10 a 25 (47,2% /n=84) y menor a 5 (2,2% /n=4). Las aceleraciones mayores de 5 (45,5% /n=81), entre 1 a 4 (44,9% /n=80) y sin aceleración (9,6% /n=17). Las desaceleraciones ausentes (69,1% /n=123) y las que presentaron DIP o variables (3,9% /n=55). Los movimientos fetales mayores a 5 (93,8% /n=167), de 1 a 4 (5,6% / n=10) y sin ningún movimiento (0,6% /n=1). CONCLUSION: en este estudio se determinaron los resultados cardiotocográficos un 90,4% Reactivos, mientras que el 74,2% tuvo circular simple de cordónen gestantes con diagnóstico de trabajo de parto y distocia funicular circular de cordón atendidas en el Hospital Sergio E. Bernales, 2019

Radio Frequency Spectra of 388 Bright 74 MHz Sources

As a service to the community, we have compiled radio frequency spectra from the literature for all sources within the VLA Low Frequency Sky Survey (VLSS) that are brighter than 15 Jy at 74 MHz. Over 160 references were used to maximize the amount of spectral data used in the compilation of the spectra, while also taking care to determine the corrections needed to put the flux densities from all reference on the same absolute flux density scale. With the new VLSS data, we are able to vastly improve upon previous efforts to compile spectra of bright radio sources to frequencies below 100 MHz because (1) the VLSS flux densities are more reliable than those from some previous low frequency surveys and (2) the VLSS covers a much larger area of the sky (declination >-30 deg.) than many other low frequency surveys (e.g., the 8C survey). In this paper, we discuss how the spectra were constructed and how parameters quantifying the shapes of the spectra were derived. Both the spectra and the shape parameters are made available here to assist in the calibration of observations made with current and future low frequency radio facilities.Comment: Accepted to ApJ