85 research outputs found
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Studies of high-field sections of a muon helical cooling channel with coil separation
The Helical Cooling Channel (HCC) was proposed for 6D cooling of muon beams required for muon collider and some other applications. HCC uses a continuous absorber inside superconducting magnets which produce solenoidal field superimposed with transverse helical dipole and helical gradient fields. HCC is usually divided into several sections each with progressively stronger fields, smaller aperture and shorter helix period to achieve the optimal muon cooling rate. This paper presents the design issues of the high field section of HCC with coil separation. The effect of coil spacing on the longitudinal and transverse field components is presented and its impact on the muon cooling discussed. The paper also describes methods for field corrections and their practical limits. The magnetic performance of the helical solenoid with coil separation was discussed in this work. The separation could be done in three different ways and the performances could be very different which is important and should be carefully described during the beam cooling simulations. The design that is currently being considered is the one that has the poorest magnetic performance because it presents ripples in all three components, in particular in the helical gradient which could be quite large. Moreover, the average gradient could be off, which could affect the cooling performance. This work summarized methods to tune the gradient regarding the average value and the ripple. The coil longitudinal thickness and the helix period can be used to tune G. Thinner coils tend to reduce the ripples and also bring G to its target value. However, this technique reduces dramatically the operational margin. Wider coils can also reduce the ripple (not as much as thinner coils) and also tune the gradient to its target value. Longer helix periods reduce ripple and correct the gradient to the target value
Multiple (inverse) binomial sums of arbitrary weight and depth and the all-order epsilon-expansion of generalized hypergeometric functions with one half-integer value of parameter
We continue the study of the construction of analytical coefficients of the
epsilon-expansion of hypergeometric functions and their connection with Feynman
diagrams. In this paper, we show the following results:
Theorem A: The multiple (inverse) binomial sums of arbitrary weight and depth
(see Eq. (1.1)) are expressible in terms of Remiddi-Vermaseren functions.
Theorem B: The epsilon expansion of a hypergeometric function with one
half-integer value of parameter (see Eq. (1.2)) is expressible in terms of the
harmonic polylogarithms of Remiddi and Vermaseren with coefficients that are
ratios of polynomials. Some extra materials are available via the www at this
http://theor.jinr.ru/~kalmykov/hypergeom/hyper.htmlComment: 24 pages, latex with amsmath and JHEP3.cls; v2: some typos corrected
and a few references added; v3: few references added
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Fabrication and test of short helical solenoid model based on YBCO tape
A helical cooling channel (HCC) is a new technique proposed for six-dimensional (6D) cooling of muon beams. To achieve the optimal cooling rate, the high field section of HCC need to be developed, which suggests using High Temperature Superconductors (HTS). This paper updates the parameters of a YBCO based helical solenoid (HS) model, describes the fabrication of HS segments (double-pancake units) and the assembly of six-coil short HS model with two dummy cavity insertions. Three HS segments and the six-coil short model were tested. The results are presented and discussed
BIOINFORMATION SEARCH AND ANALYSIS OF STRUCTURES OF CRISPR/CAS SYSTEMS IN PHAGE STAPHYLOCOCUS AUREUS GENOME AND ESTIMATION OF PROFILES OF PHAGE DETECTED THROUGH CRISPR-CASSETTE BACTERIA
The emergence of resistance among the most important bacterial pathogens is generally recognized as one of the major public health problems. The most important of these organisms are penicillin-resistant Streptococcus pneumoniae, vancomycin-resistant enterococci and methicillin- and vancomycin-resistant Staphylococcus aureus. These antibiotic resistance in common pathogens have made antimicrobial therapy of many infections. Scientists need to look for new ways of treating bacterial infections in the work, using the developed algorithm from the methods of search software in the genomic structure of Staphylococcus aureus subsp. aureus ST228, the CRISPR/Cas locus and the division structures of its CRISPR cassette. The results of the bacteriophage search through the decoded spacer sequences of CRISPR-cassettes of this strain were also obtained using the developed algorithm of the software methods of bioinformatics. It was determined that the CRISPR/Cas system of strain of ST228 of S. aureus was of type IIIA. It is shown that cas-genes are in the immediate vicinity of CRISPR cassettes. The spacer structures in the detected CRISPR cassette are the Staphylococcus, Mycobacterium, Streptococcus, Bacillus, Gordonia, Arthrobacter, Streptomyces. The implementation of the algorithm of program methods for locating CRISPR/Cas-loci can be applied to many other decoded bacterial genomes to return bacteriophage therapy
BIOINFORMATIC SEARCH OF CRISPR/CAS SYSTEM STRUCTURES IN GENOME OF PCT281 PLASMID OF BACILLUS THURINGIENSIS SUBSP. CHINENSIS STRAIN CT-43
Background. CRISPR/Cas systems loci are one of the functionally important patterns in bacterial genome which perform the role of âadaptive immune defenseâ from foreign nucleic acids. The study of CRISPR/Cas systems structure in genomes of plasmids and phages provide new information about the evolution of this systems in bacterial hosts.Aims. A search of CRISPR/Cas systems structures in pCT281 plasmid from Bacillus thuringiensis subsp. chinensis strain CT-43 using bioinformatic methods.Materials and methods. Search studies using bioinformatics methods were performed with the genome of pCT281 plasmid of B. thuringiensis subsp. chinensis strain CT-43 from the RefSeq database. To search for the CRISPR/Cas system structure MacSyFinder (ver. 1.0.5) and three combined algorithms were used: CRISPRFinder; PILER-CR; CRISPR Recognition Tool (CRT). The consensus repeat sequence was generated in WebLogo 3.Results and discussion. In pCT281 plasmid we detected one locus of CRISPR/Cas system of the type I-C which contains 2 CRISPR-cassettes and 4 cas-genes located between them. The CRISPR-cassette 1 includes 10 spacers from 32 to 35 bp and 11 repeats 32bp in length. 5 spacers (33â35 bp) separated by 6 repeats 32 bp in length were detected in the CRISPR-cassette 2.Conclusions. The bioinformatic methods used in this study enable to conduct a search of CRISPR/Cas systems structures in plasmid genomes. The presence of the CRISPR-Cas locus in pCT281 plasmid confirms a possible transfer of this system from the nucleoid to this plasmid. The detected spacers provide information about phages this bacteria was encountered
CHARACTERISTICS OF THE BAIKAL SUBTYPE OF TICK-BORNE ENCEPHALITIS VIRUS CIRCULATING IN EASTERN SIBERIA
Background. During the study of the genetic variability of the tick-borne encephalitis virus (TBEV) in Eastern Siberia, a group of 22 strains with a unique genetic structure significantly different from all known TBEV subtypes was identified. This TBEV variant was tentatively called âgroup 886â. Therefore, for this original TBEV variant it was necessary to study the genetic, biological properties of the âgroup 886â strains, clarify its TBEV taxonomic status, its range, evolutionary history, etc.Aim. The generalization of the currently available data on genetic and biological properties of TBEV â886â group.Materials and methods. The genetic structure of âgroup 886â strains was studied by the complex of molecular-genetic methods (MHNA, sequencing of fragments or the complete genome).Results. It was shown that âgroup 886â strains form a separate cluster on phylogenetic tree, and the level of genetic differences from other genotypes is more than 12 %. It was defined that this TBEV variant has its own area (Irkutsk region, Republic of Buryatia, Trans-Baikal region, Northern Mongolia). Its ecological connection with all links of the transmissive chain (ixodid ticks, small mammals, human), participation in human pathology, stability and duration of  circulation in the Baikal region, individual evolutionary history were proved. Some phenotypic characteristics of the âgroup 886â strains were considered.Conclusion. The presented data testify to the validity of the â886 groupâ isolation as an independent genetic type. Taking into account the geographical distribution of this TBEV genotype, we propose to assign it the name âBaikal genotype/subtypeâ
In silico ŃŃĐ°ĐČĐœĐžŃДлŃĐœŃĐč Đ°ĐœĐ°Đ»ĐžĐ· crispr-ŃĐžŃŃĐ”ĐŒ ŃŃĐ°ĐŒĐŒĐŸĐČ Yersinia pseudotuberculosis, ĐČŃĐ·ŃĐČĐ°ŃŃĐžŃ ŃазлОŃĐœŃĐ” ĐșĐ»ĐžĐœĐžŃĐ”ŃĐșОД ĐżŃĐŸŃĐČĐ»Đ”ĐœĐžŃ ĐżŃĐ”ĐČĐŽĐŸŃŃбДŃĐșŃĐ»ŃĐ·Đ°
The aim of this research was to analyze and compare CRIPSR loci and cas-proteins of Yersinia pseudotuberculosis strains isolated in different territories from patients with various clinical manifestations of pseudotuberculosis.Materials and Methods. Complete genomes of Y. pseudotuberculosis IP329353 (NC_006155) and IP31758 (NC_009708) were obtained from NCBI Nucleotide Database. Strains were isolated from patients with gastroenteritis and systemic infection respectively. Search, identification, and analysis of CRISPR systems were carried out by onlinetools CRISPROne, CRISPRDetect, and CRISPRTarget.Results. Analyzed strains have CRISPR-Cas systems that include one set of cas-genes and arrays situated at the long distances from each other. We defined three CRISPR arrays in Y. pseudotuberculosis IP32953: array YP1 located near cas-genes, arrays YP2 and YP3. CRISPR-Cas system of Y. pseudotuberculosis IP31758 includes two arrays â YP1 and YP3. CRISPR systems do not share similar spacers.Conclusion. CRISPR systems of the analyzed strains differ in CRISPR loci and cas-protein structures that can be used as specific molecular marks of analyzed strains during the study of intra-species variability and evolution of Y. pseudotuberculosis.ЊДлŃ: ŃŃĐ°ĐČĐœĐžŃŃ CRISPR-ŃĐžŃŃĐ”ĐŒŃ ĐŽĐČŃŃ
ŃŃĐ°ĐŒĐŒĐŸĐČ, ĐČŃĐŽĐ”Đ»Đ”ĐœĐœŃŃ
ĐœĐ° ŃазлОŃĐœŃŃ
ŃĐ”ŃŃĐžŃĐŸŃĐžŃŃ
ĐŸŃ ĐżĐ°ŃĐžĐ”ĐœŃĐŸĐČ Ń ŃĐ°Đ·ĐœŃĐŒĐž ĐșĐ»ĐžĐœĐžŃĐ”ŃĐșĐžĐŒĐž ĐżŃĐŸŃĐČĐ»Đ”ĐœĐžŃĐŒĐž ĐżŃĐ”ĐČĐŽĐŸŃŃбДŃĐșŃлДза, Đž ĐŸĐżŃДЎДлОŃŃ ŃпДŃĐžŃĐžŃĐ”ŃĐșОД ŃазлОŃĐžŃ ĐČ ŃпДĐčŃĐ”ŃĐœĐŸĐŒ ŃĐŸŃŃĐ°ĐČĐ” Đž ĐČ ŃŃŃŃĐșŃŃŃĐ” cas-бДлĐșĐŸĐČ.ĐĐ°ŃĐ”ŃĐžĐ°Đ»Ń Đž ĐŒĐ”ŃĐŸĐŽŃ: ĐżŃĐŸĐ°ĐœĐ°Đ»ĐžĐ·ĐžŃĐŸĐČĐ°ĐœŃ ĐżĐŸĐ»ĐœĐŸĐłĐ”ĐœĐŸĐŒĐœŃĐ” ĐżĐŸŃĐ»Đ”ĐŽĐŸĐČĐ°ŃДлŃĐœĐŸŃŃĐž ŃŃĐ°ĐŒĐŒĐŸĐČ Y. pseudotuberculosis IP329353 (NC_006155) Đž IP31758 (NC_009708) ŃазлОŃĐœĐŸĐłĐŸ ĐłĐ”ĐŸĐłŃĐ°ŃĐžŃĐ”ŃĐșĐŸĐłĐŸ ĐżŃĐŸĐžŃŃ
ĐŸĐ¶ĐŽĐ”ĐœĐžŃ, ĐČŃĐŽĐ”Đ»Đ”ĐœĐœŃĐ” ĐŸŃ Đ±ĐŸĐ»ŃĐœŃŃ
Ń ĐżŃĐ”ĐČĐŽĐŸŃŃбДŃĐșŃĐ»Đ”Đ·ĐŸĐŒ Ń ŃĐžĐŒĐżŃĐŸĐŒĐ°ĐŒĐž гаŃŃŃĐŸŃĐœŃĐ”ŃĐžŃĐ° Đž ŃĐžŃŃĐ”ĐŒĐœŃĐŒĐž ĐżŃĐŸŃĐČĐ»Đ”ĐœĐžŃĐŒĐž ĐžĐœŃĐ”ĐșŃОО ŃĐŸĐŸŃĐČĐ”ŃŃŃĐČĐ”ĐœĐœĐŸ. ĐĐŸĐžŃĐș, ĐžĐŽĐ”ĐœŃĐžŃĐžĐșĐ°ŃĐžŃ Đž Đ°ĐœĐ°Đ»ĐžĐ· CRISPR ŃĐžŃŃĐ”ĐŒ ĐČŃĐżĐŸĐ»ĐœĐ”ĐœŃ Ń ĐžŃĐżĐŸĐ»ŃĐ·ĐŸĐČĐ°ĐœĐžĐ”ĐŒ ĐŸĐœĐ»Đ°ĐčĐœ-ĐżŃĐžĐ»ĐŸĐ¶Đ”ĐœĐžĐč CRISPROne, CRISPRDetect Đž CRISPRTarget.РДзŃĐ»ŃŃĐ°ŃŃ: ĐČ ĐłĐ”ĐœĐŸĐŒĐ” ĐžŃŃлДЎŃĐ”ĐŒŃŃ
ŃŃĐ°ĐŒĐŒĐŸĐČ ĐŸĐ±ĐœĐ°ŃŃĐ¶Đ”ĐœŃ CRISPR-Cas ŃĐžŃŃĐ”ĐŒŃ, ĐČĐșĐ»ŃŃĐ°ŃŃОД ĐŸĐŽĐžĐœ ĐœĐ°Đ±ĐŸŃ cas-ĐłĐ”ĐœĐŸĐČ Đž ĐœĐ”ŃĐșĐŸĐ»ŃĐșĐŸ CRISPR-Đ»ĐŸĐșŃŃĐŸĐČ, Đ·ĐœĐ°ŃĐžŃДлŃĐœĐŸ ŃĐŽĐ°Đ»Đ”ĐœĐœŃŃ
ĐŽŃŃĐł ĐŸŃ ĐŽŃŃга. Đ ĐłĐ”ĐœĐŸĐŒĐ” ŃŃĐ°ĐŒĐŒĐ° Y. pseudotuberculosis IP329353 ĐżŃĐžŃŃŃŃŃĐČŃĐ”Ń ŃŃĐž Đ»ĐŸĐșŃŃĐ°: YP1, ĐœĐ°Ń
ĐŸĐŽŃŃĐžĐčŃŃ ĐČ ĐœĐ”ĐżĐŸŃŃДЎŃŃĐČĐ”ĐœĐœĐŸĐč Đ±Đ»ĐžĐ·ĐŸŃŃĐž ĐŸŃ cas-ĐłĐ”ĐœĐŸĐČ, YP2 Đž YP3. CRISPR-Cas ŃĐžŃŃĐ”ĐŒĐ° Y. pseudotuberculosis IP31758 ĐżŃДЎŃŃĐ°ĐČĐ»Đ”ĐœĐ° ŃĐŸĐ»ŃĐșĐŸ ĐŽĐČŃĐŒŃ ĐșĐ°ŃŃĐ”ŃĐ°ĐŒĐž: YP1 Đž YP3. CRISPR ŃĐžŃŃĐ”ĐŒŃ ĐžŃŃлДЎŃĐ”ĐŒŃŃ
ŃŃĐ°ĐŒĐŒĐŸĐČ ĐœĐ” ĐžĐŒĐ”ŃŃ ĐŸĐŽĐžĐœĐ°ĐșĐŸĐČŃŃ
ŃпДĐčŃĐ”ŃĐŸĐČ.ĐĐ°ĐșĐ»ŃŃĐ”ĐœĐžĐ”: CRISPR-Cas ŃĐžŃŃĐ”ĐŒŃ ĐžŃŃĐ»Đ”ĐŽĐŸĐČĐ°ĐœĐœŃŃ
ŃŃĐ°ĐŒĐŒĐŸĐČ ĐŸŃлОŃĐ°ŃŃŃŃ ĐșĐŸĐ»ĐžŃĐ”ŃŃĐČĐŸĐŒ CRISPR-Đ»ĐŸĐșŃŃĐŸĐČ, ĐžŃ
ŃпДĐčŃĐ”ŃĐœŃĐŒ ŃĐŸŃŃĐ°ĐČĐŸĐŒ Đž ŃŃŃŃĐșŃŃŃĐŸĐč cas-бДлĐșĐŸĐČ. ĐĐŸĐ»ŃŃĐ”ĐœĐœŃĐ” ŃДзŃĐ»ŃŃĐ°ŃŃ ĐŸĐżŃДЎДлŃŃŃ ĐżĐ”ŃŃпДĐșŃĐžĐČŃ ĐžŃĐżĐŸĐ»ŃĐ·ĐŸĐČĐ°ĐœĐžŃ CRISPR-Đ»ĐŸĐșŃŃĐŸĐČ ĐČ ĐșĐ°ŃĐ”ŃŃĐČĐ” ŃпДŃĐžŃĐžŃĐ”ŃĐșĐžŃ
ĐŒĐŸĐ»Đ”ĐșŃĐ»ŃŃĐœŃŃ
ĐŒĐ°ŃĐșĐ”ŃĐŸĐČ ŃŃĐ°ĐŒĐŒĐŸĐČ ĐżŃĐž ОзŃŃĐ”ĐœĐžĐž ĐČĐœŃŃŃĐžĐČĐžĐŽĐŸĐČĐŸĐłĐŸ ŃĐ°Đ·ĐœĐŸĐŸĐ±ŃĐ°Đ·ĐžŃ Đž ŃĐČĐŸĐ»ŃŃОО Y. pseudotuberculosis
The COMPASS Experiment at CERN
The COMPASS experiment makes use of the CERN SPS high-intensitymuon and
hadron beams for the investigation of the nucleon spin structure and the
spectroscopy of hadrons. One or more outgoing particles are detected in
coincidence with the incoming muon or hadron. A large polarized target inside a
superconducting solenoid is used for the measurements with the muon beam.
Outgoing particles are detected by a two-stage, large angle and large momentum
range spectrometer. The setup is built using several types of tracking
detectors, according to the expected incident rate, required space resolution
and the solid angle to be covered. Particle identification is achieved using a
RICH counter and both hadron and electromagnetic calorimeters. The setup has
been successfully operated from 2002 onwards using a muon beam. Data with a
hadron beam were also collected in 2004. This article describes the main
features and performances of the spectrometer in 2004; a short summary of the
2006 upgrade is also given.Comment: 84 papes, 74 figure
Muon Collider Forum report
A multi-TeV muon collider offers a spectacular opportunity in the direct exploration of the energy frontier. Offering a combination of unprecedented energy collisions in a comparatively clean leptonic environment, a high energy muon collider has the unique potential to provide both precision measurements and the highest energy reach in one machine that cannot be paralleled by any currently available technology. The topic generated a lot of excitement in Snowmass meetings and continues to attract a large number of supporters, including many from the early career community. In light of this very strong interest within the US particle physics community, Snowmass Energy, Theory and Accelerator Frontiers created a cross-frontier Muon Collider Forum in November of 2020. The Forum has been meeting on a monthly basis and organized several topical workshops dedicated to physics, accelerator technology, and detector R&D. Findings of the Forum are summarized in this report
HE-LHC: The High-Energy Large Hadron Collider â Future Circular Collider Conceptual Design Report Volume 4
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
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