Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Diálogos y autorreferencia: procesos de cambio en psicoterapia desde la perspectiva de los actos de habla

This article is the result of a research in the frame of therapeutic process, based on Generic Change Indicators (Krause et al., 2006a). Along with Speech Acts Theory (Searle, 2002; Aristegui et al., 2005) it is proposed to use the Dialogical Self Model (Hermans, 1996; Valsiner, 2007) as a suitable device for characterizing and differentiating change and stagnant episodes, in therapeutic conversation. The analysis unit of study is constituted by extracts from two therapies of different theoretical orientation, with change and stagnant episodes previously identified through indicators derived from Subjective Change Theory. The study of change episodes indicates dialogical characteristics of the therapeutic conversation which suppose a selfreferential language game where therapist and consultant build a self-position description (subject) that commits with certain ilocutive intentions of action. The study and comparison of change episodes with stagnate episodes integrate in the discussion the distinctions of experience focus in first person and veritative symmetry applied to self referential�performativity and the notions selfdialogicality dialogicality according to the self-dialogical theory (Hermans, 1996; Valsiner, 2007; Anderson, 1999).El presente artículo es producto del estudio realizado en el marco de la investigación de proceso en psicoterapia basada en los Indicadores de Cambio Genéricos (Krause et al., 2006a). Junto con la Teoría de los Actos de Habla (Searle, 2002; Aristegui et al., 2005) se propone utilizar el modelo del self dialógico (Hermans, 1996; Valsiner, 2007) como dispositivo para caracterizar y diferenciar los episodios de cambio y estancamiento en la conversación terapéutica. La unidad de análisis del estudio está constituida por extractos de dos terapias de distintas orientaciones teóricas con episodios de cambio y estancamiento previamente identificados a través de los indicadores derivados a partir de la teoría del cambio subjetivo. El estudio de los episodios de cambio señala características dialógicas de la conversación terapéutica que suponen un juego de lenguaje autorreferencial en el cual terapeuta y consultante van construyendo una descripción de la posición del yo (sujeto) que se compromete con acciones intencionales ilocutivas. El estudio y comparación de los episodios de cambio con episodios de estancamiento integra en la discusión las distinciones foco de la experiencia en primera persona y simetría veritativa aplicadas a la noción de performatividad-autorreferencial y la nociones dialógicoautodialógico, según la teoría del self dialógico (Hermans, 1996; Valsiner, 2007; Anderson, 1999)

Indicadores genéricos de cambio en el proceso psicoterapéutico

Se estudiarion episodios de cambio en cuatro procesos de psicoterapia: psicoanalítica breve, psicoanalítico-cognitiva, familiar contruccionista-social e integrativa de grupo. Se aplicó metodología cualitativa, confirmatoria, a sesiones observadas y grabadas en audio y video. El instrumento de análisis fue una jerarquía de indicadores de cambio genéricos, comunes a diferentes modalidades psicoterapéuticas, cuya presencia y contenido se determinó a partir del consenso intersubjetivo del grupo de investigadores-psicoterapeutas de formaciones teóricas distintas. Los resultados muestran que es posible identificar los momentos de cambio; los contenidos del cambio son efectivamente genéricos; y, los indicadores de cambio identifican el momento de evolución de las terapias y la antigtiedad de los consultantes, pudiendo tener un valor predictivo que es de relevancia no sólo teórica, sino también práctica

Comparison of international normalized ratio audit parameters in patients enrolled in GARFIELD-AF and treated with vitamin K antagonists

Vitamin K antagonist (VKA) therapy for stroke prevention in atrial fibrillation (AF) requires monitoring of the international normalized ratio (INR). We evaluated the agreement between two INR audit parameters, frequency in range (FIR) and proportion of time in the therapeutic range (TTR), using data from a global population of patients with newly diagnosed non-valvular AF, the Global Anticoagulant Registry in the FIELD\u2013Atrial Fibrillation (GARFIELD-AF). Among 17\ua0168 patients with 1-year follow-up data available at the time of the analysis, 8445 received VKA therapy (\ub1antiplatelet therapy) at enrolment, and of these patients, 5066 with 653 INR readings and for whom both FIR and TTR could be calculated were included in the analysis. In total, 70\ua0905 INRs were analysed. At the patient level, TTR showed higher values than FIR (mean, 56\ub70% vs 49\ub78%; median, 59\ub77% vs 50\ub70%). Although patient-level FIR and TTR values were highly correlated (Pearson correlation coefficient [95% confidence interval; CI], 0\ub7860 [0\ub7852\u20130\ub7867]), estimates from individuals showed widespread disagreement and variability (Lin's concordance coefficient [95% CI], 0\ub7829 [0\ub7821\u20130\ub7837]). The difference between FIR and TTR explained 17\ub74% of the total variability of measurements. These results suggest that FIR and TTR are not equivalent and cannot be used interchangeably