Modeling Interference for the Coexistence of 6G Networks and Passive Sensing Systems

Future wireless networks and sensing systems will benefit from access to large chunks of spectrum above 100 GHz, to achieve terabit-per-second data rates in 6th Generation (6G) cellular systems and improve accuracy and reach of Earth exploration and sensing and radio astronomy applications. These are extremely sensitive to interference from artificial signals, thus the spectrum above 100 GHz features several bands which are protected from active transmissions under current spectrum regulations. To provide more agile access to the spectrum for both services, active and passive users will have to coexist without harming passive sensing operations. In this paper, we provide the first, fundamental analysis of Radio Frequency Interference (RFI) that large-scale terrestrial deployments introduce in different satellite sensing systems now orbiting the Earth. We develop a geometry-based analysis and extend it into a data-driven model which accounts for realistic propagation, building obstruction, ground reflection, for network topology with up to $10^5$ nodes in more than $85$ km$^2$. We show that the presence of harmful RFI depends on several factors, including network load, density and topology, satellite orientation, and building density. The results and methodology provide the foundation for the development of coexistence solutions and spectrum policy towards 6G

Chirality Effects on Peptide Self-Assembly Unraveled from Molecules to Materials

Self-assembling short peptides are attractive minimal systems for mimicking the constituents of living systems and building (bio)materials. The combination of both D- and L-amino acids into heterochiral sequences is a versatile strategy for building durable supramolecular architectures, especially when their homochiral analogs do not self-assemble. The reasons for this divergent behavior have remained obscure until now. Here, we elucidate how and why homochiral and heterochiral peptides behave differently. We identify a key spectroscopy signature and its corresponding molecular conformation, whereby an amphiphilic structure is uniquely enabled by the peptide stereochemistry. Importantly, we unravel the self-assembly process as a continuum from the conformation of single molecules to their organization into nano- and microstructures and through to macroscopic hydrogels, which are probed for cytotoxicity in fibroblast cell culture. In this way, (bio)material properties at the macro-scale can be linked to the chemical structure of their building blocks at the angstrom scale. Nature makes pervasive use of homochirality (e.g., D-sugars and L-peptides) to assemble biomolecules, whose interactions determine life processes. D-amino acids rarely occur, and their effects are not yet completely understood. For a long time, structural complexity (e.g., polypeptides and constrained molecules) was considered a requirement for achieving defined conformations that ultimately allow biomolecule recognition and function. Here, we detail how minimalist building blocks can adopt conformations with a characteristic spectroscopic signature, whereby substitution of just one L-amino acid for its D mirror image leads to a divergent path for assembly in water. Subtle molecular variations are amplified through increasing size scale all the way to macroscopic differences that are visible to the eye. Ultimately, the design of heterochiral (bio)molecules thus provides an alternative approach to shed new light on the supramolecular interactions that define life as we know it. This work explains why and how heterochiral and homochiral tripeptides differ in their assembly in water. A characteristic spectroscopic signature is assigned to molecular conformation. We monitor the process as a continuum from the molecular scale to the macroscopic biomaterials so that the final properties are linked to chemical structure of the building blocks. This work lays the foundation for the design of supramolecular hydrogel biomaterials based on short sequences of hydrophobic D- and L-amino acids

The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry

Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with >80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes

Consensus guidelines for the use and interpretation of angiogenesis assays

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference

Architectures for Seamless Handover Support in Heterogeneous Wireless Networks

In this paper we study the performance of the ambient networks (AN) access selection architecture. We consider heterogeneous wireless networks, where mobile terminals (MTs) own multiple radio technologies and need to remain connected while on the move. We would like to provide the MTs with seamless IP services, such as video/audio streaming, so that changes in their point of attachment will not affect the experienced streaming quality. In the first part of this paper, we present the AN architecture for access selection, along with its functional entities (FEs), their interrelations and the algorithms that are to be run within each FE. Hence, we describe our ns2 simulation framework and detail two simulation scenarios. We finally discuss, through extensive simulation results, the effectiveness of the AN architecture in reaching the above goals

Routing Strategies for Coverage Extension in Heterogeneous Wireless Networks

The focus of this paper is on routing over heterogeneous networks. We consider a scenario involving both infrastructure and infrastructureless wireless networks, where a set of mobile users are interested in communicating with several access points (APs). Multi-hop routing, possibly over heterogeneous technologies, is exploited to extend the coverage for those users that are not within the transmission range of any APs. We propose a proactive tree-based approach for the dissemination of routing information and the subsequent data forwarding towards the APs. Subsequently, we compare its performance against reactive routing algorithms for ad hoc networks. The network performance is obtained via simulation through careful modeling of the considered radio interfaces. The results indicate the superiority of proactive schemes under moderate/high traffic conditions and motivate further research