10,767 research outputs found
Religion and Innovation in Europe: Implications for Product Life-Cycle Management
This paper analyzes the relationship between religion and innovation in Europe. To the best knowledge of the authors, no paper has been published about the association of religion with innovation and innovative products and services, at an individual level, for all the countries that belong to the European Union. This is the main goal of our paper. The results show that the orientation of innovativeness depends on religion. This study contains a segmentation of the main religions in Europe, taking into account their innovative profile. Connecting the characteristics of the religious segments found and the innovations life-cycle concept, companies have a tool to manage different innovationsâ evolutive stages taking into consideration the religion of their customers. The European policy-makers, still dominated by a traditional innovation approach, gain a demand-side perspective to improve citizenâs innovativeness awareness and acceptance. Finally, religiosity does not seem to have a very strong relationship with attitudes towards innovation once we control for religious affiliation
Resonances and the Weinberg--Tomozawa 56-baryon --35-meson interaction
Vector meson degrees of freedom are incorporated into the
Weinberg-Tomozawa (WT) meson-baryon chiral Lagrangian by using a scheme which
relies on spin--flavor SU(6) symmetry. The corresponding Bethe-Salpeter
approximation successfully reproduces previous SU(3)--flavor WT results for the
lowest-lying s--wave negative parity baryon resonances, and it also provides
some information on the dynamics of the heavier ones. Moreover, it also
predicts the existence of an isoscalar spin-parity bound
state (strangeness +1) with a mass around 1.7--1.8 GeV, unstable through
decay. Neglecting d-wave KN decays, this state turns out to be quite narrow
( MeV) and it might provide clear signals in reactions like
by looking at the three body
invariant mass.Comment: Talk given at the IVth International Conference on Quarks an Nuclear
Physics, Madrid, June 5th-10th 2006. Minor correction
What kind of guidance is expected by parents of ten children with congenital glaucoma, from the nurse in the hospital as seen by parents, doctors, social workers and nurses, themselves
Thesis (M.S.)--Boston Universit
Meson-Baryon s-wave Resonances with Strangeness -3
Starting from a consistent SU(6) extension of the Weinberg-Tomozawa (WT)
meson-baryon chiral Lagrangian (Phys. Rev. D74 (2006) 034025), we study the
s-wave meson-baryon resonances in the strangeness S=-3 and negative parity
sector. Those resonances are generated by solving the Bethe-Salpeter equation
with the WT interaction used as kernel. The considered mesons are those of the
35-SU(6)-plet, which includes the pseudoscalar (PS) octet of pions and the
vector (V) nonet of the rho meson. For baryons we consider the 56-SU(6)-plet,
made of the 1/2+ octet of the nucleon and the 3/2+ decuplet of the Delta.
Quantum numbers I(J^P)=0(3/2^-) are suggested for the experimental resonances
Omega*(2250)- and Omega*(2380)-. Among other, resonances with I=1 are found,
with minimal quark content sss\bar{l}l', being s the strange quark and l, l'
any of the the light up or down quarks. A clear signal for such a pentaquark
would be a baryonic resonance with strangeness -3 and electric charge of -2 or
0, in proton charge units. We suggest looking for K- Xi- resonances with masses
around 2100 and 2240 MeV in the sector 1(1/2^-), and for pi Omega- and K- Xi*-
resonances with masses around 2260 MeV in the sector 1(3/2^-).Comment: 3 pages, 1 Postscript figure, 7 table
Computing Hypercircles by Moving Hyperplanes
Let K be a field of characteristic zero, alpha algebraic of degree n over K.
Given a proper parametrization psi of a rational curve C, we present a new
algorithm to compute the hypercircle associated to the parametrization psi. As
a consequence, we can decide if the curve C is defined over K and, if not, to
compute the minimum field of definition of C containing K. The algorithm
exploits the conjugate curves of C but avoids computation in the normal closure
of K(alpha) over K.Comment: 16 page
Letter from Marino Recio to Geraldine Ferraro
Letter from Marino Recio, of Marino Recio Associates, to Geraldine Ferraro.https://ir.lawnet.fordham.edu/vice_presidential_campaign_correspondence_1984_international/1369/thumbnail.jp
Hot-spot analysis for drug discovery targeting protein-protein interactions
Introduction: Protein-protein interactions are important for biological processes and pathological situations, and are attractive targets for drug discovery. However, rational drug design targeting protein-protein interactions is still highly challenging. Hot-spot residues are seen as the best option to target such interactions, but their identification requires detailed structural and energetic characterization, which is only available for a tiny fraction of protein interactions.
Areas covered: In this review, the authors cover a variety of computational methods that have been reported for the energetic analysis of protein-protein interfaces in search of hot-spots, and the structural modeling of protein-protein complexes by docking. This can help to rationalize the discovery of small-molecule inhibitors of protein-protein interfaces of therapeutic interest. Computational analysis and docking can help to locate the interface, molecular dynamics can be used to find suitable cavities, and hot-spot predictions can focus the search for inhibitors of protein-protein interactions.
Expert opinion: A major difficulty for applying rational drug design methods to protein-protein interactions is that in the majority of cases the complex structure is not available. Fortunately, computational docking can complement experimental data. An interesting aspect to explore in the future is the integration of these strategies for targeting PPIs with large-scale mutational analysis.This work has been funded by grants BIO2016-79930-R and SEV-2015-0493 from the Spanish Ministry of Economy, Industry and Competitiveness, and grant EFA086/15 from EU Interreg V POCTEFA. M Rosell is supported by an FPI fellowship from the Severo Ochoa program. The authors are grateful for the support of the the Joint BSC-CRG-IRB Programme in Computational Biology.Peer ReviewedPostprint (author's final draft
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