Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Periodicities in the Daily Proton Fluxes from 2011 to 2019 Measured by the Alpha Magnetic Spectrometer on the International Space Station from 1 to 100 GV

We present the precision measurement of the daily proton fluxes in cosmic rays from May 20, 2011 to October 29, 2019 (a total of 2824 days or 114 Bartels rotations) in the rigidity interval from 1 to 100 GV based on 5.5×109 protons collected with the Alpha Magnetic Spectrometer aboard the International Space Station. The proton fluxes exhibit variations on multiple timescales. From 2014 to 2018, we observed recurrent flux variations with a period of 27 days. Shorter periods of 9 days and 13.5 days are observed in 2016. The strength of all three periodicities changes with time and rigidity. The rigidity dependence of the 27-day periodicity is different from the rigidity dependences of 9-day and 13.5-day periods. Unexpectedly, the strength of 9-day and 13.5-day periodicities increases with increasing rigidities up to ∼10 GV and ∼20 GV, respectively. Then the strength of the periodicities decreases with increasing rigidity up to 100 GV.</p

Precision Measurement of the Proton Flux in Primary Cosmic Rays from Rigidity 1 GV to 1.8 TV with the Alpha Magnetic Spectrometer on the International Space Station

A precise measurement of the proton flux in primary cosmic rays with rigidity (momentum/charge) from 1 GV to 1.8 TV is presented based on 300 million events. Knowledge of the rigidity dependence of the proton flux is important in understanding the origin, acceleration, and propagation of cosmic rays. We present the detailed variation with rigidity of the flux spectral index for the first time. The spectral index progressively hardens at high rigidities.</p

Si Core Level XANES of Organometallic Compounds Containing Si-Ge Bonds: Experimental and Theoretical Observations

Si K- and L2,3-edge XANES for Si(GeMe3)4 and Ge(SiMe3)4 are studied with the aid of MS-Xα calculation. Good agreement is found between the experiment and the theory. The lowest energy features are assigned to the transitions to mostly unoccupied orbitals with significant Si-Ge contribution

Power flow response based dynamic topology optimization of bi-material plate structures

Work on dynamic topology optimization of engineering structures for vibration suppression has mainly addressed the maximization of eigenfrequencies and gaps between consecutive eigenfrequencies of free vibration, minimization of the dynamic compliance subject to forced vibration, and minimization of the structural frequency response. A dynamic topology optimization method of bimaterial plate structures is presented based on power flow analysis. Topology optimization problems formulated directly with the design objective of minimizing the power flow response are dealt with. In comparison to the displacement or velocity response, the power flow response takes not only the amplitude of force and velocity into account, but also the phase relationship of the two vector quantities. The complex expression of power flow response is derived based on time-harmonic external mechanical loading and Rayleigh damping. The mathematical formulation of topology optimization is established based on power flow response and bimaterial solid isotropic material with penalization(SIMP) model. Computational optimization procedure is developed by using adjoint design sensitivity analysis and the method of moving asymptotes(MMA). Several numerical examples are presented for bimaterial plate structures with different loading frequencies, which verify the feasibility and effectiveness of this method. Additionally, optimum results between topological design of minimum power flow response and minimum dynamic compliance are compared, showing that the present method has strong adaptability for structural dynamic topology optimization problems. The proposed research provides a more accurate and effective approach for dynamic topology optimization of vibrating structures

Master Sintering Surface: A practical approach to its construction and utilization for Spark Plasma Sintering prediction

The sintering is a complex thermally activated process, thus any prediction of sintering behaviour is very welcome not only for industrial purposes. Presented paper shows the possibility of densification prediction based on concept of Master Sintering Surface (MSS) for pressure assisted Spark Plasma Sintering (SPS). User friendly software for evaluation of the MSS is presented. The concept was used for densification prediction of alumina ceramics sintered by SPS

Privacy preserving distributed DBSCAN clustering

DBSCAN is a well-known density-based clustering algorithm which offers advantages for finding clusters of arbitrary shapes compared to partitioning and hierarchical clustering methods. However, there are few papers studying the DBSCAN algorithm under the privacy preserving distributed data mining model, in which the data is distributed between two or more parties, and the parties cooperate to obtain the clustering results without revealing the data at the individual parties. In this paper, we address the problem of two-party privacy preserving DBSCAN clustering. We first propose two protocols for privacy preserving DBSCAN clustering over horizontally and vertically partitioned data respectively and then extend them to arbitrarily partitioned data. We also provide analysis of the performance and proof of privacy of our solution. Copyright 2012 ACM

Hydrogen absorption over Li-carbon complexes

Materials Research Society Symposium - Proceedings73041-46MRSP

A modified model to depict corrosion fatigue crack growth behavior for evaluating residual lives of aluminum alloys

A modified Trantina–Johnson model was developed to characterize corrosion fatigue crack growth behavior.Crack growth accumulative methodology based on the Willenborg–Chang rule was used to evaluate the residual lifetimes of corrosion fatigue crack growth. Fatigue crack growth tests were performed on 2524-T3 and 7050-T7451 aluminum alloys subjected to constant amplitude and random spectra loading under the environments of dry air and 3.5% NaCl sodium chloride solution, and the load–environment interaction and load interaction mechanisms were deduced from fractographic analysis. The developed models showed good correlation with experimental results

Nanosized nickel(or cobalt)/graphite composites for hydrogen storage

10.1021/jp020151jJournal of Physical Chemistry B106379507-9513JPCB