Recuérdame: Aplicación de apoyo para el tratamiento de personas con problema de memoria mediante terapias basadas en reminiscencia

Este proyecto presenta la creación de una aplicación que facilite a los terapeutas la realización de terapias basadas en reminiscencia para tratar a pacientes con alzheimer, haciéndolas más ágiles y rápidas. Para la realización de la aplicación hemos usado un diseño centrado en el usuario contando durante todo el desarrollo con usuarios finales que nos han ido proporcionando sus expectativas y requisitos. Para obtener los requisitos de la aplicación nos reunimos con dos terapeutas y nos encargamos de hacerles preguntas que nos permitieran saber qué es lo que necesitaban en la aplicación. Después realizamos un análisis de estos datos para conseguir los requisitos. Tras conseguir todos los requisitos, cada uno de los autores de este proyecto, realizó un prototipo de diseño de la aplicación, para realizar una iteración de diseño competitivo. El resultado de esta iteración fue evaluado por un usuario final de la aplicación. La aplicación creada es una aplicación web responsive, con una estructura Modelo Vista Controlador creada mediante lenguajes como HTML, CSS, PHP, JavaScript. Finalmente nos reunimos con los usuarios finales para realizar la evaluación final de aplicación. Los resultados de esta evaluación fueron bastantes positivos ya que, aunque a la aplicación le queda algunos detalles que reto car, los expertos se mostraron bastante contentos con el resultado final. El resultado del cuestionario SUS rellenado por los terapeutas le dio a nuestra aplicación una puntuación de 85, lo que indica que la aplicación tiene una usabilidad aceptable

Transfer-learning-based intrusion detection framework in IoT networks

Cyberattacks in the Internet of Things (IoT) are growing exponentially, especially zero-day attacks mostly driven by security weaknesses on IoT networks. Traditional intrusion detection systems (IDSs) adopted machine learning (ML), especially deep Learning (DL), to improve the detection of cyberattacks. DL-based IDSs require balanced datasets with large amounts of labeled data; however, there is a lack of such large collections in IoT networks. This paper proposes an efficient intrusion detection framework based on transfer learning (TL), knowledge transfer, and model refinement, for the effective detection of zero-day attacks. The framework is tailored to 5G IoT scenarios with unbalanced and scarce labeled datasets. The TL model is based on convolutional neural networks (CNNs). The framework was evaluated to detect a wide range of zero-day attacks. To this end, three specialized datasets were created. Experimental results show that the proposed TL-based framework achieves high accuracy and low false prediction rate (FPR). The proposed solution has better detection rates for the different families of known and zero-day attacks than any previous DL-based IDS. These results demonstrate that TL is effective in the detection of cyberattacks in IoT environments.This work was supported partially by the Generalitat de Catalunya under Grant 2017SGR962, and partially by the DRAC Project under Grant 001-P-001723.Peer ReviewedPostprint (published version

A cost-efficient QoS-aware analytical model of future software content delivery networks

Freelance, part-time, work-at-home, and other flexible jobs are changing the concept of workplace, and bringing information and content exchange problems to companies. Geographically spread corporations may use remote distribution of software and data to attend employees' demands, by exploiting emerging delivery technologies. In this context, cost-efficient software distribution is crucial to allow business evolution and make IT infrastructures more agile. On the other hand, container based virtualization technology is shaping the new trends of software deployment and infrastructure design. We envision current and future enterprise IT management trends evolving towards container based software delivery over Hybrid CDNs. This paper presents a novel cost-efficient QoS aware analytical model and a Hybrid CDN-P2P architecture for enterprise software distribution. The model would allow delivery cost minimization for a wide range of companies, from big multinationals to SMEs, using CDN-P2P distribution under various industrial hypothetical scenarios. Model constraints guarantee acceptable deployment times and keep interchanged content amounts below the bandwidth and storage network limits in our scenarios. Indeed, key model parameters account for network bandwidth, storage limits and rental prices, which are empirically determined from their offered values by the commercial delivery networks KeyCDN, MaxCDN, CDN77 and BunnyCDN. This preliminary study indicates that MaxCDN offers the best cost-QoS trade-off. The model is implemented in the network simulation tool PeerSim, and then applied to diverse testing scenarios by varying company types, number and profile (either, technical or administrative) of employees and the number and size of content requests. Hybrid simulation results show overall economic savings between 5\% and 20\%, compared to just hiring resources from a commercial CDN, while guaranteeing satisfactory QoS levels in terms of deployment times and number of served requests.This work was partially supported by Generalitat de Catalunya under the SGR Program (2017-SGR-962) and the RIS3CAT DRAC Project (001-P-001723). We have also received funding from Ministry of Science and Innovation (Spain) under the project EQC2019-005653-P.Peer ReviewedPostprint (author's final draft

Hyperoxygenated fatty acid effectiveness in the prevention of the vascular ulcers

Objetivos: conocer la eficacia de los ácidos grasos hiperoxigenados (AGHO) en la prevención de las úlceras vasculares. Determinar el nivel de evidencia existente sobre el uso de ácidos grasos hiperoxigenados en la prevención de las úlceras vasculares. Material y método: se realizó una búsqueda bibliográfica en la The Cochrane Library, The Joanna Briggs Institute, PubMed-Medline y CUIDEN. Para su evaluación se han seguido las recomendaciones del sistema GRADE para la valoración de la evidencia y la fuerza de las recomendaciones. Resultados: en The Cochrane Library y en The Joanna Briggs Institute no aparece ningún documento que haga referencia a los AGHO. En el resto de bases de datos encontramos estudios observacionales que hacen referencia a las úlceras vasculares y AGHO. Conclusiones: aun no disponiendo de ensayos clínicos que evidencien su uso, se han venido utilizando durante los últimos años, con resultados satisfactorios, en el cuidado de la piel de las personas con alteraciones vasculares en los miembros inferiores. De acuerdo con la clasificación GRADE, todos los estudios arrojan una calidad de evidencia baja, por lo cual estimamos necesario la puesta en marcha de investigaciones que aporten mayor evidencia científica.Objectives: to determine the effectiveness of hyper-oxygenated fatty acids in the prevention of vascular ulcers. Determine the level of existing evidence the use of hyper-oxygenated fatty acids in the prevention of vascular ulcers. Material and Method: we performed a literature search of Cochrane Library, The Joanna Briggs Institute, PubMed, Medline and CUIDEN. For the evaluation, have followed the recommendations of the GRADE system for assessing evidence and strength of recommendations. Results: The Cochrane Library and The Joanna Briggs Institute does not see any document referring to AGHO. In all other databases are observational studies that relate to vascular ulcers and AGHO. Conclusions: although not having clinical trials demonstrating their use, in recent years, have been used successfully in skin care for people with lower limb vascular disorders. According to the classification GRADE, all studies show a low-quality evidence, which we consider necessary for the implementation of most scientific research

Efectividad de los ácidos grasos hiperoxigenados en la prevención de las úlceras vasculares: Una revisión sistemática Hyperoxygenated fatty acid effectiveness in the prevention of the vascular ulcers

Objetivos: conocer la eficacia de los ácidos grasos hiperoxigenados (AGHO) en la prevención de las úlceras vasculares. Determinar el nivel de evidencia existente sobre el uso de ácidos grasos hiperoxigenados en la prevención de las úlceras vasculares. Material y método: se realizó una búsqueda bibliográfica en la The Cochrane Library, The Joanna Briggs Institute, PubMed-Medline y CUIDEN. Para su evaluación se han seguido las recomendaciones del sistema GRADE para la valoraciún de la evidencia y la fuerza de las recomendaciones. Resultados: en The Cochrane Library y en The Joanna Briggs Institute no aparece ningún documento que haga referencia a los AGHO. En el resto de bases de datos encontramos estudios observacionales que hacen referencia a las úlceras vasculares y AGHO. Conclusiones: aun no disponiendo de ensayos clínicos que evidencien su uso, se han venido utilizando durante los últimos años, con resultados satisfactorios, en el cuidado de la piel de las personas con alteraciones vasculares en los miembros inferiores. De acuerdo con la clasificación GRADE, todos los estudios arrojan una calidad de evidencia baja, por lo cual estimamos necesario la puesta en marcha de investigaciones que aporten mayor evidencia científica.<br>Objectives: to determine the effectiveness of hyper-oxygenated fatty acids in the prevention of vascular ulcers. Determine the level of existing evidence the use of hyper-oxygenated fatty acids in the prevention of vascular ulcers. Material and Method: we performed a literature search of Cochrane Library, The Joanna Briggs Institute, PubMed, Medline and CUIDEN. For the evaluation, have followed the recommendations of the GRADE system for assessing evidence and strength of recommendations. Results: The Cochrane Library and The Joanna Briggs Institute does not see any document referring to AGHO. In all other databases are observational studies that relate to vascular ulcers and AGHO. Conclusions: although not having clinical trials demonstrating their use, in recent years, have been used successfully in skin care for people with lower limb vascular disorders. According to the classification GRADE, all studies show a low-quality evidence, which we consider necessary for the implementation of most scientific research

Efectividad de los ácidos grasos hiperoxigenados en la prevención de las úlceras vasculares: Una revisión sistemática

Objetivos: conocer la eficacia de los ácidos grasos hiperoxigenados (AGHO) en la prevención de las úlceras vasculares. Determinar el nivel de evidencia existente sobre el uso de ácidos grasos hiperoxigenados en la prevención de las úlceras vasculares. Material y método: se realizó una búsqueda bibliográfica en la The Cochrane Library, The Joanna Briggs Institute, PubMed-Medline y CUIDEN. Para su evaluación se han seguido las recomendaciones del sistema GRADE para la valoraciún de la evidencia y la fuerza de las recomendaciones. Resultados: en The Cochrane Library y en The Joanna Briggs Institute no aparece ningún documento que haga referencia a los AGHO. En el resto de bases de datos encontramos estudios observacionales que hacen referencia a las úlceras vasculares y AGHO. Conclusiones: aun no disponiendo de ensayos clínicos que evidencien su uso, se han venido utilizando durante los últimos años, con resultados satisfactorios, en el cuidado de la piel de las personas con alteraciones vasculares en los miembros inferiores. De acuerdo con la clasificación GRADE, todos los estudios arrojan una calidad de evidencia baja, por lo cual estimamos necesario la puesta en marcha de investigaciones que aporten mayor evidencia científica

Platform-agnostic steal-time measurement in a guest operating system

Steal time is a key performance metric for applications executed in a virtualized environment. Steal time measures the amount of time the processor is preempted by code outside the virtualized environment. This, in turn, allows to compute accurately the execution time of an application inside a virtual machine (i.e. it eliminates the time the virtual machine is suspended). Unfortunately, this metric is only available in particular scenarios in which the host and the guest OS are tightly coupled. Typical examples are the Xen hypervisor and Linux-based guest OSes. In contrast, in scenarios where the steal time is not available inside the virtualized environment, performance measurements are, most often, incorrect. In this paper, we introduce a novel and platform agnostic approach to calculate this steal time within the virtualized environment and without the cooperation of the host OS. The theoretical execution time of a deterministic microbenchmark is compared to its execution time in a virtualized environment. When factoring in the virtual machine load, this solution -as simple as it is- can compute the steal time. The preliminary results show that we are able to compute the load of the physical processor within the virtual machine with high accuracy.Preprin

A cost‐efficient QoS‐aware analytical model of future software content delivery networks

Freelance, part-time, work-at-home, and other flexible jobs are changing the concept of workplace, and bringing information and content exchange problems to companies. Geographically spread corporations may use remote distribution of software and data to attend employees' demands, by exploiting emerging delivery technologies. In this context, cost-efficient software distribution is crucial to allow business evolution and make IT infrastructures more agile. On the other hand, container based virtualization technology is shaping the new trends of software deployment and infrastructure design. We envision current and future enterprise IT management trends evolving towards container based software delivery over Hybrid CDNs. This paper presents a novel cost-efficient QoS aware analytical model and a Hybrid CDN-P2P architecture for enterprise software distribution. The model would allow delivery cost minimization for a wide range of companies, from big multinationals to SMEs, using CDN-P2P distribution under various industrial hypothetical scenarios. Model constraints guarantee acceptable deployment times and keep interchanged content amounts below the bandwidth and storage network limits in our scenarios. Indeed, key model parameters account for network bandwidth, storage limits and rental prices, which are empirically determined from their offered values by the commercial delivery networks KeyCDN, MaxCDN, CDN77 and BunnyCDN. This preliminary study indicates that MaxCDN offers the best cost-QoS trade-off. The model is implemented in the network simulation tool PeerSim, and then applied to diverse testing scenarios by varying company types, number and profile (either, technical or administrative) of employees and the number and size of content requests. Hybrid simulation results show overall economic savings between 5\% and 20\%, compared to just hiring resources from a commercial CDN, while guaranteeing satisfactory QoS levels in terms of deployment times and number of served requests.This work was partially supported by Generalitat de Catalunya under the SGR Program (2017-SGR-962) and the RIS3CAT DRAC Project (001-P-001723). We have also received funding from Ministry of Science and Innovation (Spain) under the project EQC2019-005653-P.Peer ReviewedPostprint (author's final draft

Searching for genetic modulators of the phenotypic heterogeneity in Brugada syndrome.

In Brugada syndrome, even within the same family where all affected individuals share the same mutation, phenotypic variation is prominent, with variable penetrance and expressivity, presenting different degrees of involvement. It is difficult to establish a direct correlation between genotype and phenotype to predict prognosis in complications and risk of sudden death. The factors that modulate this inter- and intra-familial phenotypic variability remain to be determined. With the intention of testing whether other genetic factors, in addition to the causal mutation in SCN5A, may have a modulating effect on the Brugada phenotype and the risk of sudden death, we have studied 8 families with a causal variant in SCN5A with at least two affected individuals, one of whom has suffered cardiac arrest or sudden death. Whole exome sequencing was performed looking for additional variants that modify the phenotype and allow us to predict a better or worse prognosis for the evolution of the disease. The results did not show any clear genetic modifier; nevertheless, highlight the possible implication of the cholesterol and fibrosis pathways, as well as the circadian rhythm, as possible modulators of Brugada syndrome phenotype

Population prevalence and control of cardiovascular risk factors: What electronic medical records tell us

Objective: To analyze the prevalence, control, and management of hypertension, hypercholesterolemia, and diabetes mellitus type 2 (DM2). Design: Cross-sectional analysis of all individuals attended in the Catalan primary care centers between 2006 and 2009. Location: History of cardiovascular diseases, diagnosis and treatment of hypertension, hypercholesterolemia, DM2, lipid profile, glycemia and blood pressure data were extracted from electronic medical records. Age-standardized prevalence and levels of management and control were estimated. Participants: Individuals aged 35–74 years using primary care databases. Main measures: A total of 2,174,515 individuals were included (mean age 52 years [SD 11], 47% men). Results: Hypertension was the most prevalent cardiovascular risk factor (39% in women, 41% in men) followed by hypercholesterolemia (38% and 40%) and DM2 (12% and 16%), respectively. Diuretics and angiotensin-converting enzyme inhibitors were most often prescribed for hypertension control (<140/90 mmHg, achieved in 68% of men and 60% of women treated). Hypercholesterolemia was controlled (low-density lipoprotein cholesterol <130 mg/dl) in just 31% of men and 26% of women with no history of cardiovascular disease, despite lipid-lowering treatment, primarily (90%) with statins. The percentage of women and men with DM2 and with glycated hemoglobin <7% was 64.7% and 59.2%, respectively; treatment was predominantly with oral hypoglycemic agents alone (70%), or combined with insulin (15%). Conclusions: Hypertension was the most prevalent cardiovascular risk factor in the Catalan population attended at primary care centers. About two thirds of individuals with hypertension or DM2 were adequately controlled; hypercholesterolemia control was particularly low