Inhibitors of Plant Peptide Deformylase for Use as Broad-Spectrum Herbicides and Methods for Identifying the Same

The invention relates to a method of identifying herbicides and to the use of inhibitors of plant peptide deformylase as broad spectrum herbicides

Inhibitors of Plant Peptide Deformylase for Use as Broad-Spectrum Herbicides and Methods for Identifying the Same

The invention relates to a method of identifying herbicides and to the use of inhibitors of plant peptide deformylase as broad spectrum herbicides

Raloxifene Prevents Skeletal Fragility in Adult Female Zucker Diabetic Sprague-Dawley Rats

This project was funded by a National Institutes of Health grant (AR047838) to DBB. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Inclusion of fat in the diet of primiparous sows: effect on the reproduction and litter performance

Inclusión de grasa en dieta decerdas primíparas: efecto sobre la reproducción y performance de la camada. Rev. Vet. 31:1, 61-65, 2020. La incorporación de grasa en la dieta podría mejorar la performance reproductivade cerdos en producción, principalmente durante las épocas más calurosas. Para comprobaresta hipótesis se evaluó el efecto de la inclusión de grasa a diferentes niveles sobrevariables reproductivas de cerdas primíparas en condiciones de subtrópico. Se utilizaron 3grupos de 6 animales (n=18) a los cuales se les suministraron 3 dietas con diferentes nivelesde inclusión de grasa (0%, 3,5% y 7%) desde el día 90 de gestación y durante la lactación(21 días). Las variables medidas fueron el número de lechones nacidos totales, nacidos vivos,muertos y peso de la camada al nacimiento y al destete, mientras que sobre las hembras seregistró el intervalo de retorno al celo. Se empleó un diseño completamente aleatorizadoy los datos fueron analizados mediante ANOVA con el software estadístico Infostat®. Nose encontraron diferencias al incorporar grasa, en relación al número de lechones nacidosvivos, muertos, totales, peso al nacimiento e intervalo-destete celo (p>0,05) mientras que elnúmero y peso de lechones al destete se vio influenciado de manera significativa (p0.05), whereas number and weight of pigs at weaning were increased by the addition of fat (p<0.05). In conclusion, fat inclusion resulted in an improved number and weight of piglets at weaning; however, weaning-to-estrus and variables at birth, were not affected.Fil: Rivas, F. R.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Chaco-Formosa. Estación Experimental Agropecuaria Las Breñas; ArgentinaFil: Gonzalez, M. A.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Chaco-Formosa. Estación Experimental Agropecuaria Las Breñas; ArgentinaFil: Matiller, Valentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; ArgentinaFil: Wiliams S.I.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentin

Altrenogest en cerdas primíparas: efecto sobre la aparición de celo y el tamaño de la camada.

El objetivo del presente trabajo fue evaluar el efecto del tratamiento con Altrenogest sobre la aparición de celo y el tamaño de la camada en cerdas primíparas. Setenta y dos hembras (Landrace x Yorkshire) con un peso promedio de 155 ± 5 kg se asignaron aleatoriamente en dos grupos: GT = grupo tratamiento (n=36), al cual se le aplicó un protocolo de sincronización de celo con Altrenogest durante 18 días (20 mg/día) sobre el alimento y GC = grupo control (n=36). Se registró la concentración de los celos del grupo tratamiento para medir la eficacia del progestágeno. El número de lechones nacidos vivos (LNV), muertos (LNM) y totales (LNT) fue registrado en ambos grupos para su comparación a través de un ANOVA, usando el software estadístico INFOSTAT. No se encontraron diferencias significativas para el número de LNM y LNT, mientras que el número de LNV se vio favorecido por el tratamiento (p<0.05). El 91% de los celos se concentraron entre el cuarto y quinto día de finalizado la administración del progestágeno. Podemos concluir que el tratamiento con Altrenogest en cerdas primíparas, mejoró el número de LNV a la vez que logra concentrar eficazmente la presentación de celos entre los días 4 y 6 post-tratamiento.Fil: Rivas, F... Instituto Nacional de Tecnología Agropecuaria; ArgentinaFil: González, M. A.. Instituto Nacional de Tecnología Agropecuaria; ArgentinaFil: Matiller, Valentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; ArgentinaFil: Wiliams, S. I... Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentin

Iron localization in Acarospora colonizing schist on Signy Island

A small, inconspicuous lichen, Acarospora cf. badiofusca, was discovered colonizing ironstained quartz mica schists on the lower slope of Manhaul Rock, a recently exposed nunatak on the McLeod Glacier, Signy Island, South Orkney Islands. Thallus colour ranged from rust on exposed rock surfaces to paler orange and green in shaded crevices. This study addressed the hypothesis that colour reflects element localization, and considered substance localization within lichen tissues and responses to stress. Electron microprobe analysis of specimens confirmed that Fe is localized principally in the outer rust-coloured part of the cortex, confirming that the colour reflects Fe localization. Oxalates, widely reported as contributing to tolerance mechanisms to environmental stress, were not detected using X-ray diffraction. The upper thallus surface consisted of sub-micron particulate phases containing Fe, Al and O, suggesting mixed oxide/ hydroxide phases are present and play a role in photoprotection

Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations.

Primary open angle glaucoma (POAG) is a complex disease with a major genetic contribution. Its prevalence varies greatly among ethnic groups, and is up to five times more frequent in black African populations compared to Europeans. So far, worldwide efforts to elucidate the genetic complexity of POAG in African populations has been limited. We conducted a genome-wide association study in 1113 POAG cases and 1826 controls from Tanzanian, South African and African American study samples. Apart from confirming evidence of association at TXNRD2 (rs16984299; OR[T] 1.20; P = 0.003), we found that a genetic risk score combining the effects of the 15 previously reported POAG loci was significantly associated with POAG in our samples (OR 1.56; 95% CI 1.26-1.93; P = 4.79 × 10-5). By genome-wide association testing we identified a novel candidate locus, rs141186647, harboring EXOC4 (OR[A] 0.48; P = 3.75 × 10-8), a gene transcribing a component of the exocyst complex involved in vesicle transport. The low frequency and high degree of genetic heterogeneity at this region hampered validation of this finding in predominantly West-African replication sets. Our results suggest that established genetic risk factors play a role in African POAG, however, they do not explain the higher disease load. The high heterogeneity within Africans remains a challenge to identify the genetic commonalities for POAG in this ethnicity, and demands studies of extremely large size

Geographic Association of Rickettsia felis-Infected Opossums with Human Murine Typhus, Texas

Application of molecular diagnostic technology in the past 10 years has resulted in the discovery of several new species of pathogenic rickettsiae, including Rickettsia felis. As more sequence information for rickettsial genes has become available, the data have been used to reclassify rickettsial species and to develop new diagnostic tools for analysis of mixed rickettsial pathogens. R. felis has been associated with opossums and their fleas in Texas and California. Because R. felis can cause human illness, we investigated the distribution dynamics in the murine typhus–endemic areas of these two states. The geographic distribution of R. felis-infected opossum populations in two well-established endemic foci overlaps with that of the reported human cases of murine typhus. Descriptive epidemiologic analysis of 1998 human cases in Corpus Christi, Texas, identified disease patterns consistent with studies done in the 1980s. A close geographic association of seropositive opossums (22% R. felis; 8% R. typhi) with human murine typhus cases was also observed