Long-Duration Gamma-Ray Burst Host Galaxies in Emission and Absorption

The galaxy population hosting long-duration GRBs provides a means to constrain the progenitor and an opportunity to use these violent explosions to characterize the nature of the high-redshift universe. Studies of GRB host galaxies in emission reveal a population of star-forming galaxies with great diversity, spanning a wide range of masses, metallicities, and redshifts. However, as a population GRB hosts are significantly less massive and poorer in metals than the hosts of other core-collapse transients, suggesting that GRB production is only efficient at metallicities significantly below Solar. GRBs may also prefer compact galaxies, and dense and/or central regions of galaxies, more than other types of core-collapse explosion. Meanwhile, studies of hosts in absorption against the luminous GRB optical afterglow provide a unique means of unveiling properties of the ISM in even the faintest and most distant galaxies; these observations are helping to constrain the chemical evolution of galaxies and the properties of interstellar dust out to very high redshifts. New ground- and space-based instrumentation, and the accumulation of larger and more carefully-selected samples, are continually enhancing our view of the GRB host population. © 2016, Springer Science+Business Media Dordrecht

The chemical enrichment of long gamma-ray bursts nurseries up to z = 2

Aims. We investigate the existence of a metallicity threshold for the production of long gamma-ray bursts (LGRBs). Methods. We used the host galaxies of the Swift/BAT6 sample of LGRBs. We considered the stellar mass, star formation rate (SFR), and metallicity determined from the host galaxy photometry and spectroscopy up to z = 2 and used them to compare the distribution of host galaxies to that of field galaxies in the mass-metallicity and fundamental metallicity relation plane. Results. We find that although LGRBs also form in galaxies with relatively large stellar masses, the large majority of host galaxies have metallicities below log(O=H) ∼ 8:6. The extension to z = 2 results in a good sampling of stellar masses also above Log(M=M) ∼ 9:5 and provides evidence that LGRB host galaxies do not follow the fundamental metallicity relation. As shown by the comparison with dedicated numerical simulations of LGRB host galaxy population, these results are naturally explained by the existence of a mild (∼0:7 Z) threshold for the LGRB formation. The present statistics does not allow us to discriminate between different shapes of the metallicity cutoff, but the relatively high metallicity threshold found in this work is somewhat in disagreement to most of the standard single-star models for LGRB progenitors. © ESO, 201

Mass and metallicity scaling relations of high-redshift star-forming galaxies selected by GRBs

We present a comprehensive study of the relations between gas kinematics, metallicity and stellar mass in a sample of 82 gamma-ray burst (GRB)-selected galaxies using absorption and emission methods. We find the velocity widths of both emission and absorption profiles to be a proxy of stellar mass. We also investigate the velocity–metallicity correlation and its evolution with redshift. Using 33 GRB hosts with measured stellar mass and metallicity, we study the mass–metallicity relation for GRB host galaxies in a stellar mass range of 108.2–1011.1 M⊙ and a redshift range of z ∼ 0.3–3.4. The GRB-selected galaxies appear to track the mass–metallicity relation of star-forming galaxies but with an offset of 0.15 towards lower metallicities. This offset is comparable with the average error bar on the metallicity measurements of the GRB sample and also the scatter on the mass–metallicity relation of the general population. It is hard to decide whether this relatively small offset is due to systematic effects or the intrinsic nature of GRB hosts. We also investigate the possibility of using absorption-line metallicity measurements of GRB hosts to study the mass–metallicity relation at high redshifts. Our analysis shows that the metallicity measurements from absorption methods can significantly differ from emission metallicities and assuming identical measurements from the two methods may result in erroneous conclusions

Spectrophotometric analysis of gamma-ray burst afterglow extinction curves with X-shooter

In this work we use gamma-ray burst (GRB) afterglow spectra observed with the VLT/X-shooter spectrograph to measure rest-frame extinction in GRB lines-of-sight by modeling the broadband near-infrared (NIR) to X-ray afterglow spectral energy distributions (SEDs). Our sample consists of nine Swift GRBs, eight of them belonging to the long-duration and one to the short-duration class. Dust is modeled using the average extinction curves of the Milky Way and the two Magellanic Clouds. We derive the rest-frame extinction of the entire sample, which fall in the range $0 \lesssim {\it A}_{\rm V} \lesssim 1.2$. Moreover, the SMC extinction curve is the preferred extinction curve template for the majority of our sample, a result which is in agreement with those commonly observed in GRB lines-of-sights. In one analysed case (GRB 120119A), the common extinction curve templates fail to reproduce the observed extinction. To illustrate the advantage of using the high-quality X-shooter afterglow SEDs over the photometric SEDs, we repeat the modeling using the broadband SEDs with the NIR-to-UV photometric measurements instead of the spectra. The main result is that the spectroscopic data, thanks to a combination of excellent resolution and coverage of the blue part of the SED, are more successful in constraining the extinction curves and therefore the dust properties in GRB hosts with respect to photometric measurements. In all cases but one the extinction curve of one template is preferred over the others. We show that the modeled values of the extinction and the spectral slope, obtained through spectroscopic and photometric SED analysis, can differ significantly for individual events. Finally we stress that, regardless of the resolution of the optical-to-NIR data, the SED modeling gives reliable results only when the fit is performed on a SED covering a broader spectral region

The MUSE view of the host galaxy of GRB 100316D

The low distance, $z=0.0591$, of GRB 100316D and its association with SN 2010bh represent two important motivations for studying this host galaxy and the GRB's immediate environment with the Integral-Field Spectrographs like VLT/MUSE. Its large field-of-view allows us to create 2D maps of gas metallicity, ionization level, and the star-formation rate distribution maps, as well as to investigate the presence of possible host companions. The host is a late-type dwarf irregular galaxy with multiple star-forming regions and an extended central region with signatures of on-going shock interactions. The GRB site is characterized by the lowest metallicity, the highest star-formation rate and the youngest ($\sim$ 20-30 Myr) stellar population in the galaxy, which suggest a GRB progenitor stellar population with masses up to 20 -- 40 $M_{\odot}$. We note that the GRB site has an offset of $\sim$660pc from the most luminous SF region in the host. The observed SF activity in this galaxy may have been triggered by a relatively recent gravitational encounter between the host and a small undetected ($L_{H\alpha} \leq 10^{36}$ erg/s) companion

GRB 190114C in the nuclear region of an interacting galaxy A detailed host analysis using ALMA, the HST, and the VLT

Context. For the first time, very high energy emission up to the TeV range has been reported for a gamma-ray burst (GRB). It is still unclear whether the environmental properties of GRB 190114C might have contributed to the production of these very high energy photons, or if it is solely related to the released GRB emission. Aims. The relatively low redshift of the GRB (z = 0.425) allows us to study the host galaxy of this event in detail, and to potentially identify idiosyncrasies that could point to progenitor characteristics or environmental properties that might be responsible for this unique event. Methods. We used ultraviolet, optical, infrared, and submillimetre imaging and spectroscopy obtained with the HST, the VLT, and ALMA to obtain an extensive dataset on which the analysis of the host galaxy is based. Results. The host system is composed of a close pair of interacting galaxies (Δv = 50 km s−1), both of which are well detected by ALMA in CO(3-2). The GRB occurred within the nuclear region (∼170 pc from the centre) of the less massive but more star-forming galaxy of the pair. The host is more massive (log(M/M⊙) = 9.3) than average GRB hosts at this redshift, and the location of the GRB is rather unique. The higher star formation rate was probably triggered by tidal interactions between the two galaxies. Our ALMA observations indicate that both host galaxy and companion have a high molecular gas fraction, as has been observed before in interacting galaxy pairs. Conclusions. The location of the GRB within the core of an interacting galaxy with an extinguished line of sight is indicative of a denser environment than typically observed for GRBs and could have been crucial for the generation of the very high energy photons that were observed

Polymorphisms in the Mitochondrial Ribosome Recycling Factor EF-G2mt/MEF2 Compromise Cell Respiratory Function and Increase Atorvastatin Toxicity

Mitochondrial translation, essential for synthesis of the electron transport chain complexes in the mitochondria, is governed by nuclear encoded genes. Polymorphisms within these genes are increasingly being implicated in disease and may also trigger adverse drug reactions. Statins, a class of HMG-CoA reductase inhibitors used to treat hypercholesterolemia, are among the most widely prescribed drugs in the world. However, a significant proportion of users suffer side effects of varying severity that commonly affect skeletal muscle. The mitochondria are one of the molecular targets of statins, and these drugs have been known to uncover otherwise silent mitochondrial mutations. Based on yeast genetic studies, we identify the mitochondrial translation factor MEF2 as a mediator of atorvastatin toxicity. The human ortholog of MEF2 is the Elongation Factor Gene (EF-G) 2, which has previously been shown to play a specific role in mitochondrial ribosome recycling. Using small interfering RNA (siRNA) silencing of expression in human cell lines, we demonstrate that the EF-G2mt gene is required for cell growth on galactose medium, signifying an essential role for this gene in aerobic respiration. Furthermore, EF-G2mt silenced cell lines have increased susceptibility to cell death in the presence of atorvastatin. Using yeast as a model, conserved amino acid variants, which arise from non-synonymous single nucleotide polymorphisms (SNPs) in the EF-G2mt gene, were generated in the yeast MEF2 gene. Although these mutations do not produce an obvious growth phenotype, three mutations reveal an atorvastatin-sensitive phenotype and further analysis uncovers a decreased respiratory capacity. These findings constitute the first reported phenotype associated with SNPs in the EF-G2mt gene and implicate the human EF-G2mt gene as a pharmacogenetic candidate gene for statin toxicity in humans

Integrated Analysis of Residue Coevolution and Protein Structure in ABC Transporters

Intraprotein side chain contacts can couple the evolutionary process of amino acid substitution at one position to that at another. This coupling, known as residue coevolution, may vary in strength. Conserved contacts thus not only define 3-dimensional protein structure, but also indicate which residue-residue interactions are crucial to a protein’s function. Therefore, prediction of strongly coevolving residue-pairs helps clarify molecular mechanisms underlying function. Previously, various coevolution detectors have been employed separately to predict these pairs purely from multiple sequence alignments, while disregarding available structural information. This study introduces an integrative framework that improves the accuracy of such predictions, relative to previous approaches, by combining multiple coevolution detectors and incorporating structural contact information. This framework is applied to the ABC-B and ABC-C transporter families, which include the drug exporter P-glycoprotein involved in multidrug resistance of cancer cells, as well as the CFTR chloride channel linked to cystic fibrosis disease. The predicted coevolving pairs are further analyzed based on conformational changes inferred from outward- and inward-facing transporter structures. The analysis suggests that some pairs coevolved to directly regulate conformational changes of the alternating-access transport mechanism, while others to stabilize rigid-body-like components of the protein structure. Moreover, some identified pairs correspond to residues previously implicated in cystic fibrosis

Transitional events in the spectrophotometric regime between stripped envelope and superluminous supernovae

The division between stripped-envelope supernovae (SE-SNe) and superluminous supernovae (SLSNe) is not well-defined in either photometric or spectroscopic space. While a sharp luminosity threshold has been suggested, there remains an increasing number of transitional objects that reach this threshold without the spectroscopic signatures common to SLSNe. In this work, we present data and analysis on four SNe transitional between SE-SNe and SLSNe; the He-poor SNe 2019dwa and 2019cri, and the He-rich SNe 2019hge and 2019unb. Each object displays long-lived and variable photometric evolution with luminosities around the SLSN threshold of M-r < -19.8 mag. Spectroscopically however, these objects are similar to SE-SNe, with line velocities lower than either SE-SNe and SLSNe, and thus represent an interesting case of rare transitional events

Transmission of Mitochondrial DNA Diseases and Ways to Prevent Them

Recent reports of strong selection of mitochondrial DNA (mtDNA) during transmission in animal models of mtDNA disease, and of nuclear transfer in both animal models and humans, have important scientific implications. These are directly applicable to the genetic management of mtDNA disease. The risk that a mitochondrial disorder will be transmitted is difficult to estimate due to heteroplasmy—the existence of normal and mutant mtDNA in the same individual, tissue, or cell. In addition, the mtDNA bottleneck during oogenesis frequently results in dramatic and unpredictable inter-generational fluctuations in the proportions of mutant and wild-type mtDNA. Pre-implantation genetic diagnosis (PGD) for mtDNA disease enables embryos produced by in vitro fertilization (IVF) to be screened for mtDNA mutations. Embryos determined to be at low risk (i.e., those having low mutant mtDNA load) can be preferentially transferred to the uterus with the aim of initiating unaffected pregnancies. New evidence that some types of deleterious mtDNA mutations are eliminated within a few generations suggests that women undergoing PGD have a reasonable chance of generating embryos with a lower mutant load than their own. While nuclear transfer may become an alternative approach in future, there might be more difficulties, ethical as well as technical. This Review outlines the implications of recent advances for genetic management of these potentially devastating disorders