XAI-Driven CNN for Diabetic Retinopathy Detection

Diabetes, a chronic metabolic disorder, poses a significant health threat with potentially severe consequences, including diabetic retinopathy, a leading cause of blindness. In this project, we tackle this threat by developing a Convolutional Neural Network (CNN) to support the diagnosis based on eye images. The aim is early detection and intervention to mitigate the effects of diabetes on eye health. To enhance transparency and interpretability, we incorporate explainable AI techniques. This research not only contributes to the early diagnosis of diabetic eye disease but also advances our understanding of how deep learning models arrive at their decisions, fostering trust and clinical applicability in healthcare diagnostics. Our results show that our CNN model performs exceptionally well in classifying ocular images, attaining a 91% accuracy rate. Furthermore, we implemented explainable AI techniques, such as LIME (Local Interpretable Model-agnostic Explanations), which improves the transparency of our model’s decision-making. The areas of interest in the eye images were clarified for us by LIME, which enhanced our understanding of the model’s predictions. The high accuracy and interpretability of our approach demonstrate its potential for clinical applications and the broader field of healthcare diagnostics

Una revisión sistemática de métodos de aprendizaje profundo aplicados a imágenes oculares

Artificial intelligence is having an important effect on different areas of medicine, and ophthalmology has not been the exception. In particular, deep learning methods have been applied successfully to the detection of clinical signs and the classification of ocular diseases. This represents a great potential to increase the number of people correctly diagnosed. In ophthalmology, deep learning methods have primarily been applied to eye fundus images and optical coherence tomography. On the one hand, these methods have achieved an outstanding performance in the detection of ocular diseases such as: diabetic retinopathy, glaucoma, diabetic macular degeneration and age-related macular degeneration.  On the other hand, several worldwide challenges have shared big eye imaging datasets with segmentation of part of the eyes, clinical signs and the ocular diagnostic performed by experts. In addition, these methods are breaking the stigma of black-box models, with the delivering of interpretable clinically information. This review provides an overview of the state-of-the-art deep learning methods used in ophthalmic images, databases and potential challenges for ocular diagnosisLa inteligencia artificial está teniendo un importante impacto en diversas áreas de la medicina y a la oftalmología no ha sido la excepción. En particular, los métodos de aprendizaje profundo han sido aplicados con éxito en la detección de signos clínicos y la clasificación de enfermedades oculares. Esto representa un potencial impacto en el incremento de pacientes correctamente y oportunamente diagnosticados. En oftalmología, los métodos de aprendizaje profundo se han aplicado principalmente a imágenes de fondo de ojo y tomografía de coherencia óptica. Por un lado, estos métodos han logrado un rendimiento sobresaliente en la detección de enfermedades oculares tales como: retinopatía diabética, glaucoma, degeneración macular diabética y degeneración macular relacionada con la edad. Por otro lado, varios desafíos mundiales han compartido grandes conjuntos de datos con segmentación de parte de los ojos, signos clínicos y el diagnóstico ocular realizado por expertos. Adicionalmente, estos métodos están rompiendo el estigma de los modelos de caja negra, con la entrega de información clínica interpretable. Esta revisión proporciona una visión general de los métodos de aprendizaje profundo de última generación utilizados en imágenes oftálmicas, bases de datos y posibles desafíos para los diagnósticos oculare

Techniques for Ocular Biometric Recognition Under Non-ideal Conditions

The use of the ocular region as a biometric cue has gained considerable traction due to recent advances in automated iris recognition. However, a multitude of factors can negatively impact ocular recognition performance under unconstrained conditions (e.g., non-uniform illumination, occlusions, motion blur, image resolution, etc.). This dissertation develops techniques to perform iris and ocular recognition under challenging conditions. The first contribution is an image-level fusion scheme to improve iris recognition performance in low-resolution videos. Information fusion is facilitated by the use of Principal Components Transform (PCT), thereby requiring modest computational efforts. The proposed approach provides improved recognition accuracy when low-resolution iris images are compared against high-resolution iris images. The second contribution is a study demonstrating the effectiveness of the ocular region in improving face recognition under plastic surgery. A score-level fusion approach that combines information from the face and ocular regions is proposed. The proposed approach, unlike other previous methods in this application, is not learning-based, and has modest computational requirements while resulting in better recognition performance. The third contribution is a study on matching ocular regions extracted from RGB face images against that of near-infrared iris images. Face and iris images are typically acquired using sensors operating in visible and near-infrared wavelengths of light, respectively. To this end, a sparse representation approach which generates a joint dictionary from corresponding pairs of face and iris images is designed. The proposed joint dictionary approach is observed to outperform classical ocular recognition techniques. In summary, the techniques presented in this dissertation can be used to improve iris and ocular recognition in practical, unconstrained environments

UFPR-Periocular: A Periocular Dataset Collected by Mobile Devices in Unconstrained Scenarios

Recently, ocular biometrics in unconstrained environments using images obtained at visible wavelength have gained the researchers' attention, especially with images captured by mobile devices. Periocular recognition has been demonstrated to be an alternative when the iris trait is not available due to occlusions or low image resolution. However, the periocular trait does not have the high uniqueness presented in the iris trait. Thus, the use of datasets containing many subjects is essential to assess biometric systems' capacity to extract discriminating information from the periocular region. Also, to address the within-class variability caused by lighting and attributes in the periocular region, it is of paramount importance to use datasets with images of the same subject captured in distinct sessions. As the datasets available in the literature do not present all these factors, in this work, we present a new periocular dataset containing samples from 1,122 subjects, acquired in 3 sessions by 196 different mobile devices. The images were captured under unconstrained environments with just a single instruction to the participants: to place their eyes on a region of interest. We also performed an extensive benchmark with several Convolutional Neural Network (CNN) architectures and models that have been employed in state-of-the-art approaches based on Multi-class Classification, Multitask Learning, Pairwise Filters Network, and Siamese Network. The results achieved in the closed- and open-world protocol, considering the identification and verification tasks, show that this area still needs research and development

Learning Efficient Deep Feature Extraction For Mobile Ocular Biometrics

Title from PDF of title page viewed March 4, 2021Dissertation advisors: Reza Derakhshani and Cory BeardVitaIncludes bibliographical references (page 137-149)Thesis (Ph.D.)--School of Computing and Engineering. University of Missouri--Kansas City, 2020Ocular biometrics uses physical traits from eye regions such as iris, conjunctival vasculature, and periocular for recognizing the person. Ocular biometrics has gained popularity amongst research and industry alike for its identification capabilities, security, and simplicity in the acquisition, even using a mobile phone's selfie camera. With the rapid advancement in hardware and deep learning technologies, better performances have been obtained using Convolutional Neural Networks(CNN) for feature extraction and person recognition. Most of the early works proposed using large CNNs for ocular recognition in subject-dependent evaluation, where the subjects overlap between the training and testing set. This is difficult to scale for the large population as the CNN model needs to be re-trained every time a new subject is enrolled in the database. Also, many of the proposed CNN models are large, which renders them memory intensive and computationally costly to deploy on a mobile device. In this work, we propose CNN based robust subject-independent feature extraction for ocular biometric recognition, which is memory and computation efficient. We evaluated our proposed method on various ocular biometric datasets in the subject-independent, cross-dataset, and cross-illumination protocols.Introduction -- Previous Work -- Calculating CNN Models Computational Efficiency -- Case Study of Deep Learning Models in Ocular Biometrics -- OcularNet Model -- OcularNet-v2: Self-learned ROI detection with deep features -- LOD-V: Large Ocular Biometrics Dataset in Visible Spectrum -- Conclusion and Future Work -- Appendix A. Supplementary Materials for Chapter 4 -- Appendix B. Supplementary Materials for Chapter 5 -- Appendix C.Supplementary Materials for Chapter 6 -- Appendix D. Supplementary Materials for Chapter 7xxii, 150 page

Deep learning analysis of eye fundus images to support medical diagnosis

Machine learning techniques have been successfully applied to support medical decision making of cancer, heart diseases and degenerative diseases of the brain. In particular, deep learning methods have been used for early detection of abnormalities in the eye that could improve the diagnosis of different ocular diseases, especially in developing countries, where there are major limitations to access to specialized medical treatment. However, the early detection of clinical signs such as blood vessel, optic disc alterations, exudates, hemorrhages, drusen, and microaneurysms presents three main challenges: the ocular images can be affected by noise artifact, the features of the clinical signs depend specifically on the acquisition source, and the combination of local signs and grading disease label is not an easy task. This research approaches the problem of combining local signs and global labels of different acquisition sources of medical information as a valuable tool to support medical decision making in ocular diseases. Different models for different eye diseases were developed. Four models were developed using eye fundus images: for DME, it was designed a two-stages model that uses a shallow model to predict an exudate binary mask. Then, the binary mask is stacked with the raw fundus image into a 4-channel array as an input of a deep convolutional neural network for diabetic macular edema diagnosis; for glaucoma, it was developed three deep learning models. First, it was defined a deep learning model based on three-stages that contains an initial stage for automatically segment two binary masks containing optic disc and physiological cup segmentation, followed by an automatic morphometric features extraction stage from previous segmentations, and a final classification stage that supports the glaucoma diagnosis with intermediate medical information. Two late-data-fusion methods that fused morphometric features from cartesian and polar segmentation of the optic disc and physiological cup with features extracted from raw eye fundus images. On the other hand, two models were defined using optical coherence tomography. First, a customized convolutional neural network termed as OCT-NET to extract features from OCT volumes to classify DME, DR-DME and AMD conditions. In addition, this model generates images with highlighted local information about the clinical signs, and it estimates the number of slides inside a volume with local abnormalities. Finally, a 3D-Deep learning model that uses OCT volumes as an input to estimate the retinal thickness map useful to grade AMD. The methods were systematically evaluated using ten free public datasets. The methods were compared and validated against other state-of-the-art algorithms and the results were also qualitatively evaluated by ophthalmology experts from Fundación Oftalmológica Nacional. In addition, the proposed methods were tested as a diagnosis support tool of diabetic macular edema, glaucoma, diabetic retinopathy and age-related macular degeneration using two different ocular imaging representations. Thus, we consider that this research could be potentially a big step in building telemedicine tools that could support medical personnel for detecting ocular diseases using eye fundus images and optical coherence tomography.Las técnicas de aprendizaje automático se han aplicado con éxito para apoyar la toma de decisiones médicas sobre el cáncer, las enfermedades cardíacas y las enfermedades degenerativas del cerebro. En particular, se han utilizado métodos de aprendizaje profundo para la detección temprana de anormalidades en el ojo que podrían mejorar el diagnóstico de diferentes enfermedades oculares, especialmente en países en desarrollo, donde existen grandes limitaciones para acceder a tratamiento médico especializado. Sin embargo, la detección temprana de signos clínicos como vasos sanguíneos, alteraciones del disco óptico, exudados, hemorragias, drusas y microaneurismas presenta tres desafíos principales: las imágenes oculares pueden verse afectadas por artefactos de ruido, las características de los signos clínicos dependen específicamente de fuente de adquisición, y la combinación de signos locales y clasificación de la enfermedad no es una tarea fácil. Esta investigación aborda el problema de combinar signos locales y etiquetas globales de diferentes fuentes de adquisición de información médica como una herramienta valiosa para apoyar la toma de decisiones médicas en enfermedades oculares. Se desarrollaron diferentes modelos para diferentes enfermedades oculares. Se desarrollaron cuatro modelos utilizando imágenes de fondo de ojo: para DME, se diseñó un modelo de dos etapas que utiliza un modelo superficial para predecir una máscara binaria de exudados. Luego, la máscara binaria se apila con la imagen de fondo de ojo original en una matriz de 4 canales como entrada de una red neuronal convolucional profunda para el diagnóstico de edema macular diabético; para el glaucoma, se desarrollaron tres modelos de aprendizaje profundo. Primero, se definió un modelo de aprendizaje profundo basado en tres etapas que contiene una etapa inicial para segmentar automáticamente dos máscaras binarias que contienen disco óptico y segmentación fisiológica de la copa, seguido de una etapa de extracción de características morfométricas automáticas de segmentaciones anteriores y una etapa de clasificación final que respalda el diagnóstico de glaucoma con información médica intermedia. Dos métodos de fusión de datos tardíos que fusionaron características morfométricas de la segmentación cartesiana y polar del disco óptico y la copa fisiológica con características extraídas de imágenes de fondo de ojo crudo. Por otro lado, se definieron dos modelos mediante tomografía de coherencia óptica. Primero, una red neuronal convolucional personalizada denominada OCT-NET para extraer características de los volúmenes OCT para clasificar las condiciones DME, DR-DME y AMD. Además, este modelo genera imágenes con información local resaltada sobre los signos clínicos, y estima el número de diapositivas dentro de un volumen con anomalías locales. Finalmente, un modelo de aprendizaje 3D-Deep que utiliza volúmenes OCT como entrada para estimar el mapa de espesor retiniano útil para calificar AMD. Los métodos se evaluaron sistemáticamente utilizando diez conjuntos de datos públicos gratuitos. Los métodos se compararon y validaron con otros algoritmos de vanguardia y los resultados también fueron evaluados cualitativamente por expertos en oftalmología de la Fundación Oftalmológica Nacional. Además, los métodos propuestos se probaron como una herramienta de diagnóstico de edema macular diabético, glaucoma, retinopatía diabética y degeneración macular relacionada con la edad utilizando dos representaciones de imágenes oculares diferentes. Por lo tanto, consideramos que esta investigación podría ser potencialmente un gran paso en la construcción de herramientas de telemedicina que podrían ayudar al personal médico a detectar enfermedades oculares utilizando imágenes de fondo de ojo y tomografía de coherencia óptica.Doctorad